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Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Processed kit ligand]

 SCF_CHICK               Reviewed;         287 AA.
Q09108;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
07-NOV-2018, entry version 119.
RecName: Full=Kit ligand;
AltName: Full=Mast cell growth factor;
Short=MGF;
AltName: Full=Stem cell factor;
Short=SCF;
AltName: Full=c-Kit ligand;
Contains:
RecName: Full=Processed kit ligand;
Flags: Precursor;
Name=KITLG; Synonyms=SCF;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7684722; DOI=10.1016/0378-1119(93)90732-I;
Zhou J., Ohtaki M., Sakurai M.;
"Sequence of a cDNA encoding chicken stem cell factor.";
Gene 127:269-270(1993).
-!- FUNCTION: Ligand for the receptor-type protein-tyrosine kinase
KIT. Plays an essential role in the regulation of cell survival
and proliferation, hematopoiesis, stem cell maintenance,
gametogenesis, mast cell development, migration and function, and
in melanogenesis. KITLG/SCF binding can activate several signaling
pathways. Acts synergistically with other cytokines, probably
interleukins (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer, non-covalently linked. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P21583}.
Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane
{ECO:0000250|UniProtKB:P21583}; Single-pass type I membrane
protein {ECO:0000250}. Cell projection, lamellipodium
{ECO:0000250|UniProtKB:P21583}. Cell projection, filopodium
{ECO:0000250|UniProtKB:P21583}.
-!- SUBCELLULAR LOCATION: Processed kit ligand: Secreted
{ECO:0000250}.
-!- DEVELOPMENTAL STAGE: Acts in the early stages of hematopoiesis.
-!- PTM: A soluble form is produced by proteolytic processing of the
extracellular domain. {ECO:0000250}.
-!- SIMILARITY: Belongs to the SCF family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; D13516; BAA02733.1; -; mRNA.
PIR; JN0637; JN0637.
RefSeq; NP_990461.1; NM_205130.1.
UniGene; Gga.605; -.
ProteinModelPortal; Q09108; -.
SMR; Q09108; -.
STRING; 9031.ENSGALP00000018246; -.
PaxDb; Q09108; -.
Ensembl; ENSGALT00000018268; ENSGALP00000018246; ENSGALG00000011206.
GeneID; 396028; -.
KEGG; gga:396028; -.
CTD; 4254; -.
eggNOG; ENOG410IF3Y; Eukaryota.
eggNOG; ENOG410XYQR; LUCA.
GeneTree; ENSGT00390000018272; -.
HOGENOM; HOG000082493; -.
HOVERGEN; HBG036146; -.
InParanoid; Q09108; -.
KO; K05461; -.
OMA; VKTKGIC; -.
OrthoDB; EOG091G0I23; -.
PhylomeDB; Q09108; -.
TreeFam; TF330811; -.
Reactome; R-GGA-1257604; PIP3 activates AKT signaling.
Reactome; R-GGA-1433557; Signaling by SCF-KIT.
Reactome; R-GGA-1433559; Regulation of KIT signaling.
Reactome; R-GGA-5673001; RAF/MAP kinase cascade.
Reactome; R-GGA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
PRO; PR:Q09108; -.
Proteomes; UP000000539; Chromosome 1.
Bgee; ENSGALG00000011206; Expressed in 10 organ(s), highest expression level in heart.
ExpressionAtlas; Q09108; baseline and differential.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0030175; C:filopodium; ISS:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005173; F:stem cell factor receptor binding; IEA:Ensembl.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
GO; GO:0035162; P:embryonic hemopoiesis; IEA:Ensembl.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0033026; P:negative regulation of mast cell apoptotic process; IEA:Ensembl.
GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
GO; GO:1902035; P:positive regulation of hematopoietic stem cell proliferation; IEA:Ensembl.
GO; GO:0002687; P:positive regulation of leukocyte migration; IEA:Ensembl.
GO; GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO; GO:0070668; P:positive regulation of mast cell proliferation; IEA:Ensembl.
GO; GO:0045636; P:positive regulation of melanocyte differentiation; IEA:Ensembl.
GO; GO:0002763; P:positive regulation of myeloid leukocyte differentiation; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR003452; SCF.
PANTHER; PTHR11574; PTHR11574; 1.
Pfam; PF02404; SCF; 1.
PIRSF; PIRSF015599; SCF; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Cell adhesion; Cell membrane; Cell projection; Complete proteome;
Cytoplasm; Cytoskeleton; Disulfide bond; Glycoprotein; Growth factor;
Membrane; Reference proteome; Secreted; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 25 {ECO:0000255}.
CHAIN 26 287 Kit ligand.
/FTId=PRO_0000031919.
CHAIN 26 ? Processed kit ligand.
/FTId=PRO_0000292279.
TOPO_DOM 26 225 Extracellular. {ECO:0000255}.
TRANSMEM 226 246 Helical. {ECO:0000255}.
TOPO_DOM 247 287 Cytoplasmic. {ECO:0000255}.
CARBOHYD 100 100 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 149 149 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 200 200 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 29 117 {ECO:0000250}.
DISULFID 68 167 {ECO:0000250}.
SEQUENCE 287 AA; 32328 MW; 6AE8556ADC152578 CRC64;
MKKAQTWIIT CFCLQLLLLN PLVKAQSSCG NPVTDDVNDI AKLVGNLPND YLITLKYVPK
MDSLPNHCWL HLMVPEFSRS LHNLLQKFSD ISDMSDVLSN YSIINNLTRI INDLMACLAF
DKNKDFIKEN GHLYEEDRFI PENFFRLFNS TIEVYKEFAD SLDKNDCIMP STVETPENDS
RVAVTKTISF PPVAASSLRN DSIGSNTSSN SNKEALGFIS SSSLQGISIA LTSLLSLLIG
FILGAIYWKK THPKSRPESN ETIQCHGCQE ENEISMLQQK EKEHLQV


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