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Laccase-C1 (EC 1.10.3.2) (Benzenediol:oxygen oxidoreductase C1) (Diphenol oxidase C1) (Lac C1) (Urishiol oxidase C1) (Fragments)

 LACC1_CERUI             Reviewed;          63 AA.
P86328;
01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
11-JAN-2011, sequence version 2.
12-SEP-2018, entry version 17.
RecName: Full=Laccase-C1;
EC=1.10.3.2;
AltName: Full=Benzenediol:oxygen oxidoreductase C1 {ECO:0000250|UniProtKB:Q12718};
AltName: Full=Diphenol oxidase C1 {ECO:0000250|UniProtKB:Q12718};
AltName: Full=Lac C1;
AltName: Full=Urishiol oxidase C1 {ECO:0000250|UniProtKB:Q12718};
Flags: Fragments;
Cerrena unicolor (Canker rot fungus) (Daedalea unicolor).
Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
Agaricomycetes; Polyporales; Cerrenaceae; Cerrena.
NCBI_TaxID=90312;
[1]
PROTEIN SEQUENCE, FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION,
BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT, SUBCELLULAR LOCATION,
INDUCTION, AND GLYCOSYLATION.
STRAIN=VKM F-3196;
PubMed=20175123; DOI=10.1002/jobm.200900382;
Lisova Z.A., Lisov A.V., Leontievsky A.A.;
"Two laccase isoforms of the basidiomycete Cerrena unicolor VKMF-3196.
Induction, isolation and properties.";
J. Basic Microbiol. 50:72-82(2010).
-!- FUNCTION: Lignin degradation and detoxification of lignin-derived
products (Probable). Oxidation of a broad range of substrates
including mono-, di- and polyphenols, aromatic amines and methoxy-
substituted phenols accompanied by reduction of oxygen to water.
{ECO:0000269|PubMed:20175123, ECO:0000305}.
-!- CATALYTIC ACTIVITY: 4 benzenediol + O(2) = 4 benzosemiquinone + 2
H(2)O. {ECO:0000269|PubMed:20175123}.
-!- COFACTOR:
Name=Cu cation; Xref=ChEBI:CHEBI:23378;
Evidence={ECO:0000250|UniProtKB:Q12718};
Note=Binds 4 Cu cations per monomer.
{ECO:0000250|UniProtKB:Q12718};
-!- ACTIVITY REGULATION: Inhibited by sodium azide.
{ECO:0000269|PubMed:20175123}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=35 uM for 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic
acid) (ABTS) {ECO:0000269|PubMed:20175123};
KM=1.529 mM for 2-methoxyphenol {ECO:0000269|PubMed:20175123};
KM=1.582 mM for hydroquinone {ECO:0000269|PubMed:20175123};
KM=17.6 uM for 2,6-dimethoxyphenol
{ECO:0000269|PubMed:20175123};
KM=265 uM for pyrogallol {ECO:0000269|PubMed:20175123};
Vmax=138.9 umol/min/mg enzyme toward ABTS
{ECO:0000269|PubMed:20175123};
Vmax=1.4 umol/min/mg enzyme toward 2-methoxyphenol
{ECO:0000269|PubMed:20175123};
Vmax=9.9 umol/min/mg enzyme toward hydroquinone
{ECO:0000269|PubMed:20175123};
Vmax=11.9 umol/min/mg enzyme toward 2,6-dimethoxyphenol
{ECO:0000269|PubMed:20175123};
Vmax=8.5 umol/min/mg enzyme toward pyrogallol
{ECO:0000269|PubMed:20175123};
pH dependence:
Optimum pH is 4.4 with 2,6-dimethoxyphenol as substrate, and
less than 2.7 with ABTS as substrate.
{ECO:0000269|PubMed:20175123};
Temperature dependence:
Optimum temperature is 55 degrees Celsius. Half-life at 70
degrees Celsius is 30 minutes. {ECO:0000269|PubMed:20175123};
-!- SUBUNIT: Monomer. {ECO:0000269|PubMed:20175123}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20175123}.
-!- INDUCTION: By copper ions. {ECO:0000269|PubMed:20175123}.
-!- PTM: Glycosylated; contains 16% carbohydrates.
{ECO:0000269|PubMed:20175123}.
-!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is:
4.05, its MW is: 75 kDa.
-!- SIMILARITY: Belongs to the multicopper oxidase family.
{ECO:0000255}.
-!- CAUTION: The order of the peptides is unknown. {ECO:0000305}.
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GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0052716; F:hydroquinone:oxygen oxidoreductase activity; IDA:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0046274; P:lignin catabolic process; IDA:UniProtKB.
1: Evidence at protein level;
Copper; Direct protein sequencing; Lignin degradation; Metal-binding;
Oxidoreductase; Secreted.
CHAIN 1 >63 Laccase-C1.
/FTId=PRO_0000381738.
UNSURE 15 15 L or I.
UNSURE 20 20 Q or K.
UNSURE 22 22 L or I.
UNSURE 23 23 L or I.
UNSURE 34 34 L or I.
UNSURE 35 35 Q or K.
UNSURE 38 38 K or Q.
UNSURE 49 49 L or I.
UNSURE 51 51 L or I.
UNSURE 53 53 L or K.
UNSURE 54 54 W or GE.
UNSURE 56 56 Q or K.
UNSURE 61 61 W or GE.
UNSURE 62 62 L or I.
NON_CONS 10 11 {ECO:0000305}.
NON_CONS 24 25 {ECO:0000305}.
NON_CONS 39 40 {ECO:0000305}.
NON_CONS 50 51 {ECO:0000305}.
NON_TER 63 63
SEQUENCE 63 AA; 7148 MW; 2E1D1E2EDDD6131E CRC64;
AIGPVADIDI DVVSLGMVDQ SLLREMHEVS NVALQAMKGS DEYDFNANLR LVLWNQPDFM
WLR


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