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Kallikrein 1-related peptidase b27 (EC 3.4.21.-) (Glandular kallikrein K27) (mGK-27) (Tissue kallikrein 27) (mKlk27)

 K1B27_MOUSE             Reviewed;         263 AA.
Q9JM71; A2RSF8;
24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
20-JUN-2018, entry version 120.
RecName: Full=Kallikrein 1-related peptidase b27;
EC=3.4.21.-;
AltName: Full=Glandular kallikrein K27;
Short=mGK-27;
AltName: Full=Tissue kallikrein 27;
Short=mKlk27;
Flags: Precursor;
Name=Klk1b27; Synonyms=Klk-27, Klk27;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000312|EMBL:BAA92318.1};
[1] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, TISSUE SPECIFICITY,
DEVELOPMENTAL STAGE, AND MUTAGENESIS OF GLY-209.
TISSUE=Testis {ECO:0000269|PubMed:11082197};
PubMed=11082197; DOI=10.1046/j.1432-1033.2000.01786.x;
Matsui H., Moriyama A., Takahashi T.;
"Cloning and characterization of mouse Klk27, a novel tissue
kallikrein expressed in testicular Leydig cells and exhibiting
chymotrypsin-like specificity.";
Eur. J. Biochem. 267:6858-6865(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Serine protease with chymotrypsin-like cleavage
specificity. Shows activity towards casein, gelatin, IGFBP3 and
fibronectin but not towards laminin or collagens I and IV. Does
not hydrolyze kininogin to release Lys-bradykinin.
-!- ENZYME REGULATION: Strongly inhibited by protease inhibitors
diisopropyl fluorophosphate, phenylmethanesulfonyl fluoride and
SBTI. {ECO:0000269|PubMed:11082197}.
-!- TISSUE SPECIFICITY: Expressed in testis and submaxillary gland.
Not expressed in heart, brain, spleen, lung, liver, muscle, kidney
and ovary. In the testis, expression localized specifically to
Leydig cells in the interstitial tissues.
{ECO:0000269|PubMed:11082197}.
-!- DEVELOPMENTAL STAGE: Detectable in testis 4 weeks after birth,
becoming more prominent thereafter. {ECO:0000269|PubMed:11082197}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Kallikrein
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
-----------------------------------------------------------------------
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EMBL; AB039275; BAA92318.1; -; mRNA.
EMBL; BC132090; AAI32091.1; -; mRNA.
EMBL; BC132665; AAI32666.1; -; mRNA.
CCDS; CCDS21194.1; -.
RefSeq; NP_064664.1; NM_020268.3.
UniGene; Mm.445911; -.
ProteinModelPortal; Q9JM71; -.
SMR; Q9JM71; -.
STRING; 10090.ENSMUSP00000078786; -.
MEROPS; S01.073; -.
MaxQB; Q9JM71; -.
PaxDb; Q9JM71; -.
PRIDE; Q9JM71; -.
Ensembl; ENSMUST00000079859; ENSMUSP00000078786; ENSMUSG00000063177.
GeneID; 16619; -.
KEGG; mmu:16619; -.
UCSC; uc009gog.1; mouse.
CTD; 16619; -.
MGI; MGI:891980; Klk1b27.
eggNOG; KOG3627; Eukaryota.
eggNOG; COG5640; LUCA.
GeneTree; ENSGT00920000149111; -.
HOGENOM; HOG000251820; -.
HOVERGEN; HBG013304; -.
InParanoid; Q9JM71; -.
OrthoDB; EOG091G0DF7; -.
PhylomeDB; Q9JM71; -.
TreeFam; TF331065; -.
PRO; PR:Q9JM71; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000063177; -.
CleanEx; MM_KLK1B27; -.
Genevisible; Q9JM71; MM.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0032991; C:protein-containing complex; ISO:MGI.
GO; GO:0004175; F:endopeptidase activity; ISO:MGI.
GO; GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; ISO:MGI.
GO; GO:0008233; F:peptidase activity; IDA:MGI.
GO; GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO; GO:0006508; P:proteolysis; IDA:UniProtKB.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Protease;
Reference proteome; Serine protease; Signal; Zymogen.
SIGNAL 1 17 {ECO:0000255}.
PROPEP 18 24 Activation peptide.
{ECO:0000250|UniProtKB:P36368}.
/FTId=PRO_0000027995.
CHAIN 25 263 Kallikrein 1-related peptidase b27.
/FTId=PRO_0000027996.
DOMAIN 25 260 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 65 65 Charge relay system.
{ECO:0000250|UniProtKB:P36368}.
ACT_SITE 122 122 Charge relay system.
{ECO:0000250|UniProtKB:P36368}.
ACT_SITE 215 215 Charge relay system.
{ECO:0000250|UniProtKB:P36368}.
CARBOHYD 69 69 N-linked (GlcNAc...) asparagine.
{ECO:0000305}.
CARBOHYD 105 105 N-linked (GlcNAc...) asparagine.
{ECO:0000305}.
DISULFID 31 175 {ECO:0000250|UniProtKB:P36368,
ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 50 66 {ECO:0000250|UniProtKB:P36368,
ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 154 221 {ECO:0000250|UniProtKB:P36368,
ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 186 200 {ECO:0000250|UniProtKB:P36368,
ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 211 236 {ECO:0000250|UniProtKB:P36368,
ECO:0000255|PROSITE-ProRule:PRU00274}.
MUTAGEN 209 209 G->D: Loss of chymotryptic specificity
and acquisition of trypsin-like cleavage
specificity.
{ECO:0000269|PubMed:11082197}.
SEQUENCE 263 AA; 28742 MW; 2B396C2DD3B359FB CRC64;
MRFLILFLAL SLGGIDAAPP VQSRIIGGFK CKKNSQPWHV AVLRSNKYIC GGVLLDPNWV
LTAAHCYGND TSQHNVWLGK NKLFQREPSA QHRWVSKSFP HPDYNMSLLN DHIPHPEDKS
NDLMLLRLSK PADITDAVKP IDLPTEEPKL GSTCLASGWG SITPTKYQIP NDLQCVFIKL
LPNENCAKAY VHKVTDVMLC VGETGGGKGT CKGDSGGPLI CDGVLHGITS WGSIPCAKPN
APGVFTKLIK FTSWIKDTMA KNP


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