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Izumo sperm-egg fusion protein 1 (Oocyte binding/fusion factor) (OBF) (Sperm-specific protein izumo)

 IZUM1_RAT               Reviewed;         383 AA.
Q6AY06;
10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
13-SEP-2004, sequence version 1.
23-MAY-2018, entry version 97.
RecName: Full=Izumo sperm-egg fusion protein 1;
AltName: Full=Oocyte binding/fusion factor;
Short=OBF;
AltName: Full=Sperm-specific protein izumo;
Flags: Precursor;
Name=Izumo1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Testis;
PubMed=15759005; DOI=10.1038/nature03362;
Inoue N., Ikawa M., Isotani A., Okabe M.;
"The immunoglobulin superfamily protein Izumo is required for sperm to
fuse with eggs.";
Nature 434:234-238(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
SUBUNIT.
PubMed=19658160; DOI=10.1002/mrd.21092;
Ellerman D.A., Pei J., Gupta S., Snell W.J., Myles D., Primakoff P.;
"Izumo is part of a multiprotein family whose members form large
complexes on mammalian sperm.";
Mol. Reprod. Dev. 76:1188-1199(2009).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-339; SER-346; SER-366
AND THR-372, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Essential sperm cell-surface protein required for
fertilization by acting as a ligand for IZUMO1R/JUNO receptor on
egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion
event between sperm and egg that is required for fertilization but
is not sufficient for cell fusion. The ligand-receptor interaction
probably does not act as a membrane 'fusogen'.
{ECO:0000250|UniProtKB:Q9D9J7}.
-!- SUBUNIT: Monomer, homodimer and homooligomer (PubMed:19658160).
Interacts with IZUMO1R/JUNO. IZUMO1 and IZUMO1R/JUNO form a
complex with 1:1 stoichiometry (By similarity). Interacts with
ACE3 (By similarity). {ECO:0000250|UniProtKB:Q8IYV9,
ECO:0000250|UniProtKB:Q9D9J7, ECO:0000269|PubMed:19658160}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:Q9D9J7}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:Q9D9J7}. Cytoplasmic vesicle,
secretory vesicle, acrosome membrane
{ECO:0000250|UniProtKB:Q9D9J7}.
-!- DOMAIN: The extracellular domain assumes a distinct boomerang
shape when not bound to IZUMO1R/JUNO. Interaction with
IZUMO1R/JUNO triggers a conformation change, so that the IZUMO1
extracellular domain assumes an upright conformation.
{ECO:0000250|UniProtKB:Q8IYV9}.
-!- PTM: N-glycosylated. Glycosylation is not essential for fusion and
for proper protein trafficking in sperm.
{ECO:0000250|UniProtKB:Q9D9J7}.
-!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9D9J7}.
-!- MISCELLANEOUS: Izumo is the name of a Japanese shrine to marriage.
-!- SIMILARITY: Belongs to the Izumo family. {ECO:0000305}.
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EMBL; AB195683; BAD91013.1; -; mRNA.
EMBL; BC079244; AAH79244.1; -; mRNA.
RefSeq; NP_001017514.1; NM_001017514.1.
UniGene; Rn.125416; -.
SMR; Q6AY06; -.
STRING; 10116.ENSRNOP00000035119; -.
iPTMnet; Q6AY06; -.
PhosphoSitePlus; Q6AY06; -.
PaxDb; Q6AY06; -.
PRIDE; Q6AY06; -.
Ensembl; ENSRNOT00000033278; ENSRNOP00000035119; ENSRNOG00000024678.
GeneID; 499152; -.
KEGG; rno:499152; -.
CTD; 284359; -.
RGD; 1565454; Izumo1.
eggNOG; ENOG410IHEV; Eukaryota.
eggNOG; ENOG410Z8SJ; LUCA.
GeneTree; ENSGT00390000015014; -.
HOGENOM; HOG000113123; -.
HOVERGEN; HBG081813; -.
InParanoid; Q6AY06; -.
OMA; KEVHACR; -.
OrthoDB; EOG091G0AHL; -.
PhylomeDB; Q6AY06; -.
TreeFam; TF338356; -.
Reactome; R-RNO-1300652; Sperm:Oocyte Membrane Binding.
PRO; PR:Q6AY06; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000024678; -.
GO; GO:0002080; C:acrosomal membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0086080; F:protein binding involved in heterotypic cell-cell adhesion; ISS:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; ISS:UniProtKB.
GO; GO:0034113; P:heterotypic cell-cell adhesion; ISS:UniProtKB.
GO; GO:0007338; P:single fertilization; ISS:UniProtKB.
GO; GO:0035036; P:sperm-egg recognition; ISS:UniProtKB.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR029389; IZUMO.
InterPro; IPR032699; Izumo-Ig.
InterPro; IPR032700; IZUMO1.
PANTHER; PTHR35540; PTHR35540; 1.
Pfam; PF15005; IZUMO; 1.
Pfam; PF16706; Izumo-Ig; 1.
SUPFAM; SSF48726; SSF48726; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Cytoplasmic vesicle; Disulfide bond;
Fertilization; Glycoprotein; Immunoglobulin domain; Membrane;
Phosphoprotein; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 383 Izumo sperm-egg fusion protein 1.
/FTId=PRO_0000045484.
TOPO_DOM 22 306 Extracellular. {ECO:0000255}.
TRANSMEM 307 327 Helical. {ECO:0000255}.
TOPO_DOM 328 383 Cytoplasmic. {ECO:0000255}.
DOMAIN 167 251 Ig-like C2-type.
REGION 148 160 Important for interaction with IZUMO1R.
{ECO:0000250|UniProtKB:Q8IYV9}.
MOD_RES 339 339 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 346 346 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 366 366 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 372 372 Phosphothreonine.
{ECO:0000244|PubMed:22673903}.
CARBOHYD 204 204 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 22 149 {ECO:0000250|UniProtKB:Q8IYV9}.
DISULFID 25 152 {ECO:0000250|UniProtKB:Q8IYV9}.
DISULFID 135 159 {ECO:0000250|UniProtKB:Q8IYV9}.
DISULFID 139 165 {ECO:0000250|UniProtKB:Q8IYV9}.
DISULFID 182 233 {ECO:0000250|UniProtKB:Q8IYV9}.
SEQUENCE 383 AA; 43579 MW; B8DF109F3B09F042 CRC64;
MGLHFTLLLA ALANCLCPAR LCIICDPFVV AAIKTLEQNY LPTHLAPEHH EDVMKRVEQE
VRNFADLPLN QNTFLGVVDE DTLEQASWSF LKDLKRITDS DVKGELFVKE LFWMLRLQKD
IFATLVARFQ KEVYCPNQCG TMSQTLIWCN KCEKQMHFCR KSMDCGERQI EVHRLEDMVL
DCQLSWHHAS EGLTDYSFYR VWGNSSETLM SKGKEPYLTK TMVGPEDAGN YRCELDTVNA
GPATIIYYHV TVLPPRSVEE KPPPNIVTQE EEETPVQVIV PTLEPEPEPE PIPTVTHRPE
KKLKSRLLIL LILGFVVLVA SVIASVLHFR KTRVKSKNSN VENKTSAAEF KSEAESPQKM
GSRKLSQAEF HTDSSDKVEE ADN


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