Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H)

 LDHB_MOUSE              Reviewed;         334 AA.
P16125; Q545Y4;
01-APR-1990, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
25-OCT-2017, entry version 162.
RecName: Full=L-lactate dehydrogenase B chain;
Short=LDH-B;
EC=1.1.1.27;
AltName: Full=LDH heart subunit;
Short=LDH-H;
Name=Ldhb; Synonyms=Ldh-2, Ldh2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2338075; DOI=10.1111/j.1432-1033.1990.tb15479.x;
Hiraoka B.Y., Sharief F.S., Yang Y.W., Li W.H., Li S.S.-L.;
"The cDNA and protein sequences of mouse lactate dehydrogenase B.
Molecular evolution of vertebrate lactate dehydrogenase genes A
(muscle), B (heart) and C (testis).";
Eur. J. Biochem. 189:215-220(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Cerebellum, Head, and Kidney;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PROTEIN SEQUENCE OF 24-77; 120-127; 159-170 AND 271-299, AND
IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=C57BL/6J; TISSUE=Brain, and Hippocampus;
Lubec G., Klug S., Kang S.U.;
Submitted (APR-2007) to UniProtKB.
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-240, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=18034455; DOI=10.1021/pr0701254;
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
"Large-scale identification and evolution indexing of tyrosine
phosphorylation sites from murine brain.";
J. Proteome Res. 7:311-318(2008).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 AND SER-44, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- CATALYTIC ACTIVITY: (S)-lactate + NAD(+) = pyruvate + NADH.
-!- PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-
lactate from pyruvate: step 1/1.
-!- SUBUNIT: Homotetramer.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X51905; CAA36185.1; -; mRNA.
EMBL; AK002257; BAB21970.1; -; mRNA.
EMBL; AK019391; BAB31697.1; -; mRNA.
EMBL; AK131637; BAE20732.1; -; mRNA.
EMBL; BC046755; AAH46755.1; -; mRNA.
CCDS; CCDS20684.1; -.
PIR; S09954; S09954.
RefSeq; NP_001289694.1; NM_001302765.1.
RefSeq; NP_001303251.1; NM_001316322.1.
RefSeq; NP_032518.1; NM_008492.3.
UniGene; Mm.9745; -.
ProteinModelPortal; P16125; -.
SMR; P16125; -.
BioGrid; 201130; 4.
IntAct; P16125; 7.
MINT; MINT-4100306; -.
STRING; 10090.ENSMUSP00000032373; -.
iPTMnet; P16125; -.
PhosphoSitePlus; P16125; -.
SwissPalm; P16125; -.
REPRODUCTION-2DPAGE; P16125; -.
REPRODUCTION-2DPAGE; Q545Y4; -.
UCD-2DPAGE; P16125; -.
EPD; P16125; -.
MaxQB; P16125; -.
PaxDb; P16125; -.
PeptideAtlas; P16125; -.
PRIDE; P16125; -.
TopDownProteomics; P16125; -.
Ensembl; ENSMUST00000032373; ENSMUSP00000032373; ENSMUSG00000030246.
GeneID; 16832; -.
KEGG; mmu:16832; -.
UCSC; uc009epj.2; mouse.
CTD; 3945; -.
MGI; MGI:96763; Ldhb.
eggNOG; KOG1495; Eukaryota.
eggNOG; COG0039; LUCA.
GeneTree; ENSGT00550000074541; -.
HOGENOM; HOG000213793; -.
HOVERGEN; HBG000462; -.
InParanoid; P16125; -.
KO; K00016; -.
OMA; RQPGQTR; -.
OrthoDB; EOG091G0HME; -.
PhylomeDB; P16125; -.
TreeFam; TF314963; -.
Reactome; R-MMU-70268; Pyruvate metabolism.
UniPathway; UPA00554; UER00611.
PRO; PR:P16125; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000030246; -.
CleanEx; MM_LDHB; -.
ExpressionAtlas; P16125; baseline and differential.
Genevisible; P16125; MM.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0070062; C:extracellular exosome; ISO:MGI.
GO; GO:0016020; C:membrane; ISO:MGI.
GO; GO:0045121; C:membrane raft; ISO:MGI.
GO; GO:0005739; C:mitochondrion; IDA:MGI.
GO; GO:0043209; C:myelin sheath; IDA:UniProtKB.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0019900; F:kinase binding; IEA:Ensembl.
GO; GO:0004459; F:L-lactate dehydrogenase activity; IDA:MGI.
GO; GO:0051287; F:NAD binding; IEA:Ensembl.
GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
GO; GO:0019244; P:lactate biosynthetic process from pyruvate; IC:MGI.
GO; GO:0019674; P:NAD metabolic process; IEA:Ensembl.
Gene3D; 3.90.110.10; -; 1.
HAMAP; MF_00488; Lactate_dehydrog; 1.
InterPro; IPR001557; L-lactate/malate_DH.
InterPro; IPR011304; L-lactate_DH.
InterPro; IPR018177; L-lactate_DH_AS.
InterPro; IPR022383; Lactate/malate_DH_C.
InterPro; IPR001236; Lactate/malate_DH_N.
InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
Pfam; PF02866; Ldh_1_C; 1.
Pfam; PF00056; Ldh_1_N; 1.
PIRSF; PIRSF000102; Lac_mal_DH; 1.
PRINTS; PR00086; LLDHDRGNASE.
SUPFAM; SSF51735; SSF51735; 1.
SUPFAM; SSF56327; SSF56327; 1.
TIGRFAMs; TIGR01771; L-LDH-NAD; 1.
PROSITE; PS00064; L_LDH; 1.
1: Evidence at protein level;
Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing;
NAD; Oxidoreductase; Phosphoprotein; Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P07195}.
CHAIN 2 334 L-lactate dehydrogenase B chain.
/FTId=PRO_0000168461.
NP_BIND 30 58 NAD. {ECO:0000250}.
ACT_SITE 194 194 Proton acceptor. {ECO:0000250}.
BINDING 100 100 NAD. {ECO:0000250}.
BINDING 107 107 Substrate. {ECO:0000250}.
BINDING 139 139 NAD or substrate. {ECO:0000250}.
BINDING 170 170 Substrate. {ECO:0000250}.
BINDING 249 249 Substrate. {ECO:0000250}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:P07195}.
MOD_RES 7 7 N6-acetyllysine.
{ECO:0000250|UniProtKB:P07195}.
MOD_RES 11 11 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 44 44 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 58 58 N6-acetyllysine.
{ECO:0000250|UniProtKB:P07195}.
MOD_RES 119 119 N6-acetyllysine.
{ECO:0000250|UniProtKB:P07195}.
MOD_RES 240 240 Phosphotyrosine.
{ECO:0000244|PubMed:18034455}.
MOD_RES 329 329 N6-acetyllysine.
{ECO:0000250|UniProtKB:P07195}.
SEQUENCE 334 AA; 36572 MW; 86E6CDCDD251285D CRC64;
MATLKEKLIA SVADDEAAVP NNKITVVGVG QVGMACAISI LGKSLADELA LVDVLEDKLK
GEMMDLQHGS LFLQTPKIVA DKDYSVTANS KIVVVTAGVR QQEGESRLNL VQRNVNVFKF
IIPQIVKYSP DCTIIVVSNP VDILTYVTWK LSGLPKHRVI GSGCNLDSAR FRYLMAEKLG
IHPSSCHGWI LGEHGDSSVA VWSGVNVAGV SLQELNPEMG TDNDSENWKE VHKMVVDSAY
EVIKLKGYTN WAIGLSVADL IESMLKNLSR IHPVSTMVKG MYGIENEVFL SLPCILNARG
LTSVINQKLK DDEVAQLRKS ADTLWDIQKD LKDL


Related products :

Catalog number Product name Quantity
E2196p LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Pig,Sus scrofa
U2196p CLIA kit LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Pig,Sus scrofa 96T
E2196p ELISA LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Pig,Sus scrofa 96T
U2196p CLIA LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Pig,Sus scrofa 96T
E2196p ELISA kit LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Pig,Sus scrofa 96T
E2196Rb LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Oryctolagus cuniculus,Rabbit
E2196r LDH heart subunit,Ldh2,Ldh-2,Ldhb,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Rat,Rattus norvegicus
E2196m LDH heart subunit,Ldh2,Ldh-2,Ldhb,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Mouse,Mus musculus
U2196m CLIA LDH heart subunit,Ldh2,Ldh-2,Ldhb,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Mouse,Mus musculus 96T
E2196m ELISA kit LDH heart subunit,Ldh2,Ldh-2,Ldhb,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Mouse,Mus musculus 96T
E2196Rb ELISA kit LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Oryctolagus cuniculus,Rabbit 96T
E2196r ELISA LDH heart subunit,Ldh2,Ldh-2,Ldhb,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Rat,Rattus norvegicus 96T
E2196Rb ELISA LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Oryctolagus cuniculus,Rabbit 96T
E2196r ELISA kit LDH heart subunit,Ldh2,Ldh-2,Ldhb,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Rat,Rattus norvegicus 96T
U2196r CLIA kit LDH heart subunit,Ldh2,Ldh-2,Ldhb,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Rat,Rattus norvegicus 96T
U2196Rb CLIA LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Oryctolagus cuniculus,Rabbit 96T
E2196m ELISA LDH heart subunit,Ldh2,Ldh-2,Ldhb,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Mouse,Mus musculus 96T
U2196Rb CLIA kit LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Oryctolagus cuniculus,Rabbit 96T
U2196m CLIA kit LDH heart subunit,Ldh2,Ldh-2,Ldhb,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Mouse,Mus musculus 96T
U2196r CLIA LDH heart subunit,Ldh2,Ldh-2,Ldhb,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Rat,Rattus norvegicus 96T
E2196h Homo sapiens,Human,LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Renal carcinoma antigen NY-REN-46
E2196h ELISA kit Homo sapiens,Human,LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Renal carcinoma antigen NY-REN-46 96T
U2196h CLIA kit Homo sapiens,Human,LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Renal carcinoma antigen NY-REN-46 96T
E2196h ELISA Homo sapiens,Human,LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Renal carcinoma antigen NY-REN-46 96T
U2196h CLIA Homo sapiens,Human,LDH heart subunit,LDHB,LDH-B,LDH-H,L-lactate dehydrogenase B chain,Renal carcinoma antigen NY-REN-46 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur