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Keratin, type I cytoskeletal 15 (Cytokeratin-15) (CK-15) (Keratin-15) (K15)

 K1C15_HUMAN             Reviewed;         456 AA.
P19012; B3KQY1; B3KRA2; E0CX14; Q53XV8; Q9BUG4;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
02-NOV-2010, sequence version 3.
25-OCT-2017, entry version 161.
RecName: Full=Keratin, type I cytoskeletal 15;
AltName: Full=Cytokeratin-15;
Short=CK-15;
AltName: Full=Keratin-15;
Short=K15;
Name=KRT15; Synonyms=KRTB;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-147 AND GLY-421.
PubMed=2468493;
Bader B.L., Jahn L., Franke W.W.;
"Low level expression of cytokeratins 8, 18 and 19 in vascular smooth
muscle cells of human umbilical cord and in cultured cells derived
therefrom, with an analysis of the chromosomal locus containing the
cytokeratin 19 gene.";
Eur. J. Cell Biol. 47:300-319(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
VARIANTS ALA-147 AND GLY-421.
PubMed=2452170; DOI=10.1083/jcb.106.4.1249;
Leube R.E., Bader B.L., Bosch F.X., Zimbelmann R., Achtstaetter T.,
Franke W.W.;
"Molecular characterization and expression of the stratification-
related cytokeratins 4 and 15.";
J. Cell Biol. 106:1249-1261(1988).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10623642; DOI=10.1006/bbrc.1999.1966;
Whittock N.V., Eady R.A.J., McGrath J.A.;
"Genomic organization and amplification of the human keratin 15 and 19
genes.";
Biochem. Biophys. Res. Commun. 267:462-465(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
GLY-421.
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND
VARIANTS ARG-416 AND GLY-421.
TISSUE=Tongue;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16625196; DOI=10.1038/nature04689;
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in
the human lineage.";
Nature 440:1045-1049(2006).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
GLY-421.
TISSUE=Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
TISSUE SPECIFICITY.
PubMed=10084315; DOI=10.1046/j.1523-1747.1999.00535.x;
Waseem A., Dogan B., Tidman N., Alam Y., Purkis P., Jackson S.,
Lalli A., Machesney M., Leigh I.M.;
"Keratin 15 expression in stratified epithelia: downregulation in
activated keratinocytes.";
J. Invest. Dermatol. 112:362-369(1999).
[9]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
-!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
-!- INTERACTION:
Q9NYB9:ABI2; NbExp=4; IntAct=EBI-739566, EBI-743598;
Q08117:AES; NbExp=3; IntAct=EBI-739566, EBI-717810;
Q4VCS5-2:AMOT; NbExp=7; IntAct=EBI-739566, EBI-3891843;
Q9Y2J4-4:AMOTL2; NbExp=3; IntAct=EBI-739566, EBI-10187270;
Q96IX9:ANKRD36BP1; NbExp=4; IntAct=EBI-739566, EBI-744859;
P53365:ARFIP2; NbExp=5; IntAct=EBI-739566, EBI-638194;
P48047:ATP5O; NbExp=3; IntAct=EBI-739566, EBI-355815;
Q9BXY8:BEX2; NbExp=3; IntAct=EBI-739566, EBI-745073;
Q8TAB5:C1orf216; NbExp=4; IntAct=EBI-739566, EBI-747505;
Q53TS8:C2CD6; NbExp=3; IntAct=EBI-739566, EBI-739879;
Q9NVE4:CCDC87; NbExp=3; IntAct=EBI-739566, EBI-749261;
Q8TD31-3:CCHCR1; NbExp=5; IntAct=EBI-739566, EBI-10175300;
Q9NPC3:CCNB1IP1; NbExp=3; IntAct=EBI-739566, EBI-745269;
P24863:CCNC; NbExp=3; IntAct=EBI-739566, EBI-395261;
Q86XR8:CEP57; NbExp=3; IntAct=EBI-739566, EBI-308614;
P10606:COX5B; NbExp=3; IntAct=EBI-739566, EBI-1053725;
Q02930-3:CREB5; NbExp=3; IntAct=EBI-739566, EBI-10192698;
Q8WWE8:CYTH4; NbExp=3; IntAct=EBI-739566, EBI-10277443;
Q05D60:DEUP1; NbExp=6; IntAct=EBI-739566, EBI-748597;
Q5JVL4:EFHC1; NbExp=3; IntAct=EBI-739566, EBI-743105;
Q9H2F5:EPC1; NbExp=3; IntAct=EBI-739566, EBI-769270;
Q9BQ89:FAM110A; NbExp=5; IntAct=EBI-739566, EBI-1752811;
P14136:GFAP; NbExp=8; IntAct=EBI-739566, EBI-744302;
Q8IVS8:GLYCTK; NbExp=3; IntAct=EBI-739566, EBI-748515;
Q96CS2:HAUS1; NbExp=3; IntAct=EBI-739566, EBI-2514791;
O14964:HGS; NbExp=7; IntAct=EBI-739566, EBI-740220;
Q9P0W2:HMG20B; NbExp=3; IntAct=EBI-739566, EBI-713401;
Q70UQ0:IKBIP; NbExp=3; IntAct=EBI-739566, EBI-2557212;
Q7Z3B3:KANSL1; NbExp=4; IntAct=EBI-739566, EBI-740244;
Q5T5P2-6:KIAA1217; NbExp=3; IntAct=EBI-739566, EBI-10188326;
Q9BVG8:KIFC3; NbExp=3; IntAct=EBI-739566, EBI-2125614;
Q6P597:KLC3; NbExp=3; IntAct=EBI-739566, EBI-1643885;
Q9NSK0:KLC4; NbExp=3; IntAct=EBI-739566, EBI-949319;
P04264:KRT1; NbExp=6; IntAct=EBI-739566, EBI-298429;
P35908:KRT2; NbExp=6; IntAct=EBI-739566, EBI-1247312;
P35900:KRT20; NbExp=4; IntAct=EBI-739566, EBI-742094;
P19013:KRT4; NbExp=7; IntAct=EBI-739566, EBI-2371606;
P13647:KRT5; NbExp=7; IntAct=EBI-739566, EBI-702187;
P02538:KRT6A; NbExp=10; IntAct=EBI-739566, EBI-702198;
P04259:KRT6B; NbExp=6; IntAct=EBI-739566, EBI-740907;
P48668:KRT6C; NbExp=3; IntAct=EBI-739566, EBI-2564105;
Q3SY84:KRT71; NbExp=5; IntAct=EBI-739566, EBI-2952676;
Q86Y46:KRT73; NbExp=3; IntAct=EBI-739566, EBI-2830994;
O95678:KRT75; NbExp=4; IntAct=EBI-739566, EBI-2949715;
Q0IIN1:KRT77; NbExp=3; IntAct=EBI-739566, EBI-2511085;
Q5XKE5:KRT79; NbExp=5; IntAct=EBI-739566, EBI-2514135;
P05787:KRT8; NbExp=5; IntAct=EBI-739566, EBI-297852;
Q6KB66:KRT80; NbExp=3; IntAct=EBI-739566, EBI-3046635;
Q14533:KRT81; NbExp=3; IntAct=EBI-739566, EBI-739648;
P78386:KRT85; NbExp=4; IntAct=EBI-739566, EBI-1049371;
O43790:KRT86; NbExp=5; IntAct=EBI-739566, EBI-9996498;
P25791:LMO2; NbExp=3; IntAct=EBI-739566, EBI-739696;
P61968:LMO4; NbExp=5; IntAct=EBI-739566, EBI-2798728;
Q8TBB1:LNX1; NbExp=3; IntAct=EBI-739566, EBI-739832;
O95983:MBD3; NbExp=3; IntAct=EBI-739566, EBI-1783068;
Q6PF18:MORN3; NbExp=3; IntAct=EBI-739566, EBI-9675802;
P00540:MOS; NbExp=5; IntAct=EBI-739566, EBI-1757866;
I6L9F6:NEFL; NbExp=3; IntAct=EBI-739566, EBI-10178578;
Q9BVI4:NOC4L; NbExp=4; IntAct=EBI-739566, EBI-395927;
Q7Z3B4:NUP54; NbExp=3; IntAct=EBI-739566, EBI-741048;
O43482:OIP5; NbExp=3; IntAct=EBI-739566, EBI-536879;
O00459:PIK3R2; NbExp=3; IntAct=EBI-739566, EBI-346930;
Q16512:PKN1; NbExp=3; IntAct=EBI-739566, EBI-602382;
Q6NYC8:PPP1R18; NbExp=5; IntAct=EBI-739566, EBI-2557469;
Q8WWY3:PRPF31; NbExp=8; IntAct=EBI-739566, EBI-1567797;
P25786:PSMA1; NbExp=4; IntAct=EBI-739566, EBI-359352;
P20618:PSMB1; NbExp=5; IntAct=EBI-739566, EBI-372273;
O75771:RAD51D; NbExp=6; IntAct=EBI-739566, EBI-1055693;
Q9P2K3:RCOR3; NbExp=5; IntAct=EBI-739566, EBI-743428;
Q8N443:RIBC1; NbExp=3; IntAct=EBI-739566, EBI-10265323;
Q96ES7:SGF29; NbExp=6; IntAct=EBI-739566, EBI-743117;
Q96GM5:SMARCD1; NbExp=3; IntAct=EBI-739566, EBI-358489;
Q969G3:SMARCE1; NbExp=3; IntAct=EBI-739566, EBI-455078;
Q9NZD8:SPG21; NbExp=3; IntAct=EBI-739566, EBI-742688;
Q9Y2D8:SSX2IP; NbExp=3; IntAct=EBI-739566, EBI-2212028;
P14079:tax (xeno); NbExp=3; IntAct=EBI-739566, EBI-9675698;
Q8IYX1:TBC1D21; NbExp=4; IntAct=EBI-739566, EBI-12018146;
Q9BT92:TCHP; NbExp=4; IntAct=EBI-739566, EBI-740781;
O60220:TIMM8A; NbExp=3; IntAct=EBI-739566, EBI-1049822;
Q0P5Q0:TMSB4X; NbExp=3; IntAct=EBI-739566, EBI-10226570;
Q8IWZ5:TRIM42; NbExp=3; IntAct=EBI-739566, EBI-5235829;
P40222:TXLNA; NbExp=5; IntAct=EBI-739566, EBI-359793;
Q8N3L3:TXLNB; NbExp=5; IntAct=EBI-739566, EBI-6116822;
O75604:USP2; NbExp=5; IntAct=EBI-739566, EBI-743272;
Q9BTA9:WAC; NbExp=4; IntAct=EBI-739566, EBI-749118;
Q9BTA9-2:WAC; NbExp=3; IntAct=EBI-739566, EBI-10298216;
Q53FD0:ZC2HC1C; NbExp=4; IntAct=EBI-739566, EBI-740767;
Q68DK2-5:ZFYVE26; NbExp=3; IntAct=EBI-739566, EBI-8656416;
Q8N5A5:ZGPAT; NbExp=3; IntAct=EBI-739566, EBI-3439227;
Q8TAU3:ZNF417; NbExp=3; IntAct=EBI-739566, EBI-740727;
Q9H609:ZNF576; NbExp=3; IntAct=EBI-739566, EBI-3921014;
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P19012-1; Sequence=Displayed;
Name=2;
IsoId=P19012-2; Sequence=VSP_056507, VSP_056508, VSP_056509;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed in a discontinuous manner in the
basal cell layer of adult skin epidermis, but continuously in the
basal layer of fetal skin epidermis and nail. Also expressed in
the outer root sheath above the hair bulb in hair follicle (at
protein level). Expressed homogeneously in all cell layers of the
esophagus and exocervix, but detected in the basal cell layer only
of oral mucosa, skin and in the basal plus the next two layers of
the suprabasal epithelium of the palate.
{ECO:0000269|PubMed:10084315, ECO:0000269|PubMed:2452170}.
-!- MISCELLANEOUS: There are two types of cytoskeletal and
microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to
basic; 56-70 kDa).
-!- SIMILARITY: Belongs to the intermediate filament family.
{ECO:0000255|PROSITE-ProRule:PRU01188}.
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EMBL; X07696; CAA30535.1; -; mRNA.
EMBL; AF202320; AAF27047.1; -; Genomic_DNA.
EMBL; BT007261; AAP35925.1; -; mRNA.
EMBL; AK090604; BAG52193.1; -; mRNA.
EMBL; AK091239; BAG52314.1; -; mRNA.
EMBL; AC019349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC002641; AAH02641.1; -; mRNA.
CCDS; CCDS11398.1; -. [P19012-1]
PIR; S01069; KRHU5.
RefSeq; NP_002266.2; NM_002275.3.
UniGene; Hs.654570; -.
ProteinModelPortal; P19012; -.
SMR; P19012; -.
BioGrid; 110064; 119.
IntAct; P19012; 150.
MINT; MINT-1433992; -.
STRING; 9606.ENSP00000254043; -.
iPTMnet; P19012; -.
PhosphoSitePlus; P19012; -.
SwissPalm; P19012; -.
BioMuta; KRT15; -.
DMDM; 311033438; -.
PaxDb; P19012; -.
PeptideAtlas; P19012; -.
PRIDE; P19012; -.
DNASU; 3866; -.
Ensembl; ENST00000254043; ENSP00000254043; ENSG00000171346. [P19012-1]
Ensembl; ENST00000393976; ENSP00000377546; ENSG00000171346. [P19012-1]
GeneID; 3866; -.
KEGG; hsa:3866; -.
UCSC; uc002hwy.4; human. [P19012-1]
CTD; 3866; -.
DisGeNET; 3866; -.
EuPathDB; HostDB:ENSG00000171346.13; -.
GeneCards; KRT15; -.
HGNC; HGNC:6421; KRT15.
HPA; HPA023910; -.
HPA; HPA024554; -.
MIM; 148030; gene.
neXtProt; NX_P19012; -.
OpenTargets; ENSG00000171346; -.
PharmGKB; PA30208; -.
eggNOG; ENOG410IFTF; Eukaryota.
eggNOG; ENOG410Y9IV; LUCA.
GeneTree; ENSGT00900000140820; -.
HOGENOM; HOG000230975; -.
HOVERGEN; HBG013015; -.
InParanoid; P19012; -.
KO; K07604; -.
OMA; CEMEAQN; -.
OrthoDB; EOG091G087I; -.
PhylomeDB; P19012; -.
TreeFam; TF332742; -.
Reactome; R-HSA-6805567; Keratinization.
Reactome; R-HSA-6809371; Formation of the cornified envelope.
SIGNOR; P19012; -.
ChiTaRS; KRT15; human.
GeneWiki; Keratin_15; -.
GenomeRNAi; 3866; -.
PRO; PR:P19012; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000171346; -.
CleanEx; HS_KRT15; -.
ExpressionAtlas; P19012; baseline and differential.
Genevisible; P19012; HS.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0005882; C:intermediate filament; TAS:ProtInc.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0097110; F:scaffold protein binding; IPI:BHF-UCL.
GO; GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
GO; GO:0070268; P:cornification; TAS:Reactome.
GO; GO:0008544; P:epidermis development; TAS:ProtInc.
GO; GO:0031424; P:keratinization; TAS:Reactome.
InterPro; IPR001664; IF.
InterPro; IPR018039; Intermediate_filament_CS.
InterPro; IPR002957; Keratin_I.
PANTHER; PTHR23239; PTHR23239; 1.
Pfam; PF00038; Filament; 1.
PRINTS; PR01248; TYPE1KERATIN.
SMART; SM01391; Filament; 1.
PROSITE; PS00226; IF_ROD_1; 1.
PROSITE; PS51842; IF_ROD_2; 1.
1: Evidence at protein level;
Alternative splicing; Coiled coil; Complete proteome;
Intermediate filament; Keratin; Methylation; Phosphoprotein;
Polymorphism; Reference proteome.
CHAIN 1 456 Keratin, type I cytoskeletal 15.
/FTId=PRO_0000063657.
DOMAIN 105 417 IF rod. {ECO:0000255|PROSITE-
ProRule:PRU01188}.
REGION 1 104 Head.
REGION 105 140 Coil 1A.
REGION 141 159 Linker 1.
REGION 160 251 Coil 1B.
REGION 252 271 Linker 12.
REGION 272 413 Coil 2.
REGION 414 456 Tail.
COMPBIAS 14 103 Gly-rich.
COMPBIAS 428 431 Poly-Gly.
MOD_RES 34 34 Phosphoserine.
{ECO:0000250|UniProtKB:Q61414}.
MOD_RES 42 42 Omega-N-methylarginine.
{ECO:0000250|UniProtKB:P13646}.
MOD_RES 50 50 Omega-N-methylarginine.
{ECO:0000250|UniProtKB:P13646}.
MOD_RES 301 301 Phosphothreonine.
{ECO:0000250|UniProtKB:Q6IFV3}.
MOD_RES 323 323 Phosphothreonine.
{ECO:0000250|UniProtKB:Q6IFV3}.
MOD_RES 432 432 Phosphoserine.
{ECO:0000250|UniProtKB:Q61781}.
VAR_SEQ 3 29 TTFLQTSSSTFGGGSTRGGSLLAGGGG -> GTRSRPQPAQ
NATTANTSRPLKSSGTR (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_056507.
VAR_SEQ 30 194 Missing (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_056508.
VAR_SEQ 417 456 Missing (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_056509.
VARIANT 147 147 T -> A (in dbSNP:rs1050784).
{ECO:0000269|PubMed:2452170,
ECO:0000269|PubMed:2468493}.
/FTId=VAR_047429.
VARIANT 416 416 K -> R (in dbSNP:rs2305556).
{ECO:0000269|PubMed:14702039}.
/FTId=VAR_047430.
VARIANT 421 421 A -> G (in dbSNP:rs897420).
{ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:2452170,
ECO:0000269|PubMed:2468493,
ECO:0000269|Ref.4}.
/FTId=VAR_047431.
SEQUENCE 456 AA; 49212 MW; 812C1343905EBE41 CRC64;
MTTTFLQTSS STFGGGSTRG GSLLAGGGGF GGGSLSGGGG SRSISASSAR FVSSGSGGGY
GGGMRVCGFG GGAGSVFGGG FGGGVGGGFG GGFGGGDGGL LSGNEKITMQ NLNDRLASYL
DKVRALEEAN ADLEVKIHDW YQKQTPTSPE CDYSQYFKTI EELRDKIMAT TIDNSRVILE
IDNARLAADD FRLKYENELA LRQGVEADIN GLRRVLDELT LARTDLEMQI EGLNEELAYL
KKNHEEEMKE FSSQLAGQVN VEMDAAPGVD LTRVLAEMRE QYEAMAEKNR RDVEAWFFSK
TEELNKEVAS NTEMIQTSKT EITDLRRTMQ ELEIELQSQL SMKAGLENSL AETECRYATQ
LQQIQGLIGG LEAQLSELRC EMEAQNQEYK MLLDIKTRLE QEIATYRSLL EGQDAKMAGI
AIREASSGGG GSSSNFHINV EESVDGQVVS SHKREI


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