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Killer cell lectin-like receptor subfamily B member 1C (CD161 antigen-like family member C) (Lymphocyte antigen 55c) (Ly-55c) (NK1.1) (NKR-P1.9) (NKR-P1C) (Natural killer cell surface protein P1-40) (NKR-P1 40) (CD antigen CD161c)

 KLRBC_MOUSE             Reviewed;         223 AA.
P27814; Q541U5; Q925G3;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
09-JAN-2007, sequence version 2.
23-MAY-2018, entry version 125.
RecName: Full=Killer cell lectin-like receptor subfamily B member 1C;
AltName: Full=CD161 antigen-like family member C;
AltName: Full=Lymphocyte antigen 55c;
Short=Ly-55c;
AltName: Full=NK1.1;
AltName: Full=NKR-P1.9;
AltName: Full=NKR-P1C;
AltName: Full=Natural killer cell surface protein P1-40;
Short=NKR-P1 40;
AltName: CD_antigen=CD161c;
Name=Klrb1c; Synonyms=Ly55c, Nkrp1c;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
PubMed=1880421;
Giorda R., Trucco M.;
"Mouse NKR-P1. A family of genes selectively coexpressed in adherent
lymphokine-activated killer cells.";
J. Immunol. 147:1701-1708(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
STRAIN=C57BL/6J;
PubMed=1506685;
Ryan J.C., Turck J., Niemi E.C., Yokoyama W.M., Seaman W.E.;
"Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family
of natural killer cell activation molecules.";
J. Immunol. 149:1631-1635(1992).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=C57BL/6J;
PubMed=10229823;
Kung S.K.P., Su R.-C., Shannon J., Miller R.G.;
"The NKR-P1B gene product is an inhibitory receptor on SJL/J NK
cells.";
J. Immunol. 162:5876-5887(1999).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=11685472; DOI=10.1007/s002510100367;
Plougastel B., Matsumoto K., Dubbelde C., Yokoyama W.M.;
"Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of
genes: cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and
Nkrp1f.";
Immunogenetics 53:592-598(2001).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Thymus;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Heart, and Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
FUNCTION.
PubMed=12813047; DOI=10.1074/jbc.M212869200;
Ljutic B., Carlyle J.R., Zuniga-Pfluecker J.C.;
"Identification of upstream cis-acting regulatory elements controlling
lineage-specific expression of the mouse NK cell activation receptor,
NKR-P1C.";
J. Biol. Chem. 278:31909-31917(2003).
[8]
INTERACTION WITH LCK, MUTAGENESIS OF TYR-7 AND CYS-31, AND FUNCTION.
PubMed=15814704; DOI=10.4049/jimmunol.174.8.4789;
Ljutic B., Carlyle J.R., Filipp D., Nakagawa R., Julius M.,
Zuniga-Pfluecker J.C.;
"Functional requirements for signaling through the stimulatory and
inhibitory mouse NKR-P1 (CD161) NK cell receptors.";
J. Immunol. 174:4789-4796(2005).
[9]
ANTI-NK1.1 MONOCLONAL ANTIBODY.
STRAIN=BALB/cJ; TISSUE=Spleen;
PubMed=16751398; DOI=10.4049/jimmunol.176.12.7511;
Carlyle J.R., Mesci A., Ljutic B., Belanger S., Tai L.-H.,
Rousselle E., Troke A.D., Proteau M.-F., Makrigiannis A.P.;
"Molecular and genetic basis for strain-dependent NK1.1 alloreactivity
of mouse NK cells.";
J. Immunol. 176:7511-7524(2006).
-!- FUNCTION: Plays a stimulatory role on natural killer (NK) cells
cytotoxicity. Activation by cross-linking of the receptor induces
Ca(2+) mobilization and interferon-gamma production.
{ECO:0000269|PubMed:12813047, ECO:0000269|PubMed:15814704}.
-!- SUBUNIT: Homodimer; disulfide-linked. Interacts with tyrosine
kinase LCK. {ECO:0000269|PubMed:15814704}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane
protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P27814-1; Sequence=Displayed;
Name=2;
IsoId=P27814-2; Sequence=VSP_022317;
-!- TISSUE SPECIFICITY: Expressed in natural killer cells.
-!- MISCELLANEOUS: The anti-NK1.1 monoclonal antibody (PK136),
recognizing Klrb1b and Klrb1c genes, is known to identify NK cells
from B6 and SLJ mice, but not from BALB/c ones. A single mutation
Thr-191 present in Klrb1b and Klrb1c genes of BALB/c mice may be
responsible for lack of NK1.1 reactivity in these mice. Indeed,
when Lys-217 of BALB/c mice Klrb1c is mutated to Glu-217 present
in B6 and SLJ mice, it does not confer NK1.1 reactivity.
-----------------------------------------------------------------------
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EMBL; M77678; AAA39824.1; -; mRNA.
EMBL; AF354263; AAK39103.1; -; mRNA.
EMBL; AY007206; AAG02283.1; -; Genomic_DNA.
EMBL; AK079743; BAC37739.1; -; mRNA.
EMBL; BC061168; AAH61168.1; -; mRNA.
PIR; C46467; C46467.
RefSeq; NP_001153376.1; NM_001159904.1.
RefSeq; NP_032553.2; NM_008527.2.
UniGene; Mm.480764; -.
ProteinModelPortal; P27814; -.
SMR; P27814; -.
BioGrid; 201235; 2.
STRING; 10090.ENSMUSP00000134504; -.
SWISS-2DPAGE; P27814; -.
MaxQB; P27814; -.
PaxDb; P27814; -.
PRIDE; P27814; -.
GeneID; 17059; -.
KEGG; mmu:17059; -.
CTD; 17059; -.
MGI; MGI:107538; Klrb1c.
eggNOG; KOG4297; Eukaryota.
eggNOG; ENOG410XPJ1; LUCA.
HOGENOM; HOG000074586; -.
HOVERGEN; HBG052267; -.
InParanoid; P27814; -.
KO; K06543; -.
PhylomeDB; P27814; -.
ChiTaRS; Klrb1c; mouse.
PRO; PR:P27814; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0009986; C:cell surface; IDA:MGI.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO; GO:0042803; F:protein homodimerization activity; IDA:MGI.
GO; GO:0038023; F:signaling receptor activity; IDA:MGI.
GO; GO:0030101; P:natural killer cell activation; IDA:MGI.
GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IDA:MGI.
CDD; cd03593; CLECT_NK_receptors_like; 1.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR001304; C-type_lectin-like.
InterPro; IPR016186; C-type_lectin-like/link_sf.
InterPro; IPR016187; CTDL_fold.
InterPro; IPR033992; NKR-like_CTLD.
Pfam; PF00059; Lectin_C; 1.
SMART; SM00034; CLECT; 1.
SUPFAM; SSF56436; SSF56436; 1.
PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein;
Lectin; Membrane; Reference proteome; Signal-anchor; Transmembrane;
Transmembrane helix.
CHAIN 1 223 Killer cell lectin-like receptor
subfamily B member 1C.
/FTId=PRO_0000046678.
TOPO_DOM 1 45 Cytoplasmic. {ECO:0000255}.
TRANSMEM 46 66 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 67 223 Extracellular. {ECO:0000255}.
DOMAIN 101 211 C-type lectin. {ECO:0000255|PROSITE-
ProRule:PRU00040}.
MOTIF 31 34 LCK-binding motif. {ECO:0000255}.
CARBOHYD 83 83 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 169 169 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 186 186 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 94 105 {ECO:0000255|PROSITE-ProRule:PRU00040}.
DISULFID 122 210 {ECO:0000255|PROSITE-ProRule:PRU00040}.
DISULFID 189 202 {ECO:0000255|PROSITE-ProRule:PRU00040}.
VAR_SEQ 87 89 Missing (in isoform 2).
{ECO:0000303|PubMed:1506685,
ECO:0000303|PubMed:1880421}.
/FTId=VSP_022317.
MUTAGEN 7 7 Y->F: Decreased Ca(2+) mobilization.
{ECO:0000269|PubMed:15814704}.
MUTAGEN 31 31 C->S: Absence of Ca(2+) mobilization and
no LCK association.
{ECO:0000269|PubMed:15814704}.
SEQUENCE 223 AA; 25077 MW; F7022264A3000CDA CRC64;
MDTASIYLGL KPPRTLGAWH ESPPSLPPDA CRCPRSHRLA LKLSCAGLIL LVLTLIGMSV
LVRVLVQKPS REKCCVFIQE NLNKTTDCSV NLECPQDWLL HRDKCFHVSQ VSNTWEEGQA
DCGRKGATLL LIQDQEELRF LLDSIKEKYN SFWIGLRFTL PDMNWKWING TTFNSDVLKI
TGVTENGSCA SILGDKVTPE SCASDNRWIC QKELNHETPS NDS


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