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Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36)

 K2C73_HUMAN             Reviewed;         540 AA.
Q86Y46; Q32MB2;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
28-FEB-2018, entry version 116.
RecName: Full=Keratin, type II cytoskeletal 73;
AltName: Full=Cytokeratin-73;
Short=CK-73;
AltName: Full=Keratin-73;
Short=K73;
AltName: Full=Type II inner root sheath-specific keratin-K6irs3;
AltName: Full=Type-II keratin Kb36;
Name=KRT73; Synonyms=K6IRS3, KB36, KRT6IRS3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Scalp;
PubMed=12648212; DOI=10.1046/j.1523-1747.2003.12087.x;
Langbein L., Rogers M.A., Praetzel S., Winter H., Schweizer J.;
"K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-
specific type II epithelial keratins of the human hair follicle.";
J. Invest. Dermatol. 120:512-522(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
TISSUE SPECIFICITY.
PubMed=16874310; DOI=10.1038/sj.jid.5700494;
Langbein L., Rogers M.A., Praetzel-Wunder S., Helmke B.,
Schirmacher P., Schweizer J.;
"K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4)
represent the type I inner root sheath keratins of the human hair
follicle.";
J. Invest. Dermatol. 126:2377-2386(2006).
[5]
VARIANTS [LARGE SCALE ANALYSIS] HIS-212 AND MET-248.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: Has a role in hair formation. Specific component of
keratin intermediate filaments in the inner root sheath (IRS) of
the hair follicle (Probable). {ECO:0000305}.
-!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
-!- INTERACTION:
P19012:KRT15; NbExp=3; IntAct=EBI-2830994, EBI-739566;
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q86Y46-1; Sequence=Displayed;
Name=2;
IsoId=Q86Y46-2; Sequence=VSP_030417, VSP_030418;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Highly expressed in hair follicles from scalp.
In hair, it is specifically present in the inner root sheath (IRS)
of the hair follicle. Present in the IRS cuticle, but not in Henle
or Huxley layers of the IRS. In the IRS cuticle, it is expressed
between the lowermost bulb region of the cuticle and the region
where Henle cells undergo abrupt terminal differentiation.
Detected up to the uppermost cortex region where cuticle cells
terminally differentiate (at protein level).
{ECO:0000269|PubMed:12648212, ECO:0000269|PubMed:16874310}.
-!- MISCELLANEOUS: There are two types of cytoskeletal and
microfibrillar keratin, I (acidic) and II (neutral to basic) (40-
55 and 56-70 kDa, respectively).
-!- SIMILARITY: Belongs to the intermediate filament family.
{ECO:0000255|PROSITE-ProRule:PRU01188}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AJ508776; CAD48513.1; -; mRNA.
EMBL; CH471054; EAW96640.1; -; Genomic_DNA.
EMBL; BC109212; AAI09213.1; -; mRNA.
EMBL; BC109213; AAI09214.1; -; mRNA.
CCDS; CCDS8834.1; -. [Q86Y46-1]
RefSeq; NP_778238.1; NM_175068.2. [Q86Y46-1]
UniGene; Hs.55410; -.
ProteinModelPortal; Q86Y46; -.
SMR; Q86Y46; -.
BioGrid; 130489; 14.
IntAct; Q86Y46; 12.
STRING; 9606.ENSP00000307014; -.
iPTMnet; Q86Y46; -.
PhosphoSitePlus; Q86Y46; -.
SwissPalm; Q86Y46; -.
BioMuta; KRT73; -.
DMDM; 74750553; -.
PaxDb; Q86Y46; -.
PeptideAtlas; Q86Y46; -.
PRIDE; Q86Y46; -.
Ensembl; ENST00000305748; ENSP00000307014; ENSG00000186049. [Q86Y46-1]
GeneID; 319101; -.
KEGG; hsa:319101; -.
UCSC; uc001sas.3; human. [Q86Y46-1]
CTD; 319101; -.
DisGeNET; 319101; -.
EuPathDB; HostDB:ENSG00000186049.8; -.
GeneCards; KRT73; -.
HGNC; HGNC:28928; KRT73.
HPA; HPA044031; -.
MIM; 608247; gene.
neXtProt; NX_Q86Y46; -.
OpenTargets; ENSG00000186049; -.
PharmGKB; PA147031702; -.
eggNOG; ENOG410IQKP; Eukaryota.
eggNOG; ENOG4111AD7; LUCA.
GeneTree; ENSGT00910000144006; -.
HOGENOM; HOG000230976; -.
HOVERGEN; HBG013015; -.
InParanoid; Q86Y46; -.
KO; K07605; -.
OMA; GTYGYWP; -.
OrthoDB; EOG091G09KR; -.
PhylomeDB; Q86Y46; -.
TreeFam; TF317854; -.
Reactome; R-HSA-6805567; Keratinization.
Reactome; R-HSA-6809371; Formation of the cornified envelope.
ChiTaRS; KRT73; human.
GenomeRNAi; 319101; -.
PRO; PR:Q86Y46; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000186049; -.
CleanEx; HS_KRT73; -.
ExpressionAtlas; Q86Y46; baseline and differential.
Genevisible; Q86Y46; HS.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
GO; GO:0045095; C:keratin filament; IEA:InterPro.
GO; GO:0005634; C:nucleus; HDA:UniProtKB.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0070268; P:cornification; TAS:Reactome.
GO; GO:0031424; P:keratinization; TAS:Reactome.
InterPro; IPR001664; IF.
InterPro; IPR018039; Intermediate_filament_CS.
InterPro; IPR032444; Keratin_2_head.
InterPro; IPR003054; Keratin_II.
PANTHER; PTHR23239; PTHR23239; 1.
Pfam; PF00038; Filament; 1.
Pfam; PF16208; Keratin_2_head; 1.
PRINTS; PR01276; TYPE2KERATIN.
SMART; SM01391; Filament; 1.
PROSITE; PS00226; IF_ROD_1; 1.
PROSITE; PS51842; IF_ROD_2; 1.
1: Evidence at protein level;
Alternative splicing; Coiled coil; Complete proteome;
Intermediate filament; Keratin; Polymorphism; Reference proteome.
CHAIN 1 540 Keratin, type II cytoskeletal 73.
/FTId=PRO_0000314881.
DOMAIN 132 445 IF rod. {ECO:0000255|PROSITE-
ProRule:PRU01188}.
REGION 1 131 Head.
REGION 132 167 Coil 1A.
REGION 168 186 Linker 1.
REGION 187 278 Coil 1B.
REGION 279 302 Linker 12.
REGION 303 441 Coil 2.
REGION 442 540 Tail.
COMPBIAS 10 103 Gly-rich.
SITE 383 383 Stutter.
VAR_SEQ 371 381 CANLETAIADA -> VKGTGAFLTHS (in isoform
2). {ECO:0000305}.
/FTId=VSP_030417.
VAR_SEQ 382 540 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_030418.
VARIANT 61 61 V -> M (in dbSNP:rs35417182).
/FTId=VAR_038091.
VARIANT 96 96 P -> L (in dbSNP:rs659436).
/FTId=VAR_038092.
VARIANT 212 212 R -> H (in a colorectal cancer sample;
somatic mutation).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_038093.
VARIANT 248 248 T -> M (in a colorectal cancer sample;
somatic mutation; dbSNP:rs142246988).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_038094.
VARIANT 365 365 E -> G (in dbSNP:rs607426).
/FTId=VAR_038095.
CONFLICT 11 11 A -> P (in Ref. 3; AAI09214/AAI09213).
{ECO:0000305}.
SEQUENCE 540 AA; 58923 MW; 7B4FC058FDE3191B CRC64;
MSRQFTYKSG AAAKGGFSGC SAVLSGGSSS SYRAGGKGLS GGFSSRSLYS LGGARSISFN
VASGSGWAGG YGFGRGRASG FAGSMFGSVA LGSVCPSLCP PGGIHQVTIN KSLLAPLNVE
LDPEIQKVRA QEREQIKVLN NKFASFIDKV RFLEQQNQVL ETKWELLQQL DLNNCKNNLE
PILEGYISNL RKQLETLSGD RVRLDSELRS VREVVEDYKK RYEEEINKRT TAENEFVVLK
KDVDAAYTSK VELQAKVDAL DGEIKFFKCL YEGETAQIQS HISDTSIILS MDNNRNLDLD
SIIAEVRAQY EEIARKSKAE AEALYQTKFQ ELQLAAGRHG DDLKHTKNEI SELTRLIQRL
RSEIESVKKQ CANLETAIAD AEQRGDCALK DARAKLDELE GALQQAKEEL ARMLREYQEL
LSVKLSLDIE IATYRKLLEG EECRMSGEYT NSVSISVINS SMAGMAGTGA GFGFSNAGTY
GYWPSSVSGG YSMLPGGCVT GSGNCSPRGE ARTRLGSASE FRDSQGKTLA LSSPTKKTMR


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