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Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)]

 SCF_BOVIN               Reviewed;         274 AA.
Q28132; Q9TU74;
30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
10-MAY-2017, entry version 121.
RecName: Full=Kit ligand;
AltName: Full=Mast cell growth factor;
Short=MGF;
AltName: Full=Stem cell factor;
Short=SCF;
AltName: Full=c-Kit ligand;
Contains:
RecName: Full=Soluble KIT ligand;
Short=sKITLG;
Flags: Precursor;
Name=KITLG; Synonyms=SCF;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
TISSUE=Spleen;
PubMed=7520283; DOI=10.1016/0167-4889(94)90084-1;
Zhou J., Hikono H., Ohtaki M., Kubota T., Sakurai M.;
"Cloning and characterization of cDNAs encoding two normal isoforms of
bovine stem cell factor.";
Biochim. Biophys. Acta 1223:148-150(1994).
[2]
NUCLEOTIDE SEQUENCE (ISOFORM 1).
TISSUE=Fetal brain;
Kudo T.;
"Bovine counterpart of stem cell factor.";
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 204-239, AND VARIANT ASP-218.
STRAIN=Belgian blue;
PubMed=10384045; DOI=10.1007/s003359901076;
Seitz J.J., Schmutz S.M., Thue T.D., Buchanan F.C.;
"A missense mutation in the bovine MGF gene is associated with the
roan phenotype in Belgian Blue and Shorthorn cattle.";
Mamm. Genome 10:710-712(1999).
-!- FUNCTION: Stimulates the proliferation of mast cells. Able to
augment the proliferation of both myeloid and lymphoid
hematopoietic progenitors in bone marrow culture. Mediates also
cell-cell adhesion. Acts synergistically with other cytokines,
probably interleukins (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer, non-covalently linked. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000250};
Single-pass type I membrane protein {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Isoform 2: Cytoplasm
{ECO:0000250|UniProtKB:P21583}. Cytoplasm, cytoskeleton
{ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P21583};
Single-pass type I membrane protein {ECO:0000250}. Cell
projection, lamellipodium {ECO:0000250|UniProtKB:P21583}. Cell
projection, filopodium {ECO:0000250|UniProtKB:P21583}.
-!- SUBCELLULAR LOCATION: Soluble KIT ligand: Secreted {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q28132-1; Sequence=Displayed;
Name=2;
IsoId=Q28132-2; Sequence=VSP_006020;
-!- PTM: A soluble form is produced by proteolytic processing of
isoform 1 in the extracellular domain. {ECO:0000250}.
-!- POLYMORPHISM: The roan locus is responsible for the coat
coloration of Belgian Blue and Shorthorn cattle. The solid-colored
and white animals are homozygotes, and the roan animals, with
intermingled colored and white hairs, are heterozygous. The roan
phenotype is due to the Asp-218 mutation.
-!- SIMILARITY: Belongs to the SCF family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; D28934; BAA06061.1; -; mRNA.
EMBL; AB033716; BAA94808.1; -; mRNA.
EMBL; AF120154; AAD55355.1; -; Genomic_DNA.
PIR; S47571; S47571.
RefSeq; NP_776800.1; NM_174375.2. [Q28132-1]
UniGene; Bt.354; -.
ProteinModelPortal; Q28132; -.
STRING; 9913.ENSBTAP00000023349; -.
PaxDb; Q28132; -.
PRIDE; Q28132; -.
Ensembl; ENSBTAT00000023349; ENSBTAP00000023349; ENSBTAG00000017549. [Q28132-1]
GeneID; 281885; -.
KEGG; bta:281885; -.
CTD; 4254; -.
eggNOG; ENOG410IF3Y; Eukaryota.
eggNOG; ENOG410XYQR; LUCA.
GeneTree; ENSGT00390000018272; -.
HOGENOM; HOG000082493; -.
HOVERGEN; HBG036146; -.
InParanoid; Q28132; -.
KO; K05461; -.
OMA; VKTKGIC; -.
OrthoDB; EOG091G0I23; -.
TreeFam; TF330811; -.
Reactome; R-BTA-1257604; PIP3 activates AKT signaling.
Reactome; R-BTA-1433557; Signaling by SCF-KIT.
Reactome; R-BTA-1433559; Regulation of KIT signaling.
Reactome; R-BTA-5673001; RAF/MAP kinase cascade.
Reactome; R-BTA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Proteomes; UP000009136; Chromosome 5.
Bgee; ENSBTAG00000017549; -.
ExpressionAtlas; Q28132; baseline.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0030175; C:filopodium; ISS:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005173; F:stem cell factor receptor binding; IEA:Ensembl.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl.
GO; GO:0035162; P:embryonic hemopoiesis; IEA:Ensembl.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0033026; P:negative regulation of mast cell apoptotic process; IEA:Ensembl.
GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
GO; GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl.
GO; GO:1902035; P:positive regulation of hematopoietic stem cell proliferation; IEA:Ensembl.
GO; GO:0002687; P:positive regulation of leukocyte migration; IEA:Ensembl.
GO; GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl.
GO; GO:0070668; P:positive regulation of mast cell proliferation; IEA:Ensembl.
GO; GO:0045636; P:positive regulation of melanocyte differentiation; IEA:Ensembl.
GO; GO:0002763; P:positive regulation of myeloid leukocyte differentiation; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR003452; SCF.
PANTHER; PTHR11574; PTHR11574; 1.
Pfam; PF02404; SCF; 1.
PIRSF; PIRSF015599; SCF; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Alternative splicing; Cell adhesion; Cell membrane; Cell projection;
Complete proteome; Cytoplasm; Cytoskeleton; Disulfide bond;
Glycoprotein; Growth factor; Membrane; Polymorphism;
Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 25 {ECO:0000255}.
CHAIN 26 274 Kit ligand.
/FTId=PRO_0000031908.
CHAIN 26 191 Soluble KIT ligand. {ECO:0000250}.
/FTId=PRO_0000403386.
TOPO_DOM 26 215 Extracellular. {ECO:0000255}.
TRANSMEM 216 238 Helical. {ECO:0000255}.
TOPO_DOM 239 274 Cytoplasmic. {ECO:0000255}.
MOD_RES 26 26 Pyrrolidone carboxylic acid.
{ECO:0000250|UniProtKB:P21581}.
CARBOHYD 90 90 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 145 145 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 196 196 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 29 114 {ECO:0000250}.
DISULFID 68 164 {ECO:0000250}.
VAR_SEQ 175 203 DSRVSVTKPFMLPPVAASSLRNDSSSSNR -> G (in
isoform 2). {ECO:0000303|PubMed:7520283}.
/FTId=VSP_006020.
VARIANT 218 218 A -> D (in allele roan).
{ECO:0000269|PubMed:10384045}.
SEQUENCE 274 AA; 31015 MW; D6C1DDB77B0CB12B CRC64;
MKKTQTWIIT CIYLQLLLFN PLVHTQGICS NRVTDDVKDV TKLVANLPKD YMITLKYVPG
MDVLPSHCWI SEMVEQLSVS LTDLLDKFSN ISEGLSNYCI IDKLVKIVDD LVECMEEHSS
ENVKKSSKSP EPRQFTPEKF FGIFNKSIDA FKDLEIVASK MSECVISSTS SPEKDSRVSV
TKPFMLPPVA ASSLRNDSSS SNRKASNSIE DSSLQWAAVA LPAFFSLVIG FAFGAFYWKK
KQPNLTRTVE NRQINEEDNE ISMLQEKERE FQEV


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