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Late cornified envelope protein 2B (Late envelope protein 10) (Skin-specific protein Xp5) (Small proline-rich-like epidermal differentiation complex protein 1B)

 LCE2B_HUMAN             Reviewed;         110 AA.
O14633; Q5TA80;
09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
12-SEP-2018, entry version 114.
RecName: Full=Late cornified envelope protein 2B;
AltName: Full=Late envelope protein 10;
AltName: Full=Skin-specific protein Xp5;
AltName: Full=Small proline-rich-like epidermal differentiation complex protein 1B;
Name=LCE2B; Synonyms=LEP10, SPRL1B, XP5;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Skin;
PubMed=9344646; DOI=10.1006/geno.1997.4952;
Zhao X.P., Elder J.T.;
"Positional cloning of novel skin-specific genes from the human
epidermal differentiation complex.";
Genomics 45:250-258(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NOMENCLATURE, TISSUE SPECIFICITY, AND INDUCTION BY CALCIUM AND UVB.
PubMed=15854049; DOI=10.1111/j.0022-202X.2005.23699.x;
Jackson B., Tilli C.L., Hardman M., Avilion A., Macleod M.,
Ashcroft G., Byrne C.;
"Late cornified envelope family in differentiating epithelia
-- response to calcium and ultraviolet irradiation.";
J. Invest. Dermatol. 124:1062-1070(2005).
-!- FUNCTION: Precursors of the cornified envelope of the stratum
corneum.
-!- INTERACTION:
Q6UY14-3:ADAMTSL4; NbExp=4; IntAct=EBI-11478468, EBI-10173507;
A8MQ03:CYSRT1; NbExp=4; IntAct=EBI-11478468, EBI-3867333;
P60410:KRTAP10-8; NbExp=4; IntAct=EBI-11478468, EBI-10171774;
P60328:KRTAP12-3; NbExp=4; IntAct=EBI-11478468, EBI-11953334;
Q9BQ66:KRTAP4-12; NbExp=4; IntAct=EBI-11478468, EBI-739863;
Q9BYR5:KRTAP4-2; NbExp=4; IntAct=EBI-11478468, EBI-10172511;
Q9BYR3:KRTAP4-4; NbExp=4; IntAct=EBI-11478468, EBI-11958132;
Q701N4:KRTAP5-2; NbExp=4; IntAct=EBI-11478468, EBI-11958178;
P26371:KRTAP5-9; NbExp=4; IntAct=EBI-11478468, EBI-3958099;
Q3LI66:KRTAP6-2; NbExp=4; IntAct=EBI-11478468, EBI-11962084;
Q9BYQ0:KRTAP9-8; NbExp=4; IntAct=EBI-11478468, EBI-11958364;
Q5T7P2:LCE1A; NbExp=4; IntAct=EBI-11478468, EBI-11962058;
Q5T754:LCE1F; NbExp=4; IntAct=EBI-11478468, EBI-11958008;
Q5TA81:LCE2C; NbExp=4; IntAct=EBI-11478468, EBI-11973993;
Q5TA78:LCE4A; NbExp=4; IntAct=EBI-11478468, EBI-10246358;
-!- TISSUE SPECIFICITY: Skin-specific. Expression was readily detected
in adult trunk skin, adult arm skin, fetal skin, penal skin,
vulva, esophagus and tongue. Not expressed in the cervix, rectum,
lung, colon, or placenta. {ECO:0000269|PubMed:15854049,
ECO:0000269|PubMed:9344646}.
-!- INDUCTION: By calcium and UVB. {ECO:0000269|PubMed:15854049}.
-!- MISCELLANEOUS: Belongs to the LCE cluster present on 1q21.
-!- SIMILARITY: Belongs to the LCE family. {ECO:0000305}.
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EMBL; AF005080; AAB83960.1; -; mRNA.
EMBL; AL139247; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471121; EAW53372.1; -; Genomic_DNA.
CCDS; CCDS1020.1; -.
RefSeq; NP_055172.1; NM_014357.4.
UniGene; Hs.234766; -.
ProteinModelPortal; O14633; -.
IntAct; O14633; 62.
MINT; O14633; -.
STRING; 9606.ENSP00000357769; -.
BioMuta; LCE2B; -.
PaxDb; O14633; -.
PeptideAtlas; O14633; -.
PRIDE; O14633; -.
ProteomicsDB; 48131; -.
DNASU; 26239; -.
Ensembl; ENST00000368780; ENSP00000357769; ENSG00000159455.
GeneID; 26239; -.
KEGG; hsa:26239; -.
UCSC; uc001fai.4; human.
CTD; 26239; -.
EuPathDB; HostDB:ENSG00000159455.8; -.
GeneCards; LCE2B; -.
H-InvDB; HIX0178037; -.
HGNC; HGNC:16610; LCE2B.
MIM; 612610; gene.
neXtProt; NX_O14633; -.
OpenTargets; ENSG00000159455; -.
PharmGKB; PA38170; -.
GeneTree; ENSGT00730000111502; -.
HOGENOM; HOG000113291; -.
InParanoid; O14633; -.
OMA; CCLFSHR; -.
Reactome; R-HSA-6809371; Formation of the cornified envelope.
GenomeRNAi; 26239; -.
PRO; PR:O14633; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000159455; Expressed in 73 organ(s), highest expression level in skin of leg.
CleanEx; HS_LCE2B; -.
Genevisible; O14633; HS.
GO; GO:0001533; C:cornified envelope; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005198; F:structural molecule activity; IBA:GO_Central.
GO; GO:0008544; P:epidermis development; NAS:UniProtKB.
GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
GO; GO:0030216; P:keratinocyte differentiation; IBA:GO_Central.
GO; GO:0018149; P:peptide cross-linking; IBA:GO_Central.
InterPro; IPR028205; LCE.
InterPro; IPR026075; SPRR/LCE.
PANTHER; PTHR23263; PTHR23263; 1.
Pfam; PF14672; LCE; 1.
1: Evidence at protein level;
Complete proteome; Keratinization; Polymorphism; Reference proteome.
CHAIN 1 110 Late cornified envelope protein 2B.
/FTId=PRO_0000084366.
COMPBIAS 3 110 Cys-rich.
COMPBIAS 12 42 Pro-rich.
VARIANT 51 51 I -> S (in dbSNP:rs3737859).
/FTId=VAR_053482.
VARIANT 83 83 R -> Q (in dbSNP:rs28391399).
/FTId=VAR_062119.
SEQUENCE 110 AA; 11219 MW; 861096815ED8D9B3 CRC64;
MSCQQNQQQC QPPPKCPPKC TPKCPPKCPP KCLPQCPAPC SPAVSSCCGP ISGGCCGPSS
GGCCNSGAGG CCLSHHRPRL FHRRRHQSPD CCESEPSGGS GCCHSSGGCC


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