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Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) (Major surface antigen) [Cleaved into: Truncated S protein (St)]

 HBSAG_DHBVQ             Reviewed;         330 AA.
Q66405; Q66404; Q89748;
05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
20-DEC-2017, entry version 66.
RecName: Full=Large envelope protein;
AltName: Full=L glycoprotein;
AltName: Full=L-HBsAg;
Short=LHB;
AltName: Full=Large S protein;
AltName: Full=Large surface protein;
AltName: Full=Major surface antigen;
Contains:
RecName: Full=Truncated S protein;
Short=St;
Name=S;
Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV).
Viruses; Retro-transcribing viruses; Hepadnaviridae; Avihepadnavirus.
NCBI_TaxID=644639;
NCBI_TaxID=8835; Anas (ducks).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ISOFORM S.
Tong S., Mattes F., Blum H.E., Fernholz D., Schneider R., Will H.;
"Complete nucleotide sequence of a chinese Hepatitis B virus.";
Submitted (JUN-1991) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: The large envelope protein exists in two topological
conformations, one which is termed 'external' or Le-HBsAg and the
other 'internal' or Li-HBsAg. In its external conformation the
protein attaches the virus to cell receptors and thereby
initiating infection. This interaction determines the species
specificity and liver tropism. The large envelope protein probably
also assumes fusion between virion and host membranes. In its
internal conformation the protein plays a role in virion
morphogenesis and mediates the contact with the nucleocapsid like
a matrix protein (By similarity). {ECO:0000250}.
-!- FUNCTION: Truncated S protein may be involved in translocation of
pre-S domain through the virion membrane. {ECO:0000250}.
-!- SUBUNIT: Large internal envelope protein interacts with capsid
protein. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Virion membrane.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative initiation; Named isoforms=2;
Name=L; Synonyms=Large envelope protein, LHB, L-HBsAg;
IsoId=Q66405-1; Sequence=Displayed;
Name=S; Synonyms=Small envelope protein, SHB, S-HBsAg;
IsoId=Q66405-2; Sequence=VSP_039691;
-!- DOMAIN: The large envelope protein is synthesized with the pre-S
region at the cytosolic side of the endoplasmic reticulum and,
hence will be within the virion after budding. Therefore the pre-S
region is not N-glycosylated. Later a post-translational
translocation of N-terminal pre-S and TM1 domains occur in about
50% of proteins at the virion surface. These molecules change
their topology by an unknown mechanism, resulting in exposure of
pre-S region at virion surface.
-!- PTM: Myristoylation contributes importantly to DHBV infectivity.
It is most likely required for an early step of the life cycle
involving the entry or uncoating of virus particles.
-!- PTM: Phosphorylated on pre-S domain for about 50% of L proteins,
the L chains with internal pre-S region (Li-HBsAg).
-!- SIMILARITY: Belongs to the avihepadnavirus major surface antigen
family. {ECO:0000305}.
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EMBL; X60213; CAA42770.1; ALT_SEQ; Genomic_DNA.
EMBL; X60213; CAA42771.1; -; Genomic_DNA.
EMBL; X60213; CAA42772.1; ALT_SEQ; Genomic_DNA.
RefSeq; NP_039823.1; NC_001344.1.
RefSeq; NP_039824.1; NC_001344.1.
RefSeq; NP_039826.1; NC_001344.1.
SMR; Q66405; -.
GeneID; 2546411; -.
GeneID; 2546412; -.
GeneID; 2546415; -.
KEGG; vg:2546411; -.
KEGG; vg:2546412; -.
KEGG; vg:2546415; -.
OrthoDB; VOG090000AH; -.
Proteomes; UP000009098; Genome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
InterPro; IPR000349; HBV_HBSAG.
Pfam; PF00695; vMSA; 1.
3: Inferred from homology;
Alternative initiation; Complete proteome;
Fusion of virus membrane with host membrane; Glycoprotein;
Host-virus interaction; Lipoprotein; Membrane; Myristate;
Phosphoprotein; Reference proteome; Transmembrane;
Transmembrane helix; Viral attachment to host cell;
Viral penetration into host cytoplasm; Virion;
Virus entry into host cell.
INIT_MET 1 1 Removed; by host. {ECO:0000250}.
CHAIN 2 330 Large envelope protein.
/FTId=PRO_0000397681.
CHAIN 164 ?240 Truncated S protein.
/FTId=PRO_0000397682.
TOPO_DOM 2 238 Cytoplasmic; in internal conformation.
{ECO:0000255}.
TOPO_DOM 2 165 Extracellular; in external conformation.
{ECO:0000255}.
TRANSMEM 166 186 Helical. {ECO:0000255}.
TOPO_DOM 187 238 Cytoplasmic; in external conformation.
{ECO:0000255}.
TRANSMEM 239 259 Helical. {ECO:0000255}.
TOPO_DOM 260 292 Extracellular. {ECO:0000255}.
TRANSMEM 293 313 Helical. {ECO:0000255}.
TOPO_DOM 314 330 Cytoplasmic. {ECO:0000255}.
REGION 2 163 Pre-S. {ECO:0000250}.
REGION 166 186 TM1. {ECO:0000250}.
REGION 239 259 TM2. {ECO:0000250}.
REGION 293 313 TM3. {ECO:0000250}.
COMPBIAS 160 163 Poly-Lys.
SITE ?240 ?241 Cleavage; by host. {ECO:0000255}.
LIPID 2 2 N-myristoyl glycine; by host.
{ECO:0000250}.
CARBOHYD 262 262 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
VAR_SEQ 1 163 Missing (in isoform S). {ECO:0000305}.
/FTId=VSP_039691.
SEQUENCE 330 AA; 36959 MW; 7CE142013BB8D9F4 CRC64;
MGQQPAKSMD VRRIEGGELL LNQLAGRMIP KGTVTWSGKF PTIDHLLDHV QTMEEVNTLQ
QQGAWPAGAG RRLGLTNPTP HETPQPQWTP EEDQKAREAF RRYQEERPPE TTTIAPTSPT
PWKLQPGDDP LLENKSLLET HPLYQNPEPA VPVIKTPPLK KKKMPGTFGG ILAGLIGLLV
SFFLLIKILE ILRRLDWWWI SLSSPKGKMQ CAFQDTGAQI SQHYVGSCPW GCPGFLWTYL
RLFIIFLLIL LVAAGLLYLT DNMSIILEKL QWESVSVLFS SISSLLPSDQ KSLVALMFGL
LLIWMTSSSA TQTLVTLTQL ATLSVLFYKN


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