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Kinetochore protein Spc24 (xSpc24)

 SPC24_XENLA             Reviewed;         199 AA.
Q6NRW3;
19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
22-NOV-2017, entry version 54.
RecName: Full=Kinetochore protein Spc24;
Short=xSpc24;
Name=spc24; Synonyms=spbc24;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, IDENTIFICATION BY MASS
SPECTROMETRY, IDENTIFICATION IN THE NDC80 COMPLEX, AND SUBCELLULAR
LOCATION.
PubMed=14738735; DOI=10.1016/j.cub.2003.12.058;
McCleland M.L., Kallio M.J., Barrett-Wilt G.A., Kestner C.A.,
Shabanowitz J., Hunt D.F., Gorbsky G.J., Stukenberg P.T.;
"The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which
are required to establish and maintain kinetochore-microtubule
attachment.";
Curr. Biol. 14:131-137(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Ovary;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[3]
CHARACTERIZATION OF THE NDC80 COMPLEX, AND INTERACTION OF THE NDC80
COMPLEX WITH MIS12 AND ZWINT.
PubMed=16079178; DOI=10.1091/mbc.E05-03-0239;
Emanuele M.J., McCleland M.L., Satinover D.L., Stukenberg P.T.;
"Measuring the stoichiometry and physical interactions between
components elucidates the architecture of the vertebrate
kinetochore.";
Mol. Biol. Cell 16:4882-4892(2005).
-!- FUNCTION: Acts as a component of the essential kinetochore-
associated NDC80 complex, which is required for chromosome
segregation and spindle checkpoint activity (PubMed:14738735).
Required for kinetochore integrity and the organization of stable
microtubule binding sites in the outer plate of the kinetochore
(PubMed:14738735). The NDC80 complex synergistically enhances the
affinity of the SKA1 complex for microtubules and may allow the
NDC80 complex to track depolymerizing microtubules (By
similarity). {ECO:0000250|UniProtKB:Q8NBT2,
ECO:0000269|PubMed:14738735}.
-!- SUBUNIT: Component of the NDC80 complex, which is composed of
ndc80, cdca1, spbc24 and spbc25. The NDC80 complex interacts with
mis12 and zwint. {ECO:0000269|PubMed:14738735,
ECO:0000269|PubMed:16079178}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14738735}.
Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14738735}.
Note=Localizes to kinetochores from late prophase to anaphase.
{ECO:0000269|PubMed:14738735}.
-!- SIMILARITY: Belongs to the SPC24 family. {ECO:0000305}.
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EMBL; AY456385; AAR88649.1; -; mRNA.
EMBL; BC070597; AAH70597.1; -; mRNA.
RefSeq; NP_001084436.1; NM_001090967.1.
UniGene; Xl.23735; -.
ProteinModelPortal; Q6NRW3; -.
SMR; Q6NRW3; -.
IntAct; Q6NRW3; 4.
GeneID; 403385; -.
KEGG; xla:403385; -.
CTD; 403385; -.
Xenbase; XB-GENE-974565; spc24.
HOVERGEN; HBG083027; -.
KO; K11549; -.
GO; GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
GO; GO:0031262; C:Ndc80 complex; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
InterPro; IPR013252; Ndc80_Spc24.
PANTHER; PTHR22142; PTHR22142; 1.
Pfam; PF08286; Spc24; 1.
1: Evidence at protein level;
Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
Kinetochore; Mitosis; Nucleus.
CHAIN 1 199 Kinetochore protein Spc24.
/FTId=PRO_0000249562.
COILED 45 134 {ECO:0000255}.
SEQUENCE 199 AA; 22722 MW; 0E49B6BD9F03D46A CRC64;
MLCEQISEYV DVSREIVKVM VSDSAAGALK KSLDRQEAMI DSLLDTEVQA SQLIRDLMAV
EEKVAQKLLD TEETKQKSSS KLQKIDRELQ ERMEKNASLE SSIKFLQKDL EELKVMEEEI
ADMQREADED TTTVIPSAVY LAKLFHNVTK IDWDYNCDPS LIKGIHYGGD IAQPISIDSN
QHSKIFICNY LWSLLSTDW


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