Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Iron-regulated surface determinant protein H (Haptoglobin receptor A) (Staphylococcus aureus surface protein I)

 ISDH_STAAS              Reviewed;         895 AA.
Q6G8J7;
01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
19-JUL-2004, sequence version 1.
22-NOV-2017, entry version 82.
RecName: Full=Iron-regulated surface determinant protein H;
AltName: Full=Haptoglobin receptor A;
AltName: Full=Staphylococcus aureus surface protein I;
Flags: Precursor;
Name=isdH; Synonyms=harA, sasI; OrderedLocusNames=SAS1657;
Staphylococcus aureus (strain MSSA476).
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
Staphylococcus.
NCBI_TaxID=282459;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MSSA476;
PubMed=15213324; DOI=10.1073/pnas.0402521101;
Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
Bason N., Bentley S.D., Chillingworth C., Chillingworth T.,
Churcher C., Clark L., Corton C., Cronin A., Doggett J., Dowd L.,
Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K.,
James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K.,
Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M.,
Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G.,
Spratt B.G., Parkhill J.;
"Complete genomes of two clinical Staphylococcus aureus strains:
evidence for the rapid evolution of virulence and drug resistance.";
Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
[2]
STRUCTURE BY NMR OF 86-229, AND BINDING TO HEMOGLOBIN.
PubMed=16762363; DOI=10.1016/j.jmb.2006.05.019;
Pilpa R.M., Fadeev E.A., Villareal V.A., Wong M.L., Phillips M.,
Clubb R.T.;
"Solution structure of the NEAT (NEAr Transporter) domain from
IsdH/HarA: the human hemoglobin receptor in Staphylococcus aureus.";
J. Mol. Biol. 360:435-447(2006).
-!- FUNCTION: Binds human plasma haptoglobin-hemoglobin complexes,
haptoglobin and hemoglobin. Binds haptoglobin-hemoglobin complexes
with significantly higher affinity than haptoglobin alone
(Probable). {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000305};
Peptidoglycan-anchor {ECO:0000305}.
-!- DOMAIN: The NEAT 1 domain binds with higher affinity than the NEAT
2 domain haptoglobin-hemoglobin complexes, haptoglobin and
hemoglobin (By similarity). More than one IsdH NEAT 1 domain
interacts with a single hemoglobin. {ECO:0000250}.
-!- SIMILARITY: Belongs to the IsdH family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; BX571857; CAG43459.1; -; Genomic_DNA.
RefSeq; WP_001032759.1; NC_002953.3.
PDB; 2H3K; NMR; -; A=86-229.
PDB; 3OVU; X-ray; 2.83 A; B=86-229.
PDB; 3S48; X-ray; 3.05 A; A/B=86-229.
PDBsum; 2H3K; -.
PDBsum; 3OVU; -.
PDBsum; 3S48; -.
ProteinModelPortal; Q6G8J7; -.
SMR; Q6G8J7; -.
KEGG; sas:SAS1657; -.
HOGENOM; HOG000280077; -.
OMA; VQTGQED; -.
EvolutionaryTrace; Q6G8J7; -.
GO; GO:0005618; C:cell wall; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IEA:InterPro.
GO; GO:0020037; F:heme binding; IEA:InterPro.
CDD; cd06920; NEAT; 1.
InterPro; IPR019930; Haptoglobin-bd_HarA.
InterPro; IPR006635; NEAT_dom.
InterPro; IPR037250; NEAT_dom_sf.
InterPro; IPR005877; YSIRK_signal_dom.
Pfam; PF05031; NEAT; 3.
SMART; SM00725; NEAT; 3.
SUPFAM; SSF158911; SSF158911; 3.
TIGRFAMs; TIGR03658; IsdH_HarA; 1.
TIGRFAMs; TIGR01168; YSIRK_signal; 1.
PROSITE; PS50978; NEAT; 3.
1: Evidence at protein level;
3D-structure; Cell wall; Peptidoglycan-anchor; Repeat; Secreted;
Signal.
SIGNAL 1 40 {ECO:0000255}.
CHAIN 41 864 Iron-regulated surface determinant
protein H.
/FTId=PRO_0000285185.
PROPEP 865 895 Removed by sortase. {ECO:0000255}.
/FTId=PRO_0000285186.
DOMAIN 105 232 NEAT 1. {ECO:0000255|PROSITE-
ProRule:PRU00337}.
DOMAIN 345 471 NEAT 2. {ECO:0000255|PROSITE-
ProRule:PRU00337}.
DOMAIN 543 660 NEAT 3. {ECO:0000255|PROSITE-
ProRule:PRU00337}.
MOTIF 861 865 LPXTG sorting signal. {ECO:0000255}.
COMPBIAS 698 779 Asp-rich.
MOD_RES 864 864 Pentaglycyl murein peptidoglycan amidated
threonine. {ECO:0000255}.
TURN 86 88 {ECO:0000244|PDB:3OVU}.
HELIX 90 93 {ECO:0000244|PDB:3OVU}.
HELIX 97 99 {ECO:0000244|PDB:3OVU}.
STRAND 109 112 {ECO:0000244|PDB:3S48}.
STRAND 114 117 {ECO:0000244|PDB:3OVU}.
STRAND 121 123 {ECO:0000244|PDB:3S48}.
HELIX 125 130 {ECO:0000244|PDB:3OVU}.
STRAND 133 138 {ECO:0000244|PDB:3OVU}.
STRAND 141 151 {ECO:0000244|PDB:3OVU}.
TURN 153 155 {ECO:0000244|PDB:3OVU}.
STRAND 156 165 {ECO:0000244|PDB:3OVU}.
STRAND 166 168 {ECO:0000244|PDB:2H3K}.
STRAND 171 176 {ECO:0000244|PDB:3OVU}.
TURN 178 180 {ECO:0000244|PDB:3OVU}.
STRAND 182 189 {ECO:0000244|PDB:3OVU}.
STRAND 193 203 {ECO:0000244|PDB:3OVU}.
STRAND 205 207 {ECO:0000244|PDB:3OVU}.
STRAND 209 212 {ECO:0000244|PDB:3OVU}.
STRAND 216 223 {ECO:0000244|PDB:3OVU}.
SEQUENCE 895 AA; 100847 MW; 797BB0D67F9A0559 CRC64;
MNKHHPKLRS FYSIRKSILG VASVIVSTLF LITSQHQAQA AENTNTSDKI SENQNNNATT
TQPPKDTNQT QPATQPANTA KTYPAADESL KDAIKDPALE NKEHDIGPRE QVNFQLLDKN
NETQYYHFFS IKDPADVYYT KKKAEVELDI NTASTWKKFE VYENNQKLPV RLVSYSPVPE
DHAYIRFPVS DGTQELKIVS STQIDDGEET NYDYTKLVFA KPIYNDPSLV KSDTNDAVVT
NDQSSSDASN QTNTNTSNQN TSTINNANNQ PQATTNMSQP AQPKSSANAD QASSQPAHET
NSNGNTNDKT NESSNQSDVN QQYPPADESL QDAIKNPAII DKEHTADNWR PIDFQMKNDK
GERQFYHYAS TVEPATVIFT KTGPIIELGL KTASTWKKFE VYEGDKKLPV ELVSYDSDKD
YAYIRFPVSN GTREVKIVSS IEYGENIHED YDYTLMVFAQ PITNNPDDYV DEETYNLQKL
LAPYHKAKTL ERQVYELEKL QEKLPEKYKA EYKKKLDQTR VELADQVKSA VTEFENVTPT
NDQLTDVQEA HFVVFESEEN SESVMDGFVE HPFYTATLNG QKYVVMKTKD DSYWKDLIVE
GKRVTTVSKD PKNNSRTLIF PYIPDKAVYN AIVKVVVANI GYEGQYHVRI INQDINTKDD
DTSQNNTSEP LNVQTGQEGK VADTDVAENS STATNPKDAS DKADVIEPDS DVVKDADNNI
DKDVQHDVDH LSDMSDNNHF DKYDLKEMDT QIAKDTDRNV DKGADNSVGM SSNVDTDKDS
NKNKDKVIQL NHIADKNNHN GKAAKLDVVK QNYNNTDKVT DKKTTEHLPS DIHKTVDKTV
KTKEKAGTPS KENKLSQSKM LPKTGETTSS QSWWGLYALL GMLALFIPKF RKESK


Related products :

Catalog number Product name Quantity
EIAAB06346 Antigenic surface determinant protein OA3,CD47,Homo sapiens,Human,IAP,Integrin-associated protein,Leukocyte surface antigen CD47,MER6,Protein MER6
orb82659 HBV Surface Antigen adw protein HBsAg is the surface antigen of the Hepatitis-B-Virus (HBV). The capsid of a virus has different surface proteins from the rest of the virus. The antigen is a protein t 1 mg
EIAAB25058 CD200 cell surface glycoprotein receptor,CD200R,CD200R1,Cell surface glycoprotein CD200 receptor 1,Cell surface glycoprotein OX2 receptor 1,CRTR2,Homo sapiens,Human,MOX2R,OX2R,UNQ2522_PRO6015
orb82658 HBV Surface Antigen adr subtype protein HBsAg is the surface antigen of the Hepatitis-B-Virus (HBV). The capsid of a virus has different surface proteins from the rest of the virus. The antigen is a p 1 mg
EIAAB25056 CD200 cell surface glycoprotein receptor,Cd200r1,Cell surface glycoprotein CD200 receptor 1,Cell surface glycoprotein OX2 receptor 1,Mox2r,OX102 antigen,Ox2r,Rat,Rattus norvegicus
EIAAB25059 CD200 cell surface glycoprotein receptor,Cd200r1,Cell surface glycoprotein CD200 receptor 1,Cell surface glycoprotein OX2 receptor 1,Mouse,Mox2r,Mus musculus,Ox2r
EIAAB41252 CD96,Cell surface antigen CD96,Homo sapiens,Human,T cell-activated increased late expression protein,T-cell surface protein tactile
orb82330 Hepatitis B Surface Ag (ay) protein Hepatitis B Surface Antigen (HBsAg) (ay) is an infectious disease antigen_toxin. For research use only. 1 mg
orb82357 Hepatitis B Surface Ag (ay) protein Hepatitis B Surface Antigen (HBsAg) (ay) is an infectious disease antigen_toxin. For research use only. 1 mg
orb82507 Hepatitis B Surface Ag (ad) protein Hepatitis B Surface Antigen (HBsAg) (ad) is an infectious disease antigen_toxin. For research use only. 1 mg
orb82508 Hepatitis B Surface Ag (ay) protein Hepatitis B Surface Antigen (HBsAg) (ay) is an infectious disease antigen_toxin. For research use only. 1 mg
orb82356 Hepatitis B Surface Ag (ad) protein Hepatitis B Surface Antigen (HBsAg) (ad) is an infectious disease antigen_toxin. For research use only. 1 mg
orb82329 Hepatitis B Surface Ag (ad) protein Hepatitis B Surface Antigen (HBsAg) (ad) is an infectious disease antigen_toxin. For research use only. 1 mg
EIAAB41251 Cd96,Cell surface antigen CD96,Mouse,Mus musculus,T cell-activated increased late expression protein,T-cell surface protein tactile
EIAAB41249 Cd96,Cell surface antigen CD96,Rat,Rattus norvegicus,T cell-activated increased late expression protein,T-cell surface protein tactile
EIAAB41250 Bos taurus,Bovine,CD96,Cell surface antigen CD96,T cell-activated increased late expression protein,T-cell surface protein tactile
OBT0915 RECOMBINANT HEPATITIS B SURFACE ANTIGEN AY, Product Type Recombinant Protein, Specificity HEPATITIS B SURFACE ANTIGEN AY, Target Species Viral, Host N_A, Format Rec. Protein, Isotypes , Applicat 0.1 mg
PIP033 RECOMBINANT HEPATITIS B SURFACE ANTIGEN AY, Product Type Recombinant Protein, Specificity HEPATITIS B SURFACE ANTIGEN AY, Target Species Viral, Host N_A, Format Rec. Protein, Isotypes , Applicat 1 mg
SCH-OBT0915 RECOMBINANT HEPATITIS B SURFACE ANTIGEN AY, Product Type Recombinant Protein, Specificity HEPATITIS B SURFACE ANTIGEN AY, Target Species Viral, Host N_A, Format Rec. Protein, Isotypes , Applicat 0.1 mg
PIP002 RECOMBINANT HEPATITIS B SURFACE ANTIGEN AD, Product Type Recombinant Protein, Specificity HEPATITIS B SURFACE ANTIGEN AD, Target Species Viral, Host N_A, Format Rec. Protein, Isotypes , Applicat 0.1 mg
PIP032 RECOMBINANT HEPATITIS B SURFACE ANTIGEN AD , Product Type Recombinant Protein, Specificity HEPATITIS B SURFACE ANTIGEN AD, Target Species Viral, Host N_A, Format Rec. Protein, Isotypes , Applica 1 mg
SCH-PIP002 RECOMBINANT HEPATITIS B SURFACE ANTIGEN AD, Product Type Recombinant Protein, Specificity HEPATITIS B SURFACE ANTIGEN AD, Target Species Viral, Host N_A, Format Rec. Protein, Isotypes , Applicat 0.1 mg
EIAAB25057 Bos taurus,Bovine,CD200 cell surface glycoprotein receptor,CD200R,CD200R1,Cell surface glycoprotein CD200 receptor 1,Cell surface glycoprotein OX2 receptor 1
U1576h CLIA CD2,Erythrocyte receptor,Homo sapiens,Human,LFA-2,LFA-3 receptor,Rosette receptor,SRBC,T-cell surface antigen CD2,T-cell surface antigen T11_Leu-5 96T
E1576h ELISA kit CD2,Erythrocyte receptor,Homo sapiens,Human,LFA-2,LFA-3 receptor,Rosette receptor,SRBC,T-cell surface antigen CD2,T-cell surface antigen T11_Leu-5 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur