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Islet amyloid polypeptide (Amylin)

 IAPP_CANLF              Reviewed;          89 AA.
P17716;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
01-FEB-1994, sequence version 2.
28-MAR-2018, entry version 113.
RecName: Full=Islet amyloid polypeptide;
AltName: Full=Amylin;
Flags: Precursor;
Name=IAPP;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1543754; DOI=10.1016/0167-4781(92)90470-K;
Albrandt K., Mull E., Cooper G.J.S., Johnson M.J.;
"Nucleotide sequence of a cDNA for canine amylin.";
Biochim. Biophys. Acta 1130:97-99(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 43-68.
PubMed=2192709; DOI=10.1016/0006-291X(90)90359-U;
Jordan K., Murtaugh M.P., O'Brien T.D., Westermark P., Betsholtz C.,
Johnson K.H.;
"Canine IAPP cDNA sequence provides important clues regarding
diabetogenesis and amyloidogenesis in type 2 diabetes.";
Biochem. Biophys. Res. Commun. 169:502-508(1990).
-!- FUNCTION: Selectively inhibits insulin-stimulated glucose
utilization and glycogen deposition in muscle, while not affecting
adipocyte glucose metabolism. {ECO:0000250}.
-!- SUBUNIT: Interacts with IDE and INS. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- DOMAIN: The mature protein is largely unstructured in the absence
of a cognate ligand. {ECO:0000250}.
-!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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EMBL; X59998; CAA42616.1; -; mRNA.
EMBL; M37720; AAA30849.1; -; mRNA.
PIR; S22344; S22344.
RefSeq; NP_001003233.1; NM_001003233.2.
UniGene; Cfa.24677; -.
ProteinModelPortal; P17716; -.
SMR; P17716; -.
STRING; 9615.ENSCAFP00000039036; -.
TCDB; 1.C.49.1.1; the cytotoxic amylin (amylin) family.
PaxDb; P17716; -.
Ensembl; ENSCAFT00000047881; ENSCAFP00000039036; ENSCAFG00000029872.
GeneID; 403909; -.
KEGG; cfa:403909; -.
CTD; 3375; -.
VGNC; VGNC:41848; IAPP.
eggNOG; ENOG410J0NB; Eukaryota.
eggNOG; ENOG410Z7V7; LUCA.
GeneTree; ENSGT00510000048671; -.
HOGENOM; HOG000038203; -.
HOVERGEN; HBG096065; -.
InParanoid; P17716; -.
KO; K08039; -.
OMA; SHQMEKR; -.
OrthoDB; EOG091G15QG; -.
TreeFam; TF330783; -.
Reactome; R-CFA-418555; G alpha (s) signalling events.
Reactome; R-CFA-419812; Calcitonin-like ligand receptors.
Proteomes; UP000002254; Chromosome 27.
Bgee; ENSCAFG00000029872; -.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0045779; P:negative regulation of bone resorption; IEA:Ensembl.
GO; GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl.
GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
InterPro; IPR021117; Calcitonin-like.
InterPro; IPR021116; Calcitonin/adrenomedullin.
InterPro; IPR018360; Calcitonin_CS.
InterPro; IPR001693; Calcitonin_peptide-like.
InterPro; IPR000443; Pro-islet_amyloid_polypep.
PANTHER; PTHR10505; PTHR10505; 2.
PANTHER; PTHR10505:SF4; PTHR10505:SF4; 2.
Pfam; PF00214; Calc_CGRP_IAPP; 1.
PRINTS; PR00818; ISLETAMYLOID.
SMART; SM00113; CALCITONIN; 1.
PROSITE; PS00258; CALCITONIN; 1.
3: Inferred from homology;
Amidation; Amyloid; Cleavage on pair of basic residues;
Complete proteome; Disulfide bond; Hormone; Reference proteome;
Secreted; Signal.
SIGNAL 1 22 {ECO:0000255}.
PROPEP 23 31 {ECO:0000250}.
/FTId=PRO_0000004096.
PEPTIDE 35 70 Islet amyloid polypeptide.
/FTId=PRO_0000004097.
PROPEP 74 89 {ECO:0000250}.
/FTId=PRO_0000004098.
MOD_RES 70 70 Tyrosine amide. {ECO:0000250}.
DISULFID 35 40 {ECO:0000250}.
CONFLICT 67 67 S -> T (in Ref. 2; AAA30849).
{ECO:0000305}.
SEQUENCE 89 AA; 9800 MW; 9BF757E1C1493EEF CRC64;
MCLLKLPVVL IILSVALNHL KATPIKSHQM EKRKCNTATC ATQRLANFLV RTSNNLGAIL
SPTNVGSNTY GKRNTIEILN RGPLNYLPL


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