Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Left-right determination factor 1 (Left-right determination factor B) (Protein lefty-1) (Protein lefty-B)

 LFTY1_HUMAN             Reviewed;         366 AA.
O75610; B2R7U0; Q53H67; Q5TE94;
21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
16-JAN-2019, entry version 159.
RecName: Full=Left-right determination factor 1;
AltName: Full=Left-right determination factor B;
AltName: Full=Protein lefty-1;
AltName: Full=Protein lefty-B;
Flags: Precursor;
Name=LEFTY1; Synonyms=LEFTB, LEFTYB; ORFNames=UNQ278/PRO317;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
TISSUE=Teratocarcinoma;
PubMed=10053005; DOI=10.1086/302289;
Kosaki K., Bassi M.T., Kosaki R., Lewin M., Belmont J., Schauer G.,
Casey B.;
"Characterization and mutation analysis of human LEFTY A and LEFTY B,
homologues of murine genes implicated in left-right axis
development.";
Am. J. Hum. Genet. 64:712-721(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-92 AND
GLN-142.
TISSUE=Colon;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS SER-92 AND
GLN-142.
TISSUE=Colon;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas, and Spleen;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Required for left-right axis determination as a
regulator of LEFTY2 and NODAL.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: The processing of the protein may also occur at the second R-
X-X-R site located at AA 132-135. Processing appears to be
regulated in a cell-type specific manner.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF081507; AAC33967.1; -; Genomic_DNA.
EMBL; AF081504; AAC33967.1; JOINED; Genomic_DNA.
EMBL; AF081505; AAC33967.1; JOINED; Genomic_DNA.
EMBL; AF081506; AAC33967.1; JOINED; Genomic_DNA.
EMBL; AF081512; AAD48144.1; -; mRNA.
EMBL; AY358873; AAQ89232.1; -; mRNA.
EMBL; AK313115; BAG35937.1; -; mRNA.
EMBL; AK222714; BAD96434.1; -; mRNA.
EMBL; AL117348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC027883; AAH27883.1; -; mRNA.
CCDS; CCDS1548.1; -.
RefSeq; NP_066277.1; NM_020997.3.
UniGene; Hs.656214; -.
ProteinModelPortal; O75610; -.
SMR; O75610; -.
BioGrid; 115881; 2.
STRING; 9606.ENSP00000272134; -.
iPTMnet; O75610; -.
PhosphoSitePlus; O75610; -.
BioMuta; LEFTY1; -.
EPD; O75610; -.
jPOST; O75610; -.
PaxDb; O75610; -.
PeptideAtlas; O75610; -.
PRIDE; O75610; -.
ProteomicsDB; 50119; -.
DNASU; 10637; -.
Ensembl; ENST00000272134; ENSP00000272134; ENSG00000243709.
GeneID; 10637; -.
KEGG; hsa:10637; -.
UCSC; uc001hpo.3; human.
CTD; 10637; -.
DisGeNET; 10637; -.
EuPathDB; HostDB:ENSG00000243709.1; -.
GeneCards; LEFTY1; -.
HGNC; HGNC:6552; LEFTY1.
HPA; HPA047883; -.
HPA; HPA056210; -.
MIM; 603037; gene.
neXtProt; NX_O75610; -.
OpenTargets; ENSG00000243709; -.
PharmGKB; PA30332; -.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00390000010056; -.
HOGENOM; HOG000113317; -.
HOVERGEN; HBG074429; -.
InParanoid; O75610; -.
KO; K04668; -.
OMA; MAIPTHV; -.
OrthoDB; 751948at2759; -.
PhylomeDB; O75610; -.
TreeFam; TF106462; -.
Reactome; R-HSA-1181150; Signaling by NODAL.
Reactome; R-HSA-1433617; Regulation of signaling by NODAL.
SIGNOR; O75610; -.
ChiTaRS; LEFTY1; human.
GenomeRNAi; 10637; -.
PMAP-CutDB; O75610; -.
PRO; PR:O75610; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000243709; Expressed in 81 organ(s), highest expression level in transverse colon.
CleanEx; HS_LEFTY1; -.
ExpressionAtlas; O75610; baseline and differential.
Genevisible; O75610; HS.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:0048468; P:cell development; IBA:GO_Central.
GO; GO:0007368; P:determination of left/right symmetry; ISS:BHF-UCL.
GO; GO:0003007; P:heart morphogenesis; ISS:BHF-UCL.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:BHF-UCL.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:ProtInc.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR003942; LRDF.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
PIRSF; PIRSF037402; TGFb4; 1.
PRINTS; PR01427; TGFBETA4.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Complete proteome; Cytokine; Developmental protein; Disulfide bond;
Glycoprotein; Growth factor; Polymorphism; Reference proteome;
Secreted; Signal.
SIGNAL 1 21 {ECO:0000255}.
PROPEP 22 76 Or 135. {ECO:0000255}.
/FTId=PRO_0000033810.
CHAIN 77 366 Left-right determination factor 1.
/FTId=PRO_0000033811.
CARBOHYD 158 158 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 251 264 {ECO:0000250}.
DISULFID 263 316 {ECO:0000250}.
DISULFID 293 351 {ECO:0000250}.
DISULFID 297 353 {ECO:0000250}.
VARIANT 57 57 V -> M (in dbSNP:rs35273824).
/FTId=VAR_052567.
VARIANT 92 92 L -> S (in dbSNP:rs145431393).
{ECO:0000269|PubMed:14702039,
ECO:0000269|Ref.4}.
/FTId=VAR_070888.
VARIANT 142 142 R -> Q (in dbSNP:rs191758097).
{ECO:0000269|PubMed:14702039,
ECO:0000269|Ref.4}.
/FTId=VAR_070889.
VARIANT 322 322 D -> A (in dbSNP:rs360057).
/FTId=VAR_024231.
SEQUENCE 366 AA; 40880 MW; BCF900C71ED9AA2A CRC64;
MQPLWLCWAL WVLPLASPGA ALTGEQLLGS LLRQLQLKEV PTLDRADMEE LVIPTHVRAQ
YVALLQRSHG DRSRGKRFSQ SFREVAGRFL ALEASTHLLV FGMEQRLPPN SELVQAVLRL
FQEPVPKAAL HRHGRLSPRS ARARVTVEWL RVRDDGSNRT SLIDSRLVSV HESGWKAFDV
TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL
DLGDYGAQGD CDPEAPMTEG TRCCRQEMYI DLQGMKWAEN WVLEPPGFLA YECVGTCRQP
PEALAFKWPF LGPRQCIASE TDSLPMIVSI KEGGRTRPQV VSLPNMRVQK CSCASDGALV
PRRLQP


Related products :

Catalog number Product name Quantity
Lefty1-1765M Protein: Recombinant Mouse Left Right Determination Factor 1 25ug
Lefty1-1765M Protein Recombinant Mouse Left Right Determination Factor 1 25ug
pro-962 Recombinant Human Left-Right Determination Factor 1 1ug
RPR-962 Recombinant Human Left-Right Determination Factor 1 1ug
pro-962 Recombinant Human Left-Right Determination Factor 1 50
pro-962 Recombinant Human Left-Right Determination Factor 1 5ug
PTPRO_MOUSE Mouse ELISA Kit FOR Left-right determination factor 1 96T
UB-E10257 Rat Left per Right Determination Factor 1(LEFTY1)ELISA kit 96T
E0559r Mouse ELISA Kit FOR Left-right determination factor 1 96T
LFTY2_HUMAN Human ELISA Kit FOR Left-right determination factor 2 96T
LEKR1 LEFTY1 Gene left-right determination factor 1
LFTY1_HUMAN Human ELISA Kit FOR Left-right determination factor 1 96T
LELP1 LEFTY2 Gene left-right determination factor 2
201-20-3086 LEFTY2{left-right determination factor 2}rabbit.pAb 0.2ml
UB-E00003 Human Left per Right Determination Factor 1(LEFTY1)ELISA Kit 96T
CSB-EL012857MO Mouse Left-right determination factor 1(LEFTY1) ELISA kit 96T
CSB-EL012857HU Human Left-right determination factor 1(LEFTY1) ELISA kit 96T
UB-E20898 Mouse Left per Right Determination Factor 1(LEFTY1)ELISA kit 96T
CSB-EL012858MO Mouse Left-right determination factor 2(LEFTY2) ELISA kit 96T
CSB-EL012857MO Mouse Left-right determination factor 1(LEFTY1) ELISA kit SpeciesMouse 96T
GS-1204a left-right determination factor 2 primary antibody, Host: Rabbit 200ul
CSB-E13590h Human left-right determination factor 2(LEFTY2) ELISA Kit SpeciesHuman 96T
CSB-EL012858MO Mouse Left-right determination factor 2(LEFTY2) ELISA kit SpeciesMouse 96T
CSB-EL012857HU Human Left-right determination factor 1(LEFTY1) ELISA kit SpeciesHuman 96T
LFTY2_MOUSE ELISA Kit FOR Left-right determination factor 2; organism: Mouse; gene name: Lefty2 96T


https://antibody-antibodies.com/ | https://gentaur.com/ | https://gen-script.com/ | https://diagenox.com/ | https://clonagen.com/ | http://gentaursearch.com/ | http://gentaurpub.com/ | https://gentaur-online.com/ | http://anti-anti-pdf.com/ | http://gentaur-worldwide.com/

 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur