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Kinetochore protein Spc25 (xSpc25)

 SPC25_XENLA             Reviewed;         228 AA.
Q6SKR5; Q6DDZ6;
19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
19-SEP-2006, sequence version 2.
30-AUG-2017, entry version 48.
RecName: Full=Kinetochore protein Spc25;
Short=xSpc25;
Name=spc25; Synonyms=spbc25;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, IDENTIFICATION BY MASS
SPECTROMETRY, IDENTIFICATION IN THE NDC80 COMPLEX, AND SUBCELLULAR
LOCATION.
PubMed=14738735; DOI=10.1016/j.cub.2003.12.058;
McCleland M.L., Kallio M.J., Barrett-Wilt G.A., Kestner C.A.,
Shabanowitz J., Hunt D.F., Gorbsky G.J., Stukenberg P.T.;
"The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which
are required to establish and maintain kinetochore-microtubule
attachment.";
Curr. Biol. 14:131-137(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
[3]
CHARACTERIZATION OF THE NDC80 COMPLEX, AND INTERACTION OF THE NDC80
COMPLEX WITH MIS12 AND ZWINT.
PubMed=16079178; DOI=10.1091/mbc.E05-03-0239;
Emanuele M.J., McCleland M.L., Satinover D.L., Stukenberg P.T.;
"Measuring the stoichiometry and physical interactions between
components elucidates the architecture of the vertebrate
kinetochore.";
Mol. Biol. Cell 16:4882-4892(2005).
-!- FUNCTION: Acts as a component of the essential kinetochore-
associated NDC80 complex, which is required for chromosome
segregation and spindle checkpoint activity (PubMed:14738735).
Required for kinetochore integrity and the organization of stable
microtubule binding sites in the outer plate of the kinetochore
(PubMed:14738735). The NDC80 complex synergistically enhances the
affinity of the SKA1 complex for microtubules and may allow the
NDC80 complex to track depolymerizing microtubules.
{ECO:0000250|UniProtKB:Q9HBM1, ECO:0000269|PubMed:14738735}.
-!- SUBUNIT: Component of the NDC80 complex, which is composed of
ndc80, cdca1, spbc24 and spbc25. The NDC80 complex interacts with
mis12 and zwint. {ECO:0000269|PubMed:14738735,
ECO:0000269|PubMed:16079178}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14738735}.
Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14738735}.
Note=Localizes to kinetochores from late prophase to anaphase.
{ECO:0000250|UniProtKB:Q9HBM1}.
-!- SIMILARITY: Belongs to the SPC25 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH77354.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AY456386; AAR88650.1; -; mRNA.
EMBL; BC077354; AAH77354.1; ALT_INIT; mRNA.
RefSeq; NP_001093334.2; NM_001099864.1.
UniGene; Xl.78167; -.
SMR; Q6SKR5; -.
IntAct; Q6SKR5; 3.
MaxQB; Q6SKR5; -.
GeneID; 100101271; -.
KEGG; xla:100101271; -.
CTD; 100101271; -.
Xenbase; XB-GENE-950634; spc25.
HOVERGEN; HBG080509; -.
KO; K11550; -.
GO; GO:0000777; C:condensed chromosome kinetochore; ISS:UniProtKB.
GO; GO:0031262; C:Ndc80 complex; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0007059; P:chromosome segregation; ISS:UniProtKB.
GO; GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
InterPro; IPR013255; Spc25.
Pfam; PF08234; Spindle_Spc25; 1.
1: Evidence at protein level;
Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
Kinetochore; Mitosis; Nucleus.
CHAIN 1 228 Kinetochore protein Spc25.
/FTId=PRO_0000249568.
COILED 61 144 {ECO:0000255}.
CONFLICT 226 226 Q -> K (in Ref. 1; AAR88650).
{ECO:0000305}.
SEQUENCE 228 AA; 26704 MW; 8B4916508876C344 CRC64;
MSALKMDDEQ SLNVYMQEFR TRFINKSSDE MTSQALKESY KESAATDAWF KKYRDGELMI
EKVLEFRNEI TLQNKRIEEK QKNILQEAAK QDDHEQLKGE LTERIQRLRE ELNQKREVAL
ANRKANKERI KELQKSATLF KERLGLEIRK LRGDKLQFVF RCINPKDLDQ PYSCIISLNA
EGDYEVAGCD PPLECIAEFQ EKIRETRNFS ALLANLRKSF TALGSQVK


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