Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Left-right determination factor 1 (Left-right determination factor B) (Protein lefty-1) (Protein lefty-B)

 LFTY1_HUMAN             Reviewed;         366 AA.
O75610; B2R7U0; Q53H67; Q5TE94;
21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
20-DEC-2017, entry version 153.
RecName: Full=Left-right determination factor 1;
AltName: Full=Left-right determination factor B;
AltName: Full=Protein lefty-1;
AltName: Full=Protein lefty-B;
Flags: Precursor;
Name=LEFTY1; Synonyms=LEFTB, LEFTYB; ORFNames=UNQ278/PRO317;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Teratocarcinoma;
PubMed=10053005; DOI=10.1086/302289;
Kosaki K., Bassi M.T., Kosaki R., Lewin M., Belmont J., Schauer G.,
Casey B.;
"Characterization and mutation analysis of human LEFTY A and LEFTY B,
homologues of murine genes implicated in left-right axis
development.";
Am. J. Hum. Genet. 64:712-721(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-92 AND
GLN-142.
TISSUE=Colon;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-92 AND
GLN-142.
TISSUE=Colon;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas, and Spleen;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Required for left-right axis determination as a
regulator of LEFTY2 and NODAL.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: The processing of the protein may also occur at the second R-
X-X-R site located at AA 132-135. Processing appears to be
regulated in a cell-type specific manner.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF081507; AAC33967.1; -; Genomic_DNA.
EMBL; AF081504; AAC33967.1; JOINED; Genomic_DNA.
EMBL; AF081505; AAC33967.1; JOINED; Genomic_DNA.
EMBL; AF081506; AAC33967.1; JOINED; Genomic_DNA.
EMBL; AF081512; AAD48144.1; -; mRNA.
EMBL; AY358873; AAQ89232.1; -; mRNA.
EMBL; AK313115; BAG35937.1; -; mRNA.
EMBL; AK222714; BAD96434.1; -; mRNA.
EMBL; AL117348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC027883; AAH27883.1; -; mRNA.
CCDS; CCDS1548.1; -.
RefSeq; NP_066277.1; NM_020997.3.
UniGene; Hs.656214; -.
ProteinModelPortal; O75610; -.
SMR; O75610; -.
BioGrid; 115881; 2.
STRING; 9606.ENSP00000272134; -.
iPTMnet; O75610; -.
PhosphoSitePlus; O75610; -.
BioMuta; LEFTY1; -.
EPD; O75610; -.
PaxDb; O75610; -.
PeptideAtlas; O75610; -.
PRIDE; O75610; -.
DNASU; 10637; -.
Ensembl; ENST00000272134; ENSP00000272134; ENSG00000243709.
GeneID; 10637; -.
KEGG; hsa:10637; -.
UCSC; uc001hpo.3; human.
CTD; 10637; -.
DisGeNET; 10637; -.
EuPathDB; HostDB:ENSG00000243709.1; -.
GeneCards; LEFTY1; -.
HGNC; HGNC:6552; LEFTY1.
HPA; HPA047883; -.
HPA; HPA056210; -.
MIM; 603037; gene.
neXtProt; NX_O75610; -.
OpenTargets; ENSG00000243709; -.
PharmGKB; PA30332; -.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00390000010056; -.
HOGENOM; HOG000113317; -.
HOVERGEN; HBG074429; -.
InParanoid; O75610; -.
KO; K04668; -.
OMA; MAIPTHV; -.
OrthoDB; EOG091G09EN; -.
PhylomeDB; O75610; -.
TreeFam; TF106462; -.
Reactome; R-HSA-1181150; Signaling by NODAL.
Reactome; R-HSA-1433617; Regulation of signaling by NODAL.
SIGNOR; O75610; -.
ChiTaRS; LEFTY1; human.
GenomeRNAi; 10637; -.
PMAP-CutDB; O75610; -.
PRO; PR:O75610; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000243709; -.
CleanEx; HS_LEFTY1; -.
ExpressionAtlas; O75610; baseline and differential.
Genevisible; O75610; HS.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
GO; GO:0048468; P:cell development; IBA:GO_Central.
GO; GO:0016049; P:cell growth; IEA:InterPro.
GO; GO:0007368; P:determination of left/right symmetry; ISS:BHF-UCL.
GO; GO:0003007; P:heart morphogenesis; ISS:BHF-UCL.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:ProtInc.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR003942; LRDF.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
PIRSF; PIRSF037402; TGFb4; 1.
PRINTS; PR01427; TGFBETA4.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Complete proteome; Cytokine; Developmental protein; Disulfide bond;
Glycoprotein; Growth factor; Polymorphism; Reference proteome;
Secreted; Signal.
SIGNAL 1 21 {ECO:0000255}.
PROPEP 22 76 Or 135. {ECO:0000255}.
/FTId=PRO_0000033810.
CHAIN 77 366 Left-right determination factor 1.
/FTId=PRO_0000033811.
CARBOHYD 158 158 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 251 264 {ECO:0000250}.
DISULFID 263 316 {ECO:0000250}.
DISULFID 293 351 {ECO:0000250}.
DISULFID 297 353 {ECO:0000250}.
VARIANT 57 57 V -> M (in dbSNP:rs35273824).
/FTId=VAR_052567.
VARIANT 92 92 L -> S (in dbSNP:rs145431393).
{ECO:0000269|PubMed:14702039,
ECO:0000269|Ref.4}.
/FTId=VAR_070888.
VARIANT 142 142 R -> Q (in dbSNP:rs191758097).
{ECO:0000269|PubMed:14702039,
ECO:0000269|Ref.4}.
/FTId=VAR_070889.
VARIANT 322 322 D -> A (in dbSNP:rs360057).
/FTId=VAR_024231.
SEQUENCE 366 AA; 40880 MW; BCF900C71ED9AA2A CRC64;
MQPLWLCWAL WVLPLASPGA ALTGEQLLGS LLRQLQLKEV PTLDRADMEE LVIPTHVRAQ
YVALLQRSHG DRSRGKRFSQ SFREVAGRFL ALEASTHLLV FGMEQRLPPN SELVQAVLRL
FQEPVPKAAL HRHGRLSPRS ARARVTVEWL RVRDDGSNRT SLIDSRLVSV HESGWKAFDV
TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL
DLGDYGAQGD CDPEAPMTEG TRCCRQEMYI DLQGMKWAEN WVLEPPGFLA YECVGTCRQP
PEALAFKWPF LGPRQCIASE TDSLPMIVSI KEGGRTRPQV VSLPNMRVQK CSCASDGALV
PRRLQP


Related products :

Catalog number Product name Quantity
Lefty1-1765M Protein: Recombinant Mouse Left Right Determination Factor 1 25ug
Lefty1-1765M Protein Recombinant Mouse Left Right Determination Factor 1 25ug
pro-962 Recombinant Human Left-Right Determination Factor 1 1ug
RPR-962 Recombinant Human Left-Right Determination Factor 1 1ug
pro-962 Recombinant Human Left-Right Determination Factor 1 50
pro-962 Recombinant Human Left-Right Determination Factor 1 5ug
PTPRO_MOUSE Mouse ELISA Kit FOR Left-right determination factor 1 96T
UB-E10257 Rat Left per Right Determination Factor 1(LEFTY1)ELISA kit 96T
E0559r Mouse ELISA Kit FOR Left-right determination factor 1 96T
LFTY2_HUMAN Human ELISA Kit FOR Left-right determination factor 2 96T
LEKR1 LEFTY1 Gene left-right determination factor 1
LFTY1_HUMAN Human ELISA Kit FOR Left-right determination factor 1 96T
LELP1 LEFTY2 Gene left-right determination factor 2
201-20-3086 LEFTY2{left-right determination factor 2}rabbit.pAb 0.2ml
UB-E00003 Human Left per Right Determination Factor 1(LEFTY1)ELISA Kit 96T
CSB-EL012857MO Mouse Left-right determination factor 1(LEFTY1) ELISA kit 96T
CSB-EL012857HU Human Left-right determination factor 1(LEFTY1) ELISA kit 96T
UB-E20898 Mouse Left per Right Determination Factor 1(LEFTY1)ELISA kit 96T
CSB-EL012858MO Mouse Left-right determination factor 2(LEFTY2) ELISA kit 96T
CSB-EL012857MO Mouse Left-right determination factor 1(LEFTY1) ELISA kit SpeciesMouse 96T
GS-1204a left-right determination factor 2 primary antibody, Host: Rabbit 200ul
CSB-E13590h Human left-right determination factor 2(LEFTY2) ELISA Kit SpeciesHuman 96T
CSB-EL012858MO Mouse Left-right determination factor 2(LEFTY2) ELISA kit SpeciesMouse 96T
CSB-EL012857HU Human Left-right determination factor 1(LEFTY1) ELISA kit SpeciesHuman 96T
LFTY2_MOUSE ELISA Kit FOR Left-right determination factor 2; organism: Mouse; gene name: Lefty2 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur