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Lactate-binding periplasmic protein TTHA0766 (ABC transporter, solute-binding protein) (Extracytoplasmic solute receptor protein TTHA0766) (TRAP transporter lactate-binding subunit P)

 TLBP_THET8              Reviewed;         361 AA.
Q5SK82;
16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
28-MAR-2018, entry version 78.
RecName: Full=Lactate-binding periplasmic protein TTHA0766 {ECO:0000303|PubMed:19631222};
AltName: Full=ABC transporter, solute-binding protein {ECO:0000312|EMBL:BAD70589.1};
AltName: Full=Extracytoplasmic solute receptor protein TTHA0766 {ECO:0000250|UniProtKB:P37676};
AltName: Full=TRAP transporter lactate-binding subunit P {ECO:0000250|UniProtKB:Q3J1R2};
Flags: Precursor;
OrderedLocusNames=TTHA0766;
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579).
Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae;
Thermus.
NCBI_TaxID=300852;
[1] {ECO:0000312|EMBL:BAD70589.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HB8 / ATCC 27634 / DSM 579;
Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y.,
Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
"Complete genome sequence of Thermus thermophilus HB8.";
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000305, ECO:0000312|PDB:2ZZW}
PROTEIN SEQUENCE OF 23-32, X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN
COMPLEXES WITH CALCIUM; LACTATE AND ZINC, FUNCTION, AND SUBUNIT.
STRAIN=HB8 / ATCC 27634 / DSM 579 {ECO:0000269|PubMed:19631222};
PubMed=19631222; DOI=10.1016/j.jmb.2009.07.043;
Akiyama N., Takeda K., Miki K.;
"Crystal structure of a periplasmic substrate-binding protein in
complex with calcium lactate.";
J. Mol. Biol. 392:559-565(2009).
-!- FUNCTION: Part of the tripartite ATP-independent periplasmic
(TRAP) transport system involved in the uptake of lactate. This
protein specifically binds L-lactate.
{ECO:0000250|UniProtKB:P37676, ECO:0000269|PubMed:19631222}.
-!- SUBUNIT: Homodimer. The complex comprises the extracytoplasmic
solute receptor protein TTHA0766, and the two putative
transmembrane proteins TTHA0767 and TTHA0768.
{ECO:0000250|UniProtKB:P37676, ECO:0000269|PubMed:19631222,
ECO:0000303|PubMed:19631222}.
-!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250|UniProtKB:P37676}.
-!- SIMILARITY: Belongs to the bacterial solute-binding protein 7
family. {ECO:0000255}.
-----------------------------------------------------------------------
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EMBL; AP008226; BAD70589.1; -; Genomic_DNA.
RefSeq; WP_011228183.1; NC_006461.1.
RefSeq; YP_144032.1; NC_006461.1.
PDB; 2ZZV; X-ray; 1.40 A; A/B=1-361.
PDB; 2ZZW; X-ray; 1.95 A; A/B=1-361.
PDB; 2ZZX; X-ray; 1.75 A; A/B/C/D=1-361.
PDBsum; 2ZZV; -.
PDBsum; 2ZZW; -.
PDBsum; 2ZZX; -.
ProteinModelPortal; Q5SK82; -.
SMR; Q5SK82; -.
STRING; 300852.TTHA0766; -.
EnsemblBacteria; BAD70589; BAD70589; BAD70589.
GeneID; 3168757; -.
KEGG; ttj:TTHA0766; -.
PATRIC; fig|300852.9.peg.759; -.
eggNOG; ENOG4105CH5; Bacteria.
eggNOG; COG4663; LUCA.
HOGENOM; HOG000026269; -.
OMA; GRIWASM; -.
PhylomeDB; Q5SK82; -.
BioCyc; TTHE300852:G1GKC-784-MONOMER; -.
EvolutionaryTrace; Q5SK82; -.
Proteomes; UP000000532; Chromosome.
GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
GO; GO:0031317; C:tripartite ATP-independent periplasmic transporter complex; IGC:UniProtKB.
GO; GO:0005509; F:calcium ion binding; IDA:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO; GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO; GO:0015727; P:lactate transport; IDA:UniProtKB.
GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
Gene3D; 3.40.190.170; -; 1.
InterPro; IPR026289; SBP_mannitol/chloroaromatic.
InterPro; IPR006311; TAT_signal.
InterPro; IPR018389; TRAP_DctP/TeaA.
InterPro; IPR038404; TRAP_DctP_sf.
PANTHER; PTHR33376; PTHR33376; 1.
Pfam; PF03480; DctP; 1.
PIRSF; PIRSF039026; SiaP; 1.
PROSITE; PS51318; TAT; 1.
1: Evidence at protein level;
3D-structure; Calcium; Complete proteome; Direct protein sequencing;
Metal-binding; Periplasm; Reference proteome; Signal; Transport.
SIGNAL 1 22 Tat-type signal. {ECO:0000255|PROSITE-
ProRule:PRU00648,
ECO:0000269|PubMed:19631222}.
CHAIN 23 361 Lactate-binding periplasmic protein
TTHA0766. {ECO:0000255|PROSITE-
ProRule:PRU00648,
ECO:0000269|PubMed:19631222}.
/FTId=PRO_0000423944.
REGION 247 250 Substrate binding.
{ECO:0000269|PubMed:19631222}.
METAL 158 158 Calcium. {ECO:0000269|PubMed:19631222}.
METAL 216 216 Calcium. {ECO:0000269|PubMed:19631222}.
METAL 217 217 Calcium; via carbonyl oxygen.
{ECO:0000269|PubMed:19631222}.
METAL 247 247 Calcium. {ECO:0000269|PubMed:19631222}.
BINDING 101 101 Substrate. {ECO:0000269|PubMed:19631222}.
BINDING 158 158 Substrate. {ECO:0000269|PubMed:19631222}.
BINDING 178 178 Substrate. {ECO:0000269|PubMed:19631222}.
BINDING 217 217 Substrate; via carbonyl oxygen.
{ECO:0000269|PubMed:19631222}.
STRAND 34 42 {ECO:0000244|PDB:2ZZV}.
HELIX 47 62 {ECO:0000244|PDB:2ZZV}.
TURN 63 65 {ECO:0000244|PDB:2ZZV}.
STRAND 66 72 {ECO:0000244|PDB:2ZZV}.
STRAND 76 78 {ECO:0000244|PDB:2ZZV}.
HELIX 80 82 {ECO:0000244|PDB:2ZZV}.
HELIX 83 88 {ECO:0000244|PDB:2ZZV}.
STRAND 91 96 {ECO:0000244|PDB:2ZZV}.
HELIX 99 102 {ECO:0000244|PDB:2ZZV}.
TURN 103 105 {ECO:0000244|PDB:2ZZV}.
HELIX 107 111 {ECO:0000244|PDB:2ZZV}.
HELIX 122 130 {ECO:0000244|PDB:2ZZV}.
HELIX 134 144 {ECO:0000244|PDB:2ZZV}.
STRAND 147 153 {ECO:0000244|PDB:2ZZV}.
STRAND 160 164 {ECO:0000244|PDB:2ZZV}.
HELIX 169 172 {ECO:0000244|PDB:2ZZV}.
STRAND 176 178 {ECO:0000244|PDB:2ZZV}.
HELIX 182 190 {ECO:0000244|PDB:2ZZV}.
STRAND 194 196 {ECO:0000244|PDB:2ZZV}.
HELIX 200 202 {ECO:0000244|PDB:2ZZV}.
HELIX 203 208 {ECO:0000244|PDB:2ZZV}.
STRAND 213 216 {ECO:0000244|PDB:2ZZV}.
HELIX 220 225 {ECO:0000244|PDB:2ZZV}.
HELIX 228 231 {ECO:0000244|PDB:2ZZV}.
STRAND 233 237 {ECO:0000244|PDB:2ZZV}.
STRAND 252 257 {ECO:0000244|PDB:2ZZV}.
HELIX 258 263 {ECO:0000244|PDB:2ZZV}.
HELIX 266 300 {ECO:0000244|PDB:2ZZV}.
STRAND 304 307 {ECO:0000244|PDB:2ZZV}.
HELIX 310 328 {ECO:0000244|PDB:2ZZV}.
HELIX 332 347 {ECO:0000244|PDB:2ZZV}.
HELIX 354 356 {ECO:0000244|PDB:2ZZV}.
SEQUENCE 361 AA; 40761 MW; EF5A2126BE41302F CRC64;
MKRVSRRAFL RRLGVGVAAT AAFSPLAVAQ ARRYRWRIQT AWDAGTVGYS LFQKFTERVK
ELTDGQLEVQ PFPAGAVVGT FDMFDAVKTG VLDGMNPFTL YWAGRMPVTA FLSSYALGLD
RPDQWETWFY SLGGLDIARR AFAEQGLFYV GPVQHDLNII HSKKPIRRFE DFKGVKLRVP
GGMIAEVFAA AGASTVLLPG GEVYPALERG VIDAADFVGP AVNYNLGFHQ VAKYIIMGPP
ETPAIHQPVD LMDFTINLNR WRSLPKPLQE RFIAAVHEYS WIHYAGIQKA NLEAWPKYRQ
AGVEVIRLSN EDVRKFRRLA IPIWFKWAKM DKYSREAFAS QLEYMKGIGY VTDEELKGLS
L


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