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Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3)

 KRA93_HUMAN             Reviewed;         159 AA.
Q9BYQ3;
14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
12-SEP-2018, entry version 114.
RecName: Full=Keratin-associated protein 9-3;
AltName: Full=Keratin-associated protein 9.3;
AltName: Full=Ultrahigh sulfur keratin-associated protein 9.3;
Name=KRTAP9-3; Synonyms=KAP9.3, KRTAP9.3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Scalp;
PubMed=11279113; DOI=10.1074/jbc.M100657200;
Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
Schweizer J.;
"Characterization of a cluster of human high/ultrahigh sulfur keratin-
associated protein genes embedded in the type I keratin gene domain on
chromosome 17q12-21.";
J. Biol. Chem. 276:19440-19451(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: In the hair cortex, hair keratin intermediate filaments
are embedded in an interfilamentous matrix, consisting of hair
keratin-associated proteins (KRTAP), which are essential for the
formation of a rigid and resistant hair shaft through their
extensive disulfide bond cross-linking with abundant cysteine
residues of hair keratins. The matrix proteins include the high-
sulfur and high-glycine-tyrosine keratins.
-!- SUBUNIT: Interacts with hair keratins.
-!- INTERACTION:
Q8NEC5:CATSPER1; NbExp=4; IntAct=EBI-1043191, EBI-744545;
Q9UGL9:CRCT1; NbExp=4; IntAct=EBI-1043191, EBI-713677;
A8MQ03:CYSRT1; NbExp=4; IntAct=EBI-1043191, EBI-3867333;
P49639:HOXA1; NbExp=4; IntAct=EBI-1043191, EBI-740785;
P60410:KRTAP10-8; NbExp=4; IntAct=EBI-1043191, EBI-10171774;
P60411:KRTAP10-9; NbExp=4; IntAct=EBI-1043191, EBI-10172052;
Q9BYR5:KRTAP4-2; NbExp=4; IntAct=EBI-1043191, EBI-10172511;
P26371:KRTAP5-9; NbExp=4; IntAct=EBI-1043191, EBI-3958099;
Q9BYQ4:KRTAP9-2; NbExp=4; IntAct=EBI-1043191, EBI-1044640;
Q9BYQ0:KRTAP9-8; NbExp=4; IntAct=EBI-1043191, EBI-11958364;
Q5T7P2:LCE1A; NbExp=4; IntAct=EBI-1043191, EBI-11962058;
Q5T752:LCE1D; NbExp=4; IntAct=EBI-1043191, EBI-11741311;
Q5T753:LCE1E; NbExp=4; IntAct=EBI-1043191, EBI-11955335;
Q5T754:LCE1F; NbExp=4; IntAct=EBI-1043191, EBI-11958008;
Q5TA81:LCE2C; NbExp=4; IntAct=EBI-1043191, EBI-11973993;
Q5TA76:LCE3A; NbExp=4; IntAct=EBI-1043191, EBI-9394625;
Q5TA77:LCE3B; NbExp=4; IntAct=EBI-1043191, EBI-11974495;
Q5T5A8:LCE3C; NbExp=4; IntAct=EBI-1043191, EBI-10245291;
Q9BYE3:LCE3D; NbExp=4; IntAct=EBI-1043191, EBI-6658837;
Q5T5B0:LCE3E; NbExp=4; IntAct=EBI-1043191, EBI-10245456;
Q5TCM9:LCE5A; NbExp=4; IntAct=EBI-1043191, EBI-11955689;
Q7Z417:NUFIP2; NbExp=4; IntAct=EBI-1043191, EBI-1210753;
P32242:OTX1; NbExp=4; IntAct=EBI-1043191, EBI-740446;
P49901:SMCP; NbExp=4; IntAct=EBI-1043191, EBI-750494;
Q6EMK4:VASN; NbExp=4; IntAct=EBI-1043191, EBI-10249550;
P25490:YY1; NbExp=4; IntAct=EBI-1043191, EBI-765538;
-!- SIMILARITY: Belongs to the KRTAP type 9 family. {ECO:0000305}.
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EMBL; AJ406947; CAC27586.1; -; mRNA.
EMBL; BC074918; AAH74918.1; -; mRNA.
EMBL; BC074919; AAH74919.1; -; mRNA.
CCDS; CCDS11385.1; -.
RefSeq; NP_114168.1; NM_031962.2.
UniGene; Hs.307012; -.
ProteinModelPortal; Q9BYQ3; -.
BioGrid; 123811; 3.
IntAct; Q9BYQ3; 124.
STRING; 9606.ENSP00000392189; -.
BioMuta; KRTAP9-3; -.
DMDM; 38372388; -.
PaxDb; Q9BYQ3; -.
PeptideAtlas; Q9BYQ3; -.
PRIDE; Q9BYQ3; -.
ProteomicsDB; 79683; -.
Ensembl; ENST00000411528; ENSP00000392189; ENSG00000204873.
Ensembl; ENST00000571096; ENSP00000458819; ENSG00000262749.
GeneID; 83900; -.
KEGG; hsa:83900; -.
UCSC; uc021txg.1; human.
CTD; 83900; -.
EuPathDB; HostDB:ENSG00000204873.4; -.
GeneCards; KRTAP9-3; -.
HGNC; HGNC:16927; KRTAP9-3.
neXtProt; NX_Q9BYQ3; -.
OpenTargets; ENSG00000204873; -.
PharmGKB; PA38425; -.
eggNOG; ENOG410JE2D; Eukaryota.
eggNOG; ENOG41118YY; LUCA.
GeneTree; ENSGT00890000139484; -.
HOGENOM; HOG000234030; -.
HOVERGEN; HBG096080; -.
InParanoid; Q9BYQ3; -.
OMA; CKPCCSP; -.
PhylomeDB; Q9BYQ3; -.
TreeFam; TF351356; -.
Reactome; R-HSA-6805567; Keratinization.
GenomeRNAi; 83900; -.
PRO; PR:Q9BYQ3; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000204873; Expressed in 27 organ(s), highest expression level in upper arm skin.
CleanEx; HS_KRTAP9-3; -.
Genevisible; Q9BYQ3; HS.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0045095; C:keratin filament; IEA:InterPro.
GO; GO:0031424; P:keratinization; TAS:Reactome.
InterPro; IPR002494; KAP.
PANTHER; PTHR23262; PTHR23262; 1.
Pfam; PF13885; Keratin_B2_2; 3.
1: Evidence at protein level;
Complete proteome; Keratin; Reference proteome; Repeat.
CHAIN 1 159 Keratin-associated protein 9-3.
/FTId=PRO_0000185189.
REPEAT 8 12 1.
REPEAT 13 17 2.
REPEAT 32 36 3.
REPEAT 37 41 4.
REPEAT 46 50 5.
REPEAT 51 55 6.
REPEAT 56 60 7.
REPEAT 61 65 8.
REPEAT 70 74 9.
REPEAT 75 79 10.
REPEAT 80 84 11.
REPEAT 85 89 12.
REPEAT 129 133 13.
REPEAT 134 138 14.
REPEAT 139 143 15.
REPEAT 153 157 16.
REGION 8 157 16 X 5 AA repeats of C-C-[RQVSHE]-[SPTN]-
[TASPI].
SEQUENCE 159 AA; 16854 MW; 375CC1E52EECDE68 CRC64;
MTHCCSPCCQ PTCCRTTCWQ PTTVTTCSST PCCQPSCCVS SCCQPCCHPT CCQNTCCRTT
CCQPICVTSC CQPSCCSTPC CQPTCCGSSC GQSSSCAPVY CRRTCYHPTS VCLPGCLNQS
CGSNCCQPCC RPACCETTCC RTTCFQPTCV YSCCQPSCC


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