Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)

 LYAM1_HUMAN             Reviewed;         372 AA.
P14151; B2R6Q8; P15023; Q9UJ43;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 2.
22-NOV-2017, entry version 200.
RecName: Full=L-selectin;
AltName: Full=CD62 antigen-like family member L;
AltName: Full=Leukocyte adhesion molecule 1;
Short=LAM-1;
AltName: Full=Leukocyte surface antigen Leu-8;
AltName: Full=Leukocyte-endothelial cell adhesion molecule 1;
Short=LECAM1;
AltName: Full=Lymph node homing receptor;
AltName: Full=TQ1;
AltName: Full=gp90-MEL;
AltName: CD_antigen=CD62L;
Flags: Precursor;
Name=SELL; Synonyms=LNHR, LYAM1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT LEU-193.
TISSUE=Lymphocyte;
PubMed=2664786; DOI=10.1073/pnas.86.14.5562;
Siegelman M.H., Weissman I.L.;
"Human homologue of mouse lymph node homing receptor: evolutionary
conservation at tandem cell interaction domains.";
Proc. Natl. Acad. Sci. U.S.A. 86:5562-5566(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Tonsil;
PubMed=2473156; DOI=10.1084/jem.170.1.123;
Tedder T.F., Isaacs C.M., Ernst T.J., Demetri G.D., Adler D.A.,
Disteche C.M.;
"Isolation and chromosomal localization of cDNAs encoding a novel
human lymphocyte cell surface molecule, LAM-1. Homology with the mouse
lymphocyte homing receptor and other human adhesion proteins.";
J. Exp. Med. 170:123-133(1989).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT SER-213.
TISSUE=Lymphocyte;
PubMed=2509939; DOI=10.1038/342078a0;
Camerini D., James S.P., Stamenkovic I., Seed B.;
"Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing
receptor.";
Nature 342:78-82(1989).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT LEU-193.
TISSUE=Lymphocyte;
PubMed=2663882; DOI=10.1083/jcb.109.1.421;
Bowen B.R., Nguyen T., Lasky L.A.;
"Characterization of a human homologue of the murine peripheral lymph
node homing receptor.";
J. Cell Biol. 109:421-427(1989).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1692315;
Ord D.C., Ernst T.J., Zhou L.J., Rambaldi A., Spertini O., Griffin J.,
Tedder T.F.;
"Structure of the gene encoding the human leukocyte adhesion molecule-
1 (TQ1, Leu-8) of lymphocytes and neutrophils.";
J. Biol. Chem. 265:7760-7767(1990).
[6]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Hematopoietic;
Fieger C.B.;
Thesis (1998), Freie Universtiaet Berlin, Germany.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LEU-193; GLN-201;
SER-213 AND ASP-369.
SeattleSNPs variation discovery resource;
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[11]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-60.
TISSUE=Plasma;
PubMed=16335952; DOI=10.1021/pr0502065;
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,
Moore R.J., Smith R.D.;
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
hydrazide chemistry, and mass spectrometry.";
J. Proteome Res. 4:2070-2080(2005).
[12]
INTERACTION WITH SELPLG, AND FUNCTION.
PubMed=12403782; DOI=10.1074/jbc.M204360200;
Bernimoulin M.P., Zeng X.-L., Abbal C., Giraud S., Martinez M.,
Michielin O., Schapira M., Spertini O.;
"Molecular basis of leukocyte rolling on PSGL-1. Predominant role of
core-2 O-glycans and of tyrosine sulfate residue 51.";
J. Biol. Chem. 278:37-47(2003).
[13]
INTERACTION WITH SELPLG.
PubMed=12736247; DOI=10.1074/jbc.M303551200;
Leppaenen A., Yago T., Otto V.I., McEver R.P., Cummings R.D.;
"Model glycosulfopeptides from P-selectin glycoprotein ligand-1
require tyrosine sulfation and a core 2-branched O-glycan to bind to
L-selectin.";
J. Biol. Chem. 278:26391-26400(2003).
[14]
INTERACTION WITH PODXL2.
PubMed=18606703; DOI=10.4049/jimmunol.181.2.1480;
Kerr S.C., Fieger C.B., Snapp K.R., Rosen S.D.;
"Endoglycan, a member of the CD34 family of sialomucins, is a ligand
for the vascular selectins.";
J. Immunol. 181:1480-1490(2008).
[15]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-60 AND ASN-104.
TISSUE=Leukemic T-cell;
PubMed=19349973; DOI=10.1038/nbt.1532;
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
Schiess R., Aebersold R., Watts J.D.;
"Mass-spectrometric identification and relative quantification of N-
linked cell surface glycoproteins.";
Nat. Biotechnol. 27:378-386(2009).
[16]
3D-STRUCTURE MODELING.
PubMed=7488174; DOI=10.1006/bbrc.1995.2722;
Bajorath J., Aruffo A.;
"A template for generation and comparison of three-dimensional
selectin models.";
Biochem. Biophys. Res. Commun. 216:1018-1023(1995).
-!- FUNCTION: Cell surface adhesion protein. Mediates the adherence of
lymphocytes to endothelial cells of high endothelial venules in
peripheral lymph nodes. Promotes initial tethering and rolling of
leukocytes in endothelia. {ECO:0000269|PubMed:12403782}.
-!- SUBUNIT: Interaction with PSGL1/SELPLG and PODXL2 is required for
promoting recruitment and rolling of leukocytes. This interaction
is dependent on the sialyl Lewis X glycan modification of PSGL1
and PODXL2, and tyrosine sulfation modifications of PSGL1.
Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin
binding.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P14151-1; Sequence=Displayed;
Name=2;
IsoId=P14151-2; Sequence=VSP_042650;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed in B-cell lines and T-lymphocytes.
{ECO:0000269|PubMed:2473156}.
-!- SIMILARITY: Belongs to the selectin/LECAM family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAA34203.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Sequence=CAB43536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Sequence=CAB43537.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/sell/";
-!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
Note=L-selectin;
URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_234";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M25280; AAC63053.1; -; mRNA.
EMBL; X16150; CAA34275.1; -; mRNA.
EMBL; X17519; CAB43536.1; ALT_INIT; mRNA.
EMBL; X17519; CAB43537.1; ALT_INIT; mRNA.
EMBL; X16070; CAA34203.1; ALT_INIT; mRNA.
EMBL; M32414; AAB60700.1; -; Genomic_DNA.
EMBL; M32406; AAB60700.1; JOINED; Genomic_DNA.
EMBL; M32407; AAB60700.1; JOINED; Genomic_DNA.
EMBL; M32408; AAB60700.1; JOINED; Genomic_DNA.
EMBL; M32409; AAB60700.1; JOINED; Genomic_DNA.
EMBL; M32410; AAB60700.1; JOINED; Genomic_DNA.
EMBL; M32411; AAB60700.1; JOINED; Genomic_DNA.
EMBL; M32412; AAB60700.1; JOINED; Genomic_DNA.
EMBL; M32413; AAB60700.1; JOINED; Genomic_DNA.
EMBL; AJ246000; CAB55488.1; -; mRNA.
EMBL; AK312673; BAG35555.1; -; mRNA.
EMBL; AY233976; AAO48272.1; -; Genomic_DNA.
EMBL; AL021940; CAI19356.1; -; Genomic_DNA.
EMBL; CH471067; EAW90856.1; -; Genomic_DNA.
CCDS; CCDS53427.1; -. [P14151-2]
RefSeq; NP_000646.2; NM_000655.4. [P14151-2]
UniGene; Hs.728756; -.
PDB; 1KJB; Model; -; A=39-158.
PDB; 2LGF; NMR; -; B=349-363.
PDB; 3CFW; X-ray; 2.20 A; A=39-194.
PDB; 5VC1; X-ray; 1.94 A; A=39-195.
PDBsum; 1KJB; -.
PDBsum; 2LGF; -.
PDBsum; 3CFW; -.
PDBsum; 5VC1; -.
ProteinModelPortal; P14151; -.
SMR; P14151; -.
BioGrid; 112302; 13.
STRING; 9606.ENSP00000236147; -.
BindingDB; P14151; -.
ChEMBL; CHEMBL3161; -.
iPTMnet; P14151; -.
PhosphoSitePlus; P14151; -.
UniCarbKB; P14151; -.
BioMuta; SELL; -.
DMDM; 126178; -.
MaxQB; P14151; -.
PaxDb; P14151; -.
PeptideAtlas; P14151; -.
PRIDE; P14151; -.
DNASU; 6402; -.
Ensembl; ENST00000236147; ENSP00000236147; ENSG00000188404. [P14151-2]
GeneID; 6402; -.
KEGG; hsa:6402; -.
UCSC; uc001ggk.4; human. [P14151-1]
CTD; 6402; -.
DisGeNET; 6402; -.
EuPathDB; HostDB:ENSG00000188404.8; -.
GeneCards; SELL; -.
HGNC; HGNC:10720; SELL.
HPA; CAB002144; -.
HPA; HPA051972; -.
MIM; 153240; gene.
neXtProt; NX_P14151; -.
OpenTargets; ENSG00000188404; -.
Orphanet; 34145; Berger disease.
PharmGKB; PA35642; -.
eggNOG; ENOG410IS3T; Eukaryota.
eggNOG; ENOG410YB82; LUCA.
GeneTree; ENSGT00900000140888; -.
HOGENOM; HOG000236254; -.
HOVERGEN; HBG052375; -.
InParanoid; P14151; -.
KO; K06495; -.
OMA; EAENWGD; -.
OrthoDB; EOG091G09HU; -.
PhylomeDB; P14151; -.
TreeFam; TF326910; -.
Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
Reactome; R-HSA-6798695; Neutrophil degranulation.
EvolutionaryTrace; P14151; -.
GeneWiki; L-selectin; -.
GenomeRNAi; 6402; -.
PMAP-CutDB; P14151; -.
PRO; PR:P14151; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000188404; -.
CleanEx; HS_SELL; -.
ExpressionAtlas; P14151; baseline and differential.
Genevisible; P14151; HS.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0030667; C:secretory granule membrane; TAS:Reactome.
GO; GO:0030246; F:carbohydrate binding; TAS:ProtInc.
GO; GO:0050839; F:cell adhesion molecule binding; IEA:Ensembl.
GO; GO:0043208; F:glycosphingolipid binding; TAS:BHF-UCL.
GO; GO:0008201; F:heparin binding; TAS:BHF-UCL.
GO; GO:0002020; F:protease binding; IPI:BHF-UCL.
GO; GO:0007155; P:cell adhesion; TAS:ProtInc.
GO; GO:0050900; P:leukocyte migration; TAS:Reactome.
GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome.
GO; GO:0050776; P:regulation of immune response; TAS:Reactome.
GO; GO:0033198; P:response to ATP; IEA:Ensembl.
CDD; cd00033; CCP; 2.
CDD; cd03592; CLECT_selectins_like; 1.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR001304; C-type_lectin-like.
InterPro; IPR016186; C-type_lectin-like/link_sf.
InterPro; IPR018378; C-type_lectin_CS.
InterPro; IPR016187; CTDL_fold.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR016348; L-selectin.
InterPro; IPR033991; Selectin_CTLD.
InterPro; IPR002396; Selectin_superfamily.
InterPro; IPR035976; Sushi/SCR/CCP_sf.
InterPro; IPR000436; Sushi_SCR_CCP_dom.
Pfam; PF00059; Lectin_C; 1.
Pfam; PF00084; Sushi; 2.
PIRSF; PIRSF002421; L-selectin; 1.
PRINTS; PR00343; SELECTIN.
SMART; SM00032; CCP; 2.
SMART; SM00034; CLECT; 1.
SMART; SM00181; EGF; 1.
SUPFAM; SSF56436; SSF56436; 1.
SUPFAM; SSF57535; SSF57535; 2.
PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PROSITE; PS00022; EGF_1; 1.
PROSITE; PS01186; EGF_2; 1.
PROSITE; PS50026; EGF_3; 1.
PROSITE; PS50923; SUSHI; 2.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell adhesion; Complete proteome;
Disulfide bond; EGF-like domain; Glycoprotein; Lectin; Membrane;
Polymorphism; Reference proteome; Repeat; Signal; Sushi;
Transmembrane; Transmembrane helix.
SIGNAL 1 28
PROPEP 29 38
/FTId=PRO_0000017475.
CHAIN 39 372 L-selectin.
/FTId=PRO_0000017476.
TOPO_DOM 39 332 Extracellular. {ECO:0000255}.
TRANSMEM 333 355 Helical. {ECO:0000255}.
TOPO_DOM 356 372 Cytoplasmic. {ECO:0000255}.
DOMAIN 55 155 C-type lectin. {ECO:0000255|PROSITE-
ProRule:PRU00040}.
DOMAIN 156 192 EGF-like. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 195 256 Sushi 1. {ECO:0000255|PROSITE-
ProRule:PRU00302}.
DOMAIN 257 318 Sushi 2. {ECO:0000255|PROSITE-
ProRule:PRU00302}.
CARBOHYD 60 60 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:16335952,
ECO:0000269|PubMed:19349973}.
CARBOHYD 104 104 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:19349973}.
CARBOHYD 177 177 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 232 232 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 246 246 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 271 271 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 311 311 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 57 155 {ECO:0000250}.
DISULFID 128 147 {ECO:0000250}.
DISULFID 160 171 {ECO:0000250}.
DISULFID 165 180 {ECO:0000250}.
DISULFID 182 191 {ECO:0000250}.
DISULFID 197 241 {ECO:0000250}.
DISULFID 227 254 {ECO:0000250}.
DISULFID 259 303 {ECO:0000250}.
DISULFID 289 316 {ECO:0000250}.
VAR_SEQ 1 1 M -> MGCRRTREGPSKAM (in isoform 2).
{ECO:0000303|Ref.6}.
/FTId=VSP_042650.
VARIANT 193 193 F -> L (in dbSNP:rs1131498).
{ECO:0000269|PubMed:2663882,
ECO:0000269|PubMed:2664786,
ECO:0000269|Ref.8}.
/FTId=VAR_019134.
VARIANT 201 201 E -> Q (in dbSNP:rs2229568).
{ECO:0000269|Ref.8}.
/FTId=VAR_019135.
VARIANT 213 213 P -> S (in dbSNP:rs2229569).
{ECO:0000269|PubMed:2509939,
ECO:0000269|Ref.8}.
/FTId=VAR_019136.
VARIANT 369 369 N -> D (in dbSNP:rs4987382).
{ECO:0000269|Ref.8}.
/FTId=VAR_019137.
CONFLICT 37 37 D -> Y (in Ref. 4; CAA34203).
{ECO:0000305}.
CONFLICT 178 178 Y -> H (in Ref. 4; CAA34203).
{ECO:0000305}.
CONFLICT 214 214 L -> F (in Ref. 4; CAA34203).
{ECO:0000305}.
CONFLICT 218 220 SFS -> NFN (in Ref. 2; CAA34275).
{ECO:0000305}.
CONFLICT 242 242 G -> E (in Ref. 2; CAA34275).
{ECO:0000305}.
STRAND 40 43 {ECO:0000244|PDB:5VC1}.
HELIX 50 60 {ECO:0000244|PDB:5VC1}.
STRAND 61 64 {ECO:0000244|PDB:5VC1}.
HELIX 70 79 {ECO:0000244|PDB:5VC1}.
STRAND 90 94 {ECO:0000244|PDB:5VC1}.
STRAND 97 100 {ECO:0000244|PDB:5VC1}.
TURN 101 104 {ECO:0000244|PDB:5VC1}.
TURN 109 111 {ECO:0000244|PDB:5VC1}.
HELIX 122 124 {ECO:0000244|PDB:5VC1}.
STRAND 128 131 {ECO:0000244|PDB:5VC1}.
STRAND 136 138 {ECO:0000244|PDB:5VC1}.
STRAND 142 145 {ECO:0000244|PDB:5VC1}.
STRAND 151 157 {ECO:0000244|PDB:5VC1}.
STRAND 167 174 {ECO:0000244|PDB:5VC1}.
STRAND 177 181 {ECO:0000244|PDB:5VC1}.
STRAND 187 191 {ECO:0000244|PDB:3CFW}.
HELIX 350 362 {ECO:0000244|PDB:2LGF}.
SEQUENCE 372 AA; 42187 MW; 6EA9918ECA2D3643 CRC64;
MIFPWKCQST QRDLWNIFKL WGWTMLCCDF LAHHGTDCWT YHYSEKPMNW QRARRFCRDN
YTDLVAIQNK AEIEYLEKTL PFSRSYYWIG IRKIGGIWTW VGTNKSLTEE AENWGDGEPN
NKKNKEDCVE IYIKRNKDAG KWNDDACHKL KAALCYTASC QPWSCSGHGE CVEIINNYTC
NCDVGYYGPQ CQFVIQCEPL EAPELGTMDC THPLGNFSFS SQCAFSCSEG TNLTGIEETT
CGPFGNWSSP EPTCQVIQCE PLSAPDLGIM NCSHPLASFS FTSACTFICS EGTELIGKKK
TICESSGIWS NPSPICQKLD KSFSMIKEGD YNPLFIPVAV MVTAFSGLAF IIWLARRLKK
GKKSKRSMND PY


Related products :

Catalog number Product name Quantity
10-663-45656 L-Selectin Human - Lymph node homing receptor; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; TQ1; gp90-MEL; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; CD62L antig 0.002 mg
10-663-45656 L-Selectin Human - Lymph node homing receptor; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; TQ1; gp90-MEL; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; CD62L antig 1 mg
10-663-45656 L-Selectin Human - Lymph node homing receptor; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; TQ1; gp90-MEL; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; CD62L antig 0.01 mg
E0086m ELISA kit CD62 antigen-like family member L,LAM-1,LECAM1,Leukocyte adhesion molecule 1,Leukocyte-endothelial cell adhesion molecule 1,Lnhr,L-selectin,Ly22,Ly-22,Ly-22,Lymph node homing receptor,Lymph 96T
E0086r ELISA kit CD62 antigen-like family member L,LAM-1,LECAM1,Leukocyte adhesion molecule 1,Leukocyte-endothelial cell adhesion molecule 1,Lnhr,L-selectin,Ly-22,Ly-22,Lymph node homing receptor,Lymphocyte 96T
E0086r ELISA CD62 antigen-like family member L,LAM-1,LECAM1,Leukocyte adhesion molecule 1,Leukocyte-endothelial cell adhesion molecule 1,Lnhr,L-selectin,Ly-22,Ly-22,Lymph node homing receptor,Lymphocyte anti 96T
E0086m ELISA CD62 antigen-like family member L,LAM-1,LECAM1,Leukocyte adhesion molecule 1,Leukocyte-endothelial cell adhesion molecule 1,Lnhr,L-selectin,Ly22,Ly-22,Ly-22,Lymph node homing receptor,Lymphocyte 96T
E0086b ELISA kit Bos taurus,Bovine,CD62 antigen-like family member L,LAM-1,LECAM1,Leukocyte adhesion molecule 1,Leukocyte-endothelial cell adhesion molecule 1,L-selectin,Lymph node homing receptor,SELL 96T
U0086b CLIA Bos taurus,Bovine,CD62 antigen-like family member L,LAM-1,LECAM1,Leukocyte adhesion molecule 1,Leukocyte-endothelial cell adhesion molecule 1,L-selectin,Lymph node homing receptor,SELL 96T
E0086b ELISA Bos taurus,Bovine,CD62 antigen-like family member L,LAM-1,LECAM1,Leukocyte adhesion molecule 1,Leukocyte-endothelial cell adhesion molecule 1,L-selectin,Lymph node homing receptor,SELL 96T
U0086m CLIA CD62 antigen-like family member L,LAM-1,LECAM1,Leukocyte adhesion molecule 1,Leukocyte-endothelial cell adhesion molecule 1,Lnhr,L-selectin,Ly22,Ly-22,Ly-22,Lymph node homing receptor,Lymphocyte 96T
U0086r CLIA CD62 antigen-like family member L,LAM-1,LECAM1,Leukocyte adhesion molecule 1,Leukocyte-endothelial cell adhesion molecule 1,Lnhr,L-selectin,Ly-22,Ly-22,Lymph node homing receptor,Lymphocyte antig 96T
20-272-190476 CD62L - Mouse monoclonal [FMC46] to CD62L; Lymph node homing receptor; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; TQ1; gp90-MEL; Leukocyte-endothelial cell adhesion molecul 0.1 ml
E0086h ELISA kit CD62 antigen-like family member L,gp90-MEL,Homo sapiens,Human,LAM-1,LECAM1,Leukocyte adhesion molecule 1,Leukocyte surface antigen Leu-8,Leukocyte-endothelial cell adhesion molecule 1,LNHR, 96T
E0086h ELISA CD62 antigen-like family member L,gp90-MEL,Homo sapiens,Human,LAM-1,LECAM1,Leukocyte adhesion molecule 1,Leukocyte surface antigen Leu-8,Leukocyte-endothelial cell adhesion molecule 1,LNHR,L-sel 96T
U0086h CLIA CD62 antigen-like family member L,gp90-MEL,Homo sapiens,Human,LAM-1,LECAM1,Leukocyte adhesion molecule 1,Leukocyte surface antigen Leu-8,Leukocyte-endothelial cell adhesion molecule 1,LNHR,L-sele 96T
20-272-190477 CD62L (FITC) - Mouse monoclonal [FMC-46] to CD62L (FITC); Lymph node homing receptor; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; TQ1; gp90-MEL; Leukocyte-endothelial cell a 50 TESTS
U0029p CLIA CD62 antigen-like family member E,ELAM-1,Endothelial leukocyte adhesion molecule 1,E-selectin,LECAM2,Leukocyte-endothelial cell adhesion molecule 2,Pig,SELE,Sus scrofa 96T
E0029p ELISA kit CD62 antigen-like family member E,ELAM-1,Endothelial leukocyte adhesion molecule 1,E-selectin,LECAM2,Leukocyte-endothelial cell adhesion molecule 2,Pig,SELE,Sus scrofa 96T
E0029p ELISA CD62 antigen-like family member E,ELAM-1,Endothelial leukocyte adhesion molecule 1,E-selectin,LECAM2,Leukocyte-endothelial cell adhesion molecule 2,Pig,SELE,Sus scrofa 96T
U0029b CLIA Bos taurus,Bovine,CD62 antigen-like family member E,ELAM-1,Endothelial leukocyte adhesion molecule 1,E-selectin,LECAM2,Leukocyte-endothelial cell adhesion molecule 2,SELE 96T
E0029b ELISA Bos taurus,Bovine,CD62 antigen-like family member E,ELAM-1,Endothelial leukocyte adhesion molecule 1,E-selectin,LECAM2,Leukocyte-endothelial cell adhesion molecule 2,SELE 96T
E0029b ELISA kit Bos taurus,Bovine,CD62 antigen-like family member E,ELAM-1,Endothelial leukocyte adhesion molecule 1,E-selectin,LECAM2,Leukocyte-endothelial cell adhesion molecule 2,SELE 96T
E0029Rb ELISA kit CD62 antigen-like family member E,ELAM-1,Endothelial leukocyte adhesion molecule 1,E-selectin,LECAM2,Leukocyte-endothelial cell adhesion molecule 2,Oryctolagus cuniculus,Rabbit,SELE 96T
E0029Rb ELISA CD62 antigen-like family member E,ELAM-1,Endothelial leukocyte adhesion molecule 1,E-selectin,LECAM2,Leukocyte-endothelial cell adhesion molecule 2,Oryctolagus cuniculus,Rabbit,SELE 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur