Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]

 SCF_RAT                 Reviewed;         273 AA.
P21581; Q9QWZ4; Q9Z2E7;
01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
30-AUG-2002, sequence version 2.
10-OCT-2018, entry version 137.
RecName: Full=Kit ligand;
AltName: Full=Hematopoietic growth factor KL;
AltName: Full=Mast cell growth factor;
Short=MGF;
AltName: Full=Stem cell factor;
Short=SCF;
AltName: Full=c-Kit ligand;
Contains:
RecName: Full=Soluble KIT ligand;
Short=sKITLG;
Flags: Precursor;
Name=Kitlg; Synonyms=Kitl, Mgf;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Teramoto T., Nagashima M., Thorgeirsson S.S.;
Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-201, AND PARTIAL PROTEIN SEQUENCE.
PubMed=2208279; DOI=10.1016/0092-8674(90)90301-T;
Martin F.H., Suggs S.V., Langley K.E., Lu H.S., Ting J., Okino K.H.,
Morris C.F., McNiece I.K., Jacobsen F.W., Mendiaz E.A., Birkett N.C.,
Smith K.A., Johnson M.J., Parker V.P., Flores J.C., Patel A.C.,
Fisher E.F., Erjavec H.O., Herrera C.J., Wypych J., Sachdev R.K.,
Pope J.A., Leslie I., Wen D., Lin C.-H., Cupples R.L., Zsebo K.M.;
"Primary structure and functional expression of rat and human stem
cell factor DNAs.";
Cell 63:203-211(1990).
[3]
PROTEIN SEQUENCE OF 26-190, PYROGLUTAMATE FORMATION AT GLN-26,
GLYCOSYLATION AT ASN-90; ASN-145; SER-167; THR-168; THR-180 AND
ASN-195, LACK OF GLYCOSYLATION AT ASN-97, AND DISULFIDE BONDS.
STRAIN=Buffalo; TISSUE=Liver;
PubMed=1708771;
Lu H.S., Clogston C.L., Wypych J., Fausset P.R., Lauren S.,
Mendiaz E.A., Zsebo K.M., Langley K.E.;
"Amino acid sequence and post-translational modification of stem cell
factor isolated from buffalo rat liver cell-conditioned medium.";
J. Biol. Chem. 266:8102-8107(1991).
[4]
PROTEIN SEQUENCE OF 26-39.
PubMed=2208278; DOI=10.1016/0092-8674(90)90300-4;
Zsebo K.M., Wypych J., McNiece I.K., Lu H.S., Smith K.A.,
Karkare S.B., Sachdev R.K., Yuschenkoff V.N., Birkett N.C.,
Williams L.R., Satyagal V.N., Tung W., Bosselman R.A., Mendiaz E.A.,
Langley K.E.;
"Identification, purification, and biological characterization of
hematopoietic stem cell factor from buffalo rat liver-conditioned
medium.";
Cell 63:195-201(1990).
-!- FUNCTION: Ligand for the receptor-type protein-tyrosine kinase
KIT. Plays an essential role in the regulation of cell survival
and proliferation, hematopoiesis, stem cell maintenance,
gametogenesis, mast cell development, migration and function, and
in melanogenesis. KITLG/SCF binding can activate several signaling
pathways. Promotes phosphorylation of PIK3R1, the regulatory
subunit of phosphatidylinositol 3-kinase, and subsequent
activation of the kinase AKT1. KITLG/SCF and KIT also transmit
signals via GRB2 and activation of RAS, RAF1 and the MAP kinases
MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation
of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT
promote activation of PLCG1, leading to the production of the
cellular signaling molecules diacylglycerol and inositol 1,4,5-
trisphosphate. KITLG/SCF acts synergistically with other
cytokines, probably interleukins.
-!- SUBUNIT: Homodimer, non-covalently linked (Probable).
Heterotetramer with KIT, binding two KIT molecules; thereby
mediates KIT dimerization and subsequent activation by
autophosphorylation. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000250};
Single-pass type I membrane protein {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Isoform 2: Cytoplasm
{ECO:0000250|UniProtKB:P21583}. Cytoplasm, cytoskeleton
{ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P21583};
Single-pass type I membrane protein {ECO:0000250}. Cell
projection, lamellipodium {ECO:0000250|UniProtKB:P21583}. Cell
projection, filopodium {ECO:0000250|UniProtKB:P21583}.
-!- SUBCELLULAR LOCATION: Soluble KIT ligand: Secreted {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=KL-1;
IsoId=P21581-1; Sequence=Displayed;
Name=2; Synonyms=KL-2;
IsoId=P21581-2; Sequence=VSP_006025;
-!- DEVELOPMENTAL STAGE: Acts in the early stages of hematopoiesis.
-!- PTM: A soluble form is produced by proteolytic processing of
isoform 1 in the extracellular domain.
-!- PTM: The identity of N- and O-linked saccharides are not reported
in PubMed:1708771. The O-linked polysaccharides are probably the
mucin type linked to GalNAc. {ECO:0000269|PubMed:1708771}.
-!- SIMILARITY: Belongs to the SCF family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF071204; AAD02827.1; -; mRNA.
EMBL; AF071205; AAD02828.1; -; mRNA.
EMBL; M59966; AAA42117.1; -; mRNA.
PIR; B35974; B35974.
RefSeq; NP_068615.1; NM_021843.4. [P21581-1]
UniGene; Rn.44216; -.
ProteinModelPortal; P21581; -.
SMR; P21581; -.
STRING; 10116.ENSRNOP00000008471; -.
iPTMnet; P21581; -.
PhosphoSitePlus; P21581; -.
PaxDb; P21581; -.
Ensembl; ENSRNOT00000007231; ENSRNOP00000007231; ENSRNOG00000005386. [P21581-2]
Ensembl; ENSRNOT00000008471; ENSRNOP00000008471; ENSRNOG00000005386. [P21581-1]
GeneID; 60427; -.
KEGG; rno:60427; -.
CTD; 4254; -.
RGD; 3086; Kitlg.
eggNOG; ENOG410IF3Y; Eukaryota.
eggNOG; ENOG410XYQR; LUCA.
GeneTree; ENSGT00390000018272; -.
HOGENOM; HOG000082493; -.
HOVERGEN; HBG036146; -.
InParanoid; P21581; -.
KO; K05461; -.
OMA; VKTKGIC; -.
OrthoDB; EOG091G0I23; -.
PhylomeDB; P21581; -.
TreeFam; TF330811; -.
Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
Reactome; R-RNO-1433557; Signaling by SCF-KIT.
Reactome; R-RNO-1433559; Regulation of KIT signaling.
Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
PRO; PR:P21581; -.
Proteomes; UP000002494; Chromosome 7.
Bgee; ENSRNOG00000005386; Expressed in 10 organ(s), highest expression level in lung.
ExpressionAtlas; P21581; baseline and differential.
Genevisible; P21581; RN.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0030175; C:filopodium; ISS:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005173; F:stem cell factor receptor binding; IEA:Ensembl.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0033026; P:negative regulation of mast cell apoptotic process; IEA:Ensembl.
GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
GO; GO:0001541; P:ovarian follicle development; IDA:RGD.
GO; GO:0008284; P:positive regulation of cell proliferation; IDA:RGD.
GO; GO:1902035; P:positive regulation of hematopoietic stem cell proliferation; IEA:Ensembl.
GO; GO:0002687; P:positive regulation of leukocyte migration; IEA:Ensembl.
GO; GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO; GO:0070668; P:positive regulation of mast cell proliferation; IEA:Ensembl.
GO; GO:0045636; P:positive regulation of melanocyte differentiation; IEA:Ensembl.
GO; GO:0002763; P:positive regulation of myeloid leukocyte differentiation; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR003452; SCF.
PANTHER; PTHR11574; PTHR11574; 1.
Pfam; PF02404; SCF; 1.
PIRSF; PIRSF015599; SCF; 1.
SUPFAM; SSF47266; SSF47266; 1.
1: Evidence at protein level;
Alternative splicing; Cell adhesion; Cell membrane; Cell projection;
Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing;
Disulfide bond; Glycoprotein; Growth factor; Membrane;
Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 25 {ECO:0000269|PubMed:1708771,
ECO:0000269|PubMed:2208278}.
CHAIN 26 273 Kit ligand.
/FTId=PRO_0000031917.
CHAIN 26 190 Soluble KIT ligand. {ECO:0000250}.
/FTId=PRO_0000403393.
TOPO_DOM 26 214 Extracellular. {ECO:0000255}.
TRANSMEM 215 237 Helical. {ECO:0000255}.
TOPO_DOM 238 273 Cytoplasmic. {ECO:0000255}.
SITE 97 97 Not glycosylated.
{ECO:0000269|PubMed:1708771}.
MOD_RES 26 26 Pyrrolidone carboxylic acid.
{ECO:0000269|PubMed:1708771}.
CARBOHYD 90 90 N-linked (GlcNAc...) asparagine; partial.
{ECO:0000269|PubMed:1708771}.
CARBOHYD 145 145 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:1708771}.
CARBOHYD 167 167 O-linked (GalNAc...) serine.
{ECO:0000305|PubMed:1708771}.
CARBOHYD 168 168 O-linked (GalNAc...) threonine.
{ECO:0000305|PubMed:1708771}.
CARBOHYD 180 180 O-linked (GalNAc...) threonine.
{ECO:0000305|PubMed:1708771}.
CARBOHYD 195 195 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 29 114 {ECO:0000269|PubMed:1708771}.
DISULFID 68 163 {ECO:0000269|PubMed:1708771}.
VAR_SEQ 174 202 DSRVSVTKPFMLPPVAASSLRNDSSSSNR -> G (in
isoform 2). {ECO:0000303|Ref.1}.
/FTId=VSP_006025.
CONFLICT 207 207 S -> P (in Ref. 1; AAD02828).
{ECO:0000305}.
SEQUENCE 273 AA; 30712 MW; C0F56527DC93FD27 CRC64;
MKKTQTWIIT CIYLQLLLFN PLVKTQEICR NPVTDNVKDI TKLVANLPND YMITLNYVAG
MDVLPSHCWL RDMVTHLSVS LTTLLDKFSN ISEGLSNYSI IDKLGKIVDD LVACMEENAP
KNVKESLKKP ETRNFTPEEF FSIFNRSIDA FKDFMVASDT SDCVLSSTLG PEKDSRVSVT
KPFMLPPVAA SSLRNDSSSS NRKAAKSPED PGLQWTAMAL PALISLVIGF AFGALYWKKK
QSSLTRAVEN IQINEEDNEI SMLQQKEREF QEV


Related products :

Catalog number Product name Quantity
E0120m ELISA kit c-Kit ligand,Hematopoietic growth factor KL,Kit ligand,Kitl,Kitlg,Mast cell growth factor,MGF,Mgf,Mouse,Mus musculus,SCF,Sl,Slf,Steel factor,Stem cell factor 96T
U0120m CLIA c-Kit ligand,Hematopoietic growth factor KL,Kit ligand,Kitl,Kitlg,Mast cell growth factor,MGF,Mgf,Mouse,Mus musculus,SCF,Sl,Slf,Steel factor,Stem cell factor 96T
E0120m ELISA c-Kit ligand,Hematopoietic growth factor KL,Kit ligand,Kitl,Kitlg,Mast cell growth factor,MGF,Mgf,Mouse,Mus musculus,SCF,Sl,Slf,Steel factor,Stem cell factor 96T
U0120r CLIA c-Kit ligand,Hematopoietic growth factor KL,Kit ligand,Kitl,Kitlg,Mast cell growth factor,MGF,Mgf,Rat,Rattus norvegicus,SCF,Stem cell factor 96T
E0120r ELISA kit c-Kit ligand,Hematopoietic growth factor KL,Kit ligand,Kitl,Kitlg,Mast cell growth factor,MGF,Mgf,Rat,Rattus norvegicus,SCF,Stem cell factor 96T
E0120r ELISA c-Kit ligand,Hematopoietic growth factor KL,Kit ligand,Kitl,Kitlg,Mast cell growth factor,MGF,Mgf,Rat,Rattus norvegicus,SCF,Stem cell factor 96T
100-097-SC SCF Human Host: E. coli KITLG; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; kit-ligand; stem cell factor; Mast cell growth factor; c-Kit ligand 50
100-097 SCF Human Host: E. coli KITLG; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; kit-ligand; stem cell factor; Mast cell growth factor; c-Kit ligand 10
100-097S SCF Human Host: E. coli KITLG; SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; kit-ligand; stem cell factor; Mast cell growth factor; c-Kit ligand 2
E0120h ELISA c-Kit ligand,Homo sapiens,Human,Kit ligand,KITLG,Mast cell growth factor,MGF,MGF,SCF,SCF,Stem cell factor 96T
U0120h CLIA c-Kit ligand,Homo sapiens,Human,Kit ligand,KITLG,Mast cell growth factor,MGF,MGF,SCF,SCF,Stem cell factor 96T
E0120h ELISA kit c-Kit ligand,Homo sapiens,Human,Kit ligand,KITLG,Mast cell growth factor,MGF,MGF,SCF,SCF,Stem cell factor 96T
E0120b ELISA Bos taurus,Bovine,c-Kit ligand,Kit ligand,KITLG,Mast cell growth factor,MGF,SCF,SCF,Stem cell factor 96T
U0120b CLIA Bos taurus,Bovine,c-Kit ligand,Kit ligand,KITLG,Mast cell growth factor,MGF,SCF,SCF,Stem cell factor 96T
E0120b ELISA kit Bos taurus,Bovine,c-Kit ligand,Kit ligand,KITLG,Mast cell growth factor,MGF,SCF,SCF,Stem cell factor 96T
E0120p ELISA c-Kit ligand,Kit ligand,KITLG,Mast cell growth factor,MGF,MGF,Pig,SCF,Stem cell factor,Sus scrofa 96T
U0120p CLIA c-Kit ligand,Kit ligand,KITLG,Mast cell growth factor,MGF,MGF,Pig,SCF,Stem cell factor,Sus scrofa 96T
E0120p ELISA kit c-Kit ligand,Kit ligand,KITLG,Mast cell growth factor,MGF,MGF,Pig,SCF,Stem cell factor,Sus scrofa 96T
E0120c ELISA Chicken,c-Kit ligand,Gallus gallus,Kit ligand,KITLG,Mast cell growth factor,MGF,SCF,SCF,Stem cell factor 96T
E0120c ELISA kit Chicken,c-Kit ligand,Gallus gallus,Kit ligand,KITLG,Mast cell growth factor,MGF,SCF,SCF,Stem cell factor 96T
U0120c CLIA Chicken,c-Kit ligand,Gallus gallus,Kit ligand,KITLG,Mast cell growth factor,MGF,SCF,SCF,Stem cell factor 96T
18-783-78902 GOAT ANTI HUMAN STEM CELL FACTOR Biotin - SCF; C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF Polyclonal 0.05 mg
18-783-75592 GOAT ANTI HUMAN STEM CELL FACTOR - SCF; C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF Polyclonal 0.1 mg
BMAhKL12 Stem Cell Factor (SCF), c_Kit Ligand, Mast Cell Growth Factor, Steel Factor, Clone hKL 12, Mab anti_Human; frozen_paraffin, IH_ELISA_WB 200 µg.
10-663-45248 Stem Cell Factor - glycosylated (SCF) Human - C-kit ligand; Stem cell factor; SCF; Mast cell growth factor; MGF N_A 1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur