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Keratin, type I cuticular Ha1 (Hair keratin, type I Ha1) (Keratin-31) (K31)

 K1H1_HUMAN              Reviewed;         416 AA.
Q15323; Q9UE12;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
14-OCT-2008, sequence version 3.
25-OCT-2017, entry version 141.
RecName: Full=Keratin, type I cuticular Ha1;
AltName: Full=Hair keratin, type I Ha1;
AltName: Full=Keratin-31;
Short=K31;
Name=KRT31; Synonyms=HHA1, HKA1, KRTHA1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Hair;
PubMed=7578244; DOI=10.1016/0167-4781(95)00122-W;
Fink P., Rogers M.A., Krieg T., Winter H., Schweizer J.;
"A cDNA encoding the human type I hair keratin hHal.";
Biochim. Biophys. Acta 1264:12-14(1995).
[2]
SEQUENCE REVISION.
Rogers M.A.;
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
PubMed=9756910; DOI=10.1074/jbc.273.41.26683;
Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.;
"Characterization of a 190-kilobase pair domain of human type I hair
keratin genes.";
J. Biol. Chem. 273:26683-26691(1998).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
TISSUE SPECIFICITY.
PubMed=9457912; DOI=10.1046/j.1523-1747.1998.00097.x;
Bowden P.E., Hainey S.D., Parker G., Jones D.O., Zimonjic D.,
Popescu N., Hodgins M.B.;
"Characterization and chromosomal localization of human hair-specific
keratin genes and comparative expression during the hair growth
cycle.";
J. Invest. Dermatol. 110:158-164(1998).
-!- INTERACTION:
Q53FW8:-; NbExp=3; IntAct=EBI-948001, EBI-10242473;
Q8N9J2:-; NbExp=5; IntAct=EBI-948001, EBI-10268244;
Q9NYB9:ABI2; NbExp=3; IntAct=EBI-948001, EBI-743598;
Q9P2A4:ABI3; NbExp=4; IntAct=EBI-948001, EBI-742038;
Q08117:AES; NbExp=3; IntAct=EBI-948001, EBI-717810;
O95994:AGR2; NbExp=5; IntAct=EBI-948001, EBI-712648;
P43353:ALDH3B1; NbExp=3; IntAct=EBI-948001, EBI-2558314;
Q4VCS5-2:AMOT; NbExp=5; IntAct=EBI-948001, EBI-3891843;
Q9Y2J4-4:AMOTL2; NbExp=3; IntAct=EBI-948001, EBI-10187270;
Q96IX9:ANKRD36BP1; NbExp=3; IntAct=EBI-948001, EBI-744859;
P29972:AQP1; NbExp=3; IntAct=EBI-948001, EBI-745213;
P55064:AQP5; NbExp=3; IntAct=EBI-948001, EBI-746103;
Q9H6L4:ARMC7; NbExp=5; IntAct=EBI-948001, EBI-742909;
Q8N5N6:ARSJ; NbExp=3; IntAct=EBI-948001, EBI-10266832;
O95671:ASMTL; NbExp=5; IntAct=EBI-948001, EBI-743231;
Q9BZE9:ASPSCR1; NbExp=3; IntAct=EBI-948001, EBI-1993677;
Q7Z3C6:ATG9A; NbExp=3; IntAct=EBI-948001, EBI-727146;
Q9ULK2:ATXN7L1; NbExp=3; IntAct=EBI-948001, EBI-310660;
Q9BXY8:BEX2; NbExp=5; IntAct=EBI-948001, EBI-745073;
P35070:BTC; NbExp=5; IntAct=EBI-948001, EBI-6590057;
Q13895:BYSL; NbExp=3; IntAct=EBI-948001, EBI-358049;
Q9H741:C12orf49; NbExp=3; IntAct=EBI-948001, EBI-2836158;
Q9NVV2:C19orf73; NbExp=3; IntAct=EBI-948001, EBI-2859285;
Q9NX04:C1orf109; NbExp=5; IntAct=EBI-948001, EBI-8643161;
Q8TAB5:C1orf216; NbExp=5; IntAct=EBI-948001, EBI-747505;
Q53TS8:C2CD6; NbExp=5; IntAct=EBI-948001, EBI-739879;
A6NFR6-4:C5orf60; NbExp=3; IntAct=EBI-948001, EBI-10173955;
Q8N4G4:CA6; NbExp=3; IntAct=EBI-948001, EBI-10265475;
Q9H257:CARD9; NbExp=3; IntAct=EBI-948001, EBI-751319;
Q7Z7H3:CATIP; NbExp=5; IntAct=EBI-948001, EBI-10258233;
Q8NEF3:CCDC112; NbExp=3; IntAct=EBI-948001, EBI-745040;
Q96HB5-4:CCDC120; NbExp=3; IntAct=EBI-948001, EBI-10185348;
Q96LX7:CCDC17; NbExp=3; IntAct=EBI-948001, EBI-719840;
Q8TC90:CCER1; NbExp=3; IntAct=EBI-948001, EBI-746041;
Q8TD31-3:CCHCR1; NbExp=5; IntAct=EBI-948001, EBI-10175300;
P24863:CCNC; NbExp=7; IntAct=EBI-948001, EBI-395261;
P20138:CD33; NbExp=5; IntAct=EBI-948001, EBI-3906571;
Q86Y33:CDC20B; NbExp=3; IntAct=EBI-948001, EBI-10260504;
Q07002:CDK18; NbExp=3; IntAct=EBI-948001, EBI-746238;
P38936:CDKN1A; NbExp=5; IntAct=EBI-948001, EBI-375077;
Q86X02:CDR2L; NbExp=4; IntAct=EBI-948001, EBI-11063830;
Q86XR8:CEP57; NbExp=3; IntAct=EBI-948001, EBI-308614;
Q8IYX8:CEP57L1; NbExp=3; IntAct=EBI-948001, EBI-1104570;
Q8IYX8-2:CEP57L1; NbExp=3; IntAct=EBI-948001, EBI-10181988;
Q8NHQ1:CEP70; NbExp=3; IntAct=EBI-948001, EBI-739624;
Q8IYR0:CFAP206; NbExp=3; IntAct=EBI-948001, EBI-749051;
Q9Y6H1:CHCHD2; NbExp=3; IntAct=EBI-948001, EBI-2321769;
P07510:CHRNG; NbExp=3; IntAct=EBI-948001, EBI-9008836;
P07510-2:CHRNG; NbExp=5; IntAct=EBI-948001, EBI-11979451;
P57739:CLDN2; NbExp=3; IntAct=EBI-948001, EBI-751440;
Q86WW8:COA5; NbExp=3; IntAct=EBI-948001, EBI-5458774;
P21964-2:COMT; NbExp=3; IntAct=EBI-948001, EBI-10200977;
P20674:COX5A; NbExp=3; IntAct=EBI-948001, EBI-715032;
P10606:COX5B; NbExp=3; IntAct=EBI-948001, EBI-1053725;
P06850:CRH; NbExp=3; IntAct=EBI-948001, EBI-3870390;
P08311:CTSG; NbExp=3; IntAct=EBI-948001, EBI-5462635;
Q9BY27:DGCR6L; NbExp=3; IntAct=EBI-948001, EBI-742953;
Q9NQL9:DMRT3; NbExp=5; IntAct=EBI-948001, EBI-9679045;
O60941:DTNB; NbExp=3; IntAct=EBI-948001, EBI-740402;
O60573:EIF4E2; NbExp=3; IntAct=EBI-948001, EBI-398610;
Q8IYI6:EXOC8; NbExp=3; IntAct=EBI-948001, EBI-742102;
Q9BTL3:FAM103A1; NbExp=5; IntAct=EBI-948001, EBI-744023;
Q9BQ89:FAM110A; NbExp=5; IntAct=EBI-948001, EBI-1752811;
Q9H5Z6:FAM124B; NbExp=3; IntAct=EBI-948001, EBI-741626;
Q8NEG0:FAM71C; NbExp=5; IntAct=EBI-948001, EBI-752049;
Q5TZK3:FAM74A6; NbExp=5; IntAct=EBI-948001, EBI-10247271;
Q86YD7:FAM90A1; NbExp=5; IntAct=EBI-948001, EBI-6658203;
O95363:FARS2; NbExp=3; IntAct=EBI-948001, EBI-2513774;
Q8TES7-6:FBF1; NbExp=3; IntAct=EBI-948001, EBI-10244131;
Q969U6:FBXW5; NbExp=5; IntAct=EBI-948001, EBI-741068;
P68106:FKBP1B; NbExp=3; IntAct=EBI-948001, EBI-6693977;
Q99853:FOXB1; NbExp=3; IntAct=EBI-948001, EBI-3916225;
P55040:GEM; NbExp=5; IntAct=EBI-948001, EBI-744104;
Q9NXC2:GFOD1; NbExp=3; IntAct=EBI-948001, EBI-8799578;
O76003:GLRX3; NbExp=3; IntAct=EBI-948001, EBI-374781;
P04899:GNAI2; NbExp=3; IntAct=EBI-948001, EBI-353997;
Q9Y223:GNE; NbExp=3; IntAct=EBI-948001, EBI-4291090;
P50151:GNG10; NbExp=3; IntAct=EBI-948001, EBI-10211741;
P63218:GNG5; NbExp=3; IntAct=EBI-948001, EBI-10220734;
Q13227:GPS2; NbExp=6; IntAct=EBI-948001, EBI-713355;
P09211:GSTP1; NbExp=5; IntAct=EBI-948001, EBI-353467;
Q96CS2:HAUS1; NbExp=3; IntAct=EBI-948001, EBI-2514791;
P56524:HDAC4; NbExp=3; IntAct=EBI-948001, EBI-308629;
O14964:HGS; NbExp=5; IntAct=EBI-948001, EBI-740220;
P49639:HOXA1; NbExp=5; IntAct=EBI-948001, EBI-740785;
Q96MM6:HSPA12B; NbExp=5; IntAct=EBI-948001, EBI-10291310;
P10809:HSPD1; NbExp=3; IntAct=EBI-948001, EBI-352528;
Q14773-3:ICAM4; NbExp=5; IntAct=EBI-948001, EBI-10233928;
Q8IUU6:IL16; NbExp=4; IntAct=EBI-948001, EBI-746574;
Q92835:INPP5D; NbExp=3; IntAct=EBI-948001, EBI-1380477;
Q9BT40:INPP5K; NbExp=5; IntAct=EBI-948001, EBI-749162;
P06213:INSR; NbExp=3; IntAct=EBI-948001, EBI-475899;
Q15040:JOSD1; NbExp=3; IntAct=EBI-948001, EBI-2510602;
Q9BVG8:KIFC3; NbExp=3; IntAct=EBI-948001, EBI-2125614;
Q07866:KLC1; NbExp=3; IntAct=EBI-948001, EBI-721019;
Q9NSK0:KLC4; NbExp=5; IntAct=EBI-948001, EBI-949319;
Q2WGJ6:KLHL38; NbExp=5; IntAct=EBI-948001, EBI-6426443;
P35908:KRT2; NbExp=9; IntAct=EBI-948001, EBI-1247312;
P13647:KRT5; NbExp=5; IntAct=EBI-948001, EBI-702187;
P02538:KRT6A; NbExp=11; IntAct=EBI-948001, EBI-702198;
P04259:KRT6B; NbExp=5; IntAct=EBI-948001, EBI-740907;
P48668:KRT6C; NbExp=5; IntAct=EBI-948001, EBI-2564105;
Q3SY84:KRT71; NbExp=5; IntAct=EBI-948001, EBI-2952676;
Q0IIN1:KRT77; NbExp=3; IntAct=EBI-948001, EBI-2511085;
Q5XKE5:KRT79; NbExp=5; IntAct=EBI-948001, EBI-2514135;
P05787:KRT8; NbExp=5; IntAct=EBI-948001, EBI-297852;
Q14533:KRT81; NbExp=7; IntAct=EBI-948001, EBI-739648;
Q9NSB4:KRT82; NbExp=4; IntAct=EBI-948001, EBI-1045341;
P78385:KRT83; NbExp=7; IntAct=EBI-948001, EBI-10221390;
Q6PJG3:LATS1; NbExp=3; IntAct=EBI-948001, EBI-10253976;
Q5T7P3:LCE1B; NbExp=4; IntAct=EBI-948001, EBI-10245913;
Q5T5A8:LCE3C; NbExp=4; IntAct=EBI-948001, EBI-10245291;
Q9BYE3:LCE3D; NbExp=4; IntAct=EBI-948001, EBI-6658837;
Q5TA78:LCE4A; NbExp=3; IntAct=EBI-948001, EBI-10246358;
Q96BZ8:LENG1; NbExp=5; IntAct=EBI-948001, EBI-726510;
Q96GY3:LIN37; NbExp=3; IntAct=EBI-948001, EBI-748884;
A0A1B0GWI1:LINC00238; NbExp=5; IntAct=EBI-948001, EBI-10181422;
Q96FQ7:LINC00526; NbExp=5; IntAct=EBI-948001, EBI-10286106;
Q9BU23:LMF2; NbExp=3; IntAct=EBI-948001, EBI-10298556;
P61968:LMO4; NbExp=5; IntAct=EBI-948001, EBI-2798728;
Q17RB8:LONRF1; NbExp=5; IntAct=EBI-948001, EBI-2341787;
P57077-4:MAP3K7CL; NbExp=3; IntAct=EBI-948001, EBI-10215880;
O60336:MAPKBP1; NbExp=5; IntAct=EBI-948001, EBI-947402;
Q6IPE9:MARK4; NbExp=3; IntAct=EBI-948001, EBI-10250211;
Q96GZ3:MARK4; NbExp=3; IntAct=EBI-948001, EBI-10286833;
Q4ZG74:MGC13033; NbExp=3; IntAct=EBI-948001, EBI-10241963;
P00540:MOS; NbExp=4; IntAct=EBI-948001, EBI-1757866;
Q9NQ50:MRPL40; NbExp=3; IntAct=EBI-948001, EBI-1053902;
Q8NEY1-4:NAV1; NbExp=3; IntAct=EBI-948001, EBI-10270828;
Q8IW45:NAXD; NbExp=3; IntAct=EBI-948001, EBI-8650724;
Q9HC98:NEK6; NbExp=3; IntAct=EBI-948001, EBI-740364;
P48146:NPBWR2; NbExp=7; IntAct=EBI-948001, EBI-10210114;
Q9BWI9:OTUB2; NbExp=3; IntAct=EBI-948001, EBI-10300896;
C6KE32:P2RX7; NbExp=3; IntAct=EBI-948001, EBI-10176325;
Q8IVL6-2:P3H3; NbExp=4; IntAct=EBI-948001, EBI-12149899;
Q13526:PIN1; NbExp=5; IntAct=EBI-948001, EBI-714158;
Q16512:PKN1; NbExp=5; IntAct=EBI-948001, EBI-602382;
Q494U1-3:PLEKHN1; NbExp=4; IntAct=EBI-948001, EBI-12014286;
Q6NYC8:PPP1R18; NbExp=5; IntAct=EBI-948001, EBI-2557469;
P14222:PRF1; NbExp=5; IntAct=EBI-948001, EBI-724466;
P54646:PRKAA2; NbExp=3; IntAct=EBI-948001, EBI-1383852;
O43741:PRKAB2; NbExp=4; IntAct=EBI-948001, EBI-1053424;
A6NJB7:PRR19; NbExp=3; IntAct=EBI-948001, EBI-10174045;
P25786:PSMA1; NbExp=3; IntAct=EBI-948001, EBI-359352;
Q969U7:PSMG2; NbExp=5; IntAct=EBI-948001, EBI-723276;
Q8WXF1:PSPC1; NbExp=3; IntAct=EBI-948001, EBI-1392258;
P43115-12:PTGER3; NbExp=5; IntAct=EBI-948001, EBI-10234038;
Q8WUK0:PTPMT1; NbExp=5; IntAct=EBI-948001, EBI-7199479;
Q96JH8:RADIL; NbExp=5; IntAct=EBI-948001, EBI-744267;
Q9P2K3:RCOR3; NbExp=3; IntAct=EBI-948001, EBI-743428;
Q8N443:RIBC1; NbExp=5; IntAct=EBI-948001, EBI-10265323;
Q6P087:RPUSD3; NbExp=3; IntAct=EBI-948001, EBI-5458784;
Q9UHP6:RSPH14; NbExp=5; IntAct=EBI-948001, EBI-748350;
Q9BWG6:SCNM1; NbExp=5; IntAct=EBI-948001, EBI-748391;
Q9C0C4:SEMA4C; NbExp=5; IntAct=EBI-948001, EBI-10303490;
Q6NXQ0:SFRS2; NbExp=3; IntAct=EBI-948001, EBI-10251550;
Q92529:SHC3; NbExp=5; IntAct=EBI-948001, EBI-79084;
Q05CH4:SLC15A3; NbExp=3; IntAct=EBI-948001, EBI-10223741;
Q9UHI7:SLC23A1; NbExp=3; IntAct=EBI-948001, EBI-1759386;
Q86VD7:SLC25A42; NbExp=4; IntAct=EBI-948001, EBI-6598313;
P12236:SLC25A6; NbExp=3; IntAct=EBI-948001, EBI-356254;
Q96GM5:SMARCD1; NbExp=4; IntAct=EBI-948001, EBI-358489;
Q969G3:SMARCE1; NbExp=5; IntAct=EBI-948001, EBI-455078;
P49901:SMCP; NbExp=5; IntAct=EBI-948001, EBI-750494;
Q9H0W8:SMG9; NbExp=5; IntAct=EBI-948001, EBI-2872322;
O95863:SNAI1; NbExp=3; IntAct=EBI-948001, EBI-1045459;
Q9BV90:SNRNP25; NbExp=3; IntAct=EBI-948001, EBI-9675976;
Q86W54:SPATA24; NbExp=3; IntAct=EBI-948001, EBI-3916986;
Q9BUD6:SPON2; NbExp=5; IntAct=EBI-948001, EBI-10298801;
Q9Y2D8:SSX2IP; NbExp=3; IntAct=EBI-948001, EBI-2212028;
Q9BT49:THAP7; NbExp=5; IntAct=EBI-948001, EBI-741350;
Q9BVX2:TMEM106C; NbExp=7; IntAct=EBI-948001, EBI-2821497;
Q9H6L2:TMEM231; NbExp=3; IntAct=EBI-948001, EBI-10307654;
Q0P5Q0:TMSB4X; NbExp=3; IntAct=EBI-948001, EBI-10226570;
Q9BUZ4:TRAF4; NbExp=5; IntAct=EBI-948001, EBI-3650647;
Q12815:TROAP; NbExp=3; IntAct=EBI-948001, EBI-2349743;
Q99816:TSG101; NbExp=5; IntAct=EBI-948001, EBI-346882;
Q5W5X9:TTC23; NbExp=3; IntAct=EBI-948001, EBI-6447954;
Q5W5X9-3:TTC23; NbExp=4; IntAct=EBI-948001, EBI-9090990;
P40222:TXLNA; NbExp=5; IntAct=EBI-948001, EBI-359793;
Q8N6Y0:USHBP1; NbExp=3; IntAct=EBI-948001, EBI-739895;
Q9BRU9:UTP23; NbExp=3; IntAct=EBI-948001, EBI-5457544;
Q9UBK9:UXT; NbExp=5; IntAct=EBI-948001, EBI-357355;
Q64LD2:WDR25; NbExp=3; IntAct=EBI-948001, EBI-744560;
Q96HA8:WDYHV1; NbExp=3; IntAct=EBI-948001, EBI-741158;
Q9BQ24:ZFYVE21; NbExp=3; IntAct=EBI-948001, EBI-2849569;
Q15973:ZNF124; NbExp=3; IntAct=EBI-948001, EBI-2555767;
Q9UQR1:ZNF148; NbExp=3; IntAct=EBI-948001, EBI-2688184;
P17024:ZNF20; NbExp=3; IntAct=EBI-948001, EBI-717634;
Q5MCW4:ZNF569; NbExp=5; IntAct=EBI-948001, EBI-4395687;
Q7Z3I7:ZNF572; NbExp=3; IntAct=EBI-948001, EBI-10172590;
Q9UC07:ZNF69; NbExp=3; IntAct=EBI-948001, EBI-10320266;
Q9UC07-2:ZNF69; NbExp=4; IntAct=EBI-948001, EBI-12310821;
-!- TISSUE SPECIFICITY: Present in scalp but not in hairless skin.
Abundantly expressed in the differentiating cortex of growing
(anagen) hair. Expression is restricted to the keratinocytes of
the hair cortex and is absent from inner root sheath and medulla.
{ECO:0000269|PubMed:9457912, ECO:0000269|PubMed:9756910}.
-!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin,
I (acidic) and II (neutral to basic).
-!- SIMILARITY: Belongs to the intermediate filament family.
{ECO:0000255|PROSITE-ProRule:PRU01188}.
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EMBL; X86570; CAA60378.1; -; mRNA.
EMBL; Y16787; CAA76383.1; -; Genomic_DNA.
EMBL; CH471152; EAW60730.1; -; Genomic_DNA.
EMBL; BC114468; AAI14469.1; -; mRNA.
CCDS; CCDS11391.1; -.
PIR; S60034; S60034.
RefSeq; NP_002268.2; NM_002277.2.
UniGene; Hs.41696; -.
ProteinModelPortal; Q15323; -.
SMR; Q15323; -.
BioGrid; 110079; 198.
IntAct; Q15323; 361.
MINT; MINT-2860287; -.
STRING; 9606.ENSP00000251645; -.
iPTMnet; Q15323; -.
PhosphoSitePlus; Q15323; -.
SwissPalm; Q15323; -.
BioMuta; KRT31; -.
DMDM; 209572740; -.
PaxDb; Q15323; -.
PeptideAtlas; Q15323; -.
PRIDE; Q15323; -.
Ensembl; ENST00000251645; ENSP00000251645; ENSG00000094796.
Ensembl; ENST00000573281; ENSP00000460739; ENSG00000262993.
GeneID; 3881; -.
KEGG; hsa:3881; -.
UCSC; uc002hwn.4; human.
CTD; 3881; -.
DisGeNET; 3881; -.
EuPathDB; HostDB:ENSG00000094796.4; -.
GeneCards; KRT31; -.
H-InvDB; HIX0039252; -.
HGNC; HGNC:6448; KRT31.
HPA; HPA049550; -.
HPA; HPA055194; -.
MIM; 601077; gene.
neXtProt; NX_Q15323; -.
OpenTargets; ENSG00000094796; -.
PharmGKB; PA30237; -.
eggNOG; ENOG410IF9P; Eukaryota.
eggNOG; ENOG410YK2A; LUCA.
GeneTree; ENSGT00900000140814; -.
HOGENOM; HOG000230975; -.
HOVERGEN; HBG013015; -.
InParanoid; Q15323; -.
KO; K07604; -.
OMA; NPCVSRT; -.
OrthoDB; EOG091G087I; -.
PhylomeDB; Q15323; -.
TreeFam; TF332742; -.
Reactome; R-HSA-6805567; Keratinization.
Reactome; R-HSA-6809371; Formation of the cornified envelope.
GeneWiki; KRT31; -.
GenomeRNAi; 3881; -.
PRO; PR:Q15323; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000094796; -.
CleanEx; HS_KRT31; -.
Genevisible; Q15323; HS.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0005882; C:intermediate filament; TAS:ProtInc.
GO; GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
GO; GO:0070268; P:cornification; TAS:Reactome.
GO; GO:0008544; P:epidermis development; TAS:ProtInc.
GO; GO:0031424; P:keratinization; TAS:Reactome.
InterPro; IPR001664; IF.
InterPro; IPR018039; Intermediate_filament_CS.
InterPro; IPR002957; Keratin_I.
PANTHER; PTHR23239; PTHR23239; 1.
Pfam; PF00038; Filament; 1.
PRINTS; PR01248; TYPE1KERATIN.
SMART; SM01391; Filament; 1.
PROSITE; PS00226; IF_ROD_1; 1.
PROSITE; PS51842; IF_ROD_2; 1.
1: Evidence at protein level;
Coiled coil; Complete proteome; Intermediate filament; Keratin;
Polymorphism; Reference proteome.
CHAIN 1 416 Keratin, type I cuticular Ha1.
/FTId=PRO_0000063684.
DOMAIN 56 367 IF rod. {ECO:0000255|PROSITE-
ProRule:PRU01188}.
REGION 1 56 Head.
REGION 57 91 Coil 1A.
REGION 92 102 Linker 1.
REGION 103 203 Coil 1B.
REGION 204 219 Linker 12.
REGION 220 363 Coil 2.
REGION 364 416 Tail.
SITE 305 305 Stutter.
VARIANT 39 39 A -> G (in dbSNP:rs6503628).
/FTId=VAR_046989.
VARIANT 82 82 A -> V (in dbSNP:rs6503627).
/FTId=VAR_046990.
VARIANT 377 377 A -> V (in dbSNP:rs34293483).
/FTId=VAR_046991.
CONFLICT 153 154 QL -> HV (in Ref. 1; CAA60378).
{ECO:0000305}.
SEQUENCE 416 AA; 47237 MW; C284DD33A4896009 CRC64;
MPYNFCLPSL SCRTSCSSRP CVPPSCHSCT LPGACNIPAN VSNCNWFCEG SFNGSEKETM
QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCT
KSENARLVVQ IDNAKLAADD FRTKYQTELS LRQLVESDIN GLRRILDELT LCKSDLEAQV
ESLKEELLCL KSNHEQEVNT LRCQLGDRLN VEVDAAPTVD LNRVLNETRS QYEALVETNR
REVEQWFTTQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL
ESEDCNLPSN PCATTNACSK PIGPCLSNPC TSCVPPAPCT PCAPRPRCGP CNSFVR


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