Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Inward rectifier potassium channel 2 (Inward rectifier K( ) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)

 KCNJ2_RABIT             Reviewed;         427 AA.
P49656;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
30-AUG-2017, entry version 123.
RecName: Full=Inward rectifier potassium channel 2;
AltName: Full=Inward rectifier K(+) channel Kir2.1;
Short=IRK-1;
AltName: Full=Potassium channel, inwardly rectifying subfamily J member 2;
Name=KCNJ2; Synonyms=IRK1;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=New Zealand white; TISSUE=Heart;
PubMed=8307148; DOI=10.1016/0014-5793(94)80126-6;
Ishii K., Yamagishi T., Taira N.;
"Cloning and functional expression of a cardiac inward rectifier K+
channel.";
FEBS Lett. 338:107-111(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=New Zealand white; TISSUE=Lens epithelium;
PubMed=9533862; DOI=10.1006/exer.1997.0432;
Rae J.L., Shepard A.R.;
"Inwardly rectifying potassium channels in lens epithelium are from
the IRK1 (Kir 2.1) family.";
Exp. Eye Res. 66:347-359(1998).
-!- FUNCTION: Probably participates in establishing action potential
waveform and excitability of neuronal and muscle tissues. Inward
rectifier potassium channels are characterized by a greater
tendency to allow potassium to flow into the cell rather than out
of it. Their voltage dependence is regulated by the concentration
of extracellular potassium; as external potassium is raised, the
voltage range of the channel opening shifts to more positive
voltages. The inward rectification is mainly due to the blockage
of outward current by internal magnesium. Can be blocked by
extracellular barium and cesium.
-!- SUBUNIT: Homomultimeric and heteromultimeric association with
KCNJ4/Kir2.3. Association, via its PDZ-recognition domain, with
LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 plays a key role in its
localization and trafficking (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Membrane; Lipid-anchor {ECO:0000250|UniProtKB:P63252}.
-!- TISSUE SPECIFICITY: Highly expressed in the ventricle and skeletal
muscle, moderately in cerebrum and cerebellum. Only low levels are
detected in kidney or lung.
-!- PTM: S-nitrosylation increases the open probability and inward
rectifying currents. {ECO:0000250}.
-!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
(TC 1.A.2.1) family. KCNJ2 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; D21057; BAA04636.1; -; mRNA.
EMBL; AF021138; AAB88796.1; -; mRNA.
PIR; S41087; S41087.
RefSeq; NP_001075667.1; NM_001082198.1.
RefSeq; XP_017204295.1; XM_017348806.1.
RefSeq; XP_017204296.1; XM_017348807.1.
UniGene; Ocu.2469; -.
ProteinModelPortal; P49656; -.
SMR; P49656; -.
STRING; 9986.ENSOCUP00000008971; -.
Ensembl; ENSOCUT00000010415; ENSOCUP00000008971; ENSOCUG00000010416.
GeneID; 100008987; -.
KEGG; ocu:100008987; -.
CTD; 3759; -.
eggNOG; KOG3827; Eukaryota.
eggNOG; ENOG410XQ62; LUCA.
GeneTree; ENSGT00760000118842; -.
HOGENOM; HOG000237325; -.
HOVERGEN; HBG006178; -.
InParanoid; P49656; -.
KO; K04996; -.
OMA; VFSHNAT; -.
OrthoDB; EOG091G08HC; -.
TreeFam; TF313676; -.
Proteomes; UP000001811; Chromosome 19.
Bgee; ENSOCUG00000010416; -.
GO; GO:0031224; C:intrinsic component of membrane; ISS:UniProtKB.
GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0005242; F:inward rectifier potassium channel activity; ISS:UniProtKB.
GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
GO; GO:0086008; F:voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; IEA:Ensembl.
GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
GO; GO:0015693; P:magnesium ion transport; IEA:Ensembl.
GO; GO:0010107; P:potassium ion import; IEA:Ensembl.
GO; GO:0006813; P:potassium ion transport; ISS:UniProtKB.
GO; GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
GO; GO:0060306; P:regulation of membrane repolarization; IEA:Ensembl.
GO; GO:0014861; P:regulation of skeletal muscle contraction via regulation of action potential; IEA:Ensembl.
GO; GO:0055119; P:relaxation of cardiac muscle; IEA:Ensembl.
GO; GO:0090076; P:relaxation of skeletal muscle; IEA:Ensembl.
Gene3D; 2.60.40.1400; -; 1.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR016449; K_chnl_inward-rec_Kir.
InterPro; IPR003271; K_chnl_inward-rec_Kir2.1.
InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
InterPro; IPR013673; K_chnl_inward-rec_Kir_N.
PANTHER; PTHR11767; PTHR11767; 1.
PANTHER; PTHR11767:SF67; PTHR11767:SF67; 1.
Pfam; PF01007; IRK; 1.
Pfam; PF08466; IRK_N; 1.
PIRSF; PIRSF005465; GIRK_kir; 1.
PRINTS; PR01324; KIR21CHANNEL.
PRINTS; PR01320; KIRCHANNEL.
SUPFAM; SSF81296; SSF81296; 1.
2: Evidence at transcript level;
Complete proteome; Ion channel; Ion transport; Lipoprotein; Membrane;
Myristate; Potassium; Potassium transport; Reference proteome;
S-nitrosylation; Transmembrane; Transmembrane helix; Transport;
Voltage-gated channel.
INIT_MET 1 1 Removed.
CHAIN 2 427 Inward rectifier potassium channel 2.
/FTId=PRO_0000154927.
TOPO_DOM 2 81 Cytoplasmic. {ECO:0000250}.
TRANSMEM 82 106 Helical; Name=M1. {ECO:0000250}.
TOPO_DOM 107 128 Extracellular. {ECO:0000250}.
INTRAMEM 129 140 Helical; Pore-forming; Name=H5.
{ECO:0000250}.
INTRAMEM 141 147 Pore-forming. {ECO:0000250}.
TOPO_DOM 148 156 Extracellular. {ECO:0000250}.
TRANSMEM 157 178 Helical; Name=M2. {ECO:0000250}.
TOPO_DOM 179 427 Cytoplasmic. {ECO:0000250}.
MOTIF 142 147 Selectivity filter. {ECO:0000250}.
MOTIF 425 427 PDZ-binding. {ECO:0000255}.
SITE 172 172 Role in the control of polyamine-mediated
channel gating and in the blocking by
intracellular magnesium. {ECO:0000250}.
MOD_RES 76 76 S-nitrosocysteine.
{ECO:0000250|UniProtKB:P63252}.
LIPID 2 2 N-myristoyl glycine.
{ECO:0000250|UniProtKB:P63252}.
SEQUENCE 427 AA; 48350 MW; 1A57A8BB19B8A4A3 CRC64;
MGSVRTNRYS IVSSEEDGMK LATMAVANGF GNGKSKVHTR QQCRSRFVKK DGHCNVQFIN
VGEKGQRYLA DIFTTCVDIR WRWMLVIFCL AFVLSWLFFG CVFWLIALLH GDLDASRESK
ACVSEVNSFT AAFLFSIETQ TTIGYGFRCV TDECPVAVFM VVFQSIVGCI IDAFIIGAVM
AKMAKPKKRN ETLVFSHNAV IAMRDGKLCL MWRVGNLRKS HLVEAHVRAQ LLKSRITSEG
EYIPLDQIDI NVGFDSGIDR IFLVSPITIV HEIDEDSPLY DLSKQDMDNA DFEIVVILEG
MVEATAMTTQ CRSSYLANEI LWGHRYEPVL FEEKHYYKVD YSRFHKTYEV PNTPLCSARD
LAEKKYILSN ANSFCYENEV ALTSKEEDDS ENGVPESTST DTPPDIDLHN QASVPLEPRP
LRRESEI


Related products :

Catalog number Product name Quantity
28-297 This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. 0.1 mg
18-003-42641 Potassium channel subfamily K member 10 - Outward rectifying potassium channel protein TREK-2; TREK-2 K(+) channel subunit Polyclonal 0.1 mg Protein A
18-003-42642 Potassium channel subfamily K member 10 - Outward rectifying potassium channel protein TREK-2; TREK-2 K(+) channel subunit Polyclonal 0.1 mg Protein A
18-003-42653 Potassium channel subfamily K member 10 - Outward rectifying potassium channel protein TREK-2; TREK-2 K(+) channel subunit Polyclonal 0.1 mg Protein A
KCNJ16 KCNJ14 Gene potassium inwardly-rectifying channel, subfamily J, member 14
KCNJ18 KCNJ15 Gene potassium inwardly-rectifying channel, subfamily J, member 15
KCNJ2 KCNJ16 Gene potassium inwardly-rectifying channel, subfamily J, member 16
KCNJ4 KCNJ2 Gene potassium inwardly-rectifying channel, subfamily J, member 2
KCNJ5 KCNJ3 Gene potassium inwardly-rectifying channel, subfamily J, member 3
KCNJ6 KCNJ4 Gene potassium inwardly-rectifying channel, subfamily J, member 4
KCNJ8 KCNJ5 Gene potassium inwardly-rectifying channel, subfamily J, member 5
KCNJ9 KCNJ6 Gene potassium inwardly-rectifying channel, subfamily J, member 6
KCNK1 KCNJ8 Gene potassium inwardly-rectifying channel, subfamily J, member 8
KCNK10 KCNJ9 Gene potassium inwardly-rectifying channel, subfamily J, member 9
KCNJ15 KCNJ13 Gene potassium inwardly-rectifying channel, subfamily J, member 13
KCNJ14 KCNJ12 Gene potassium inwardly-rectifying channel, subfamily J, member 12
KCNJ13 KCNJ11 Gene potassium inwardly-rectifying channel, subfamily J, member 11
201-20-2916 KCNJ16{potassium inwardly-rectifying channel, subfamily J, member 16}rabbit.pAb 0.2ml
201-20-2915 KCNJ15{potassium inwardly-rectifying channel, subfamily J, member 15}rabbit.pAb 0.2ml
201-20-2914 KCNJ13{potassium inwardly-rectifying channel, subfamily J, member 13}rabbit.pAb 0.2ml
201-20-2913 KCNJ12{potassium inwardly-rectifying channel, subfamily J, member 12}rabbit.pAb 0.2ml
201-20-2912 KCNJ11{potassium inwardly-rectifying channel, subfamily J, member 11}rabbit.pAb 0.2ml
201-20-2911 KCNJ10{potassium inwardly-rectifying channel, subfamily J, member 10}rabbit.pAb 0.2ml
201-20-2910 KCNJ1{potassium inwardly-rectifying channel, subfamily J, member 1}rabbit.pAb 0.2ml
UB-E10187 Rat Potassium Inwardly Rectifying Channel Subfamily J, Member 5(KCNJ5) )ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur