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Keratin, type I cytoskeletal 40 (Cytokeratin-40) (CK-40) (Keratin-40) (K40) (Type I hair keratin Ka36)

 K1C40_HUMAN             Reviewed;         431 AA.
Q6A162; Q6IFU5;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
15-JAN-2008, sequence version 2.
30-AUG-2017, entry version 113.
RecName: Full=Keratin, type I cytoskeletal 40;
AltName: Full=Cytokeratin-40;
Short=CK-40;
AltName: Full=Keratin-40;
Short=K40;
AltName: Full=Type I hair keratin Ka36;
Name=KRT40; Synonyms=KA36;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS SER-85
AND TYR-265.
TISSUE=Scalp;
PubMed=15617563; DOI=10.1111/j.1432-0436.2004.07209006.x;
Rogers M.A., Winter H., Langbein L., Bleiler R., Schweizer J.;
"The human type I keratin gene family: characterization of new hair
follicle specific members and evaluation of the chromosome 17q21.2
gene domain.";
Differentiation 72:527-540(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
IDENTIFICATION.
PubMed=15085952; DOI=10.1078/0171-9335-00354;
Hesse M., Zimek A., Weber K., Magin T.M.;
"Comprehensive analysis of keratin gene clusters in humans and
rodents.";
Eur. J. Cell Biol. 83:19-26(2004).
[4]
POSSIBLE FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=17301834; DOI=10.1038/sj.jid.5700734;
Langbein L., Rogers M.A., Praetzel-Wunder S., Boeckler D.,
Schirmacher P., Schweizer J.;
"Novel type I hair keratins K39 and K40 are the last to be expressed
in differentiation of the hair: completion of the human hair keratin
catalog.";
J. Invest. Dermatol. 127:1532-1535(2007).
-!- FUNCTION: May play a role in late hair differentiation.
-!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
-!- INTERACTION:
Q53FW8:-; NbExp=3; IntAct=EBI-10171697, EBI-10242473;
Q5BKY6:-; NbExp=3; IntAct=EBI-10171697, EBI-10243533;
Q5W150:-; NbExp=3; IntAct=EBI-10171697, EBI-10248148;
Q8N9J2:-; NbExp=5; IntAct=EBI-10171697, EBI-10268244;
Q96GB0:-; NbExp=3; IntAct=EBI-10171697, EBI-10286297;
Q9H6F0:-; NbExp=3; IntAct=EBI-10171697, EBI-10307481;
Q9NWL9:-; NbExp=3; IntAct=EBI-10171697, EBI-10315054;
P82987:ADAMTSL3; NbExp=3; IntAct=EBI-10171697, EBI-10221726;
Q8WTP8:AEN; NbExp=3; IntAct=EBI-10171697, EBI-8637627;
Q08117:AES; NbExp=3; IntAct=EBI-10171697, EBI-717810;
Q08117-2:AES; NbExp=4; IntAct=EBI-10171697, EBI-11741437;
Q02040-3:AKAP17A; NbExp=3; IntAct=EBI-10171697, EBI-10222656;
P43353:ALDH3B1; NbExp=3; IntAct=EBI-10171697, EBI-2558314;
Q96IX9:ANKRD36BP1; NbExp=3; IntAct=EBI-10171697, EBI-744859;
Q9BXS5:AP1M1; NbExp=5; IntAct=EBI-10171697, EBI-541426;
P29972:AQP1; NbExp=3; IntAct=EBI-10171697, EBI-745213;
P55064:AQP5; NbExp=3; IntAct=EBI-10171697, EBI-746103;
C9J1Q0:ARID5A; NbExp=3; IntAct=EBI-10171697, EBI-10176351;
Q9H6L4:ARMC7; NbExp=5; IntAct=EBI-10171697, EBI-742909;
Q5FYB1:ARSI; NbExp=3; IntAct=EBI-10171697, EBI-10243706;
O95671:ASMTL; NbExp=3; IntAct=EBI-10171697, EBI-743231;
Q8N5M1:ATPAF2; NbExp=7; IntAct=EBI-10171697, EBI-1166928;
Q5T686:AVPI1; NbExp=3; IntAct=EBI-10171697, EBI-8640233;
Q8TBE0:BAHD1; NbExp=3; IntAct=EBI-10171697, EBI-742750;
Q99728:BARD1; NbExp=3; IntAct=EBI-10171697, EBI-473181;
O75934:BCAS2; NbExp=3; IntAct=EBI-10171697, EBI-1050106;
Q9BXY8:BEX2; NbExp=3; IntAct=EBI-10171697, EBI-745073;
Q13895:BYSL; NbExp=7; IntAct=EBI-10171697, EBI-358049;
Q5T681:C10orf62; NbExp=3; IntAct=EBI-10171697, EBI-744052;
Q6NUJ2:C11orf87; NbExp=3; IntAct=EBI-10171697, EBI-6660291;
Q17R99:C14orf105; NbExp=3; IntAct=EBI-10171697, EBI-10238351;
B2RAB7:C18orf45; NbExp=3; IntAct=EBI-10171697, EBI-743338;
Q0VDD7:C19orf57; NbExp=3; IntAct=EBI-10171697, EBI-741210;
Q9NVV2:C19orf73; NbExp=3; IntAct=EBI-10171697, EBI-2859285;
Q9NX04:C1orf109; NbExp=3; IntAct=EBI-10171697, EBI-8643161;
Q8TAB5:C1orf216; NbExp=3; IntAct=EBI-10171697, EBI-747505;
Q53TS8:C2CD6; NbExp=3; IntAct=EBI-10171697, EBI-739879;
A6NFR6-4:C5orf60; NbExp=3; IntAct=EBI-10171697, EBI-10173955;
Q5I0X4:C6orf226; NbExp=3; IntAct=EBI-10171697, EBI-10244057;
Q96LL4:C8orf48; NbExp=3; IntAct=EBI-10171697, EBI-751596;
Q8N4G4:CA6; NbExp=3; IntAct=EBI-10171697, EBI-10265475;
Q9H257:CARD9; NbExp=3; IntAct=EBI-10171697, EBI-751319;
Q7Z7H3:CATIP; NbExp=3; IntAct=EBI-10171697, EBI-10258233;
Q9HC52:CBX8; NbExp=5; IntAct=EBI-10171697, EBI-712912;
Q8NEF3:CCDC112; NbExp=3; IntAct=EBI-10171697, EBI-745040;
Q96HB5-4:CCDC120; NbExp=3; IntAct=EBI-10171697, EBI-10185348;
Q8IYE0-2:CCDC146; NbExp=3; IntAct=EBI-10171697, EBI-10247802;
Q8N715:CCDC185; NbExp=5; IntAct=EBI-10171697, EBI-740814;
Q8TAB7:CCDC26; NbExp=3; IntAct=EBI-10171697, EBI-10271580;
Q8TC90:CCER1; NbExp=3; IntAct=EBI-10171697, EBI-746041;
Q8TD31-3:CCHCR1; NbExp=5; IntAct=EBI-10171697, EBI-10175300;
P51959:CCNG1; NbExp=3; IntAct=EBI-10171697, EBI-3905829;
P20138:CD33; NbExp=3; IntAct=EBI-10171697, EBI-3906571;
Q86Y33:CDC20B; NbExp=3; IntAct=EBI-10171697, EBI-10260504;
Q07002:CDK18; NbExp=3; IntAct=EBI-10171697, EBI-746238;
Q8N619:CDK5R1; NbExp=3; IntAct=EBI-10171697, EBI-10266998;
Q86XR8:CEP57; NbExp=3; IntAct=EBI-10171697, EBI-308614;
Q8IYX8:CEP57L1; NbExp=3; IntAct=EBI-10171697, EBI-1104570;
Q8IYX8-2:CEP57L1; NbExp=3; IntAct=EBI-10171697, EBI-10181988;
Q8IYR0:CFAP206; NbExp=5; IntAct=EBI-10171697, EBI-749051;
Q9Y6H1:CHCHD2; NbExp=3; IntAct=EBI-10171697, EBI-2321769;
Q9NX63:CHCHD3; NbExp=3; IntAct=EBI-10171697, EBI-743375;
Q9UKJ5:CHIC2; NbExp=3; IntAct=EBI-10171697, EBI-741528;
A5D8T8:CLEC18A; NbExp=3; IntAct=EBI-10171697, EBI-10173491;
Q8NE01:CNNM3; NbExp=4; IntAct=EBI-10171697, EBI-741032;
P26441:CNTF; NbExp=3; IntAct=EBI-10171697, EBI-1050897;
P27658:COL8A1; NbExp=3; IntAct=EBI-10171697, EBI-747133;
P21964-2:COMT; NbExp=3; IntAct=EBI-10171697, EBI-10200977;
P20674:COX5A; NbExp=3; IntAct=EBI-10171697, EBI-715032;
Q02930-3:CREB5; NbExp=5; IntAct=EBI-10171697, EBI-10192698;
Q9UBR2:CTSZ; NbExp=3; IntAct=EBI-10171697, EBI-8636823;
Q2TBE0:CWF19L2; NbExp=3; IntAct=EBI-10171697, EBI-5453285;
P99999:CYCS; NbExp=6; IntAct=EBI-10171697, EBI-446479;
Q8WWE8:CYTH4; NbExp=3; IntAct=EBI-10171697, EBI-10277443;
Q6DCB0:DAAM2; NbExp=3; IntAct=EBI-10171697, EBI-10249414;
A2VCK2:DCDC2B; NbExp=3; IntAct=EBI-10171697, EBI-10173222;
O43602:DCX; NbExp=3; IntAct=EBI-10171697, EBI-8646694;
P26196:DDX6; NbExp=3; IntAct=EBI-10171697, EBI-351257;
Q9P1A6:DLGAP2; NbExp=3; IntAct=EBI-10171697, EBI-1753397;
Q9NQL9:DMRT3; NbExp=5; IntAct=EBI-10171697, EBI-9679045;
Q92608:DOCK2; NbExp=5; IntAct=EBI-10171697, EBI-448771;
Q8NF50:DOCK8; NbExp=3; IntAct=EBI-10171697, EBI-2548605;
O60941:DTNB; NbExp=3; IntAct=EBI-10171697, EBI-740402;
O60573:EIF4E2; NbExp=3; IntAct=EBI-10171697, EBI-398610;
Q6ISP9:ELA2B; NbExp=3; IntAct=EBI-10171697, EBI-10250477;
Q14241:ELOA; NbExp=3; IntAct=EBI-10171697, EBI-742350;
Q8N2X6:EXOC3-AS1; NbExp=3; IntAct=EBI-10171697, EBI-749333;
O95990-3:FAM107A; NbExp=3; IntAct=EBI-10171697, EBI-10192902;
Q9H5Z6:FAM124B; NbExp=3; IntAct=EBI-10171697, EBI-741626;
Q32MH5:FAM214A; NbExp=3; IntAct=EBI-10171697, EBI-2866142;
Q08E93:FAM27E3; NbExp=3; IntAct=EBI-10171697, EBI-2602739;
Q8NEG0:FAM71C; NbExp=3; IntAct=EBI-10171697, EBI-752049;
Q5TZK3:FAM74A6; NbExp=5; IntAct=EBI-10171697, EBI-10247271;
Q86YD7:FAM90A1; NbExp=5; IntAct=EBI-10171697, EBI-6658203;
O95363:FARS2; NbExp=5; IntAct=EBI-10171697, EBI-2513774;
P48023:FASLG; NbExp=3; IntAct=EBI-10171697, EBI-495538;
Q8TES7-6:FBF1; NbExp=3; IntAct=EBI-10171697, EBI-10244131;
Q96D16:FBXL18; NbExp=3; IntAct=EBI-10171697, EBI-744419;
Q9NWN3:FBXO34; NbExp=3; IntAct=EBI-10171697, EBI-719816;
Q969U6:FBXW5; NbExp=3; IntAct=EBI-10171697, EBI-741068;
P68106:FKBP1B; NbExp=3; IntAct=EBI-10171697, EBI-6693977;
Q9H5C5:FLJ23584; NbExp=5; IntAct=EBI-10171697, EBI-7226406;
Q9BVV2:FNDC11; NbExp=3; IntAct=EBI-10171697, EBI-744935;
Q99853:FOXB1; NbExp=3; IntAct=EBI-10171697, EBI-3916225;
Q14331:FRG1; NbExp=3; IntAct=EBI-10171697, EBI-2515248;
P23769:GATA2; NbExp=3; IntAct=EBI-10171697, EBI-2806671;
Q86YP4-3:GATAD2A; NbExp=3; IntAct=EBI-10171697, EBI-10261080;
P55040:GEM; NbExp=3; IntAct=EBI-10171697, EBI-744104;
Q9NXC2:GFOD1; NbExp=3; IntAct=EBI-10171697, EBI-8799578;
Q86UU5:GGN; NbExp=3; IntAct=EBI-10171697, EBI-10259069;
P04899:GNAI2; NbExp=3; IntAct=EBI-10171697, EBI-353997;
P63218:GNG5; NbExp=3; IntAct=EBI-10171697, EBI-10220734;
Q8N9W4-2:GOLGA6L2; NbExp=3; IntAct=EBI-10171697, EBI-10268729;
Q9NWQ4:GPATCH2L; NbExp=3; IntAct=EBI-10171697, EBI-5666657;
Q9Y5Q8:GTF3C5; NbExp=3; IntAct=EBI-10171697, EBI-1045409;
Q96NT3:GUCD1; NbExp=3; IntAct=EBI-10171697, EBI-8293751;
Q96CS2:HAUS1; NbExp=3; IntAct=EBI-10171697, EBI-2514791;
P69905:HBA2; NbExp=3; IntAct=EBI-10171697, EBI-714680;
P02008:HBZ; NbExp=3; IntAct=EBI-10171697, EBI-719843;
P08631:HCK; NbExp=3; IntAct=EBI-10171697, EBI-346340;
P56524:HDAC4; NbExp=3; IntAct=EBI-10171697, EBI-308629;
V9HWJ5:HEL-S-90n; NbExp=3; IntAct=EBI-10171697, EBI-10330335;
O14964:HGS; NbExp=3; IntAct=EBI-10171697, EBI-740220;
P49639:HOXA1; NbExp=3; IntAct=EBI-10171697, EBI-740785;
P31273:HOXC8; NbExp=4; IntAct=EBI-10171697, EBI-1752118;
Q96MM6:HSPA12B; NbExp=3; IntAct=EBI-10171697, EBI-10291310;
P10809:HSPD1; NbExp=3; IntAct=EBI-10171697, EBI-352528;
Q8WYH8:ING5; NbExp=3; IntAct=EBI-10171697, EBI-488533;
Q92835:INPP5D; NbExp=3; IntAct=EBI-10171697, EBI-1380477;
Q8NA54:IQUB; NbExp=3; IntAct=EBI-10171697, EBI-10220600;
Q9H1K1:ISCU; NbExp=3; IntAct=EBI-10171697, EBI-1047335;
L7RT22:ITGB5; NbExp=3; IntAct=EBI-10171697, EBI-10178729;
Q15040:JOSD1; NbExp=5; IntAct=EBI-10171697, EBI-2510602;
Q92993:KAT5; NbExp=3; IntAct=EBI-10171697, EBI-399080;
Q7L273:KCTD9; NbExp=3; IntAct=EBI-10171697, EBI-4397613;
Q9BVG8:KIFC3; NbExp=3; IntAct=EBI-10171697, EBI-2125614;
Q2WGJ6:KLHL38; NbExp=3; IntAct=EBI-10171697, EBI-6426443;
P52292:KPNA2; NbExp=3; IntAct=EBI-10171697, EBI-349938;
P35908:KRT2; NbExp=10; IntAct=EBI-10171697, EBI-1247312;
P35900:KRT20; NbExp=3; IntAct=EBI-10171697, EBI-742094;
P19013:KRT4; NbExp=5; IntAct=EBI-10171697, EBI-2371606;
P13647:KRT5; NbExp=5; IntAct=EBI-10171697, EBI-702187;
P02538:KRT6A; NbExp=10; IntAct=EBI-10171697, EBI-702198;
P48668:KRT6C; NbExp=5; IntAct=EBI-10171697, EBI-2564105;
Q3SY84:KRT71; NbExp=5; IntAct=EBI-10171697, EBI-2952676;
Q14CN4:KRT72; NbExp=3; IntAct=EBI-10171697, EBI-1221280;
P05787:KRT8; NbExp=5; IntAct=EBI-10171697, EBI-297852;
Q14533:KRT81; NbExp=7; IntAct=EBI-10171697, EBI-739648;
Q14657:LAGE3; NbExp=5; IntAct=EBI-10171697, EBI-1052105;
Q5T5B0:LCE3E; NbExp=3; IntAct=EBI-10171697, EBI-10245456;
Q96BZ8:LENG1; NbExp=7; IntAct=EBI-10171697, EBI-726510;
Q7Z4I7-5:LIMS2; NbExp=3; IntAct=EBI-10171697, EBI-10257651;
Q96GY3:LIN37; NbExp=3; IntAct=EBI-10171697, EBI-748884;
Q9BU23:LMF2; NbExp=3; IntAct=EBI-10171697, EBI-10298556;
P25800:LMO1; NbExp=3; IntAct=EBI-10171697, EBI-8639312;
P25791:LMO2; NbExp=3; IntAct=EBI-10171697, EBI-739696;
P61968:LMO4; NbExp=3; IntAct=EBI-10171697, EBI-2798728;
O75427:LRCH4; NbExp=3; IntAct=EBI-10171697, EBI-718707;
Q9Y586:MAB21L2; NbExp=3; IntAct=EBI-10171697, EBI-6659161;
Q96A72:MAGOHB; NbExp=3; IntAct=EBI-10171697, EBI-746778;
O60336:MAPKBP1; NbExp=3; IntAct=EBI-10171697, EBI-947402;
Q6IPE9:MARK4; NbExp=3; IntAct=EBI-10171697, EBI-10250211;
Q96G25-2:MED8; NbExp=3; IntAct=EBI-10171697, EBI-10286267;
Q9H7H0:METTL17; NbExp=3; IntAct=EBI-10171697, EBI-749353;
P55081:MFAP1; NbExp=3; IntAct=EBI-10171697, EBI-1048159;
Q4ZG74:MGC13033; NbExp=3; IntAct=EBI-10171697, EBI-10241963;
Q70IA8:MOB3C; NbExp=3; IntAct=EBI-10171697, EBI-9679267;
P00540:MOS; NbExp=3; IntAct=EBI-10171697, EBI-1757866;
Q9Y3B7:MRPL11; NbExp=3; IntAct=EBI-10171697, EBI-5453723;
Q13330:MTA1; NbExp=3; IntAct=EBI-10171697, EBI-714236;
P50539-3:MXI1; NbExp=3; IntAct=EBI-10171697, EBI-10211940;
Q6XQN6-2:NAPRT; NbExp=3; IntAct=EBI-10171697, EBI-10254820;
Q9GZM8:NDEL1; NbExp=3; IntAct=EBI-10171697, EBI-928842;
Q9HC98:NEK6; NbExp=3; IntAct=EBI-10171697, EBI-740364;
Q8NI38:NFKBID; NbExp=3; IntAct=EBI-10171697, EBI-10271199;
Q92982:NINJ1; NbExp=3; IntAct=EBI-10171697, EBI-2802124;
P48146:NPBWR2; NbExp=3; IntAct=EBI-10171697, EBI-10210114;
P16860:NPPB; NbExp=3; IntAct=EBI-10171697, EBI-747044;
Q6NSM0:NR1D2; NbExp=3; IntAct=EBI-10171697, EBI-10250949;
Q9UBU9:NXF1; NbExp=3; IntAct=EBI-10171697, EBI-398874;
A8K0Y0:OPCML; NbExp=3; IntAct=EBI-10171697, EBI-10174172;
Q9BWI9:OTUB2; NbExp=3; IntAct=EBI-10171697, EBI-10300896;
Q96HC4:PDLIM5; NbExp=3; IntAct=EBI-10171697, EBI-751267;
Q96BD5:PHF21A; NbExp=3; IntAct=EBI-10171697, EBI-745085;
Q96S52:PIGS; NbExp=3; IntAct=EBI-10171697, EBI-2908273;
Q9BSJ6:PIMREG; NbExp=3; IntAct=EBI-10171697, EBI-2568609;
Q13526:PIN1; NbExp=3; IntAct=EBI-10171697, EBI-714158;
Q13563:PKD2; NbExp=3; IntAct=EBI-10171697, EBI-7813714;
Q8WUT1:POLDIP3; NbExp=3; IntAct=EBI-10171697, EBI-10276663;
Q9UGP5-2:POLL; NbExp=3; IntAct=EBI-10171697, EBI-10320765;
Q969H6:POP5; NbExp=3; IntAct=EBI-10171697, EBI-366525;
Q6NYC8:PPP1R18; NbExp=3; IntAct=EBI-10171697, EBI-2557469;
Q96QH2:PRAM1; NbExp=3; IntAct=EBI-10171697, EBI-2860740;
Q13131:PRKAA1; NbExp=3; IntAct=EBI-10171697, EBI-1181405;
O43741:PRKAB2; NbExp=7; IntAct=EBI-10171697, EBI-1053424;
Q8WWY3:PRPF31; NbExp=6; IntAct=EBI-10171697, EBI-1567797;
P25786:PSMA1; NbExp=3; IntAct=EBI-10171697, EBI-359352;
P62195:PSMC5; NbExp=3; IntAct=EBI-10171697, EBI-357745;
P43115-12:PTGER3; NbExp=3; IntAct=EBI-10171697, EBI-10234038;
Q8WUK0:PTPMT1; NbExp=3; IntAct=EBI-10171697, EBI-7199479;
Q8TBN0:RAB3IL1; NbExp=3; IntAct=EBI-10171697, EBI-743796;
Q96QF0:RAB3IP; NbExp=3; IntAct=EBI-10171697, EBI-747844;
P63000:RAC1; NbExp=3; IntAct=EBI-10171697, EBI-413628;
Q8WWW0:RASSF5; NbExp=3; IntAct=EBI-10171697, EBI-367390;
Q96IZ5:RBM41; NbExp=3; IntAct=EBI-10171697, EBI-740773;
Q9P2K3:RCOR3; NbExp=3; IntAct=EBI-10171697, EBI-743428;
Q6P9E2:RECK; NbExp=3; IntAct=EBI-10171697, EBI-10253121;
Q63HN8-6:RNF213; NbExp=3; IntAct=EBI-10171697, EBI-10248548;
P62913:RPL11; NbExp=3; IntAct=EBI-10171697, EBI-354380;
Q9UHP6:RSPH14; NbExp=3; IntAct=EBI-10171697, EBI-748350;
Q14D33:RTP5; NbExp=3; IntAct=EBI-10171697, EBI-10217913;
P57060:RWDD2B; NbExp=5; IntAct=EBI-10171697, EBI-724442;
Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-10171697, EBI-10313866;
Q9UIL1:SCOC; NbExp=3; IntAct=EBI-10171697, EBI-2686537;
Q9C0C4:SEMA4C; NbExp=3; IntAct=EBI-10171697, EBI-10303490;
Q9C0A6-2:SETD5; NbExp=3; IntAct=EBI-10171697, EBI-10303449;
Q6NXQ0:SFRS2; NbExp=3; IntAct=EBI-10171697, EBI-10251550;
Q9H788:SH2D4A; NbExp=5; IntAct=EBI-10171697, EBI-747035;
Q92529:SHC3; NbExp=5; IntAct=EBI-10171697, EBI-79084;
Q9UBX3:SLC25A10; NbExp=3; IntAct=EBI-10171697, EBI-750394;
Q9GZT3:SLIRP; NbExp=3; IntAct=EBI-10171697, EBI-1050793;
O95391:SLU7; NbExp=3; IntAct=EBI-10171697, EBI-750559;
Q969G3:SMARCE1; NbExp=5; IntAct=EBI-10171697, EBI-455078;
Q9NRQ5:SMCO4; NbExp=3; IntAct=EBI-10171697, EBI-8640191;
O95863:SNAI1; NbExp=3; IntAct=EBI-10171697, EBI-1045459;
P14678-2:SNRPB; NbExp=3; IntAct=EBI-10171697, EBI-372475;
Q13573:SNW1; NbExp=3; IntAct=EBI-10171697, EBI-632715;
Q9Y4P9:SPEF1; NbExp=3; IntAct=EBI-10171697, EBI-740053;
Q9UQ90:SPG7; NbExp=3; IntAct=EBI-10171697, EBI-717201;
Q16385:SSX2B; NbExp=3; IntAct=EBI-10171697, EBI-2210673;
Q9Y2D8:SSX2IP; NbExp=3; IntAct=EBI-10171697, EBI-2212028;
Q5T7P8-2:SYT6; NbExp=3; IntAct=EBI-10171697, EBI-10246152;
Q9NU19:TBC1D22B; NbExp=3; IntAct=EBI-10171697, EBI-8787464;
Q15560:TCEA2; NbExp=3; IntAct=EBI-10171697, EBI-710310;
Q9BT92:TCHP; NbExp=3; IntAct=EBI-10171697, EBI-740781;
Q9BT49:THAP7; NbExp=3; IntAct=EBI-10171697, EBI-741350;
P35590:TIE1; NbExp=3; IntAct=EBI-10171697, EBI-2256865;
Q9H6L2:TMEM231; NbExp=3; IntAct=EBI-10171697, EBI-10307654;
Q0P5Q0:TMSB4X; NbExp=3; IntAct=EBI-10171697, EBI-10226570;
Q96KP6:TNIP3; NbExp=4; IntAct=EBI-10171697, EBI-2509913;
P13805:TNNT1; NbExp=3; IntAct=EBI-10171697, EBI-726527;
Q9BUZ4:TRAF4; NbExp=5; IntAct=EBI-10171697, EBI-3650647;
Q8IWZ5:TRIM42; NbExp=3; IntAct=EBI-10171697, EBI-5235829;
Q12815:TROAP; NbExp=3; IntAct=EBI-10171697, EBI-2349743;
Q9Y260:TRPV6; NbExp=3; IntAct=EBI-10171697, EBI-750052;
Q8IV54:TSC22D4; NbExp=3; IntAct=EBI-10171697, EBI-10261521;
Q3SY00:TSGA10IP; NbExp=3; IntAct=EBI-10171697, EBI-10241197;
Q63HK5:TSHZ3; NbExp=3; IntAct=EBI-10171697, EBI-9053916;
Q5W5X9:TTC23; NbExp=3; IntAct=EBI-10171697, EBI-6447954;
Q96NG3:TTC25; NbExp=3; IntAct=EBI-10171697, EBI-1046387;
Q6ZVT0:TTLL10; NbExp=3; IntAct=EBI-10171697, EBI-7844656;
P40222:TXLNA; NbExp=5; IntAct=EBI-10171697, EBI-359793;
Q99757:TXN2; NbExp=3; IntAct=EBI-10171697, EBI-2932492;
Q86UY0:TXNDC5; NbExp=5; IntAct=EBI-10171697, EBI-2825190;
P29597:TYK2; NbExp=3; IntAct=EBI-10171697, EBI-1383454;
Q06418:TYRO3; NbExp=3; IntAct=EBI-10171697, EBI-3951628;
Q9BZF9:UACA; NbExp=3; IntAct=EBI-10171697, EBI-350510;
P57075:UBASH3A; NbExp=3; IntAct=EBI-10171697, EBI-2105393;
Q8N6Y0:USHBP1; NbExp=3; IntAct=EBI-10171697, EBI-739895;
O75604:USP2; NbExp=5; IntAct=EBI-10171697, EBI-743272;
Q9UK80:USP21; NbExp=3; IntAct=EBI-10171697, EBI-373242;
Q08E77:UTP14C; NbExp=3; IntAct=EBI-10171697, EBI-10225961;
Q9BRU9:UTP23; NbExp=3; IntAct=EBI-10171697, EBI-5457544;
Q9UBK9:UXT; NbExp=3; IntAct=EBI-10171697, EBI-357355;
Q64LD2:WDR25; NbExp=3; IntAct=EBI-10171697, EBI-744560;
P19544:WT1; NbExp=3; IntAct=EBI-10171697, EBI-2320534;
Q06250:WT1-AS; NbExp=3; IntAct=EBI-10171697, EBI-10223946;
Q05516:ZBTB16; NbExp=5; IntAct=EBI-10171697, EBI-711925;
O43167:ZBTB24; NbExp=3; IntAct=EBI-10171697, EBI-744471;
Q53FD0:ZC2HC1C; NbExp=3; IntAct=EBI-10171697, EBI-740767;
Q15911-2:ZFHX3; NbExp=3; IntAct=EBI-10171697, EBI-10237226;
Q6ZN57:ZFP2; NbExp=5; IntAct=EBI-10171697, EBI-7236323;
Q9UJL9:ZFP69B; NbExp=3; IntAct=EBI-10171697, EBI-10322364;
Q9BQ24:ZFYVE21; NbExp=3; IntAct=EBI-10171697, EBI-2849569;
Q96H43:ZFYVE26; NbExp=5; IntAct=EBI-10171697, EBI-10286915;
Q8N5A5:ZGPAT; NbExp=3; IntAct=EBI-10171697, EBI-3439227;
Q8N5A5-2:ZGPAT; NbExp=3; IntAct=EBI-10171697, EBI-10183064;
Q96NC0:ZMAT2; NbExp=3; IntAct=EBI-10171697, EBI-2682299;
Q8IZC7:ZNF101; NbExp=3; IntAct=EBI-10171697, EBI-5278328;
Q15973:ZNF124; NbExp=3; IntAct=EBI-10171697, EBI-2555767;
P52744-2:ZNF138; NbExp=3; IntAct=EBI-10171697, EBI-10213071;
Q53Z40:ZNF165; NbExp=3; IntAct=EBI-10171697, EBI-10186058;
P17024:ZNF20; NbExp=3; IntAct=EBI-10171697, EBI-717634;
O95125:ZNF202; NbExp=5; IntAct=EBI-10171697, EBI-751960;
Q9UIE0:ZNF230; NbExp=3; IntAct=EBI-10171697, EBI-1105361;
P15622-3:ZNF250; NbExp=5; IntAct=EBI-10171697, EBI-10177272;
P17031:ZNF26; NbExp=3; IntAct=EBI-10171697, EBI-2841331;
Q14584:ZNF266; NbExp=5; IntAct=EBI-10171697, EBI-7115319;
Q9HBT8-2:ZNF286A; NbExp=3; IntAct=EBI-10171697, EBI-10310244;
Q96PQ6-4:ZNF317; NbExp=3; IntAct=EBI-10171697, EBI-10292528;
Q86UD4:ZNF329; NbExp=3; IntAct=EBI-10171697, EBI-7233259;
Q9Y3M9:ZNF337; NbExp=3; IntAct=EBI-10171697, EBI-714987;
Q8TAU3:ZNF417; NbExp=5; IntAct=EBI-10171697, EBI-740727;
Q8NDP4:ZNF439; NbExp=5; IntAct=EBI-10171697, EBI-747580;
Q9NWS9-2:ZNF446; NbExp=5; IntAct=EBI-10171697, EBI-740232;
Q96MN9:ZNF488; NbExp=3; IntAct=EBI-10171697, EBI-948288;
Q8TBZ8:ZNF564; NbExp=3; IntAct=EBI-10171697, EBI-10273713;
Q5MCW4:ZNF569; NbExp=3; IntAct=EBI-10171697, EBI-4395687;
Q9P0T4:ZNF581; NbExp=5; IntAct=EBI-10171697, EBI-745520;
Q96SQ5:ZNF587; NbExp=5; IntAct=EBI-10171697, EBI-6427977;
Q96I27:ZNF625; NbExp=3; IntAct=EBI-10171697, EBI-4395587;
Q8N720:ZNF655; NbExp=3; IntAct=EBI-10171697, EBI-625509;
Q8N508:ZNF697; NbExp=3; IntAct=EBI-10171697, EBI-10265733;
Q9H963:ZNF702P; NbExp=3; IntAct=EBI-10171697, EBI-10309738;
Q3KQV3:ZNF792; NbExp=3; IntAct=EBI-10171697, EBI-10240849;
Q08AG5:ZNF844; NbExp=5; IntAct=EBI-10171697, EBI-10225757;
Q9Y5A6:ZSCAN21; NbExp=3; IntAct=EBI-10171697, EBI-10281938;
-!- TISSUE SPECIFICITY: Expressed in skin and scalp. Also very weakly
expressed in tongue, breast, colon and small intestine. In the
hair follicle, it is specifically present in the upper hair
cuticle. Not present in the upper cortex (at protein level).
{ECO:0000269|PubMed:15617563, ECO:0000269|PubMed:17301834}.
-!- DEVELOPMENTAL STAGE: During differentiation of the hair, it is one
of the last keratins expressed. {ECO:0000269|PubMed:17301834}.
-!- MISCELLANEOUS: There are two types of cytoskeletal and
microfibrillar keratin, I (acidic) and II (neutral to basic) (40-
55 and 56-70 kDa, respectively).
-!- SIMILARITY: Belongs to the intermediate filament family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AJ786658; CAH10353.1; -; mRNA.
EMBL; BC130396; AAI30397.1; -; mRNA.
EMBL; BC150174; AAI50175.1; -; mRNA.
EMBL; BC150191; AAI50192.1; -; mRNA.
EMBL; BK004055; DAA04488.1; -; mRNA.
CCDS; CCDS42320.1; -.
RefSeq; NP_872303.2; NM_182497.3.
UniGene; Hs.534929; -.
ProteinModelPortal; Q6A162; -.
SMR; Q6A162; -.
BioGrid; 125917; 313.
IntAct; Q6A162; 368.
iPTMnet; Q6A162; -.
SwissPalm; Q6A162; -.
BioMuta; KRT40; -.
DMDM; 166218814; -.
PaxDb; Q6A162; -.
PeptideAtlas; Q6A162; -.
PRIDE; Q6A162; -.
DNASU; 125115; -.
Ensembl; ENST00000377755; ENSP00000366984; ENSG00000204889.
Ensembl; ENST00000398486; ENSP00000381500; ENSG00000204889.
Ensembl; ENST00000576967; ENSP00000459621; ENSG00000262845.
Ensembl; ENST00000610983; ENSP00000479080; ENSG00000262845.
GeneID; 125115; -.
KEGG; hsa:125115; -.
UCSC; uc010cxh.2; human.
CTD; 125115; -.
GeneCards; KRT40; -.
HGNC; HGNC:26707; KRT40.
MIM; 616679; gene.
neXtProt; NX_Q6A162; -.
OpenTargets; ENSG00000204889; -.
PharmGKB; PA147357651; -.
eggNOG; ENOG410IFTS; Eukaryota.
eggNOG; ENOG41119VC; LUCA.
GeneTree; ENSGT00760000118808; -.
HOGENOM; HOG000230975; -.
HOVERGEN; HBG013015; -.
InParanoid; Q6A162; -.
KO; K07604; -.
OMA; IDNVENQ; -.
OrthoDB; EOG091G087I; -.
PhylomeDB; Q6A162; -.
TreeFam; TF332742; -.
Reactome; R-HSA-6805567; Keratinization.
Reactome; R-HSA-6809371; Formation of the cornified envelope.
GenomeRNAi; 125115; -.
PRO; PR:Q6A162; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000204889; -.
CleanEx; HS_KRT40; -.
ExpressionAtlas; Q6A162; baseline and differential.
Genevisible; Q6A162; HS.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0070268; P:cornification; TAS:Reactome.
GO; GO:0031424; P:keratinization; TAS:Reactome.
InterPro; IPR001664; IF.
InterPro; IPR002957; Keratin_I.
PANTHER; PTHR23239; PTHR23239; 1.
Pfam; PF00038; Filament; 1.
PRINTS; PR01248; TYPE1KERATIN.
SMART; SM01391; Filament; 1.
1: Evidence at protein level;
Coiled coil; Complete proteome; Intermediate filament; Keratin;
Polymorphism; Reference proteome.
CHAIN 1 431 Keratin, type I cytoskeletal 40.
/FTId=PRO_0000314857.
REGION 1 89 Head.
REGION 90 396 Rod.
REGION 90 124 Coil 1A.
REGION 125 135 Linker 1.
REGION 136 236 Coil 1B.
REGION 237 252 Linker 12.
REGION 253 396 Coil 2.
REGION 397 431 Tail.
SITE 338 338 Stutter.
VARIANT 37 37 T -> A (in dbSNP:rs1510069).
/FTId=VAR_038078.
VARIANT 85 85 F -> S (in dbSNP:rs17843015).
{ECO:0000269|PubMed:15617563}.
/FTId=VAR_038079.
VARIANT 102 102 S -> N (in dbSNP:rs1510068).
/FTId=VAR_038080.
VARIANT 153 153 T -> M (in dbSNP:rs9908304).
/FTId=VAR_038081.
VARIANT 235 235 R -> H (in dbSNP:rs2010027).
/FTId=VAR_049787.
VARIANT 265 265 C -> Y (in dbSNP:rs721957).
{ECO:0000269|PubMed:15617563}.
/FTId=VAR_049788.
VARIANT 286 286 E -> D (in dbSNP:rs721958).
/FTId=VAR_049789.
VARIANT 303 303 M -> T (in dbSNP:rs9908389).
/FTId=VAR_049790.
VARIANT 406 406 S -> L (in dbSNP:rs16968862).
/FTId=VAR_049791.
CONFLICT 241 241 R -> C (in Ref. 1; CAH10353).
{ECO:0000305}.
CONFLICT 349 349 C -> R (in Ref. 1; CAH10353).
{ECO:0000305}.
CONFLICT 408 408 T -> I (in Ref. 1; CAH10353).
{ECO:0000305}.
SEQUENCE 431 AA; 48139 MW; D57C5153D50E7D41 CRC64;
MTSDCSSTHC SPESCGTASG CAPASSCSVE TACLPGTCAT SRCQTPSFLS RSRGLTGCLL
PCYFTGSCNS PCLVGNCAWC EDGVFTSNEK ETMQFLNDRL ASYLEKVRSL EETNAELESR
IQEQCEQDIP MVCPDYQRYF NTIEDLQQKI LCTKAENSRL AVQLDNCKLA TDDFKSKYES
ELSLRQLLEA DISSLHGILE ELTLCKSDLE AHVESLKEDL LCLKKNHEEE VNLLREQLGD
RLSVELDTAP TLDLNRVLDE MRCQCETVLA NNRREAEEWL AVQTEELNQQ QLSSAEQLQG
CQMEILELKR TASALEIELQ AQQSLTESLE CTVAETEAQY SSQLAQIQCL IDNLENQLAE
IRCDLERQNQ EYQVLLDVKA RLEGEINTYW GLLDSEDSRL SCSPCSTTCT SSNTCEPCSA
YVICTVENCC L


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