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Ketohexokinase (EC 2.7.1.3) (Hepatic fructokinase)

 KHK_PONAB               Reviewed;         297 AA.
Q5RD71;
24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
12-SEP-2018, entry version 63.
RecName: Full=Ketohexokinase;
EC=2.7.1.3;
AltName: Full=Hepatic fructokinase;
Name=KHK;
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the phosphorylation of the ketose sugar
fructose to fructose-1-phosphate. {ECO:0000250|UniProtKB:P50053}.
-!- CATALYTIC ACTIVITY: ATP + D-fructose = ADP + D-fructose 1-
phosphate.
-!- ACTIVITY REGULATION: Requires potassium. Inhibition by ADP (By
similarity). {ECO:0000250}.
-!- PATHWAY: Carbohydrate metabolism; fructose metabolism.
-!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P50053}.
-!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
{ECO:0000305}.
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EMBL; CR858045; CAH90286.1; -; Transcribed_RNA.
UniGene; Pab.10702; -.
ProteinModelPortal; Q5RD71; -.
SMR; Q5RD71; -.
STRING; 9601.ENSPPYP00000014032; -.
eggNOG; KOG2947; Eukaryota.
eggNOG; ENOG4111F4Q; LUCA.
HOVERGEN; HBG003335; -.
InParanoid; Q5RD71; -.
UniPathway; UPA00202; -.
Proteomes; UP000001595; Unplaced.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004454; F:ketohexokinase activity; IEA:UniProtKB-EC.
GO; GO:0006000; P:fructose metabolic process; IEA:UniProtKB-UniPathway.
CDD; cd01939; Ketohexokinase; 1.
Gene3D; 3.40.1190.20; -; 1.
InterPro; IPR034093; KHK.
InterPro; IPR011611; PfkB_dom.
InterPro; IPR029056; Ribokinase-like.
Pfam; PF00294; PfkB; 1.
SUPFAM; SSF53613; SSF53613; 1.
3: Inferred from homology;
ATP-binding; Carbohydrate metabolism; Complete proteome; Kinase;
Nucleotide-binding; Reference proteome; Transferase.
CHAIN 1 297 Ketohexokinase.
/FTId=PRO_0000080090.
NP_BIND 254 257 ATP. {ECO:0000250}.
BINDING 15 15 D-fructose. {ECO:0000250}.
BINDING 41 41 D-fructose; via amide nitrogen.
{ECO:0000250}.
BINDING 42 42 D-fructose. {ECO:0000250}.
BINDING 45 45 D-fructose. {ECO:0000250}.
BINDING 107 107 ATP. {ECO:0000250}.
BINDING 257 257 D-fructose. {ECO:0000250}.
SEQUENCE 297 AA; 32476 MW; 049C7C1FA74DEF16 CRC64;
MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTVL SLLGAPCAFM
GSMAPGHVAF LVADFRRRGV DVSQVAWQSK GDTPSSCCII NNSNGNRTIV LHDTSLPDVS
ATDFEKVDLT QFKWIHIEGR NASEQVKMLQ RIDTHNTRQP PEQKIRVSVE VEKPQEELFQ
LFGYGDVVFV SKDVAKHLGF QSAEAALRGL YGRVRKGAVL VCAWAEEGAD ALGPDDKLFH
SDAFPPPRVV DTLGAGDTFN ASVIFSLSQG RSMQEALRFG CQVAGKKCGL QGFDGIV


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