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Kinetochore protein Nuf2-A (xNuf2) (Cell division cycle-associated protein 1-A)

 NUF2A_XENLA             Reviewed;         462 AA.
Q8AWF4;
19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
05-JUL-2017, entry version 56.
RecName: Full=Kinetochore protein Nuf2-A;
Short=xNuf2;
AltName: Full=Cell division cycle-associated protein 1-A;
Name=nuf2-a; Synonyms=cdca1-a;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH NDC80, AND
SUBCELLULAR LOCATION.
PubMed=12514103; DOI=10.1101/gad.1040903;
McCleland M.L., Gardner R.D., Kallio M.J., Daum J.R., Gorbsky G.J.,
Burke D.J., Stukenberg P.T.;
"The highly conserved Ndc80 complex is required for kinetochore
assembly, chromosome congression, and spindle checkpoint activity.";
Genes Dev. 17:101-114(2003).
[2]
IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE NDC80
COMPLEX.
PubMed=14738735; DOI=10.1016/j.cub.2003.12.058;
McCleland M.L., Kallio M.J., Barrett-Wilt G.A., Kestner C.A.,
Shabanowitz J., Hunt D.F., Gorbsky G.J., Stukenberg P.T.;
"The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which
are required to establish and maintain kinetochore-microtubule
attachment.";
Curr. Biol. 14:131-137(2004).
[3]
CHARACTERIZATION OF THE NDC80 COMPLEX, INTERACTION OF THE NDC80
COMPLEX WITH MIS12 AND ZWINT, AND SUBCELLULAR LOCATION.
PubMed=16079178; DOI=10.1091/mbc.E05-03-0239;
Emanuele M.J., McCleland M.L., Satinover D.L., Stukenberg P.T.;
"Measuring the stoichiometry and physical interactions between
components elucidates the architecture of the vertebrate
kinetochore.";
Mol. Biol. Cell 16:4882-4892(2005).
-!- FUNCTION: Acts as a component of the essential kinetochore-
associated NDC80 complex, which is required for chromosome
segregation and spindle checkpoint activity (PubMed:12514103).
Required for kinetochore integrity and the organization of stable
microtubule binding sites in the outer plate of the kinetochore
(By similarity). The NDC80 complex synergistically enhances the
affinity of the SKA1 complex for microtubules and may allow the
NDC80 complex to track depolymerizing microtubules (By
similarity). {ECO:0000250|UniProtKB:Q9BZD4,
ECO:0000269|PubMed:12514103}.
-!- SUBUNIT: Component of the NDC80 complex, which is composed of
ndc80, cdca1, spbc24 and spbc25. The NDC80 complex interacts with
mis12 and zwint. {ECO:0000269|PubMed:12514103,
ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:16079178}.
-!- INTERACTION:
Q8AWF5:ndc80; NbExp=8; IntAct=EBI-1000342, EBI-1000337;
-!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere,
kinetochore. Note=Localizes to kinetochores from late prophase to
anaphase.
-!- SIMILARITY: Belongs to the NUF2 family. {ECO:0000305}.
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EMBL; AY168014; AAN87032.1; -; mRNA.
RefSeq; NP_001082370.1; NM_001088901.1.
RefSeq; XP_018112035.1; XM_018256546.1.
UniGene; Xl.16455; -.
ProteinModelPortal; Q8AWF4; -.
SMR; Q8AWF4; -.
IntAct; Q8AWF4; 5.
PRIDE; Q8AWF4; -.
GeneID; 398428; -.
KEGG; xla:398428; -.
CTD; 398428; -.
Xenbase; XB-GENE-1001444; nuf2.
HOVERGEN; HBG082069; -.
KO; K11548; -.
GO; GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
GO; GO:0031262; C:Ndc80 complex; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0000278; P:mitotic cell cycle; IEA:InterPro.
InterPro; IPR005549; Kinetochore_Nuf2.
Pfam; PF03800; Nuf2; 1.
1: Evidence at protein level;
Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
Kinetochore; Mitosis; Nucleus.
CHAIN 1 462 Kinetochore protein Nuf2-A.
/FTId=PRO_0000249818.
COILED 143 277 {ECO:0000255}.
COILED 308 461 {ECO:0000255}.
SEQUENCE 462 AA; 54453 MW; 4C2E5299D9ED6CB0 CRC64;
MDKLTFPIFP AADLVNFFRQ NILTGTEAKN FNKNDIFPNP KPEMVQKLYM RILQQVFNYG
VEQFYMVPMD LDIQYPHLVE GFAPVANILK LMARFLPMCR VYDFHPSDVL NPKGKRTLHS
LSGIVNFLHF SATRKEVYFE YCSSYKSALE NVRQLQKANQ EAEIKIEKLT TVPPEQQAEF
KALSSEIHDL QQIISQEYRA KDVAFQEKIA QRKTEFAEKN KRLNEQKLAI ATMKEEQERM
KSQIVESPEQ RKSKTERMKE TVHRLKQARQ ETNDKCDYYR DRVAFACMWQ TDVQGYLKKL
QGIDTNLEIH RKIREEIRHS EEQVVNLNLE LKSLSNEDAQ LKRIILVKKE KLAKVDIKNK
KKQEDFNQQK QEILEVCSRI QEKRQVVHGR VAQVLQEIQQ TIGKKEQLLE TTEAGKKKCQ
EVITDFRAAL EKYHDSLQKA SERSADRRRE KIAELNRRLS RR


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