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Left-right determination factor 2 (Left-right determination factor B) (Protein lefty-2) (Protein lefty-B)

 LFTY2_MOUSE             Reviewed;         368 AA.
P57785; Q8BMF7;
21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
06-FEB-2007, sequence version 2.
25-APR-2018, entry version 119.
RecName: Full=Left-right determination factor 2;
AltName: Full=Left-right determination factor B;
AltName: Full=Protein lefty-2;
AltName: Full=Protein lefty-B;
Flags: Precursor;
Name=Lefty2; Synonyms=Leftb;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=9348041; DOI=10.1046/j.1365-2443.1997.1400338.x;
Meno C., Ito Y., Saijoh Y., Matsuda Y., Tashiro K., Kuhara S.,
Hamada H.;
"Two closely-related left-right asymmetrically expressed genes, lefty-
1 and lefty-2: their distinct expression domains, chromosomal linkage
and direct neuralizing activity in Xenopus embryos.";
Genes Cells 2:513-524(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Testis;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=129/Sv X 129SvCp; TISSUE=Embryonic stem cell;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Required for left-right asymmetry determination of organ
systems in mammals.
-!- SUBCELLULAR LOCATION: Secreted.
-!- DEVELOPMENTAL STAGE: At the primitive streak stage (E7.0),
expressed in the emerging mesoderm. By E8.0, expressed exclusively
on the left side of developing embryos with expression
predominantly in the lateral-plate mesoderm (LPM). Weak expression
in the prospective floor plate (PFP).
-!- PTM: The processing of the protein may also occur at the second R-
X-X-R site located at AA 132-135. Processing appears to be
regulated in a cell-type specific manner.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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EMBL; AK031621; BAC27483.1; -; mRNA.
EMBL; BC066224; AAH66224.1; -; mRNA.
CCDS; CCDS15575.1; -.
RefSeq; NP_796073.1; NM_177099.4.
UniGene; Mm.87078; -.
ProteinModelPortal; P57785; -.
STRING; 10090.ENSMUSP00000082952; -.
iPTMnet; P57785; -.
PhosphoSitePlus; P57785; -.
PaxDb; P57785; -.
PeptideAtlas; P57785; -.
PRIDE; P57785; -.
Ensembl; ENSMUST00000085797; ENSMUSP00000082952; ENSMUSG00000066652.
GeneID; 320202; -.
KEGG; mmu:320202; -.
UCSC; uc007dwu.1; mouse.
CTD; 7044; -.
MGI; MGI:2443573; Lefty2.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00390000010056; -.
HOGENOM; HOG000113317; -.
HOVERGEN; HBG074429; -.
InParanoid; P57785; -.
KO; K04668; -.
OMA; MAIPTHV; -.
OrthoDB; EOG091G09EN; -.
PhylomeDB; P57785; -.
TreeFam; TF106462; -.
Reactome; R-MMU-114608; Platelet degranulation.
PRO; PR:P57785; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000066652; -.
CleanEx; MM_LEFTY2; -.
Genevisible; P57785; MM.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005160; F:transforming growth factor beta receptor binding; IBA:GO_Central.
GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
GO; GO:0048468; P:cell development; IBA:GO_Central.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR003942; LRDF.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
PIRSF; PIRSF037402; TGFb4; 1.
PRINTS; PR01427; TGFBETA4.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Complete proteome; Cytokine;
Developmental protein; Disulfide bond; Glycoprotein; Growth factor;
Reference proteome; Secreted; Signal.
SIGNAL 1 21 {ECO:0000250}.
PROPEP 22 77 Or 135. {ECO:0000255}.
/FTId=PRO_0000033812.
CHAIN 78 368 Left-right determination factor 2.
/FTId=PRO_0000033813.
CARBOHYD 158 158 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 253 266 {ECO:0000250}.
DISULFID 265 318 {ECO:0000250}.
DISULFID 295 353 {ECO:0000250}.
DISULFID 299 355 {ECO:0000250}.
CONFLICT 82 82 F -> L (in Ref. 1). {ECO:0000305}.
SEQUENCE 368 AA; 41175 MW; 5BEE8B2F1305A44B CRC64;
MKSLWLCWAL WVLPLAGPGA AMTEEQVLSS LLQQLQLSQA PTLDSADVEE MAIPTHVRSQ
YVALLQGSHA DRSRGKRFSQ NFREVAGRFL MSETSTHLLV FGMEQRLPPN SELVQAVLRL
FQEPVPRTAL RRFERLSPHS ARARVTIEWL RVREDGSNRT ALIDSRLVSI HESGWKAFDV
TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP GTWSAHKLVR FAAQGTPDGK GQGEPQLELH
TLDLKDYGAQ GNCDPEVPVT EGTRCCRQEM YLDLQGMKWA ENWILEPPGF LTYECVGSCL
QLPESLTIGW PFLGPRQCVA SEMTSLPMIV SVKEGGRTRP QVVSLPNMRV QTCSCASDGA
LIPRGIDL


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