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LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein LMX-2) (Homeobox protein Lim-1)

 LHX1_MESAU              Reviewed;         406 AA.
P63008; P36199;
31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
31-AUG-2004, sequence version 1.
27-SEP-2017, entry version 79.
RecName: Full=LIM/homeobox protein Lhx1;
Short=LIM homeobox protein 1;
AltName: Full=Homeobox protein LMX-2;
AltName: Full=Homeobox protein Lim-1;
Name=Lhx1; Synonyms=Lim-1, Lim1, Lmx2;
Mesocricetus auratus (Golden hamster).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Mesocricetus.
NCBI_TaxID=10036;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pancreatic islet;
PubMed=7991607; DOI=10.1073/pnas.91.25.12203;
Rudnick A., Ling T.Y., Odagiri H., Rutter W.J., German M.S.;
"Pancreatic beta cells express a diverse set of homeobox genes.";
Proc. Natl. Acad. Sci. U.S.A. 91:12203-12207(1994).
-!- FUNCTION: Potential transcription factor. May play a role in early
mesoderm formation and later in lateral mesoderm differentiation
and neurogenesis (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with LDB1 via the tandem LIM domains.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- DOMAIN: The LIM domains exert a negative regulatory function and
disruption of the LIM domains produces an activated form. In
addition, two activation domains and a negative regulatory domain
exist C-terminally to the homeobox (By similarity). {ECO:0000250}.
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EMBL; X81407; CAA57164.1; -; mRNA.
PIR; I48186; I48186.
RefSeq; NP_001268538.1; NM_001281609.1.
ProteinModelPortal; P63008; -.
SMR; P63008; -.
GeneID; 101828732; -.
CTD; 3975; -.
HOVERGEN; HBG006263; -.
OrthoDB; EOG091G0BSD; -.
Proteomes; UP000189706; Genome assembly.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0043234; C:protein complex; ISS:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; ISS:UniProtKB.
GO; GO:0009653; P:anatomical structure morphogenesis; ISS:UniProtKB.
GO; GO:0009948; P:anterior/posterior axis specification; ISS:UniProtKB.
GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0007267; P:cell-cell signaling; ISS:UniProtKB.
GO; GO:0021702; P:cerebellar Purkinje cell differentiation; ISS:UniProtKB.
GO; GO:0021937; P:cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation; ISS:UniProtKB.
GO; GO:0021549; P:cerebellum development; ISS:UniProtKB.
GO; GO:0060067; P:cervix development; ISS:UniProtKB.
GO; GO:0072049; P:comma-shaped body morphogenesis; ISS:UniProtKB.
GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
GO; GO:0001705; P:ectoderm formation; ISS:UniProtKB.
GO; GO:0009880; P:embryonic pattern specification; ISS:UniProtKB.
GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; ISS:UniProtKB.
GO; GO:0048703; P:embryonic viscerocranium morphogenesis; ISS:UniProtKB.
GO; GO:0001706; P:endoderm formation; ISS:UniProtKB.
GO; GO:0060429; P:epithelium development; ISS:UniProtKB.
GO; GO:0021871; P:forebrain regionalization; ISS:UniProtKB.
GO; GO:0001702; P:gastrulation with mouth forming second; ISS:UniProtKB.
GO; GO:0060322; P:head development; ISS:UniProtKB.
GO; GO:0035852; P:horizontal cell localization; IEA:Ensembl.
GO; GO:0001822; P:kidney development; ISS:UniProtKB.
GO; GO:0097477; P:lateral motor column neuron migration; ISS:UniProtKB.
GO; GO:0072283; P:metanephric renal vesicle morphogenesis; IEA:Ensembl.
GO; GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Ensembl.
GO; GO:0008045; P:motor neuron axon guidance; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0035849; P:nephric duct elongation; IEA:Ensembl.
GO; GO:0072178; P:nephric duct morphogenesis; ISS:UniProtKB.
GO; GO:0060066; P:oviduct development; ISS:UniProtKB.
GO; GO:0035846; P:oviduct epithelium development; ISS:UniProtKB.
GO; GO:0061205; P:paramesonephric duct development; ISS:UniProtKB.
GO; GO:0007389; P:pattern specification process; ISS:UniProtKB.
GO; GO:2000744; P:positive regulation of anterior head development; ISS:UniProtKB.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
GO; GO:0040019; P:positive regulation of embryonic development; ISS:UniProtKB.
GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
GO; GO:2000768; P:positive regulation of nephron tubule epithelial cell differentiation; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0009791; P:post-embryonic development; ISS:UniProtKB.
GO; GO:0090009; P:primitive streak formation; ISS:UniProtKB.
GO; GO:0048793; P:pronephros development; IEA:Ensembl.
GO; GO:0010468; P:regulation of gene expression; ISS:UniProtKB.
GO; GO:0072077; P:renal vesicle morphogenesis; ISS:UniProtKB.
GO; GO:0010842; P:retina layer formation; ISS:UniProtKB.
GO; GO:0072050; P:S-shaped body morphogenesis; ISS:UniProtKB.
GO; GO:0032525; P:somite rostral/caudal axis specification; IEA:Ensembl.
GO; GO:0021527; P:spinal cord association neuron differentiation; ISS:UniProtKB.
GO; GO:0021537; P:telencephalon development; IEA:Ensembl.
GO; GO:0006366; P:transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0001657; P:ureteric bud development; ISS:UniProtKB.
GO; GO:0001655; P:urogenital system development; ISS:UniProtKB.
GO; GO:0035847; P:uterine epithelium development; ISS:UniProtKB.
GO; GO:0060065; P:uterus development; ISS:UniProtKB.
GO; GO:0060068; P:vagina development; ISS:UniProtKB.
GO; GO:0021517; P:ventral spinal cord development; IEA:Ensembl.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR001781; Znf_LIM.
Pfam; PF00046; Homeobox; 1.
Pfam; PF00412; LIM; 2.
SMART; SM00389; HOX; 1.
SMART; SM00132; LIM; 2.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
PROSITE; PS00478; LIM_DOMAIN_1; 2.
PROSITE; PS50023; LIM_DOMAIN_2; 2.
2: Evidence at transcript level;
Complete proteome; Developmental protein; Differentiation;
DNA-binding; Homeobox; LIM domain; Metal-binding; Neurogenesis;
Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription;
Transcription regulation; Zinc.
CHAIN 1 406 LIM/homeobox protein Lhx1.
/FTId=PRO_0000075770.
DOMAIN 4 54 LIM zinc-binding 1. {ECO:0000255|PROSITE-
ProRule:PRU00125}.
DOMAIN 63 117 LIM zinc-binding 2. {ECO:0000255|PROSITE-
ProRule:PRU00125}.
DNA_BIND 180 239 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
MOD_RES 162 162 Phosphoserine.
{ECO:0000250|UniProtKB:P63007}.
SEQUENCE 406 AA; 44780 MW; CC8637984998ADAF CRC64;
MVHCAGCKRP ILDRFLLNVL DRAWHVKCVQ CCECKCNLTE KCFSREGKLY CKNDFFRCFG
TKCAGCAQGI SPSDLVRRAR SKVFHLNCFT CMMCNKQLST GEELYIIDEN KFVCKEDYLS
NSSVAKENSL HSATTGSDPS LSPDSQDPSQ DDAKDSESAN VSDKEGGSNE NDDQNLGAKR
RGPRTTIKAK QLETLKAAFA ATPKPTRHIR EQLAQETGLN MRVIQVWFQN RRSKERRMKQ
LSALGARRHA FFRSPRRMRP LVDRLEPGEL IPNGPFSFYG DYQSEYYGPG GNYDFFPQGP
PSSQAQTPVD LPFVPSSGPS GTPLGGLDHP LPGHHPSSEA QRFTDILAHP PGDSPSPEPS
LPGPLHSMSA EVFGPSPPFS SLSVNGGASY GNHLSHPPEM NEAAVW


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