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Keratin, ultra high-sulfur matrix protein (UHS keratin)

 KRUC_SHEEP              Reviewed;         182 AA.
P26372;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
01-AUG-1992, sequence version 1.
25-OCT-2017, entry version 69.
RecName: Full=Keratin, ultra high-sulfur matrix protein;
AltName: Full=UHS keratin;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Hair follicle;
PubMed=1703541; DOI=10.1083/jcb.111.6.2587;
McKinnon P.J., Powell B.C., Rogers G.E.;
"Structure and expression of genes for a class of cysteine-rich
proteins of the cuticle layers of differentiating wool and hair
follicles.";
J. Cell Biol. 111:2587-2600(1990).
-!- FUNCTION: The keratin products of mammalian epidermal derivatives
such as wool and hair consist of microfibrils embedded in a rigid
matrix of other proteins. The matrix proteins include the high-
sulfur and high-tyrosine keratins, having molecular weights of 6-
20 kDa, whereas the microfibrils contain the larger, low-sulfur
keratins (40-56 kDa).
-!- TISSUE SPECIFICITY: Cuticle layers of differentiating wool
follicles.
-!- DEVELOPMENTAL STAGE: At a late stage of fiber differentiation.
-!- DOMAIN: Mainly composed of Cys-rich (CR), Gly-rich (GR) and Ser-
rich (SR) repeats.
-!- SIMILARITY: Belongs to the KRTAP type 5 family. {ECO:0000305}.
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EMBL; X55294; CAA39006.1; -; mRNA.
PIR; A36686; A36686.
RefSeq; NP_001009807.1; NM_001009807.1.
UniGene; Oar.439; -.
ProteinModelPortal; P26372; -.
PRIDE; P26372; -.
GeneID; 443402; -.
KEGG; oas:443402; -.
Proteomes; UP000002356; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:InterPro.
GO; GO:0045095; C:keratin filament; IEA:InterPro.
GO; GO:0006952; P:defense response; IEA:InterPro.
InterPro; IPR006081; Alpha-defensin.
InterPro; IPR002494; KAP.
PANTHER; PTHR23262; PTHR23262; 3.
2: Evidence at transcript level;
Complete proteome; Keratin; Reference proteome; Repeat.
CHAIN 1 182 Keratin, ultra high-sulfur matrix
protein.
/FTId=PRO_0000184110.
SEQUENCE 182 AA; 16101 MW; 9BDD4901FCB13295 CRC64;
MGCSGCSGGC GSSCGGCGSR CGGCSSSCCV PVCCCKPVCC CVPACSCSSC GKGGCGSSCG
GSKGGCGSCG GSKGGCGSCG GCGSSCCKPV CCCVPACSCS SCGKGGCGSC GGSKGGCGSC
GGSKGGCGSC GGCGSGCGSS CCVPVCCCVP ACSCSSCGKG GCGSCGCSQS SCCVPVCCQR
KI


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