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Killer cell lectin-like receptor 8 (Lymphocyte antigen 49h) (Ly-49h) (T-cell surface glycoprotein Ly-49H)

 KLRA8_MOUSE             Reviewed;         266 AA.
Q60682; O78027;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
22-NOV-2017, entry version 136.
RecName: Full=Killer cell lectin-like receptor 8;
AltName: Full=Lymphocyte antigen 49h;
Short=Ly-49h;
AltName: Full=T-cell surface glycoprotein Ly-49H;
Name=Klra8; Synonyms=Ly-49h, Ly49-h, Ly49H;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H1).
STRAIN=C57BL/6 X CBA; TISSUE=Lung;
PubMed=7964501; DOI=10.1084/jem.180.6.2287;
Brennan J., Mager D., Jefferies W., Takei F.;
"Expression of different members of the Ly-49 gene family defines
distinct natural killer cell subsets and cell adhesion properties.";
J. Exp. Med. 180:2287-2295(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
STRAIN=C57BL/6J;
PubMed=8824161; DOI=10.1007/BF02602811;
Silver E.T., Elliott J.F., Kane K.P.;
"Alternatively spliced Ly-49D and H transcripts are found in IL-2-
activated NK cells.";
Immunogenetics 44:478-482(1996).
-!- FUNCTION: Receptor on natural killer (NK) cells for class I MHC.
-!- SUBUNIT: Homodimer; disulfide-linked.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane
protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=H1;
IsoId=Q60682-1; Sequence=Displayed;
Name=H2;
IsoId=Q60682-2; Sequence=VSP_003071;
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EMBL; U12889; AAA58704.1; -; mRNA.
EMBL; L78253; AAC32668.1; -; mRNA.
CCDS; CCDS51927.1; -. [Q60682-1]
PIR; I49114; I49114.
RefSeq; NP_001095090.1; NM_001101620.1. [Q60682-1]
RefSeq; NP_034780.1; NM_010650.3. [Q60682-2]
UniGene; Mm.439698; -.
PDB; 4JO8; X-ray; 3.20 A; B=110-266.
PDBsum; 4JO8; -.
ProteinModelPortal; Q60682; -.
SMR; Q60682; -.
STRING; 10090.ENSMUSP00000014476; -.
PaxDb; Q60682; -.
PRIDE; Q60682; -.
DNASU; 16639; -.
Ensembl; ENSMUST00000014476; ENSMUSP00000014476; ENSMUSG00000089727. [Q60682-1]
GeneID; 16639; -.
KEGG; mmu:16639; -.
UCSC; uc009ehp.3; mouse. [Q60682-1]
CTD; 16639; -.
MGI; MGI:102968; Klra8.
eggNOG; KOG4297; Eukaryota.
eggNOG; ENOG410XPJ1; LUCA.
GeneTree; ENSGT00390000008117; -.
HOGENOM; HOG000113237; -.
HOVERGEN; HBG053176; -.
InParanoid; Q60682; -.
OMA; QERWDSE; -.
OrthoDB; EOG091G0EQU; -.
PhylomeDB; Q60682; -.
TreeFam; TF336674; -.
PRO; PR:Q60682; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000089727; -.
Genevisible; Q60682; MM.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; TAS:MGI.
GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0009615; P:response to virus; IDA:MGI.
CDD; cd03593; CLECT_NK_receptors_like; 1.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR001304; C-type_lectin-like.
InterPro; IPR016186; C-type_lectin-like/link_sf.
InterPro; IPR016187; CTDL_fold.
InterPro; IPR013600; Ly49_N.
InterPro; IPR033992; NKR-like_CTLD.
Pfam; PF00059; Lectin_C; 1.
Pfam; PF08391; Ly49; 1.
SMART; SM00034; CLECT; 1.
SUPFAM; SSF56436; SSF56436; 1.
PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell adhesion; Complete proteome;
Disulfide bond; Glycoprotein; Lectin; Membrane; Receptor;
Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
CHAIN 1 266 Killer cell lectin-like receptor 8.
/FTId=PRO_0000046686.
TOPO_DOM 1 44 Cytoplasmic. {ECO:0000255}.
TRANSMEM 45 66 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 67 266 Extracellular. {ECO:0000255}.
DOMAIN 143 261 C-type lectin. {ECO:0000255|PROSITE-
ProRule:PRU00040}.
CARBOHYD 87 87 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 104 104 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 149 154 {ECO:0000255|PROSITE-ProRule:PRU00040}.
DISULFID 167 255 {ECO:0000255|PROSITE-ProRule:PRU00040}.
DISULFID 171 257 {ECO:0000255|PROSITE-ProRule:PRU00040}.
DISULFID 236 249 {ECO:0000255|PROSITE-ProRule:PRU00040}.
VAR_SEQ 39 41 Missing (in isoform H2). {ECO:0000305}.
/FTId=VSP_003071.
HELIX 113 131 {ECO:0000244|PDB:4JO8}.
SEQUENCE 266 AA; 31393 MW; 3CB5A8EF2EB401E2 CRC64;
MSEQEVTFPT MRFHKSSGLN SQVRLEGTQR SRKAGLRVCS VPWQLIVIAL GILCSLRLVI
VAVFVTKFFQ YSQHKQEINE TLNHRHNCSN MQRDFNLKEE MLTNKSIDCR PSYELLEYIK
REQERWDSET KSVSDSSRDT GRGVKYWFCY GTKCYYFIMN KTTWSGCKAN CQHYSVPIVK
IEDEDELKFL QRHVILESYW IGLSYDKKKK EWAWIHNGQS KLDMKIKKMN FTSRGCVFLS
KARIEDTDCN TPYYCICGKK LDKFPD


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