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Keratin, type I cuticular Ha7 (Hair keratin, type I Ha7) (Keratin-37) (K37)

 KRT37_HUMAN             Reviewed;         449 AA.
O76014;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
13-APR-2004, sequence version 3.
12-SEP-2018, entry version 136.
RecName: Full=Keratin, type I cuticular Ha7;
AltName: Full=Hair keratin, type I Ha7;
AltName: Full=Keratin-37;
Short=K37;
Name=KRT37; Synonyms=HHA7, HKA7, KRTHA7;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9756910; DOI=10.1074/jbc.273.41.26683;
Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.;
"Characterization of a 190-kilobase pair domain of human type I hair
keratin genes.";
J. Biol. Chem. 273:26683-26691(1998).
[2]
SEQUENCE REVISION.
Schweizer J.;
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
-!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin,
I (acidic) and II (neutral to basic).
-!- SIMILARITY: Belongs to the intermediate filament family.
{ECO:0000255|PROSITE-ProRule:PRU01188}.
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EMBL; Y16793; CAA76389.3; -; Genomic_DNA.
CCDS; CCDS32653.1; -.
RefSeq; NP_003761.3; NM_003770.4.
UniGene; Hs.673852; -.
ProteinModelPortal; O76014; -.
SMR; O76014; -.
BioGrid; 114235; 1.
IntAct; O76014; 45.
iPTMnet; O76014; -.
PhosphoSitePlus; O76014; -.
BioMuta; KRT37; -.
PaxDb; O76014; -.
PeptideAtlas; O76014; -.
PRIDE; O76014; -.
ProteomicsDB; 12651; -.
ProteomicsDB; 50346; -.
DNASU; 8688; -.
Ensembl; ENST00000225550; ENSP00000225550; ENSG00000108417.
Ensembl; ENST00000574588; ENSP00000458693; ENSG00000263022.
GeneID; 8688; -.
KEGG; hsa:8688; -.
UCSC; uc002hwp.2; human.
CTD; 8688; -.
EuPathDB; HostDB:ENSG00000108417.3; -.
GeneCards; KRT37; -.
HGNC; HGNC:6455; KRT37.
MIM; 604541; gene.
neXtProt; NX_O76014; -.
OpenTargets; ENSG00000108417; -.
PharmGKB; PA30244; -.
eggNOG; ENOG410J94T; Eukaryota.
eggNOG; ENOG4111D61; LUCA.
GeneTree; ENSGT00900000140814; -.
HOGENOM; HOG000230975; -.
HOVERGEN; HBG013015; -.
InParanoid; O76014; -.
KO; K07604; -.
OMA; ANAASMC; -.
OrthoDB; EOG091G05GB; -.
PhylomeDB; O76014; -.
TreeFam; TF332742; -.
Reactome; R-HSA-6805567; Keratinization.
Reactome; R-HSA-6809371; Formation of the cornified envelope.
GenomeRNAi; 8688; -.
PRO; PR:O76014; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000108417; Expressed in 12 organ(s), highest expression level in ectocervix.
CleanEx; HS_KRT37; -.
Genevisible; O76014; HS.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
GO; GO:0005198; F:structural molecule activity; TAS:ProtInc.
GO; GO:0070268; P:cornification; TAS:Reactome.
GO; GO:0031424; P:keratinization; TAS:Reactome.
InterPro; IPR001664; IF.
InterPro; IPR018039; IF_conserved.
InterPro; IPR039008; IF_rod_dom.
InterPro; IPR002957; Keratin_I.
PANTHER; PTHR23239; PTHR23239; 1.
Pfam; PF00038; Filament; 1.
PRINTS; PR01248; TYPE1KERATIN.
SMART; SM01391; Filament; 1.
PROSITE; PS00226; IF_ROD_1; 1.
PROSITE; PS51842; IF_ROD_2; 1.
3: Inferred from homology;
Coiled coil; Complete proteome; Intermediate filament; Keratin;
Polymorphism; Reference proteome.
CHAIN 1 449 Keratin, type I cuticular Ha7.
/FTId=PRO_0000063694.
DOMAIN 104 415 IF rod. {ECO:0000255|PROSITE-
ProRule:PRU01188}.
REGION 1 104 Head.
REGION 105 139 Coil 1A.
REGION 140 150 Linker 1.
REGION 151 251 Coil 1B.
REGION 252 267 Linker 12.
REGION 268 411 Coil 2.
REGION 416 449 Tail.
SITE 353 353 Stutter.
VARIANT 13 13 G -> C (in dbSNP:rs9910204).
/FTId=VAR_049795.
VARIANT 39 39 N -> S (in dbSNP:rs9916724).
/FTId=VAR_049796.
VARIANT 72 72 T -> A (in dbSNP:rs9916484).
/FTId=VAR_049797.
VARIANT 73 73 S -> C (in dbSNP:rs9916475).
/FTId=VAR_049798.
VARIANT 217 217 A -> V (in dbSNP:rs16966811).
/FTId=VAR_049799.
VARIANT 306 306 A -> D (in dbSNP:rs2071607).
/FTId=VAR_049800.
VARIANT 421 421 S -> F (in dbSNP:rs35371972).
/FTId=VAR_049801.
VARIANT 422 422 T -> M (in dbSNP:rs8071814).
/FTId=VAR_049802.
VARIANT 434 434 P -> S (in dbSNP:rs17737019).
/FTId=VAR_049803.
SEQUENCE 449 AA; 49747 MW; E503974DFD8FCBAD CRC64;
MTSFYSTSSC PLGCTMAPGA RNVFVSPIDV GCQPVAEANA ASMCLLANVA HANRVRVGST
PLGRPSLCLP PTSHTACPLP GTCHIPGNIG ICGAYGKNTL NGHEKETMKF LNDRLANYLE
KVRQLEQENA ELETTLLERS KCHESTVCPD YQSYFRTIEE LQQKILCSKA ENARLIVQID
NAKLAADDFR IKLESERSLH QLVEADKCGT QKLLDDATLA KADLEAQQES LKEEQLSLKS
NHEQEVKILR SQLGEKFRIE LDIEPTIDLN RVLGEMRAQY EAMVETNHQD VEQWFQAQSE
GISLQAMSCS EELQCCQSEI LELRCTVNAL EVERQAQHTL KDCLQNSLCE AEDRYGTELA
QMQSLISNLE EQLSEIRADL ERQNQEYQVL LDVKARLENE IATYRNLLES EDCKLPCNPC
STPASCTSCP SCGPVTGGSP SGHGASMGR


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