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Keratin-associated protein 10-5 (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5)

 KR105_HUMAN             Reviewed;         271 AA.
P60370; Q0VAR7; Q0VAR8; Q70LJ3;
16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
25-NOV-2008, sequence version 2.
25-OCT-2017, entry version 107.
RecName: Full=Keratin-associated protein 10-5;
AltName: Full=High sulfur keratin-associated protein 10.5;
AltName: Full=Keratin-associated protein 10.5;
AltName: Full=Keratin-associated protein 18-5;
AltName: Full=Keratin-associated protein 18.5;
Name=KRTAP10-5;
Synonyms=KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS LEU-235
AND PRO-268.
TISSUE=Hair root;
PubMed=15028290; DOI=10.1016/j.ygeno.2003.09.024;
Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J.,
Shimizu N.;
"A cluster of 21 keratin-associated protein genes within introns of
another gene on human chromosome 21q22.3.";
Genomics 83:679-693(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=10830953; DOI=10.1038/35012518;
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T.,
Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y.,
Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K.,
Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D.,
Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W.,
Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S.,
Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E.,
Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P.,
Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H.,
Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E.,
Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F.,
Lehrach H., Reinhardt R., Yaspo M.-L.;
"The DNA sequence of human chromosome 21.";
Nature 405:311-319(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-20.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 261-271, AND TISSUE SPECIFICITY.
TISSUE=Scalp;
PubMed=14962103; DOI=10.1046/j.0022-202X.2003.22128.x;
Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S.,
Schweizer J.;
"Hair keratin associated proteins: characterization of a second high
sulfur KAP gene domain on human chromosome 21.";
J. Invest. Dermatol. 122:147-158(2004).
-!- FUNCTION: In the hair cortex, hair keratin intermediate filaments
are embedded in an interfilamentous matrix, consisting of hair
keratin-associated proteins (KRTAP), which are essential for the
formation of a rigid and resistant hair shaft through their
extensive disulfide bond cross-linking with abundant cysteine
residues of hair keratins. The matrix proteins include the high-
sulfur and high-glycine-tyrosine keratins.
-!- SUBUNIT: Interacts with hair keratins.
-!- INTERACTION:
Self; NbExp=3; IntAct=EBI-10172150, EBI-10172150;
Q5BKY6:-; NbExp=3; IntAct=EBI-10172150, EBI-10243533;
Q5XG85:-; NbExp=3; IntAct=EBI-10172150, EBI-10248413;
Q9NWL9:-; NbExp=3; IntAct=EBI-10172150, EBI-10315054;
Q6UY14-3:ADAMTSL4; NbExp=5; IntAct=EBI-10172150, EBI-10173507;
Q8WTP8:AEN; NbExp=3; IntAct=EBI-10172150, EBI-8637627;
P43353:ALDH3B1; NbExp=3; IntAct=EBI-10172150, EBI-2558314;
Q9Y2J4-4:AMOTL2; NbExp=3; IntAct=EBI-10172150, EBI-10187270;
A8KA13:BCL6B; NbExp=3; IntAct=EBI-10172150, EBI-10174813;
A8K571:BMP7; NbExp=3; IntAct=EBI-10172150, EBI-10174327;
Q13895:BYSL; NbExp=5; IntAct=EBI-10172150, EBI-358049;
Q6NUJ2:C11orf87; NbExp=3; IntAct=EBI-10172150, EBI-6660291;
Q9H257:CARD9; NbExp=3; IntAct=EBI-10172150, EBI-751319;
Q9H2X0:CHRD; NbExp=3; IntAct=EBI-10172150, EBI-947551;
Q8NE01:CNNM3; NbExp=3; IntAct=EBI-10172150, EBI-741032;
Q02930-3:CREB5; NbExp=5; IntAct=EBI-10172150, EBI-10192698;
Q6P158:DHX57; NbExp=3; IntAct=EBI-10172150, EBI-1051531;
P42892:ECE1; NbExp=3; IntAct=EBI-10172150, EBI-2859983;
O60573:EIF4E2; NbExp=3; IntAct=EBI-10172150, EBI-398610;
Q9H0I2:ENKD1; NbExp=3; IntAct=EBI-10172150, EBI-744099;
Q5TZK3:FAM74A6; NbExp=3; IntAct=EBI-10172150, EBI-10247271;
Q5HYJ3:FAM76B; NbExp=5; IntAct=EBI-10172150, EBI-751192;
O95363:FARS2; NbExp=3; IntAct=EBI-10172150, EBI-2513774;
P15976:GATA1; NbExp=3; IntAct=EBI-10172150, EBI-3909284;
O76003:GLRX3; NbExp=5; IntAct=EBI-10172150, EBI-374781;
Q9Y223:GNE; NbExp=3; IntAct=EBI-10172150, EBI-4291090;
Q0D2H9:GOLGA8DP; NbExp=3; IntAct=EBI-10172150, EBI-10181276;
Q03014:HHEX; NbExp=3; IntAct=EBI-10172150, EBI-747421;
P49639:HOXA1; NbExp=5; IntAct=EBI-10172150, EBI-740785;
P37235:HPCAL1; NbExp=3; IntAct=EBI-10172150, EBI-749311;
Q07627:KRTAP1-1; NbExp=4; IntAct=EBI-10172150, EBI-11959885;
P60409:KRTAP10-7; NbExp=3; IntAct=EBI-10172150, EBI-10172290;
P59990:KRTAP12-1; NbExp=3; IntAct=EBI-10172150, EBI-10210845;
P59991:KRTAP12-2; NbExp=3; IntAct=EBI-10172150, EBI-10176379;
P0C7H8:KRTAP2-3; NbExp=3; IntAct=EBI-10172150, EBI-10196781;
Q6PEX3:KRTAP26-1; NbExp=3; IntAct=EBI-10172150, EBI-3957672;
Q9BYR7:KRTAP3-2; NbExp=5; IntAct=EBI-10172150, EBI-751260;
Q9BQ66:KRTAP4-12; NbExp=3; IntAct=EBI-10172150, EBI-739863;
Q9BYR5:KRTAP4-2; NbExp=7; IntAct=EBI-10172150, EBI-10172511;
Q6L8G9:KRTAP5-6; NbExp=3; IntAct=EBI-10172150, EBI-10250562;
P26371:KRTAP5-9; NbExp=9; IntAct=EBI-10172150, EBI-3958099;
Q9BYQ4:KRTAP9-2; NbExp=5; IntAct=EBI-10172150, EBI-1044640;
Q9BYQ2:KRTAP9-4; NbExp=5; IntAct=EBI-10172150, EBI-10185730;
Q9BYQ0:KRTAP9-8; NbExp=4; IntAct=EBI-10172150, EBI-11958364;
Q5T7P3:LCE1B; NbExp=9; IntAct=EBI-10172150, EBI-10245913;
Q5TA79:LCE2A; NbExp=5; IntAct=EBI-10172150, EBI-10246607;
Q5TA82:LCE2D; NbExp=3; IntAct=EBI-10172150, EBI-10246750;
Q5T5A8:LCE3C; NbExp=6; IntAct=EBI-10172150, EBI-10245291;
Q5T5B0:LCE3E; NbExp=5; IntAct=EBI-10172150, EBI-10245456;
Q5TA78:LCE4A; NbExp=3; IntAct=EBI-10172150, EBI-10246358;
Q7Z4I7-5:LIMS2; NbExp=3; IntAct=EBI-10172150, EBI-10257651;
Q9P127:LUZP4; NbExp=3; IntAct=EBI-10172150, EBI-10198848;
P50222:MEOX2; NbExp=5; IntAct=EBI-10172150, EBI-748397;
Q13875:MOBP; NbExp=3; IntAct=EBI-10172150, EBI-10230628;
A1L3X4:MT1DP; NbExp=3; IntAct=EBI-10172150, EBI-10172129;
P50539-3:MXI1; NbExp=3; IntAct=EBI-10172150, EBI-10211940;
P41227:NAA10; NbExp=3; IntAct=EBI-10172150, EBI-747693;
Q92692:NECTIN2; NbExp=3; IntAct=EBI-10172150, EBI-718419;
Q7Z3S9:NOTCH2NL; NbExp=7; IntAct=EBI-10172150, EBI-945833;
Q9NQX5:NPDC1; NbExp=3; IntAct=EBI-10172150, EBI-748927;
P22736:NR4A1; NbExp=3; IntAct=EBI-10172150, EBI-721550;
Q7Z417:NUFIP2; NbExp=11; IntAct=EBI-10172150, EBI-1210753;
P32242:OTX1; NbExp=5; IntAct=EBI-10172150, EBI-740446;
O43741:PRKAB2; NbExp=3; IntAct=EBI-10172150, EBI-1053424;
P54619:PRKAG1; NbExp=4; IntAct=EBI-10172150, EBI-1181439;
Q9NZ81:PRR13; NbExp=3; IntAct=EBI-10172150, EBI-740924;
Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-10172150, EBI-10313866;
Q9BWG6:SCNM1; NbExp=3; IntAct=EBI-10172150, EBI-748391;
Q9UHI7:SLC23A1; NbExp=3; IntAct=EBI-10172150, EBI-1759386;
Q9NP91:SLC6A20; NbExp=3; IntAct=EBI-10172150, EBI-10311198;
P49901:SMCP; NbExp=3; IntAct=EBI-10172150, EBI-750494;
Q96E40:SPACA9; NbExp=3; IntAct=EBI-10172150, EBI-722584;
O43609:SPRY1; NbExp=3; IntAct=EBI-10172150, EBI-3866665;
O43597:SPRY2; NbExp=3; IntAct=EBI-10172150, EBI-742487;
O75716:STK16; NbExp=3; IntAct=EBI-10172150, EBI-749295;
Q9P2Z0:THAP10; NbExp=3; IntAct=EBI-10172150, EBI-745404;
Q4VB56:TNP2; NbExp=3; IntAct=EBI-10172150, EBI-10241829;
Q63HR2:TNS2; NbExp=3; IntAct=EBI-10172150, EBI-949753;
Q9Y260:TRPV6; NbExp=3; IntAct=EBI-10172150, EBI-750052;
O75386:TULP3; NbExp=3; IntAct=EBI-10172150, EBI-5357290;
Q86UY0:TXNDC5; NbExp=3; IntAct=EBI-10172150, EBI-2825190;
Q8TAI1:TYMSOS; NbExp=3; IntAct=EBI-10172150, EBI-742060;
Q9BRU9:UTP23; NbExp=3; IntAct=EBI-10172150, EBI-5457544;
Q96HA8:WDYHV1; NbExp=3; IntAct=EBI-10172150, EBI-741158;
Q06250:WT1-AS; NbExp=3; IntAct=EBI-10172150, EBI-10223946;
O43167:ZBTB24; NbExp=3; IntAct=EBI-10172150, EBI-744471;
P10074:ZBTB48; NbExp=3; IntAct=EBI-10172150, EBI-744864;
Q9BQ24:ZFYVE21; NbExp=3; IntAct=EBI-10172150, EBI-2849569;
P17024:ZNF20; NbExp=3; IntAct=EBI-10172150, EBI-717634;
Q14C61:ZNF264; NbExp=3; IntAct=EBI-10172150, EBI-2826570;
Q14593:ZNF273; NbExp=3; IntAct=EBI-10172150, EBI-3922471;
Q9HBT8-2:ZNF286A; NbExp=3; IntAct=EBI-10172150, EBI-10310244;
P17041:ZNF32; NbExp=3; IntAct=EBI-10172150, EBI-1965483;
A2RRD8:ZNF320; NbExp=3; IntAct=EBI-10172150, EBI-10173019;
Q86UD4:ZNF329; NbExp=3; IntAct=EBI-10172150, EBI-7233259;
Q8IZ26:ZNF34; NbExp=3; IntAct=EBI-10172150, EBI-10264496;
Q8TAU3:ZNF417; NbExp=5; IntAct=EBI-10172150, EBI-740727;
Q8N7K0:ZNF433; NbExp=3; IntAct=EBI-10172150, EBI-10267553;
Q8NDP4:ZNF439; NbExp=3; IntAct=EBI-10172150, EBI-747580;
Q9BR84:ZNF559; NbExp=3; IntAct=EBI-10172150, EBI-746605;
Q7Z3I7:ZNF572; NbExp=3; IntAct=EBI-10172150, EBI-10172590;
Q96SQ5:ZNF587; NbExp=7; IntAct=EBI-10172150, EBI-6427977;
Q9BS34:ZNF670; NbExp=3; IntAct=EBI-10172150, EBI-745276;
Q8IYX0:ZNF679; NbExp=3; IntAct=EBI-10172150, EBI-745567;
Q8N508:ZNF697; NbExp=3; IntAct=EBI-10172150, EBI-10265733;
Q96C28:ZNF707; NbExp=3; IntAct=EBI-10172150, EBI-748111;
A8K8V0:ZNF785; NbExp=3; IntAct=EBI-10172150, EBI-3925400;
Q3KQV3:ZNF792; NbExp=3; IntAct=EBI-10172150, EBI-10240849;
Q9Y5A6:ZSCAN21; NbExp=3; IntAct=EBI-10172150, EBI-10281938;
Q16670:ZSCAN26; NbExp=3; IntAct=EBI-10172150, EBI-3920053;
-!- TISSUE SPECIFICITY: Restricted to a narrow region of the hair
fiber cuticle, lying approximately 20 cell layers above the apex
of the dermal papilla of the hair root; not detected in any other
tissues. {ECO:0000269|PubMed:14962103,
ECO:0000269|PubMed:15028290}.
-!- SIMILARITY: Belongs to the KRTAP type 10 family. {ECO:0000305}.
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EMBL; AB076352; BAD01539.1; -; mRNA.
EMBL; AL773602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC120949; AAI20950.1; -; mRNA.
EMBL; BC120950; AAI20951.1; -; mRNA.
EMBL; AJ566384; CAD97464.1; -; mRNA.
CCDS; CCDS42958.1; -.
UniGene; Hs.688629; -.
ProteinModelPortal; P60370; -.
IntAct; P60370; 134.
STRING; 9606.ENSP00000383223; -.
BioMuta; KRTAP10-5; -.
DMDM; 215274018; -.
PaxDb; P60370; -.
PeptideAtlas; P60370; -.
PRIDE; P60370; -.
Ensembl; ENST00000400372; ENSP00000383223; ENSG00000241123.
UCSC; uc002zfl.2; human.
EuPathDB; HostDB:ENSG00000241123.1; -.
GeneCards; KRTAP10-5; -.
HGNC; HGNC:22969; KRTAP10-5.
neXtProt; NX_P60370; -.
PharmGKB; PA134950015; -.
eggNOG; ENOG410JH3R; Eukaryota.
eggNOG; ENOG4111BSI; LUCA.
HOGENOM; HOG000234031; -.
InParanoid; P60370; -.
OrthoDB; EOG091G17RC; -.
PhylomeDB; P60370; -.
TreeFam; TF351356; -.
Reactome; R-HSA-6805567; Keratinization.
PRO; PR:P60370; -.
Proteomes; UP000005640; Chromosome 21.
Bgee; ENSG00000241123; -.
CleanEx; HS_KRTAP10-5; -.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0045095; C:keratin filament; IEA:InterPro.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0031424; P:keratinization; TAS:Reactome.
InterPro; IPR002494; KAP.
PANTHER; PTHR23262; PTHR23262; 4.
Pfam; PF13885; Keratin_B2_2; 2.
1: Evidence at protein level;
Complete proteome; Keratin; Polymorphism; Reference proteome; Repeat.
CHAIN 1 271 Keratin-associated protein 10-5.
/FTId=PRO_0000185213.
REPEAT 26 30 1.
REPEAT 51 55 2.
REPEAT 73 77 3.
REPEAT 78 82 4.
REPEAT 88 92 5.
REPEAT 93 97 6.
REPEAT 98 102 7.
REPEAT 110 114 8.
REPEAT 120 124 9.
REPEAT 130 134 10.
REPEAT 135 139 11.
REPEAT 140 144 12.
REPEAT 152 156 13.
REPEAT 162 166 14.
REPEAT 177 181 15.
REPEAT 187 191 16.
REPEAT 199 203 17.
REPEAT 209 213 18.
REPEAT 214 218 19.
REPEAT 233 237 20.
REPEAT 240 244 21.
REPEAT 251 255 22.
REGION 26 255 22 X 5 AA repeats of C-C-X(3).
VARIANT 4 4 C -> S (in dbSNP:rs5017208).
/FTId=VAR_062113.
VARIANT 20 20 D -> N (in dbSNP:rs2020221).
{ECO:0000269|PubMed:15489334}.
/FTId=VAR_017696.
VARIANT 183 183 F -> C (in dbSNP:rs380585).
/FTId=VAR_047505.
VARIANT 235 235 V -> L (in dbSNP:rs464424).
{ECO:0000269|PubMed:15028290}.
/FTId=VAR_017697.
VARIANT 247 247 Y -> C (in dbSNP:rs7509970).
/FTId=VAR_047506.
VARIANT 268 268 R -> P (in dbSNP:rs464391).
{ECO:0000269|PubMed:15028290}.
/FTId=VAR_047507.
SEQUENCE 271 AA; 27626 MW; 20E32DB102D523ED CRC64;
MAACTMSVCS SACSDSWRVD DCPESCCEPP CGTAPCLTLV CTPVSCVSSP CCQAACEPSP
CQSGCTSSCT PSCCQPACCA SSPCQQACCV PVCCKPVCCL PTCSKDSSSC CQQSSCQPTC
CASSSCQQSC CVPVCCKPVC CVPTCSEDSS SCCQHSSCQP TCCTSSPCQQ SCYVPVCCKP
VCFKPICCVP VCSGASTSCC QQSSCQPACC TTSCCRPSSS VSLLCRPICR PACCVPISSC
CAPASSYQAS CCRPASCVSL LCRPACSRLA C


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18-785-210249 Keratin 18 (Phospho-Ser33) - Cytokeratin-18; CK-18; Keratin-18; K18; Cell proliferation-inducing gene 46 protein Polyclonal 0.05 mg
18-003-43546 Keratin. type I cytoskeletal 18 - Cytokeratin-18; CK-18; Keratin-18; K18; Cell proliferation-inducing gene 46 protein Polyclonal 0.1 mg Protein A
U1240h CLIA CK-20,Cytokeratin-20,Homo sapiens,Human,K20,Keratin, type I cytoskeletal 20,Keratin-20,KRT20,Protein IT 96T
18-003-43545 Keratin. type I cytoskeletal 18 - Cytokeratin-18; CK-18; Keratin-18; K18; Cell proliferation-inducing gene 46 protein Polyclonal 0.1 mg Protein A
E1240h ELISA kit CK-20,Cytokeratin-20,Homo sapiens,Human,K20,Keratin, type I cytoskeletal 20,Keratin-20,KRT20,Protein IT 96T
18-785-210249 Keratin 18 (Phospho-Ser33) - Cytokeratin-18; CK-18; Keratin-18; K18; Cell proliferation-inducing gene 46 protein Polyclonal 0.1 mg


 

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