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L-lactate dehydrogenase (L-LDH) (EC 1.1.1.27)

 LDH_MESFL               Reviewed;         317 AA.
Q6F0L9;
30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
16-AUG-2004, sequence version 1.
25-OCT-2017, entry version 98.
RecName: Full=L-lactate dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00488};
Short=L-LDH {ECO:0000255|HAMAP-Rule:MF_00488};
EC=1.1.1.27 {ECO:0000255|HAMAP-Rule:MF_00488};
Name=ldh {ECO:0000255|HAMAP-Rule:MF_00488}; OrderedLocusNames=Mfl596;
Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1)
(Acholeplasma florum).
Bacteria; Tenericutes; Mollicutes; Entomoplasmatales;
Entomoplasmataceae; Mesoplasma.
NCBI_TaxID=265311;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 33453 / NBRC 100688 / NCTC 11704 / L1;
Birren B.W., Stange-Thomann N., Hafez N., DeCaprio D., Fisher S.,
Butler J., Elkins T., Kodira C.D., Major J., Wang S., Nicol R.,
Nusbaum C.;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
-!- CATALYTIC ACTIVITY: (S)-lactate + NAD(+) = pyruvate + NADH.
{ECO:0000255|HAMAP-Rule:MF_00488}.
-!- PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-
lactate from pyruvate: step 1/1. {ECO:0000255|HAMAP-
Rule:MF_00488}.
-!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00488}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00488}.
-!- SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.
{ECO:0000255|HAMAP-Rule:MF_00488}.
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EMBL; AE017263; AAT75954.1; -; Genomic_DNA.
RefSeq; WP_011183494.1; NC_006055.1.
RefSeq; YP_053838.1; NC_006055.1.
ProteinModelPortal; Q6F0L9; -.
SMR; Q6F0L9; -.
STRING; 265311.Mfl596; -.
EnsemblBacteria; AAT75954; AAT75954; Mfl596.
GeneID; 2897599; -.
KEGG; mfl:Mfl596; -.
PATRIC; fig|265311.5.peg.600; -.
eggNOG; ENOG4105C80; Bacteria.
eggNOG; COG0039; LUCA.
HOGENOM; HOG000213793; -.
KO; K00016; -.
OMA; MDLMQTA; -.
OrthoDB; POG091H02EQ; -.
UniPathway; UPA00554; UER00611.
Proteomes; UP000006647; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0004459; F:L-lactate dehydrogenase activity; IEA:UniProtKB-EC.
GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
Gene3D; 3.90.110.10; -; 1.
HAMAP; MF_00488; Lactate_dehydrog; 1.
InterPro; IPR001557; L-lactate/malate_DH.
InterPro; IPR011304; L-lactate_DH.
InterPro; IPR018177; L-lactate_DH_AS.
InterPro; IPR022383; Lactate/malate_DH_C.
InterPro; IPR001236; Lactate/malate_DH_N.
InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
Pfam; PF02866; Ldh_1_C; 1.
Pfam; PF00056; Ldh_1_N; 1.
PIRSF; PIRSF000102; Lac_mal_DH; 1.
PRINTS; PR00086; LLDHDRGNASE.
SUPFAM; SSF51735; SSF51735; 1.
SUPFAM; SSF56327; SSF56327; 1.
TIGRFAMs; TIGR01771; L-LDH-NAD; 1.
PROSITE; PS00064; L_LDH; 1.
3: Inferred from homology;
Complete proteome; Cytoplasm; NAD; Oxidoreductase; Phosphoprotein;
Reference proteome.
CHAIN 1 317 L-lactate dehydrogenase.
/FTId=PRO_0000237550.
NP_BIND 14 42 NAD. {ECO:0000255|HAMAP-Rule:MF_00488}.
ACT_SITE 178 178 Proton acceptor.
BINDING 91 91 Substrate. {ECO:0000255|HAMAP-
Rule:MF_00488}.
BINDING 123 123 NAD or substrate. {ECO:0000255|HAMAP-
Rule:MF_00488}.
BINDING 154 154 Substrate. {ECO:0000255|HAMAP-
Rule:MF_00488}.
BINDING 231 231 Substrate. {ECO:0000255|HAMAP-
Rule:MF_00488}.
MOD_RES 222 222 Phosphotyrosine. {ECO:0000255|HAMAP-
Rule:MF_00488}.
SEQUENCE 317 AA; 34083 MW; 20875F57187E648C CRC64;
MKKTSNKVVL VGTGAVGMSF IYSAVNQGLA EEYVLIDVNT KAAEGNAIDI QDTMAVLDKP
FTIKAGTYED CKDADLIVIT AGRPQRPGET RLELIADNSR IMKGIAEAIK ASGFNGVTVI
ASNPCDVLTT VYQQVTGYDE HSVVGAGTTL DSARLRRLVA EKLNVAPKSV NAYIMGEHGD
SSVAAYSKAT VMGQPISKYL AEGKITEADL EECWTRAIRM AYEIIERKGA TYYGIGVCLN
AISSAILRDE KTTFMVGAKL NGEYGQKGFY TGVPVILGSK GWETIIEWDL SDAEKAAFKK
SCDALDATYQ KAKEAIA


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