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Iron-regulated surface determinant protein B (Fur-regulated protein B) (Staphylococcal iron-regulated protein H) (Staphylococcus aureus surface protein J)

 ISDB_STAA9              Reviewed;         645 AA.
A5IS15;
20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
26-JUN-2007, sequence version 1.
22-NOV-2017, entry version 70.
RecName: Full=Iron-regulated surface determinant protein B;
AltName: Full=Fur-regulated protein B;
AltName: Full=Staphylococcal iron-regulated protein H;
AltName: Full=Staphylococcus aureus surface protein J;
Flags: Precursor;
Name=isdB; Synonyms=frpB, sasJ, sirH; OrderedLocusNames=SaurJH9_1188;
Staphylococcus aureus (strain JH9).
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
Staphylococcus.
NCBI_TaxID=359786;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=JH9;
US DOE Joint Genome Institute;
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
Hauser L., Kyrpides N., Kim E., Tomasz A., Richardson P.;
"Complete sequence of chromosome of Staphylococcus aureus subsp.
aureus JH9.";
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Seems to function as the primary receptor for hemoglobin
since its inactivation inhibits the ability of S.aureus to bind
hemoglobin. Binds hemoglobin in a dose-dependent way. Required for
S.aureus growth using hemoglobin as the sole iron source. Also
required for virulence. IsdA and/or IsdB promote resistance to
hydrogen peroxide and killing by neutrophils (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
ProRule:PRU00477}.
-!- INDUCTION: Repressed by fur in the presence of iron.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the IsdB family. {ECO:0000305}.
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EMBL; CP000703; ABQ48988.1; -; Genomic_DNA.
RefSeq; WP_001041583.1; NC_009487.1.
ProteinModelPortal; A5IS15; -.
SMR; A5IS15; -.
EnsemblBacteria; ABQ48988; ABQ48988; SaurJH9_1188.
KEGG; saj:SaurJH9_1188; -.
HOGENOM; HOG000280077; -.
OMA; KADNNTY; -.
PRO; PR:A5IS15; -.
GO; GO:0005618; C:cell wall; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IEA:InterPro.
GO; GO:0015232; F:heme transporter activity; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:UniProtKB-KW.
CDD; cd06920; NEAT; 1.
InterPro; IPR019948; Gram-positive_anchor.
InterPro; IPR019929; Iron-reg_IsdB.
InterPro; IPR006635; NEAT_dom.
InterPro; IPR037250; NEAT_dom_sf.
InterPro; IPR005877; YSIRK_signal_dom.
Pfam; PF00746; Gram_pos_anchor; 1.
Pfam; PF05031; NEAT; 2.
Pfam; PF04650; YSIRK_signal; 1.
SMART; SM00725; NEAT; 2.
SUPFAM; SSF158911; SSF158911; 2.
TIGRFAMs; TIGR03657; IsdB; 1.
TIGRFAMs; TIGR01168; YSIRK_signal; 1.
PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PROSITE; PS50978; NEAT; 2.
3: Inferred from homology;
Cell wall; Iron; Metal-binding; Peptidoglycan-anchor; Repeat;
Secreted; Signal; Virulence.
SIGNAL 1 40 {ECO:0000255}.
CHAIN 41 613 Iron-regulated surface determinant
protein B.
/FTId=PRO_5000247261.
PROPEP 614 645 Removed by sortase A.
{ECO:0000255|PROSITE-ProRule:PRU00477}.
/FTId=PRO_0000333245.
DOMAIN 144 269 NEAT 1. {ECO:0000255|PROSITE-
ProRule:PRU00337}.
DOMAIN 341 458 NEAT 2. {ECO:0000255|PROSITE-
ProRule:PRU00337}.
MOTIF 610 614 LPXTG sorting signal.
{ECO:0000255|PROSITE-ProRule:PRU00477}.
MOD_RES 613 613 Pentaglycyl murein peptidoglycan amidated
threonine. {ECO:0000255|PROSITE-
ProRule:PRU00477}.
SEQUENCE 645 AA; 72162 MW; 524BF70EC0C4F9D8 CRC64;
MNKQQKEFKS FYSIRKSSLG VASVAISTLL LLMSNGEAQA AAEETGGTNT EAQPKTEAVA
SPTTTSEKAP ETKPVANAVS VSNKEVEAPT SETKEAKEVK EVKAPKETKA VKPAAKATNN
TYPILNQELR EAIKNPAIKD KDHSAPNSRP IDFEMKKENG EQQFYHYASS VKPARVIFTD
SKPEIELGLQ SGQFWRKFEV YEGDKKLPIK LVSYDTVKDY AYIRFSVSNG TKAVKIVSST
HFNNKEEKYD YTLMEFAQPI YNSADKFKTE EDYKAEKLLA PYKKAKTLER QVYELNKIQD
KLPEKLKAEY KKKLEDTKKA LDEQVKSAIT EFQNVQPTNE KMTDLQDTKY VVYESVENNE
SMMDTFVKHP IKTGMLNGKK YMVMETTNDD YWKDFMVEGQ RVRTISKDAK NNTRTIIFPY
VEGKTLYDAI VKVHVKTIDY DGQYHVRIVD KEAFTKANTD KSNKKEQQDN SAKKEATPAT
PSKPTPSPVE KESQKQDSQK DDNKQLPSVE KENDASSESG KDKTPATKPT KGEVESSSTT
PTKVVSTTQN VAKPTTASSK TTKDVVQTSA GSSEAKDSAP LQKANIKNTN DGHTQSQNNK
NTQENKAKSL PQTGEESNKD MTLPLMALLA LSSIVAFVLP RKRKN


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