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JNK-interacting protein (JIP) (JNK MAP kinase scaffold protein) (Uncoordinated protein 16)

 JIP_CAEEL               Reviewed;        1157 AA.
P34609; Q95V72;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
25-NOV-2002, sequence version 3.
10-OCT-2018, entry version 137.
RecName: Full=JNK-interacting protein;
Short=JIP;
AltName: Full=JNK MAP kinase scaffold protein;
AltName: Full=Uncoordinated protein 16;
Name=unc-16; ORFNames=ZK1098.10;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM C), FUNCTION, INTERACTION WITH
JNK-1; JKK-1 AND SEK-1, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=10393177; DOI=10.1093/emboj/18.13.3604;
Kawasaki M., Hisamoto N., Iino Y., Yamamoto M., Ninomiya-Tsuji J.,
Matsumoto K.;
"A Caenorhabditis elegans JNK signal transduction pathway regulates
coordinated movement via type-D GABAergic motor neurons.";
EMBO J. 18:3604-3615(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=7906398; DOI=10.1038/368032a0;
Wilson R., Ainscough R., Anderson K., Baynes C., Berks M.,
Bonfield J., Burton J., Connell M., Copsey T., Cooper J., Coulson A.,
Craxton M., Dear S., Du Z., Durbin R., Favello A., Fraser A.,
Fulton L., Gardner A., Green P., Hawkins T., Hillier L., Jier M.,
Johnston L., Jones M., Kershaw J., Kirsten J., Laisster N.,
Latreille P., Lightning J., Lloyd C., Mortimore B., O'Callaghan M.,
Parsons J., Percy C., Rifken L., Roopra A., Saunders D., Shownkeen R.,
Sims M., Smaldon N., Smith A., Smith M., Sonnhammer E., Staden R.,
Sulston J., Thierry-Mieg J., Thomas K., Vaudin M., Vaughan K.,
Waterston R., Watson A., Weinstock L., Wilkinson-Sproat J.,
Wohldman P.;
"2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
elegans.";
Nature 368:32-38(1994).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
SPLICING.
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[4]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION
WITH JNK-1; JKK-1 AND SEK-1.
PubMed=11738026; DOI=10.1016/S0896-6273(01)00532-3;
Byrd D.T., Kawasaki M., Walcoff M., Hisamoto N., Matsumoto K., Jin Y.;
"UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport
in C. elegans.";
Neuron 32:787-800(2001).
-!- FUNCTION: The JNK-interacting protein (JIP) group of scaffold
proteins selectively mediates JNK signaling by aggregating
specific components of the MAPK cascade to form a functional JNK
signaling module. May function as a regulator of synaptic vesicle
transport, through interactions with the JNK-signaling components
and motor proteins. Binds specific components of the JNK signaling
pathway namely jnk-1, jkk-1 and sek-1. Associates with components
of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding
complexes are then transported as a cargo of kinesin, to the
required subcellular location. {ECO:0000269|PubMed:10393177,
ECO:0000269|PubMed:11738026}.
-!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
{ECO:0000269|PubMed:10393177, ECO:0000269|PubMed:11738026}.
Note=Diffusely localized throughout cell body but intensely
localized in regions adjacent to nucleus and at presumptive tips
of neural processes.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=b;
IsoId=P34609-1; Sequence=Displayed;
Note=No experimental confirmation available.;
Name=a;
IsoId=P34609-2; Sequence=VSP_002781;
Note=No experimental confirmation available.;
Name=c;
IsoId=P34609-3; Sequence=VSP_002781, VSP_002782;
-!- TISSUE SPECIFICITY: Expressed in neurons of the ventral cord,
retrovesicular and preanal ganglia and nerve ring, intestinal
cells, seam and hypodermal cells, body wall, head muscle and
pharynx. {ECO:0000269|PubMed:10393177,
ECO:0000269|PubMed:11738026}.
-!- SIMILARITY: Belongs to the JIP scaffold family. {ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AF424978; AAL23934.1; -; mRNA.
EMBL; Z22176; CAA80140.1; -; Genomic_DNA.
EMBL; Z22176; CAD45611.1; -; Genomic_DNA.
PIR; S40932; S40932.
RefSeq; NP_001022981.1; NM_001027810.3. [P34609-1]
RefSeq; NP_741263.3; NM_171221.4. [P34609-3]
UniGene; Cel.34202; -.
ProteinModelPortal; P34609; -.
BioGrid; 41544; 7.
DIP; DIP-25590N; -.
IntAct; P34609; 6.
STRING; 6239.ZK1098.10e; -.
iPTMnet; P34609; -.
PaxDb; P34609; -.
PeptideAtlas; P34609; -.
PRIDE; P34609; -.
EnsemblMetazoa; ZK1098.10a; ZK1098.10a; WBGene00006755. [P34609-3]
EnsemblMetazoa; ZK1098.10b; ZK1098.10b; WBGene00006755. [P34609-1]
GeneID; 176349; -.
UCSC; ZK1098.10b.1; c. elegans. [P34609-1]
CTD; 176349; -.
WormBase; ZK1098.10a; CE00363; WBGene00006755; unc-16. [P34609-3]
WormBase; ZK1098.10b; CE31846; WBGene00006755; unc-16. [P34609-1]
eggNOG; KOG2077; Eukaryota.
eggNOG; ENOG410XQ19; LUCA.
GeneTree; ENSGT00670000097546; -.
HOGENOM; HOG000290716; -.
InParanoid; P34609; -.
PRO; PR:P34609; -.
Proteomes; UP000001940; Chromosome III.
Bgee; WBGene00006755; Expressed in 5 organ(s), highest expression level in multi-cellular organism.
GO; GO:0030424; C:axon; IDA:WormBase.
GO; GO:0043194; C:axon initial segment; IDA:WormBase.
GO; GO:0043679; C:axon terminus; IDA:WormBase.
GO; GO:0044297; C:cell body; IDA:WormBase.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0008432; F:JUN kinase binding; IBA:GO_Central.
GO; GO:0019900; F:kinase binding; IDA:WormBase.
GO; GO:0019894; F:kinesin binding; IMP:UniProtKB.
GO; GO:0005078; F:MAP-kinase scaffold activity; IPI:UniProtKB.
GO; GO:0030159; F:receptor signaling complex scaffold activity; IDA:WormBase.
GO; GO:0007257; P:activation of JUN kinase activity; IBA:GO_Central.
GO; GO:0030421; P:defecation; IMP:WormBase.
GO; GO:0040011; P:locomotion; IMP:WormBase.
GO; GO:0018991; P:oviposition; IMP:WormBase.
GO; GO:0046328; P:regulation of JNK cascade; IDA:UniProtKB.
GO; GO:0048489; P:synaptic vesicle transport; IMP:WormBase.
GO; GO:0016192; P:vesicle-mediated transport; IMP:UniProtKB.
InterPro; IPR032486; JIP_LZII.
InterPro; IPR019143; JNK/Rab-associated_protein-1_N.
InterPro; IPR034743; RH1.
InterPro; IPR034744; RH2.
InterPro; IPR036322; WD40_repeat_dom_sf.
Pfam; PF16471; JIP_LZII; 1.
Pfam; PF09744; Jnk-SapK_ap_N; 1.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS51776; RH1; 1.
PROSITE; PS51777; RH2; 1.
1: Evidence at protein level;
Alternative splicing; Coiled coil; Complete proteome; Cytoplasm;
Reference proteome.
CHAIN 1 1157 JNK-interacting protein.
/FTId=PRO_0000220637.
DOMAIN 24 112 RH1. {ECO:0000255|PROSITE-
ProRule:PRU01112}.
DOMAIN 423 509 RH2. {ECO:0000255|PROSITE-
ProRule:PRU01113}.
COILED 73 181 {ECO:0000255}.
COILED 319 474 {ECO:0000255}.
COILED 621 645 {ECO:0000255}.
VAR_SEQ 1 36 Missing (in isoform a and isoform c).
{ECO:0000303|PubMed:10393177}.
/FTId=VSP_002781.
VAR_SEQ 331 331 G -> GNLVDPAEFASAVNDTFIG (in isoform c).
{ECO:0000303|PubMed:10393177}.
/FTId=VSP_002782.
SEQUENCE 1157 AA; 130480 MW; 44FA445C96B78A59 CRC64;
MACNLSPVNE MADSITSSTP SEIVYGGPGS PDEHRTMSDK VQTMASAIYR ELETMIKVHG
EDGVKTLMPL VVNVLEALDL AYLERDEQTA ELEMLKEDNE QLQTQYEREK ALRKQTEQKY
IEIEDTLIGQ NKELDKKIES LESIMRMLEL KAKNATDHAS RLEEREVEQK LEFDRLHERY
NTLLRTHVDH MERTKYLMGS EKFELMQNMP LPNMQLRNKM GMAASVDASS IRGVSDLISA
HMTQSTTMDV NLANHITNED WQDEFSSDIE PSPRDIPQSS ADALTSPITT KEPTPKREAA
SPKQSEEEEA DETTSVDPKE NNDLLGADLT GMGREVENLI KENSELLDMK NALNIVKNDL
INQVDELNSE NMILRDENLS RQMVSEKMQE QITKHEEEIK TLKQKLMEKE NEQEEDDVPM
AMRKRFTRSE MQRVLMDRNA YKEKLMELEE SIKWTEMQRA KKMQQQQQNV NQKKSGGIWE
FFSSLLGDSV TPPASSRGNR ASSSRGKMTR SVEYIDPDMI SERRAAERRE QYKLVREHVK
KEDGRIEAYG WSLPNVEAEV SSVPIPVCCR PLLDNEPSLK IWCATGVVLR GGRDERGQWI
VGDPIYFAPA SMKKTKTSNH RPELEDEIKR ARNLDARESE LDEWQSSSLV WVVSSNQGKS
LIAVLDANNP NNIIETFPAC DSHLLCIQAV SGVMEGEPEM NEEQSKKYLS GGGKIKDLPE
GLDGTDLGAC EWVELRKMED SEDGVPTYCS NDMKPSPKRT RDFSISEVAP VDSSAPVKED
PLPPPANRPG GRAALPPHIR DAMSKYDGVS GQMSGALPTV WMGGQNQYIY IHSAVTAWKQ
CLRRIKMPDA VLSIVHYKSR IFAALANGTI AIFHRNKHGE WSDEGYHSLR VGSATSSVRS
LCLVSTNIWA TYKNCVVVLD AESLQIVKVF AAHPRKDSQV RNMQWVGAGV WLSIRLDSTL
RLYHAHTYEH LQDVDIEPYV TKMLGTSKLD FSYMRTTALL VSNRRLWIGT GTGVIISVPF
SGQLEKKIET KDSKRPAGPG GLVRVYGATS ENATNDEKTN DDFIPYCNLA HAQLSFHGHK
DSVKFFLGVP GASKNGEDES AEVTLRRMLI MSGGDGYIDF RIGEENEPEL TGQSIRPRDM
SHLIIWEVDA ELPILSK


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