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Kappa-casein

 CASK_HUMAN              Reviewed;         182 AA.
P07498; Q13575;
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 3.
16-JAN-2019, entry version 179.
RecName: Full=Kappa-casein;
Flags: Precursor;
Name=CSN3; Synonyms=CASK, CSN10, CSNK;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-145.
Menon R.S., Jeffers K.F., Chang Y.F., Ham R.G.;
Submitted (JUL-1991) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary gland;
PubMed=1296818; DOI=10.3109/10425179209034024;
Bergstroem S., Hansson L., Hernell O., Loennerdal B., Nilsson A.K.,
Stroemqvist M.;
"Cloning and sequencing of human kappa-casein cDNA.";
DNA Seq. 3:245-246(1992).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANT LEU-110.
PubMed=8863730; DOI=10.1016/0378-1119(96)00351-4;
Edlund A., Johansson T., Leidvik B., Hansson L.;
"Structure of the human kappa-casein gene.";
Gene 174:65-69(1996).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-75.
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PROTEIN SEQUENCE OF 25-182.
PubMed=4018271; DOI=10.1016/0014-5793(85)80872-3;
Brignon G., Chtourou A., Ribadeau-Dumas B.;
"Preparation and amino acid sequence of human kappa-casein.";
FEBS Lett. 188:48-54(1985).
[6]
PROTEIN SEQUENCE OF 118-182, AND GLYCOSYLATION AT THR-133; THR-143;
THR-148; THR-151; THR-157; THR-167 AND THR-169.
PubMed=7460900; DOI=10.1111/j.1432-1033.1980.tb04946.x;
Fiat A.-M., Jolles J., Aubert J.-P., Loucheux-Lefebvre M.H.,
Jolles P.;
"Localisation and importance of the sugar part of human casein.";
Eur. J. Biochem. 111:333-339(1980).
[7]
STRUCTURE BY NMR OF 108-125.
PubMed=10191473;
Plowman J.E., Creamer L.K., Liddell M.J., Cross J.J.;
"Structural features of a peptide corresponding to human kappa-casein
residues 84-101 by 1H-nuclear magnetic resonance spectroscopy.";
J. Dairy Res. 66:53-63(1999).
-!- FUNCTION: Kappa-casein stabilizes micelle formation, preventing
casein precipitation in milk.
-!- SUBUNIT: Heteromultimers composed of alpha-s1 casein and kappa
casein linked by disulfide bonds.
-!- INTERACTION:
Q93062:RBPMS; NbExp=3; IntAct=EBI-2602175, EBI-740322;
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
-!- PTM: The N-terminus is blocked.
-!- SIMILARITY: Belongs to the kappa-casein family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Protein Spotlight; Note=Of buttons, digestion
and glue - Issue 16 of November 2001;
URL="https://web.expasy.org/spotlight/back_issues/016";
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EMBL; M73628; AAA59456.1; -; mRNA.
EMBL; X66417; CAA47048.1; -; mRNA.
EMBL; U51899; AAC50772.1; -; Genomic_DNA.
EMBL; BC010935; AAH10935.1; -; mRNA.
CCDS; CCDS3538.1; -.
PIR; JC4957; KKHU.
RefSeq; NP_005203.2; NM_005212.2.
RefSeq; XP_011529922.1; XM_011531620.2.
RefSeq; XP_016863250.1; XM_017007761.1.
UniGene; Hs.54415; -.
ProteinModelPortal; P07498; -.
BioGrid; 107835; 8.
IntAct; P07498; 7.
MINT; P07498; -.
STRING; 9606.ENSP00000304822; -.
ChEMBL; CHEMBL3621024; -.
Allergome; 1064; Hom s 8.
GlyConnect; 308; -.
iPTMnet; P07498; -.
PhosphoSitePlus; P07498; -.
SwissPalm; P07498; -.
UniCarbKB; P07498; -.
BioMuta; CSN3; -.
PaxDb; P07498; -.
PeptideAtlas; P07498; -.
PRIDE; P07498; -.
ProteomicsDB; 52011; -.
TopDownProteomics; P07498; -.
DNASU; 1448; -.
Ensembl; ENST00000304954; ENSP00000304822; ENSG00000171209.
GeneID; 1448; -.
KEGG; hsa:1448; -.
UCSC; uc003hfe.5; human.
CTD; 1448; -.
DisGeNET; 1448; -.
EuPathDB; HostDB:ENSG00000171209.3; -.
GeneCards; CSN3; -.
HGNC; HGNC:2446; CSN3.
HPA; HPA035953; -.
HPA; HPA035954; -.
MIM; 601695; gene.
neXtProt; NX_P07498; -.
OpenTargets; ENSG00000171209; -.
PharmGKB; PA26949; -.
eggNOG; ENOG410JCVG; Eukaryota.
eggNOG; ENOG4111E7Q; LUCA.
GeneTree; ENSGT00390000009184; -.
HOGENOM; HOG000111309; -.
HOVERGEN; HBG005246; -.
InParanoid; P07498; -.
KO; K17282; -.
OMA; RPHAQIP; -.
OrthoDB; 856254at2759; -.
PhylomeDB; P07498; -.
TreeFam; TF338369; -.
Reactome; R-HSA-5223345; Miscellaneous transport and binding events.
GeneWiki; CSN3_(gene); -.
GenomeRNAi; 1448; -.
PMAP-CutDB; P07498; -.
PRO; PR:P07498; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000171209; Expressed in 38 organ(s), highest expression level in minor salivary gland.
CleanEx; HS_CASK; -.
CleanEx; HS_CSN3; -.
Genevisible; P07498; HS.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0007595; P:lactation; IDA:UniProtKB.
GO; GO:0050821; P:protein stabilization; IDA:UniProtKB.
GO; GO:0055085; P:transmembrane transport; TAS:Reactome.
InterPro; IPR000117; Casein_kappa.
PANTHER; PTHR11470; PTHR11470; 1.
Pfam; PF00997; Casein_kappa; 1.
PIRSF; PIRSF002374; Casein_kappa; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Disulfide bond;
Glycoprotein; Milk protein; Phosphoprotein; Polymorphism;
Reference proteome; Secreted; Signal.
SIGNAL 1 20
CHAIN 21 182 Kappa-casein.
/FTId=PRO_0000004498.
SITE 117 118 Cleavage; by chymosin/rennin.
MOD_RES 157 157 Phosphothreonine; alternate.
{ECO:0000250|UniProtKB:P02668}.
CARBOHYD 133 133 O-linked (GalNAc...) threonine.
{ECO:0000269|PubMed:7460900}.
CARBOHYD 143 143 O-linked (GalNAc...) threonine.
{ECO:0000269|PubMed:7460900}.
CARBOHYD 148 148 O-linked (GalNAc...) threonine.
{ECO:0000269|PubMed:7460900}.
CARBOHYD 151 151 O-linked (GalNAc...) threonine.
{ECO:0000269|PubMed:7460900}.
CARBOHYD 157 157 O-linked (GalNAc...) threonine;
alternate. {ECO:0000269|PubMed:7460900}.
CARBOHYD 167 167 O-linked (GalNAc...) threonine.
{ECO:0000269|PubMed:7460900}.
CARBOHYD 169 169 O-linked (GalNAc...) threonine.
{ECO:0000269|PubMed:7460900}.
CARBOHYD 178 178 O-linked (GalNAc...) threonine.
{ECO:0000250|UniProtKB:P02668}.
VARIANT 75 75 Y -> C (in dbSNP:rs17850702).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_026338.
VARIANT 110 110 R -> L (in dbSNP:rs1048152).
{ECO:0000269|PubMed:8863730}.
/FTId=VAR_026339.
VARIANT 145 145 A -> T (in dbSNP:rs3775739).
{ECO:0000269|Ref.1}.
/FTId=VAR_026340.
CONFLICT 25 27 QKQ -> EQK (in Ref. 5; AA sequence).
{ECO:0000305}.
CONFLICT 153 153 D -> N (in Ref. 5; AA sequence).
{ECO:0000305}.
CONFLICT 161 161 F -> T (in Ref. 6; AA sequence).
{ECO:0000305}.
CONFLICT 162 162 S -> T (in Ref. 5; AA sequence and 6; AA
sequence). {ECO:0000305}.
CONFLICT 173 173 T -> P (in Ref. 5; AA sequence and 6; AA
sequence). {ECO:0000305}.
CONFLICT 178 181 TPPT -> PTTS (in Ref. 5; AA sequence and
6; AA sequence). {ECO:0000305}.
SEQUENCE 182 AA; 20305 MW; 8A1609D2D5C94895 CRC64;
MKSFLLVVNA LALTLPFLAV EVQNQKQPAC HENDERPFYQ KTAPYVPMYY VPNSYPYYGT
NLYQRRPAIA INNPYVPRTY YANPAVVRPH AQIPQRQYLP NSHPPTVVRR PNLHPSFIAI
PPKKIQDKII IPTINTIATV EPTPAPATEP TVDSVVTPEA FSESIITSTP ETTTVAVTPP
TA


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