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L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (LDH-M)

 LDHA_FUNHE              Reviewed;         332 AA.
Q92055;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
25-OCT-2017, entry version 97.
RecName: Full=L-lactate dehydrogenase A chain;
Short=LDH-A;
EC=1.1.1.27;
AltName: Full=LDH-M;
Name=ldha;
Fundulus heteroclitus (Killifish) (Mummichog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Ovalentaria; Atherinomorphae; Cyprinodontiformes; Fundulidae;
Fundulus.
NCBI_TaxID=8078;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Muscle;
PubMed=7670598;
Quattro J.M., Pollock D.D., Powell M., Woods H.A., Powers D.A.;
"Evolutionary relations among vertebrate muscle-type lactate
dehydrogenases.";
Mol. Mar. Biol. Biotechnol. 4:224-231(1995).
-!- CATALYTIC ACTIVITY: (S)-lactate + NAD(+) = pyruvate + NADH.
-!- PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-
lactate from pyruvate: step 1/1.
-!- SUBUNIT: Homotetramer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.
{ECO:0000305}.
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EMBL; L43525; AAA99462.1; -; mRNA.
RefSeq; NP_001296844.1; NM_001309915.1.
RefSeq; XP_012708710.1; XM_012853256.1.
UniGene; Fhe.2636; -.
ProteinModelPortal; Q92055; -.
SMR; Q92055; -.
PRIDE; Q92055; -.
GeneID; 105918221; -.
HOVERGEN; HBG000462; -.
OrthoDB; EOG091G0HME; -.
UniPathway; UPA00554; UER00611.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0004459; F:L-lactate dehydrogenase activity; IEA:UniProtKB-EC.
GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
Gene3D; 3.90.110.10; -; 1.
HAMAP; MF_00488; Lactate_dehydrog; 1.
InterPro; IPR001557; L-lactate/malate_DH.
InterPro; IPR011304; L-lactate_DH.
InterPro; IPR018177; L-lactate_DH_AS.
InterPro; IPR022383; Lactate/malate_DH_C.
InterPro; IPR001236; Lactate/malate_DH_N.
InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
Pfam; PF02866; Ldh_1_C; 1.
Pfam; PF00056; Ldh_1_N; 1.
PIRSF; PIRSF000102; Lac_mal_DH; 1.
PRINTS; PR00086; LLDHDRGNASE.
SUPFAM; SSF51735; SSF51735; 1.
SUPFAM; SSF56327; SSF56327; 1.
TIGRFAMs; TIGR01771; L-LDH-NAD; 1.
PROSITE; PS00064; L_LDH; 1.
2: Evidence at transcript level;
Cytoplasm; NAD; Oxidoreductase.
INIT_MET 1 1 Removed. {ECO:0000250}.
CHAIN 2 332 L-lactate dehydrogenase A chain.
/FTId=PRO_0000168438.
NP_BIND 29 57 NAD. {ECO:0000250}.
ACT_SITE 193 193 Proton acceptor. {ECO:0000250}.
BINDING 99 99 NAD. {ECO:0000250}.
BINDING 106 106 Substrate. {ECO:0000250}.
BINDING 138 138 NAD or substrate. {ECO:0000250}.
BINDING 169 169 Substrate. {ECO:0000250}.
BINDING 248 248 Substrate. {ECO:0000250}.
SEQUENCE 332 AA; 36334 MW; E518179F537C8D88 CRC64;
MSTQEKLISH VMKEEPVGCR NKVTVVGVGM VGMASAISVL LKDLCDELAL VDVMEDKLKG
EAMDLQHGAL FLKTHKIVAD KDYSVTANSK VVVVTAGARQ QEGESRLNLV QRNVNIFKFI
IPNIVKYSPN CILLVVSNPV DILTYVAWKL SGFPRHRVIG SGTNLDSARF RHLMGEKFHL
HPSSCHGWIV GEHGDSSVAV WSGVNIAGVS LQTLNPNMGA DGDSENWKEL HKKVVDGAYE
VIKLKGYTSW AIGMSVADLV ESIVKNLHKV HPVSTLVQGM HGVKDEVFLS IPCVLGNSGL
TDVIHMTLKP EEEKQLVKSA ETLWGVQKEL TL


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