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Keratin-associated protein 10-8 (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8)

 KR108_HUMAN             Reviewed;         259 AA.
P60410; A0JNW4;
16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
17-OCT-2006, sequence version 2.
25-OCT-2017, entry version 110.
RecName: Full=Keratin-associated protein 10-8;
AltName: Full=High sulfur keratin-associated protein 10.8;
AltName: Full=Keratin-associated protein 10.8;
AltName: Full=Keratin-associated protein 18-8;
AltName: Full=Keratin-associated protein 18.8;
Name=KRTAP10-8;
Synonyms=KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT ARG-26.
TISSUE=Hair root;
PubMed=15028290; DOI=10.1016/j.ygeno.2003.09.024;
Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J.,
Shimizu N.;
"A cluster of 21 keratin-associated protein genes within introns of
another gene on human chromosome 21q22.3.";
Genomics 83:679-693(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=10830953; DOI=10.1038/35012518;
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T.,
Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y.,
Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K.,
Polley A., Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D.,
Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W.,
Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S.,
Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E.,
Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P.,
Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H.,
Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E.,
Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F.,
Lehrach H., Reinhardt R., Yaspo M.-L.;
"The DNA sequence of human chromosome 21.";
Nature 405:311-319(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-26.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
TISSUE SPECIFICITY.
PubMed=14962103; DOI=10.1046/j.0022-202X.2003.22128.x;
Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S.,
Schweizer J.;
"Hair keratin associated proteins: characterization of a second high
sulfur KAP gene domain on human chromosome 21.";
J. Invest. Dermatol. 122:147-158(2004).
[5]
VARIANTS [LARGE SCALE ANALYSIS] ASN-64 AND PHE-159.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: In the hair cortex, hair keratin intermediate filaments
are embedded in an interfilamentous matrix, consisting of hair
keratin-associated proteins (KRTAP), which are essential for the
formation of a rigid and resistant hair shaft through their
extensive disulfide bond cross-linking with abundant cysteine
residues of hair keratins. The matrix proteins include the high-
sulfur and high-glycine-tyrosine keratins.
-!- SUBUNIT: Interacts with hair keratins.
-!- INTERACTION:
Self; NbExp=3; IntAct=EBI-10171774, EBI-10171774;
Q5BKY6:-; NbExp=5; IntAct=EBI-10171774, EBI-10243533;
Q5XG85:-; NbExp=3; IntAct=EBI-10171774, EBI-10248413;
Q6ZVW3:-; NbExp=3; IntAct=EBI-10171774, EBI-10255586;
Q9NWL9:-; NbExp=3; IntAct=EBI-10171774, EBI-10315054;
P82987:ADAMTSL3; NbExp=5; IntAct=EBI-10171774, EBI-10221726;
Q6UY14-3:ADAMTSL4; NbExp=5; IntAct=EBI-10171774, EBI-10173507;
Q8WTP8:AEN; NbExp=3; IntAct=EBI-10171774, EBI-8637627;
Q08117:AES; NbExp=3; IntAct=EBI-10171774, EBI-717810;
P43353:ALDH3B1; NbExp=5; IntAct=EBI-10171774, EBI-2558314;
P09923:ALPI; NbExp=3; IntAct=EBI-10171774, EBI-1052631;
B3KTP4:APOL6; NbExp=3; IntAct=EBI-10171774, EBI-10175904;
Q9BZE9:ASPSCR1; NbExp=3; IntAct=EBI-10171774, EBI-1993677;
Q7Z3C6:ATG9A; NbExp=3; IntAct=EBI-10171774, EBI-727146;
Q9BXY8:BEX2; NbExp=5; IntAct=EBI-10171774, EBI-745073;
A8K571:BMP7; NbExp=3; IntAct=EBI-10171774, EBI-10174327;
Q6NUJ2:C11orf87; NbExp=5; IntAct=EBI-10171774, EBI-6660291;
Q9BWT7:CARD10; NbExp=4; IntAct=EBI-10171774, EBI-3866279;
Q9Y2V2:CARHSP1; NbExp=5; IntAct=EBI-10171774, EBI-718719;
Q8NEC5:CATSPER1; NbExp=9; IntAct=EBI-10171774, EBI-744545;
Q8TAB7:CCDC26; NbExp=5; IntAct=EBI-10171774, EBI-10271580;
F6RF56:CCNJL; NbExp=3; IntAct=EBI-10171774, EBI-10177725;
Q9UKJ5:CHIC2; NbExp=5; IntAct=EBI-10171774, EBI-741528;
Q9H2X0:CHRD; NbExp=5; IntAct=EBI-10171774, EBI-947551;
P07510:CHRNG; NbExp=3; IntAct=EBI-10171774, EBI-9008836;
P07510-2:CHRNG; NbExp=5; IntAct=EBI-10171774, EBI-11979451;
Q9HAZ1:CLK4; NbExp=3; IntAct=EBI-10171774, EBI-633400;
Q8NE01:CNNM3; NbExp=5; IntAct=EBI-10171774, EBI-741032;
P27658:COL8A1; NbExp=5; IntAct=EBI-10171774, EBI-747133;
Q9UGL9:CRCT1; NbExp=5; IntAct=EBI-10171774, EBI-713677;
Q02930-3:CREB5; NbExp=9; IntAct=EBI-10171774, EBI-10192698;
Q96SQ9:CYP2S1; NbExp=4; IntAct=EBI-10171774, EBI-8633740;
A8MQ03:CYSRT1; NbExp=4; IntAct=EBI-10171774, EBI-3867333;
O43602:DCX; NbExp=3; IntAct=EBI-10171774, EBI-8646694;
Q8NHQ9:DDX55; NbExp=3; IntAct=EBI-10171774, EBI-5459844;
P26196:DDX6; NbExp=5; IntAct=EBI-10171774, EBI-351257;
Q9GZP9:DERL2; NbExp=3; IntAct=EBI-10171774, EBI-7962814;
Q96LJ7:DHRS1; NbExp=5; IntAct=EBI-10171774, EBI-746300;
Q6P158:DHX57; NbExp=5; IntAct=EBI-10171774, EBI-1051531;
Q9NQL9:DMRT3; NbExp=5; IntAct=EBI-10171774, EBI-9679045;
Q92608:DOCK2; NbExp=5; IntAct=EBI-10171774, EBI-448771;
O60573:EIF4E2; NbExp=3; IntAct=EBI-10171774, EBI-398610;
P16930:FAH; NbExp=3; IntAct=EBI-10171774, EBI-4397076;
A6H8Z2:FAM221B; NbExp=4; IntAct=EBI-10171774, EBI-12006844;
Q08E93:FAM27E3; NbExp=5; IntAct=EBI-10171774, EBI-2602739;
Q8NEG0:FAM71C; NbExp=4; IntAct=EBI-10171774, EBI-752049;
Q5TZK3:FAM74A6; NbExp=7; IntAct=EBI-10171774, EBI-10247271;
Q5HYJ3:FAM76B; NbExp=3; IntAct=EBI-10171774, EBI-751192;
Q969U6:FBXW5; NbExp=5; IntAct=EBI-10171774, EBI-741068;
Q99853:FOXB1; NbExp=3; IntAct=EBI-10171774, EBI-3916225;
Q9NXC2:GFOD1; NbExp=3; IntAct=EBI-10171774, EBI-8799578;
P43220:GLP1R; NbExp=3; IntAct=EBI-10171774, EBI-7466542;
O76003:GLRX3; NbExp=7; IntAct=EBI-10171774, EBI-374781;
Q6IB77:GLYAT; NbExp=3; IntAct=EBI-10171774, EBI-715463;
P04899:GNAI2; NbExp=3; IntAct=EBI-10171774, EBI-353997;
Q9Y223:GNE; NbExp=3; IntAct=EBI-10171774, EBI-4291090;
Q0D2H9:GOLGA8DP; NbExp=5; IntAct=EBI-10171774, EBI-10181276;
V9HWJ5:HEL-S-90n; NbExp=3; IntAct=EBI-10171774, EBI-10330335;
Q03014:HHEX; NbExp=5; IntAct=EBI-10171774, EBI-747421;
P49639:HOXA1; NbExp=7; IntAct=EBI-10171774, EBI-740785;
P37235:HPCAL1; NbExp=5; IntAct=EBI-10171774, EBI-749311;
Q9H2F3:HSD3B7; NbExp=5; IntAct=EBI-10171774, EBI-3918847;
P10809:HSPD1; NbExp=3; IntAct=EBI-10171774, EBI-352528;
Q969P0:IGSF8; NbExp=5; IntAct=EBI-10171774, EBI-8293590;
P22301:IL10; NbExp=4; IntAct=EBI-10171774, EBI-1031632;
Q9C086:INO80B; NbExp=4; IntAct=EBI-10171774, EBI-715611;
L7RT22:ITGB5; NbExp=3; IntAct=EBI-10171774, EBI-10178729;
P18084:ITGB5; NbExp=4; IntAct=EBI-10171774, EBI-1223434;
Q15040:JOSD1; NbExp=5; IntAct=EBI-10171774, EBI-2510602;
Q2WGJ6:KLHL38; NbExp=5; IntAct=EBI-10171774, EBI-6426443;
P35900:KRT20; NbExp=5; IntAct=EBI-10171774, EBI-742094;
P78385:KRT83; NbExp=3; IntAct=EBI-10171774, EBI-10221390;
P60409:KRTAP10-7; NbExp=3; IntAct=EBI-10171774, EBI-10172290;
P60411:KRTAP10-9; NbExp=5; IntAct=EBI-10171774, EBI-10172052;
P59990:KRTAP12-1; NbExp=5; IntAct=EBI-10171774, EBI-10210845;
P59991:KRTAP12-2; NbExp=3; IntAct=EBI-10171774, EBI-10176379;
Q9BYQ6:KRTAP4-11; NbExp=7; IntAct=EBI-10171774, EBI-10302392;
Q9BQ66:KRTAP4-12; NbExp=7; IntAct=EBI-10171774, EBI-739863;
Q9BYR5:KRTAP4-2; NbExp=7; IntAct=EBI-10171774, EBI-10172511;
Q9BYR0:KRTAP4-7; NbExp=3; IntAct=EBI-10171774, EBI-10302547;
Q6L8G9:KRTAP5-6; NbExp=5; IntAct=EBI-10171774, EBI-10250562;
P26371:KRTAP5-9; NbExp=7; IntAct=EBI-10171774, EBI-3958099;
Q9BYQ4:KRTAP9-2; NbExp=7; IntAct=EBI-10171774, EBI-1044640;
Q9BYQ3:KRTAP9-3; NbExp=4; IntAct=EBI-10171774, EBI-1043191;
Q9BYQ2:KRTAP9-4; NbExp=3; IntAct=EBI-10171774, EBI-10185730;
Q9BYQ0:KRTAP9-8; NbExp=4; IntAct=EBI-10171774, EBI-11958364;
Q14657:LAGE3; NbExp=4; IntAct=EBI-10171774, EBI-1052105;
Q5T7P2:LCE1A; NbExp=4; IntAct=EBI-10171774, EBI-11962058;
Q5T7P3:LCE1B; NbExp=7; IntAct=EBI-10171774, EBI-10245913;
Q5T752:LCE1D; NbExp=4; IntAct=EBI-10171774, EBI-11741311;
Q5T753:LCE1E; NbExp=4; IntAct=EBI-10171774, EBI-11955335;
Q5T754:LCE1F; NbExp=4; IntAct=EBI-10171774, EBI-11958008;
Q5TA79:LCE2A; NbExp=7; IntAct=EBI-10171774, EBI-10246607;
O14633:LCE2B; NbExp=4; IntAct=EBI-10171774, EBI-11478468;
Q5TA81:LCE2C; NbExp=6; IntAct=EBI-10171774, EBI-11973993;
Q5TA82:LCE2D; NbExp=5; IntAct=EBI-10171774, EBI-10246750;
Q5TA76:LCE3A; NbExp=4; IntAct=EBI-10171774, EBI-9394625;
Q5T5A8:LCE3C; NbExp=5; IntAct=EBI-10171774, EBI-10245291;
Q9BYE3:LCE3D; NbExp=4; IntAct=EBI-10171774, EBI-6658837;
Q5T5B0:LCE3E; NbExp=7; IntAct=EBI-10171774, EBI-10245456;
Q5TA78:LCE4A; NbExp=7; IntAct=EBI-10171774, EBI-10246358;
Q17RD9:LOC200261; NbExp=3; IntAct=EBI-10171774, EBI-10239007;
O75427:LRCH4; NbExp=3; IntAct=EBI-10171774, EBI-718707;
Q9P127:LUZP4; NbExp=3; IntAct=EBI-10171774, EBI-10198848;
Q9Y5Y7:LYVE1; NbExp=3; IntAct=EBI-10171774, EBI-10329546;
O60336:MAPKBP1; NbExp=5; IntAct=EBI-10171774, EBI-947402;
O15232:MATN3; NbExp=3; IntAct=EBI-10171774, EBI-6262458;
P50222:MEOX2; NbExp=5; IntAct=EBI-10171774, EBI-748397;
Q6P2C6:MLLT6; NbExp=3; IntAct=EBI-10171774, EBI-5773143;
Q13330:MTA1; NbExp=3; IntAct=EBI-10171774, EBI-714236;
P50539-3:MXI1; NbExp=5; IntAct=EBI-10171774, EBI-10211940;
Q15742:NAB2; NbExp=3; IntAct=EBI-10171774, EBI-8641936;
Q8IW45:NAXD; NbExp=5; IntAct=EBI-10171774, EBI-8650724;
Q9NQS3:NECTIN3; NbExp=3; IntAct=EBI-10171774, EBI-2826725;
Q7Z3S9:NOTCH2NL; NbExp=5; IntAct=EBI-10171774, EBI-945833;
Q7Z417:NUFIP2; NbExp=7; IntAct=EBI-10171774, EBI-1210753;
P32242:OTX1; NbExp=9; IntAct=EBI-10171774, EBI-740446;
C6KE32:P2RX7; NbExp=3; IntAct=EBI-10171774, EBI-10176325;
Q9H1Q7:PCED1A; NbExp=3; IntAct=EBI-10171774, EBI-748452;
Q92824:PCSK5; NbExp=3; IntAct=EBI-10171774, EBI-751290;
Q92824-2:PCSK5; NbExp=4; IntAct=EBI-10171774, EBI-11956269;
O76083:PDE9A; NbExp=3; IntAct=EBI-10171774, EBI-742764;
Q96S52:PIGS; NbExp=3; IntAct=EBI-10171774, EBI-2908273;
Q13526:PIN1; NbExp=4; IntAct=EBI-10171774, EBI-714158;
Q13563:PKD2; NbExp=3; IntAct=EBI-10171774, EBI-7813714;
O43741:PRKAB2; NbExp=5; IntAct=EBI-10171774, EBI-1053424;
Q8WWY3:PRPF31; NbExp=8; IntAct=EBI-10171774, EBI-1567797;
Q9NZ81:PRR13; NbExp=5; IntAct=EBI-10171774, EBI-740924;
P43115-12:PTGER3; NbExp=3; IntAct=EBI-10171774, EBI-10234038;
Q8WUK0:PTPMT1; NbExp=5; IntAct=EBI-10171774, EBI-7199479;
Q9HD43:PTPRH; NbExp=3; IntAct=EBI-10171774, EBI-1267176;
P15151:PVR; NbExp=5; IntAct=EBI-10171774, EBI-3919694;
Q9Y2K5-2:R3HDM2; NbExp=3; IntAct=EBI-10171774, EBI-10326419;
P62857:RPS28; NbExp=3; IntAct=EBI-10171774, EBI-353027;
Q86UN2:RTN4RL1; NbExp=3; IntAct=EBI-10171774, EBI-10258951;
Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-10171774, EBI-10313866;
Q14162:SCARF1; NbExp=4; IntAct=EBI-10171774, EBI-12056025;
Q9BWG6:SCNM1; NbExp=5; IntAct=EBI-10171774, EBI-748391;
Q86YT5:SLC13A5; NbExp=4; IntAct=EBI-10171774, EBI-12002412;
A1A5C7:SLC22A23; NbExp=3; IntAct=EBI-10171774, EBI-10171756;
Q9UHI7:SLC23A1; NbExp=3; IntAct=EBI-10171774, EBI-1759386;
Q9UBX3:SLC25A10; NbExp=3; IntAct=EBI-10171774, EBI-750394;
Q9NP91:SLC6A20; NbExp=5; IntAct=EBI-10171774, EBI-10311198;
P49901:SMCP; NbExp=7; IntAct=EBI-10171774, EBI-750494;
Q9H4F8:SMOC1; NbExp=3; IntAct=EBI-10171774, EBI-2801103;
Q96E40:SPACA9; NbExp=3; IntAct=EBI-10171774, EBI-722584;
Q99932-2:SPAG8; NbExp=4; IntAct=EBI-10171774, EBI-11959123;
O43609:SPRY1; NbExp=5; IntAct=EBI-10171774, EBI-3866665;
O43597:SPRY2; NbExp=3; IntAct=EBI-10171774, EBI-742487;
O75716:STK16; NbExp=5; IntAct=EBI-10171774, EBI-749295;
Q92537:SUSD6; NbExp=5; IntAct=EBI-10171774, EBI-2866213;
Q9NUY8:TBC1D23; NbExp=3; IntAct=EBI-10171774, EBI-2853126;
Q7Z6R9:TFAP2D; NbExp=4; IntAct=EBI-10171774, EBI-11952651;
Q9P2Z0:THAP10; NbExp=3; IntAct=EBI-10171774, EBI-745404;
Q9BT49:THAP7; NbExp=5; IntAct=EBI-10171774, EBI-741350;
Q86TG1:TMEM150A; NbExp=3; IntAct=EBI-10171774, EBI-2799342;
Q96KP6:TNIP3; NbExp=3; IntAct=EBI-10171774, EBI-2509913;
Q4VB56:TNP2; NbExp=3; IntAct=EBI-10171774, EBI-10241829;
Q63HR2:TNS2; NbExp=3; IntAct=EBI-10171774, EBI-949753;
Q9Y260:TRPV6; NbExp=3; IntAct=EBI-10171774, EBI-750052;
Q86UY0:TXNDC5; NbExp=5; IntAct=EBI-10171774, EBI-2825190;
Q8TAI1:TYMSOS; NbExp=5; IntAct=EBI-10171774, EBI-742060;
Q06418:TYRO3; NbExp=3; IntAct=EBI-10171774, EBI-3951628;
Q9BRU9:UTP23; NbExp=5; IntAct=EBI-10171774, EBI-5457544;
Q9UBK9:UXT; NbExp=5; IntAct=EBI-10171774, EBI-357355;
Q9H270:VPS11; NbExp=5; IntAct=EBI-10171774, EBI-373380;
Q9Y5W5:WIF1; NbExp=5; IntAct=EBI-10171774, EBI-3922719;
O96014:WNT11; NbExp=4; IntAct=EBI-10171774, EBI-8058160;
P19544:WT1; NbExp=3; IntAct=EBI-10171774, EBI-2320534;
Q06250:WT1-AS; NbExp=5; IntAct=EBI-10171774, EBI-10223946;
Q9GZM5:YIPF3; NbExp=3; IntAct=EBI-10171774, EBI-743787;
O43167:ZBTB24; NbExp=5; IntAct=EBI-10171774, EBI-744471;
Q9BQ24:ZFYVE21; NbExp=3; IntAct=EBI-10171774, EBI-2849569;
Q15973:ZNF124; NbExp=5; IntAct=EBI-10171774, EBI-2555767;
P52744-2:ZNF138; NbExp=3; IntAct=EBI-10171774, EBI-10213071;
P17024:ZNF20; NbExp=3; IntAct=EBI-10171774, EBI-717634;
P17027:ZNF23; NbExp=4; IntAct=EBI-10171774, EBI-5657766;
P17041:ZNF32; NbExp=3; IntAct=EBI-10171774, EBI-1965483;
Q8TAU3:ZNF417; NbExp=5; IntAct=EBI-10171774, EBI-740727;
Q8NDP4:ZNF439; NbExp=5; IntAct=EBI-10171774, EBI-747580;
Q8IYI8:ZNF440; NbExp=4; IntAct=EBI-10171774, EBI-726439;
Q8N0Y2-2:ZNF444; NbExp=4; IntAct=EBI-10171774, EBI-12010736;
Q8WTR7:ZNF473; NbExp=5; IntAct=EBI-10171774, EBI-751409;
Q7Z3I7:ZNF572; NbExp=8; IntAct=EBI-10171774, EBI-10172590;
Q3MI94:ZNF578; NbExp=3; IntAct=EBI-10171774, EBI-10241108;
Q96SQ5:ZNF587; NbExp=5; IntAct=EBI-10171774, EBI-6427977;
Q8N508:ZNF697; NbExp=3; IntAct=EBI-10171774, EBI-10265733;
Q3KQV3:ZNF792; NbExp=4; IntAct=EBI-10171774, EBI-10240849;
Q9Y5A6:ZSCAN21; NbExp=5; IntAct=EBI-10171774, EBI-10281938;
-!- TISSUE SPECIFICITY: Restricted to a narrow region of the hair
fiber cuticle, lying approximately 20 cell layers above the apex
of the dermal papilla of the hair root; not detected in any other
tissues. {ECO:0000269|PubMed:14962103,
ECO:0000269|PubMed:15028290}.
-!- SIMILARITY: Belongs to the KRTAP type 10 family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB076355; BAD01542.1; -; mRNA.
EMBL; AL773602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC127016; AAI27017.1; -; mRNA.
CCDS; CCDS13713.1; -.
RefSeq; NP_941968.2; NM_198695.2.
UniGene; Hs.528021; -.
ProteinModelPortal; P60410; -.
BioGrid; 132132; 164.
IntAct; P60410; 383.
STRING; 9606.ENSP00000335565; -.
iPTMnet; P60410; -.
PhosphoSitePlus; P60410; -.
BioMuta; KRTAP10-8; -.
DMDM; 116242612; -.
PaxDb; P60410; -.
PeptideAtlas; P60410; -.
PRIDE; P60410; -.
Ensembl; ENST00000334662; ENSP00000335565; ENSG00000187766.
GeneID; 386681; -.
KEGG; hsa:386681; -.
UCSC; uc002zfo.1; human.
CTD; 386681; -.
EuPathDB; HostDB:ENSG00000187766.1; -.
GeneCards; KRTAP10-8; -.
H-InvDB; HIX0040851; -.
HGNC; HGNC:20525; KRTAP10-8.
neXtProt; NX_P60410; -.
OpenTargets; ENSG00000187766; -.
PharmGKB; PA134968895; -.
eggNOG; ENOG410JBGI; Eukaryota.
eggNOG; ENOG41118FU; LUCA.
GeneTree; ENSGT00880000137966; -.
HOGENOM; HOG000234031; -.
HOVERGEN; HBG108072; -.
InParanoid; P60410; -.
OMA; CEPRSCA; -.
OrthoDB; EOG091G15M8; -.
PhylomeDB; P60410; -.
TreeFam; TF351356; -.
Reactome; R-HSA-6805567; Keratinization.
GenomeRNAi; 386681; -.
PRO; PR:P60410; -.
Proteomes; UP000005640; Chromosome 21.
Bgee; ENSG00000187766; -.
CleanEx; HS_KRTAP10-8; -.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0045095; C:keratin filament; IEA:InterPro.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0031424; P:keratinization; TAS:Reactome.
InterPro; IPR002494; KAP.
InterPro; IPR007951; KRTAP_PMG.
PANTHER; PTHR23262; PTHR23262; 3.
Pfam; PF13885; Keratin_B2_2; 1.
Pfam; PF05287; PMG; 1.
1: Evidence at protein level;
Complete proteome; Keratin; Polymorphism; Reference proteome; Repeat.
CHAIN 1 259 Keratin-associated protein 10-8.
/FTId=PRO_0000185216.
REPEAT 50 54 1.
REPEAT 60 64 2.
REPEAT 65 69 3.
REPEAT 98 102 4.
REPEAT 108 112 5.
REPEAT 118 122 6.
REPEAT 123 127 7.
REPEAT 133 137 8.
REPEAT 145 149 9.
REPEAT 155 159 10.
REPEAT 165 169 11.
REPEAT 170 174 12.
REPEAT 175 179 13.
REPEAT 187 191 14.
REPEAT 197 201 15.
REPEAT 202 206 16.
REPEAT 221 225 17.
REPEAT 228 232 18.
REPEAT 239 243 19.
REGION 26 243 19 X 5 AA repeats of C-C-X(3).
VARIANT 26 26 H -> R (in dbSNP:rs411254).
{ECO:0000269|PubMed:15028290,
ECO:0000269|PubMed:15489334}.
/FTId=VAR_028234.
VARIANT 64 64 S -> N (in a colorectal cancer sample;
somatic mutation).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036560.
VARIANT 159 159 S -> F (in a breast cancer sample;
somatic mutation; dbSNP:rs763238933).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036561.
SEQUENCE 259 AA; 26299 MW; 180307276CAB4607 CRC64;
MADACCTRTY VIAASTMSVC SSDVGHVSRV SSPSTCTGSS WQVDNCQESC CEPRSCASSC
CTPSCCAPAP CLALVCAPVS CEPSPCQSGC TDSCTPSCCQ QSSCQPACCT SSPCQQACCV
PVCCKSNCCK PVCCVSICSG ASSPCCQQSS CQSACCTFSP CQQACCVPIC CKPICCVPVC
SGASSLCCQK SSCQPACCTT SCCRPSSSVS LLCRPVCRPA CCVPVPSCCV PASSCQPSCC
HPASCLSFLC RPACSRLAC


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