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Keratin-associated protein 5-9 (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (Keratin-associated protein 5.9) (UHS keratin A) (UHS KerA) (Ultrahigh sulfur keratin-associated protein 5.9)

 KRA59_HUMAN             Reviewed;         169 AA.
P26371; Q14564; Q3MIP8;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
01-AUG-1992, sequence version 1.
27-SEP-2017, entry version 123.
RecName: Full=Keratin-associated protein 5-9;
AltName: Full=Keratin, cuticle, ultrahigh sulfur 1;
AltName: Full=Keratin, ultra high-sulfur matrix protein A;
AltName: Full=Keratin-associated protein 5.9;
AltName: Full=UHS keratin A;
Short=UHS KerA;
AltName: Full=Ultrahigh sulfur keratin-associated protein 5.9;
Name=KRTAP5-9; Synonyms=KAP5.9, KRN1, KRTAP5.9, UHSK1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Hair follicle;
PubMed=1703541; DOI=10.1083/jcb.111.6.2587;
McKinnon P.J., Powell B.C., Rogers G.E.;
"Structure and expression of genes for a class of cysteine-rich
proteins of the cuticle layers of differentiating wool and hair
follicles.";
J. Cell Biol. 111:2587-2600(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10023043; DOI=10.1016/S0378-1119(98)00616-7;
Perez C., Auriol J., Gerst C., Bernard B.A., Egly J.-M.;
"Genomic organization and promoter characterization of two human UHS
keratin genes.";
Gene 227:137-148(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT CYS-40.
TISSUE=Testis;
Drabent B., Doenecke D.;
Submitted (DEC-1991) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Hair root;
PubMed=15144888; DOI=10.1016/j.bbrc.2004.04.074;
Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J.,
Shimizu N.;
"Identification of two novel clusters of ultrahigh-sulfur keratin-
associated protein genes on human chromosome 11.";
Biochem. Biophys. Res. Commun. 318:655-664(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: In the hair cortex, hair keratin intermediate filaments
are embedded in an interfilamentous matrix, consisting of hair
keratin-associated protein (KRTAP), which are essential for the
formation of a rigid and resistant hair shaft through their
extensive disulfide bond cross-linking with abundant cysteine
residues of hair keratins. The matrix proteins include the high-
sulfur and high-glycine-tyrosine keratins.
-!- SUBUNIT: Interacts with hair keratins.
-!- INTERACTION:
Q5BKY6:-; NbExp=3; IntAct=EBI-3958099, EBI-10243533;
Q9NWL9:-; NbExp=3; IntAct=EBI-3958099, EBI-10315054;
Q6UY14-3:ADAMTSL4; NbExp=11; IntAct=EBI-3958099, EBI-10173507;
P43353:ALDH3B1; NbExp=4; IntAct=EBI-3958099, EBI-2558314;
P05187:ALPP; NbExp=5; IntAct=EBI-3958099, EBI-1211484;
Q7Z3C6:ATG9A; NbExp=3; IntAct=EBI-3958099, EBI-727146;
Q9BXY8:BEX2; NbExp=3; IntAct=EBI-3958099, EBI-745073;
A8K571:BMP7; NbExp=3; IntAct=EBI-3958099, EBI-10174327;
Q5T681:C10orf62; NbExp=3; IntAct=EBI-3958099, EBI-744052;
Q6NUJ2:C11orf87; NbExp=3; IntAct=EBI-3958099, EBI-6660291;
Q8NEC5:CATSPER1; NbExp=7; IntAct=EBI-3958099, EBI-744545;
Q9UKJ5:CHIC2; NbExp=5; IntAct=EBI-3958099, EBI-741528;
Q9H2X0:CHRD; NbExp=5; IntAct=EBI-3958099, EBI-947551;
P61024:CKS1B; NbExp=3; IntAct=EBI-3958099, EBI-456371;
Q8NE01:CNNM3; NbExp=5; IntAct=EBI-3958099, EBI-741032;
P21964-2:COMT; NbExp=3; IntAct=EBI-3958099, EBI-10200977;
Q9UGL9:CRCT1; NbExp=5; IntAct=EBI-3958099, EBI-713677;
Q9UBR2:CTSZ; NbExp=6; IntAct=EBI-3958099, EBI-8636823;
A8MQ03:CYSRT1; NbExp=4; IntAct=EBI-3958099, EBI-3867333;
Q96LJ7:DHRS1; NbExp=3; IntAct=EBI-3958099, EBI-746300;
Q9NQL9:DMRT3; NbExp=3; IntAct=EBI-3958099, EBI-9679045;
Q92608:DOCK2; NbExp=5; IntAct=EBI-3958099, EBI-448771;
P16930:FAH; NbExp=3; IntAct=EBI-3958099, EBI-4397076;
Q9H5Z6:FAM124B; NbExp=3; IntAct=EBI-3958099, EBI-741626;
Q3B820:FAM161A; NbExp=5; IntAct=EBI-3958099, EBI-719941;
Q5TZK3:FAM74A6; NbExp=5; IntAct=EBI-3958099, EBI-10247271;
Q5HYJ3:FAM76B; NbExp=3; IntAct=EBI-3958099, EBI-751192;
O76003:GLRX3; NbExp=7; IntAct=EBI-3958099, EBI-374781;
Q9Y223:GNE; NbExp=3; IntAct=EBI-3958099, EBI-4291090;
P49639:HOXA1; NbExp=9; IntAct=EBI-3958099, EBI-740785;
P09022:Hoxa1 (xeno); NbExp=3; IntAct=EBI-3958099, EBI-3957603;
P17482:HOXB9; NbExp=3; IntAct=EBI-3958099, EBI-745290;
P37235:HPCAL1; NbExp=3; IntAct=EBI-3958099, EBI-749311;
Q9H2F3:HSD3B7; NbExp=4; IntAct=EBI-3958099, EBI-3918847;
P10809:HSPD1; NbExp=3; IntAct=EBI-3958099, EBI-352528;
Q15040:JOSD1; NbExp=3; IntAct=EBI-3958099, EBI-2510602;
Q2WGJ6:KLHL38; NbExp=5; IntAct=EBI-3958099, EBI-6426443;
P60412:KRTAP10-11; NbExp=5; IntAct=EBI-3958099, EBI-10217483;
P60370:KRTAP10-5; NbExp=9; IntAct=EBI-3958099, EBI-10172150;
P60409:KRTAP10-7; NbExp=5; IntAct=EBI-3958099, EBI-10172290;
P60410:KRTAP10-8; NbExp=7; IntAct=EBI-3958099, EBI-10171774;
P60411:KRTAP10-9; NbExp=5; IntAct=EBI-3958099, EBI-10172052;
P59990:KRTAP12-1; NbExp=5; IntAct=EBI-3958099, EBI-10210845;
P59991:KRTAP12-2; NbExp=5; IntAct=EBI-3958099, EBI-10176379;
Q9BYQ6:KRTAP4-11; NbExp=5; IntAct=EBI-3958099, EBI-10302392;
Q9BQ66:KRTAP4-12; NbExp=7; IntAct=EBI-3958099, EBI-739863;
Q9BYR5:KRTAP4-2; NbExp=7; IntAct=EBI-3958099, EBI-10172511;
Q6L8H1:KRTAP5-4; NbExp=4; IntAct=EBI-3958099, EBI-11963072;
Q6L8G9:KRTAP5-6; NbExp=7; IntAct=EBI-3958099, EBI-10250562;
Q9BYQ4:KRTAP9-2; NbExp=5; IntAct=EBI-3958099, EBI-1044640;
Q9BYQ3:KRTAP9-3; NbExp=4; IntAct=EBI-3958099, EBI-1043191;
Q9BYQ2:KRTAP9-4; NbExp=3; IntAct=EBI-3958099, EBI-10185730;
Q9BYQ0:KRTAP9-8; NbExp=4; IntAct=EBI-3958099, EBI-11958364;
Q5T7P3:LCE1B; NbExp=5; IntAct=EBI-3958099, EBI-10245913;
Q5T752:LCE1D; NbExp=4; IntAct=EBI-3958099, EBI-11741311;
Q5T753:LCE1E; NbExp=4; IntAct=EBI-3958099, EBI-11955335;
Q5T754:LCE1F; NbExp=4; IntAct=EBI-3958099, EBI-11958008;
Q5TA79:LCE2A; NbExp=7; IntAct=EBI-3958099, EBI-10246607;
O14633:LCE2B; NbExp=6; IntAct=EBI-3958099, EBI-11478468;
Q5TA81:LCE2C; NbExp=4; IntAct=EBI-3958099, EBI-11973993;
Q5TA76:LCE3A; NbExp=4; IntAct=EBI-3958099, EBI-9394625;
Q5TA77:LCE3B; NbExp=4; IntAct=EBI-3958099, EBI-11974495;
Q5T5A8:LCE3C; NbExp=5; IntAct=EBI-3958099, EBI-10245291;
Q5T5B0:LCE3E; NbExp=7; IntAct=EBI-3958099, EBI-10245456;
Q5TA78:LCE4A; NbExp=5; IntAct=EBI-3958099, EBI-10246358;
O94772:LY6H; NbExp=3; IntAct=EBI-3958099, EBI-724687;
O60336:MAPKBP1; NbExp=5; IntAct=EBI-3958099, EBI-947402;
P50222:MEOX2; NbExp=5; IntAct=EBI-3958099, EBI-748397;
Q549C5:MST065; NbExp=3; IntAct=EBI-3958099, EBI-10243297;
Q8IW45:NAXD; NbExp=3; IntAct=EBI-3958099, EBI-8650724;
Q969V3-2:NCLN; NbExp=3; IntAct=EBI-3958099, EBI-10281480;
Q92692:NECTIN2; NbExp=3; IntAct=EBI-3958099, EBI-718419;
Q9UBE8:NLK; NbExp=3; IntAct=EBI-3958099, EBI-366978;
P48645:NMU; NbExp=5; IntAct=EBI-3958099, EBI-10210351;
Q7Z3S9:NOTCH2NL; NbExp=5; IntAct=EBI-3958099, EBI-945833;
P48146:NPBWR2; NbExp=3; IntAct=EBI-3958099, EBI-10210114;
Q9NQX5:NPDC1; NbExp=5; IntAct=EBI-3958099, EBI-748927;
Q9P121:NTM; NbExp=3; IntAct=EBI-3958099, EBI-4315078;
Q9HB63:NTN4; NbExp=3; IntAct=EBI-3958099, EBI-743459;
Q9HB63-3:NTN4; NbExp=3; IntAct=EBI-3958099, EBI-10310092;
Q7Z417:NUFIP2; NbExp=5; IntAct=EBI-3958099, EBI-1210753;
P32242:OTX1; NbExp=9; IntAct=EBI-3958099, EBI-740446;
Q99571:P2RX4; NbExp=3; IntAct=EBI-3958099, EBI-2828248;
Q92824:PCSK5; NbExp=3; IntAct=EBI-3958099, EBI-751290;
P17858:PFKL; NbExp=3; IntAct=EBI-3958099, EBI-487243;
O43741:PRKAB2; NbExp=7; IntAct=EBI-3958099, EBI-1053424;
P25786:PSMA1; NbExp=5; IntAct=EBI-3958099, EBI-359352;
Q8WUK0:PTPMT1; NbExp=5; IntAct=EBI-3958099, EBI-7199479;
O60896:RAMP3; NbExp=3; IntAct=EBI-3958099, EBI-720447;
O76081:RGS20; NbExp=3; IntAct=EBI-3958099, EBI-1052678;
O76081-6:RGS20; NbExp=5; IntAct=EBI-3958099, EBI-10178530;
Q6ZNA4:RNF111; NbExp=4; IntAct=EBI-3958099, EBI-2129175;
Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-3958099, EBI-10313866;
Q8WTV0:SCARB1; NbExp=3; IntAct=EBI-3958099, EBI-78657;
A0A0S2Z4U3:SDC3; NbExp=6; IntAct=EBI-3958099, EBI-10204280;
O00560:SDCBP; NbExp=5; IntAct=EBI-3958099, EBI-727004;
A1A5C7:SLC22A23; NbExp=3; IntAct=EBI-3958099, EBI-10171756;
Q9UBX3:SLC25A10; NbExp=3; IntAct=EBI-3958099, EBI-750394;
P49901:SMCP; NbExp=9; IntAct=EBI-3958099, EBI-750494;
P20155:SPINK2; NbExp=3; IntAct=EBI-3958099, EBI-10200479;
O43597:SPRY2; NbExp=3; IntAct=EBI-3958099, EBI-742487;
Q8IV04:TBC1D10C; NbExp=3; IntAct=EBI-3958099, EBI-10261452;
Q15560:TCEA2; NbExp=3; IntAct=EBI-3958099, EBI-710310;
Q8N8B7:TCEANC; NbExp=3; IntAct=EBI-3958099, EBI-954696;
P49638:TTPA; NbExp=4; IntAct=EBI-3958099, EBI-10210710;
Q06418:TYRO3; NbExp=4; IntAct=EBI-3958099, EBI-3951628;
Q96HA8:WDYHV1; NbExp=5; IntAct=EBI-3958099, EBI-741158;
Q9GZM5:YIPF3; NbExp=3; IntAct=EBI-3958099, EBI-743787;
O43167:ZBTB24; NbExp=3; IntAct=EBI-3958099, EBI-744471;
Q9BQ24:ZFYVE21; NbExp=3; IntAct=EBI-3958099, EBI-2849569;
Q15973:ZNF124; NbExp=5; IntAct=EBI-3958099, EBI-2555767;
Q14584:ZNF266; NbExp=3; IntAct=EBI-3958099, EBI-7115319;
Q8TAU3:ZNF417; NbExp=5; IntAct=EBI-3958099, EBI-740727;
Q8NDP4:ZNF439; NbExp=5; IntAct=EBI-3958099, EBI-747580;
Q9P0T4:ZNF581; NbExp=3; IntAct=EBI-3958099, EBI-745520;
Q96SQ5:ZNF587; NbExp=5; IntAct=EBI-3958099, EBI-6427977;
-!- TISSUE SPECIFICITY: Restricted to hair root, not detected in any
other tissues. Expressed in cuticle layers of differentiating hair
follicles. {ECO:0000269|PubMed:15144888}.
-!- DEVELOPMENTAL STAGE: At a late stage of fiber differentiation.
-!- SIMILARITY: Belongs to the KRTAP type 5 family. {ECO:0000305}.
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EMBL; X55293; CAA39005.1; -; Genomic_DNA.
EMBL; AJ006693; CAA07189.1; -; Genomic_DNA.
EMBL; X63755; CAA45283.1; -; mRNA.
EMBL; AB126078; BAD20205.1; -; mRNA.
EMBL; BC069531; AAH69531.1; -; mRNA.
EMBL; BC101744; AAI01745.2; -; mRNA.
CCDS; CCDS53677.1; -.
PIR; S18946; S18946.
RefSeq; NP_005544.4; NM_005553.3.
UniGene; Hs.709220; -.
ProteinModelPortal; P26371; -.
BioGrid; 110044; 108.
IntAct; P26371; 185.
STRING; 9606.ENSP00000431443; -.
iPTMnet; P26371; -.
PhosphoSitePlus; P26371; -.
BioMuta; KRTAP5-9; -.
PaxDb; P26371; -.
PRIDE; P26371; -.
DNASU; 3846; -.
Ensembl; ENST00000528743; ENSP00000431443; ENSG00000254997.
GeneID; 3846; -.
KEGG; hsa:3846; -.
UCSC; uc001oqs.2; human.
CTD; 3846; -.
DisGeNET; 3846; -.
EuPathDB; HostDB:ENSG00000254997.3; -.
GeneCards; KRTAP5-9; -.
HGNC; HGNC:23604; KRTAP5-9.
MIM; 148021; gene.
neXtProt; NX_P26371; -.
OpenTargets; ENSG00000254997; -.
PharmGKB; PA134946701; -.
OMA; NCAPPFY; -.
Reactome; R-HSA-6805567; Keratinization.
GenomeRNAi; 3846; -.
PRO; PR:P26371; -.
Proteomes; UP000005640; Chromosome 11.
Bgee; ENSG00000254997; -.
CleanEx; HS_KRTAP5-9; -.
Genevisible; P26371; HS.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0045095; C:keratin filament; IEA:InterPro.
GO; GO:0008544; P:epidermis development; TAS:ProtInc.
GO; GO:0031424; P:keratinization; TAS:Reactome.
InterPro; IPR002494; KAP.
PANTHER; PTHR23262; PTHR23262; 1.
1: Evidence at protein level;
Complete proteome; Keratin; Polymorphism; Reference proteome; Repeat.
CHAIN 1 169 Keratin-associated protein 5-9.
/FTId=PRO_0000184107.
REPEAT 35 38 1.
REPEAT 41 44 2.
REPEAT 47 50 3.
REPEAT 82 85 4.
REPEAT 101 104 5.
REPEAT 130 134 6.
REPEAT 149 152 7.
REPEAT 159 162 8.
REGION 35 162 8 X 4 AA repeats of C-C-X-P.
VARIANT 8 8 G -> R (in dbSNP:rs34213141).
/FTId=VAR_053731.
VARIANT 40 40 Y -> C (in dbSNP:rs10792769).
{ECO:0000269|Ref.3}.
/FTId=VAR_053732.
SEQUENCE 169 AA; 16276 MW; 219B14FEEB49D4AB CRC64;
MGCCGCSGGC GSSCGGCDSS CGSCGSGCRG CGPSCCAPVY CCKPVCCCVP ACSCSSCGKR
GCGSCGGSKG GCGSCGCSQC SCCKPCCCSS GCGSSCCQCS CCKPYCSQCS CCKPCCSSSG
RGSSCCQSSC CKPCCSSSGC GSSCCQSSCC KPCCSQSRCC VPVCYQCKI


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18-785-210250 Keratin 18 (Ab-33) - Cytokeratin-18; CK-18; Keratin-18; K18; Cell proliferation-inducing gene 46 protein Polyclonal 0.1 mg
18-785-210250 Keratin 18 (Ab-33) - Cytokeratin-18; CK-18; Keratin-18; K18; Cell proliferation-inducing gene 46 protein Polyclonal 0.05 mg
E2282c Canis familiaris,Canis lupus familiaris,CK-1,Cytokeratin-1,Dog,Epithelial keratin-1,K1,KER1,Keratin, type II cytoskeletal 1,Keratin-1,KRT1,Type-II keratin Kb1
E1240h ELISA CK-20,Cytokeratin-20,Homo sapiens,Human,K20,Keratin, type I cytoskeletal 20,Keratin-20,KRT20,Protein IT 96T


 

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