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Isocitrate dehydrogenase [NADP] (EC 1.1.1.42)

 O65853_TOBAC            Unreviewed;       482 AA.
O65853;
01-AUG-1998, integrated into UniProtKB/TrEMBL.
01-AUG-1998, sequence version 1.
25-OCT-2017, entry version 94.
RecName: Full=Isocitrate dehydrogenase [NADP] {ECO:0000256|PIRNR:PIRNR000108};
EC=1.1.1.42 {ECO:0000256|PIRNR:PIRNR000108};
Nicotiana tabacum (Common tobacco).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; asterids; lamiids; Solanales; Solanaceae;
Nicotianoideae; Nicotianeae; Nicotiana.
NCBI_TaxID=4097 {ECO:0000313|EMBL:CAA65503.1};
[1] {ECO:0000313|EMBL:CAA65503.1}
NUCLEOTIDE SEQUENCE.
PubMed=9636233; DOI=10.1073/pnas.95.13.7813;
Galvez S., Roche O., Bismuth E., Brown S., Gadal P., Hodges M.;
"Mitochondrial localization of a NADP-dependent [corrected] isocitrate
dehydrogenase isoenzyme by using the green fluorescent protein as a
marker.";
Proc. Natl. Acad. Sci. U.S.A. 95:7813-7818(1998).
-!- CATALYTIC ACTIVITY: Isocitrate + NADP(+) = 2-oxoglutarate + CO(2)
+ NADPH. {ECO:0000256|PIRNR:PIRNR000108}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|PIRNR:PIRNR000108,
ECO:0000256|PIRSR:PIRSR000108-3};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Evidence={ECO:0000256|PIRNR:PIRNR000108,
ECO:0000256|PIRSR:PIRSR000108-3};
Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
{ECO:0000256|PIRNR:PIRNR000108, ECO:0000256|PIRSR:PIRSR000108-3};
-!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
dehydrogenases family. {ECO:0000256|PIRNR:PIRNR000108}.
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EMBL; X96728; CAA65503.1; -; mRNA.
PIR; T04355; T04355.
PIR; T04356; T04356.
RefSeq; NP_001312629.1; NM_001325700.1.
UniGene; Nta.4240; -.
ProteinModelPortal; O65853; -.
GeneID; 107801694; -.
KEGG; nta:107801694; -.
KO; K00031; -.
BRENDA; 1.1.1.42; 3645.
GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO; GO:0051287; F:NAD binding; IEA:InterPro.
GO; GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
InterPro; IPR004790; Isocitrate_DH_NADP.
InterPro; IPR024084; IsoPropMal-DH-like_dom.
PANTHER; PTHR11822; PTHR11822; 1.
Pfam; PF00180; Iso_dh; 1.
PIRSF; PIRSF000108; IDH_NADP; 1.
SMART; SM01329; Iso_dh; 1.
TIGRFAMs; TIGR00127; nadp_idh_euk; 1.
PROSITE; PS00470; IDH_IMDH; 1.
2: Evidence at transcript level;
Magnesium {ECO:0000256|PIRNR:PIRNR000108,
ECO:0000256|PIRSR:PIRSR000108-3};
Manganese {ECO:0000256|PIRNR:PIRNR000108,
ECO:0000256|PIRSR:PIRSR000108-3};
Metal-binding {ECO:0000256|PIRNR:PIRNR000108,
ECO:0000256|PIRSR:PIRSR000108-3};
NADP {ECO:0000256|PIRNR:PIRNR000108, ECO:0000256|PIRSR:PIRSR000108-4};
Oxidoreductase {ECO:0000256|PIRNR:PIRNR000108,
ECO:0000313|EMBL:CAA65503.1};
Tricarboxylic acid cycle {ECO:0000256|PIRNR:PIRNR000108}.
DOMAIN 78 468 Iso_dh. {ECO:0000259|SMART:SM01329}.
NP_BIND 144 146 NADP. {ECO:0000256|PIRSR:PIRSR000108-4}.
NP_BIND 378 383 NADP. {ECO:0000256|PIRSR:PIRSR000108-4}.
REGION 163 169 Substrate binding.
{ECO:0000256|PIRSR:PIRSR000108-2}.
METAL 320 320 Magnesium or manganese.
{ECO:0000256|PIRSR:PIRSR000108-3}.
METAL 343 343 Magnesium or manganese.
{ECO:0000256|PIRSR:PIRSR000108-3}.
BINDING 146 146 Substrate.
{ECO:0000256|PIRSR:PIRSR000108-2}.
BINDING 151 151 NADP. {ECO:0000256|PIRSR:PIRSR000108-4}.
BINDING 178 178 Substrate.
{ECO:0000256|PIRSR:PIRSR000108-2}.
BINDING 201 201 Substrate.
{ECO:0000256|PIRSR:PIRSR000108-2}.
BINDING 328 328 NADP. {ECO:0000256|PIRSR:PIRSR000108-4}.
BINDING 396 396 NADP; via amide nitrogen and carbonyl
oxygen. {ECO:0000256|PIRSR:PIRSR000108-
4}.
SITE 208 208 Critical for catalysis.
{ECO:0000256|PIRSR:PIRSR000108-1}.
SITE 280 280 Critical for catalysis.
{ECO:0000256|PIRSR:PIRSR000108-1}.
SEQUENCE 482 AA; 53918 MW; E32D6714D099A119 CRC64;
MLTTRLRLRC SAMASVASFI SSSSASTSSA VTKNLPFSII SNRQLFKNRV YLLHRIPNAS
IRSFASTTAS SKIRVENPIV EMDGDEMTRV IWTMIKEKLI YPYLELDTKY YDLGILNRDA
TDDQVTVESA EATLKYNVAV KCATITPDET RVKEFGLKSM WRSPNATIRN ILNGTVFREP
ILCKNVPRIV PGWKKPICIG RHAFGDQYRA TDAVINGPGK LKMVFEPENG EAPTELDVYD
FKGPGVALAM YNVDQSIRAF AESSMSMAFS KKWPLYLSTK NTILKKYDGR FKDIFEEVYE
EKWKQQFEEH SIWYEHRLID DMVAYALKSG GGYVWACKNY DGDVQSDLLA QGFGSLGLMT
SVLLSSDGKT LEAEAAHGTV TRHFRLHQKG QETSTNSVAS IFAWARGLGH RAQLDGNQKL
SEFVHALEAA CVGTIESGKM TKDLAILVHG PKVSREHYLN TEEFIDPVAQ KLQEKLGACA
VV


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