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Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16)

 K1C16_MOUSE             Reviewed;         469 AA.
Q9Z2K1;
19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
25-OCT-2017, entry version 123.
RecName: Full=Keratin, type I cytoskeletal 16;
AltName: Full=Cytokeratin-16;
Short=CK-16;
AltName: Full=Keratin-16;
Short=K16;
Name=Krt16; Synonyms=Krt1-16;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J;
PubMed=9822705; DOI=10.1074/jbc.273.48.32265;
Porter R.M., Hutcheson A.M., Rugg E.L., Quinlan R.A., Lane E.B.;
"cDNA cloning, expression, and assembly characteristics of mouse
keratin 16.";
J. Biol. Chem. 273:32265-32272(1998).
[2]
INDUCTION, AND SUBUNIT.
PubMed=8636216; DOI=10.1083/jcb.132.3.381;
Paladini R.D., Takahashi K., Bravo N.S., Coulombe P.A.;
"Onset of re-epithelialization after skin injury correlates with a
reorganization of keratin filaments in wound edge keratinocytes:
defining a potential role for keratin 16.";
J. Cell Biol. 132:381-397(1996).
[3]
FUNCTION.
PubMed=11029038; DOI=10.1091/mbc.11.10.3315;
Wawersik M., Coulombe P.A.;
"Forced expression of keratin 16 alters the adhesion, differentiation,
and migration of mouse skin keratinocytes.";
Mol. Biol. Cell 11:3315-3327(2000).
[4]
TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=12445204; DOI=10.1046/j.1523-1747.2002.19518.x;
Bernot K.M., Coulombe P.A., McGowan K.M.;
"Keratin 16 expression defines a subset of epithelial cells during
skin morphogenesis and the hair cycle.";
J. Invest. Dermatol. 119:1137-1149(2002).
[5]
INTERACTION WITH TRADD.
PubMed=16702408; DOI=10.1101/gad.1387406;
Tong X., Coulombe P.A.;
"Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent
fashion.";
Genes Dev. 20:1353-1364(2006).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[7]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=22336941; DOI=10.1038/jid.2012.6;
Lessard J.C., Coulombe P.A.;
"Keratin 16-null mice develop palmoplantar keratoderma, a hallmark
feature of pachyonychia congenita and related disorders.";
J. Invest. Dermatol. 132:1384-1391(2012).
[8]
FUNCTION.
PubMed=24218583; DOI=10.1073/pnas.1309576110;
Lessard J.C., Pina-Paz S., Rotty J.D., Hickerson R.P., Kaspar R.L.,
Balmain A., Coulombe P.A.;
"Keratin 16 regulates innate immunity in response to epidermal barrier
breach.";
Proc. Natl. Acad. Sci. U.S.A. 110:19537-19542(2013).
-!- FUNCTION: Epidermis-specific type I keratin that plays a key role
in skin (PubMed:22336941, PubMed:24218583). Acts as a regulator of
innate immunity in response to skin barrier breach: required for
some inflammatory checkpoint for the skin barrier maintenance
(PubMed:24218583). {ECO:0000269|PubMed:11029038,
ECO:0000269|PubMed:22336941, ECO:0000269|PubMed:24218583}.
-!- SUBUNIT: Heterodimer of a type I and a type II keratin. KRT16
associates with KRT6 isomers (KRT6A or KRT6B) (PubMed:8636216).
Interacts with TCHP (By similarity). Interacts with TRADD
(PubMed:16702408). {ECO:0000250|UniProtKB:P08779,
ECO:0000269|PubMed:16702408, ECO:0000269|PubMed:8636216}.
-!- TISSUE SPECIFICITY: Epidermis-specific. Expressed in stratified
epithelia of glabrous skin, the oral mucosa and several
appendages. In mature hair follicles, expressed in the companion
layer of the outer root sheath during anagen and in the club hair
sheath during catagen and telogen. {ECO:0000269|PubMed:12445204}.
-!- DEVELOPMENTAL STAGE: During embryonic development, initially
localizes within early hair germs, but rapidly shifts to a subset
of cells at the interface of basal and suprabasal cells above and
around the hair germ. {ECO:0000269|PubMed:12445204}.
-!- INDUCTION: In response to epidermal stress such as wounding.
{ECO:0000269|PubMed:8636216}.
-!- DISRUPTION PHENOTYPE: Mice were born alive at approximately
Mendelian ratios but increased postnatal mortality is observed.
Surviving mice show oral lesions as well as palmoplantar
keratoderma-like hyperkeratotic calluses on front and hind paws,
which impair the ability to walk. {ECO:0000269|PubMed:22336941}.
-!- MISCELLANEOUS: There are two types of cytoskeletal and
microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to
basic; 56-70 kDa).
-!- SIMILARITY: Belongs to the intermediate filament family.
{ECO:0000255|PROSITE-ProRule:PRU01188}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF053235; AAC79424.1; -; mRNA.
CCDS; CCDS25414.1; -.
RefSeq; NP_001300887.1; NM_001313958.1.
RefSeq; NP_032496.1; NM_008470.1.
UniGene; Mm.422799; -.
ProteinModelPortal; Q9Z2K1; -.
SMR; Q9Z2K1; -.
BioGrid; 201021; 5.
IntAct; Q9Z2K1; 2.
MINT; MINT-4099313; -.
STRING; 10090.ENSMUSP00000007280; -.
iPTMnet; Q9Z2K1; -.
PhosphoSitePlus; Q9Z2K1; -.
PaxDb; Q9Z2K1; -.
PRIDE; Q9Z2K1; -.
Ensembl; ENSMUST00000007280; ENSMUSP00000007280; ENSMUSG00000053797.
GeneID; 16666; -.
KEGG; mmu:16666; -.
UCSC; uc007lkq.2; mouse.
CTD; 3868; -.
MGI; MGI:96690; Krt16.
eggNOG; ENOG410IFTF; Eukaryota.
eggNOG; ENOG410Y9IV; LUCA.
GeneTree; ENSGT00900000140820; -.
HOVERGEN; HBG013015; -.
InParanoid; Q9Z2K1; -.
KO; K07604; -.
OMA; FEHELMM; -.
OrthoDB; EOG091G087I; -.
TreeFam; TF332742; -.
Reactome; R-MMU-6805567; Keratinization.
Reactome; R-MMU-6809371; Formation of the cornified envelope.
PRO; PR:Q9Z2K1; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000053797; -.
CleanEx; MM_KRT16; -.
ExpressionAtlas; Q9Z2K1; baseline and differential.
Genevisible; Q9Z2K1; MM.
GO; GO:0005856; C:cytoskeleton; ISO:MGI.
GO; GO:0070062; C:extracellular exosome; ISO:MGI.
GO; GO:0005882; C:intermediate filament; IDA:MGI.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0005200; F:structural constituent of cytoskeleton; IDA:MGI.
GO; GO:0007568; P:aging; ISO:MGI.
GO; GO:0061436; P:establishment of skin barrier; IMP:UniProtKB.
GO; GO:0042633; P:hair cycle; ISO:MGI.
GO; GO:0006954; P:inflammatory response; IMP:UniProtKB.
GO; GO:0045087; P:innate immune response; IMP:UniProtKB.
GO; GO:0045104; P:intermediate filament cytoskeleton organization; IDA:MGI.
GO; GO:0031424; P:keratinization; IDA:UniProtKB.
GO; GO:0030216; P:keratinocyte differentiation; IDA:UniProtKB.
GO; GO:0051546; P:keratinocyte migration; IDA:UniProtKB.
GO; GO:0002009; P:morphogenesis of an epithelium; IMP:UniProtKB.
GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
InterPro; IPR001664; IF.
InterPro; IPR018039; Intermediate_filament_CS.
InterPro; IPR002957; Keratin_I.
PANTHER; PTHR23239; PTHR23239; 1.
Pfam; PF00038; Filament; 1.
PRINTS; PR01248; TYPE1KERATIN.
SMART; SM01391; Filament; 1.
PROSITE; PS00226; IF_ROD_1; 1.
PROSITE; PS51842; IF_ROD_2; 1.
1: Evidence at protein level;
Coiled coil; Complete proteome; Immunity; Innate immunity;
Intermediate filament; Keratin; Reference proteome.
CHAIN 1 469 Keratin, type I cytoskeletal 16.
/FTId=PRO_0000063663.
DOMAIN 113 424 IF rod. {ECO:0000255|PROSITE-
ProRule:PRU01188}.
REGION 1 112 Head.
REGION 113 148 Coil 1A.
REGION 149 166 Linker 1.
REGION 167 258 Coil 1B.
REGION 259 281 Linker 12.
REGION 282 420 Coil 2.
REGION 421 469 Tail.
SEQUENCE 469 AA; 51606 MW; 13B8028CF28B64D5 CRC64;
MATCSRQFTS SSSMKGSCGI GGGSSRMSSI LAGGSCRAPS TCGGMSVTSS RFSSGGVCGI
GGGYGGSFSS SSFGGGLGSG FGGRFDGFGG GFGAGLGGGL GGGIGDGLLV GSEKVTMQNL
NDRLATYLDK VRALEEANRD LEVKIRDWYQ RQRPTEIKDY SPYFKTIEDL KSKIIIATQE
NAQFTLQIDN ARLAADDFRT KYENELFLRQ SVEGDINGLR KVLDELTLSR ADLEMQIENL
REELAFLKKN HEEEMLALRG QTGGDVNVEM DAAPGVDLSR ILNEMRDQYE QMAEKNRRDV
EAWFLRKTEE LNKEVASNSD LIQSNRSEVA ELRRVFQGLE IELQSQLSMK ASLENSLEET
KGRYCMQLSQ IQGLISSVEE QLAQLRCEME QQSQEYNILL DVKTRLEQEI ATYRRLLDGE
NIHSSSQHSS GQSYSSREVF SSSSRQPRSI LKEQGSTSFS QSQSQSSRD


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