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Kappa-casein (Kappa-CN)

 CASK_CAPHI              Reviewed;         192 AA.
P02670; Q8SPM9; Q8SPN0; Q8SPV1; Q8SPW6; Q8SPW7; Q8SPW8; Q8WMV5;
Q8WN74;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
01-AUG-1992, sequence version 2.
10-MAY-2017, entry version 101.
RecName: Full=Kappa-casein;
Short=Kappa-CN;
Flags: Precursor;
Name=CSN3; Synonyms=CSN10, CSNK;
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Ssp. aegagrus; TISSUE=Mammary gland;
PubMed=8226388;
Coll A., Folch J.M., Sanchez A.;
"Nucleotide sequence of the goat kappa-casein cDNA.";
J. Anim. Sci. 71:2833-2833(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8587130; DOI=10.1007/BF00173165;
Chikuni K., Mori Y., Tabata T., Saito M., Monma M., Kosugiyama M.;
"Molecular phylogeny based on the kappa-casein and cytochrome b
sequences in the mammalian suborder ruminantia.";
J. Mol. Evol. 41:859-866(1995).
[3]
PROTEIN SEQUENCE OF 22-192, AND PYROGLUTAMATE FORMATION AT GLN-22.
PubMed=16386026; DOI=10.1016/0014-5793(76)80972-6;
Mercier J.-C., Chobert J.-M., Addeo F.;
"Comparative study of the amino acid sequences of the
caseinomacropeptides from seven species.";
FEBS Lett. 72:208-214(1976).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-192, AND VARIANTS ARG-65;
ILE-86; ILE-140 AND PRO-180.
PubMed=11531704; DOI=10.1046/j.1365-2052.2001.00765.x;
Caroli A., Jann O., Budelli E., Bolla P., Jaeger S., Erhardt G.;
"Genetic polymorphism of goat kappa-casein (CSN3) in different breeds
and characterization at DNA level.";
Anim. Genet. 32:226-230(2001).
[5]
NUCLEOTIDE SEQUENCE OF 31-192, AND VARIANTS ILE-86; ILE-140; VAL-177
AND PRO-180.
PubMed=11504385;
Yahyaoui M.H., Coll A., Sanchez A., Folch J.M.;
"Genetic polymorphism of the caprine kappa casein gene.";
J. Dairy Res. 68:209-216(2001).
[6]
NUCLEOTIDE SEQUENCE OF 31-192, AND VARIANTS GLY-111 AND ILE-140.
Angiolillo A., Yahyaoui M.H., Sanchez A., Pilla F., Folch J.M.;
"Characterization of a new genetic variant in the caprine k-casein
gene.";
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE OF 31-192, AND VARIANTS ARG-65; ILE-86; ILE-140
AND PRO-180.
Yahyaoui M.H., Sanchez A., Folch J.M.;
"Characterization of new genetic variants and genotyping of the
caprine kappa casein gene.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE OF 31-189, AND VARIANT ILE-140.
Feligini M., Cubric-Curik V., Parma P., Curik I., Greppi G., Enne G.;
"Polymorphism of kappa-casein in Italian goat breeds: a new ACRS-PCR
designed DNA test for discrimination of A and B alleles.";
Food Technol. Biotechnol. 40:293-298(2002).
[9]
PROTEIN SEQUENCE OF 127-192, AND PHOSPHORYLATION AT SER-172 AND
SER-189.
PubMed=1016651;
Mercier J.-C., Addeo F., Pelissier J.-P.;
"Primary structure of the casein macropeptide of caprine kappa
casein.";
Biochimie 58:1303-1310(1976).
-!- FUNCTION: Kappa-casein stabilizes micelle formation, preventing
casein precipitation in milk.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Mammary gland specific. Secreted in milk.
-!- SIMILARITY: Belongs to the kappa-casein family. {ECO:0000305}.
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EMBL; D14373; BAA03286.1; -; Genomic_DNA.
EMBL; X60763; CAA43174.1; -; mRNA.
EMBL; AY027868; AAK17010.1; -; Genomic_DNA.
EMBL; AF485339; AAL90871.1; -; Genomic_DNA.
EMBL; AF485340; AAL90872.1; -; Genomic_DNA.
EMBL; AF485341; AAL90873.1; -; Genomic_DNA.
EMBL; AF486523; AAL93193.1; -; Genomic_DNA.
EMBL; AY090465; AAM12025.1; -; Genomic_DNA.
EMBL; AY090466; AAM12026.1; -; Genomic_DNA.
EMBL; AY090467; AAM12027.1; -; Genomic_DNA.
EMBL; AF434988; AAL31535.1; -; Genomic_DNA.
PIR; A94479; KKGT.
PIR; S15513; S15513.
RefSeq; NP_001272516.1; NM_001285587.1.
UniGene; Chi.520; -.
ProteinModelPortal; P02670; -.
Allergome; 1242; Cap h 8.
Allergome; 2969; Cap h 12.
iPTMnet; P02670; -.
GeneID; 100861231; -.
KEGG; chx:100861231; -.
CTD; 1448; -.
HOVERGEN; HBG005246; -.
KO; K17282; -.
OrthoDB; EOG091G105X; -.
PMAP-CutDB; P02670; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
InterPro; IPR000117; Casein_kappa.
PANTHER; PTHR11470; PTHR11470; 1.
Pfam; PF00997; Casein_kappa; 1.
PIRSF; PIRSF002374; Casein_kappa; 1.
1: Evidence at protein level;
Direct protein sequencing; Glycoprotein; Milk protein; Phosphoprotein;
Polymorphism; Pyrrolidone carboxylic acid; Secreted; Signal.
SIGNAL 1 21 {ECO:0000269|PubMed:16386026}.
CHAIN 22 192 Kappa-casein.
/FTId=PRO_0000004492.
SITE 126 127 Cleavage; by chymosin/rennin.
MOD_RES 22 22 Pyrrolidone carboxylic acid.
{ECO:0000269|PubMed:16386026}.
MOD_RES 148 148 Phosphoserine.
{ECO:0000250|UniProtKB:P02668}.
MOD_RES 172 172 Phosphoserine; alternate.
{ECO:0000269|PubMed:1016651}.
MOD_RES 189 189 Phosphoserine.
{ECO:0000269|PubMed:1016651}.
CARBOHYD 152 152 O-linked (GalNAc...) threonine.
{ECO:0000250|UniProtKB:P02668}.
CARBOHYD 155 155 O-linked (GalNAc...) serine.
{ECO:0000250|UniProtKB:P02668}.
CARBOHYD 156 156 O-linked (GalNAc...) threonine.
{ECO:0000250|UniProtKB:P02668}.
CARBOHYD 159 159 O-linked (GalNAc...) threonine.
{ECO:0000250|UniProtKB:P02668}.
CARBOHYD 165 165 O-linked (GalNAc...) threonine.
{ECO:0000250|UniProtKB:P02668}.
CARBOHYD 172 172 O-linked (GalNAc...) serine; alternate.
{ECO:0000250|UniProtKB:P02668}.
CARBOHYD 188 188 O-linked (GalNAc...) threonine.
{ECO:0000250|UniProtKB:P02668}.
VARIANT 65 65 Q -> R (in allele CSN3-B).
{ECO:0000269|PubMed:11531704,
ECO:0000269|Ref.7}.
VARIANT 86 86 V -> I (in allele CSN3-B, allele C and
allele G). {ECO:0000269|PubMed:11504385,
ECO:0000269|PubMed:11531704,
ECO:0000269|Ref.7}.
VARIANT 111 111 D -> G (in allele E).
{ECO:0000269|Ref.6}.
VARIANT 140 140 V -> I (in allele CSN3-B, allele B,
allele C, allele E, allele F and allele
G). {ECO:0000269|PubMed:11504385,
ECO:0000269|PubMed:11531704,
ECO:0000269|Ref.6, ECO:0000269|Ref.7,
ECO:0000269|Ref.8}.
VARIANT 177 177 A -> V (in allele C).
{ECO:0000269|PubMed:11504385}.
VARIANT 180 180 S -> P (in allele CSN3-B, allele C,
allele F and allele G).
{ECO:0000269|PubMed:11504385,
ECO:0000269|PubMed:11531704,
ECO:0000269|Ref.7}.
CONFLICT 134 134 D -> N (in Ref. 3; AA sequence).
{ECO:0000305}.
SEQUENCE 192 AA; 21441 MW; 009F5858F4BFB178 CRC64;
MMKSFFLVVT ILALTLPFLG AQEQNQEQPI CCEKDERFFD DKIAKYIPIQ YVLSRYPSYG
LNYYQQRPVA LINNQFLPYP YYAKPVAVRS PAQTLQWQVL PNTVPAKSCQ DQPTTLARHP
HPHLSFMAIP PKKDQDKTEV PAINTIASAE PTVHSTPTTE AIVNTVDNPE ASSESIASAS
ETNTAQVTST EV


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