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Leptin (Obesity factor)

 LEP_PANTR               Reviewed;         146 AA.
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
16-JAN-2019, entry version 97.
RecName: Full=Leptin;
AltName: Full=Obesity factor;
Name=LEP; Synonyms=OB;
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
Schoner B., Basinski M.B., Smith D.P., Hsiung H.M., Zhang X.,
Rockey P.K., Rosteck P.R.;
"Cloning of obese genes from different species: a comparison of the
gene structures and the sequences of the obese gene products,
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Key player in the regulation of energy balance and body
weight control. Once released into the circulation, has central
and peripheral effects by binding LEPR, found in many tissues,
which results in the activation of several major signaling
pathways (By similarity). In the hypothalamus, acts as an
appetite-regulating factor that induces a decrease in food intake
and an increase in energy consumption by inducing anorexinogenic
factors and suppressing orexigenic neuropeptides, also regulates
bone mass and secretion of hypothalamo-pituitary-adrenal hormones.
In the periphery, increases basal metabolism, influences
reproductive function, regulates pancreatic beta-cell function and
insulin secretion, is pro-angiogenic for endothelial cell and
affects innate and adaptive immunity (By similarity). In the
arcuate nucleus of the hypothalamus, activates by depolarization
POMC neurons inducing FOS and SOCS3 expression to release
anorexigenic peptides and inhibits by hyperpolarization NPY
neurons inducing SOCS3 with a consequent reduction on release of
orexigenic peptides (By similarity). In addition to its known
satiety inducing effect, has a modulatory role in nutrient
absorption. In the intestine, reduces glucose absorption by
enterocytes by activating PKC and leading to a sequential
activation of p38, PI3K and ERK signaling pathways which exerts an
inhibitory effect on glucose absorption (By similarity). Acts as a
growth factor on certain tissues, through the activation of
different signaling pathways increases expression of genes
involved in cell cycle regulation such as CCND1, via JAK2-STAT3
pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By
similarity). May also play an apoptotic role via JAK2-STAT3
pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has
mitogenic activity on vascular endothelial cells and plays a role
in matrix remodeling by regulating the expression of matrix
metalloproteinases (MMPs) and tissue inhibitors of
metalloproteinases (TIMPs). In innate immunity, modulates the
activity and function of neutrophils by increasing chemotaxis and
the secretion of oxygen radicals. Increases phagocytosis by
macrophages and enhances secretion of pro-inflammatory mediators.
Increases cytotoxic ability of NK cells. Plays a pro-inflammatory
role, in synergy with IL1B, by inducing NOS2 wich promotes the
production of IL6, IL8 and Prostaglandin E2, through a signaling
pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (By
similarity). In adaptive immunity, promotes the switch of memory
T-cells towards T helper-1 cell immune responses (By similarity).
Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy
during TCR (T-cell receptor) stimulation, through MTOR signaling
pathway activation and BCL2 up-regulation (By similarity).
{ECO:0000250|UniProtKB:P41159, ECO:0000250|UniProtKB:P41160,
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P41159}.
-!- SIMILARITY: Belongs to the leptin family. {ECO:0000305}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; U96450; AAB54023.1; -; mRNA.
RefSeq; NP_001180601.1; NM_001193672.1.
UniGene; Ptr.6237; -.
ProteinModelPortal; O02750; -.
SMR; O02750; -.
STRING; 9598.ENSPTRP00000033657; -.
PaxDb; O02750; -.
PRIDE; O02750; -.
GeneID; 449638; -.
KEGG; ptr:449638; -.
CTD; 3952; -.
eggNOG; ENOG410IVT0; Eukaryota.
HOGENOM; HOG000252923; -.
HOVERGEN; HBG007860; -.
InParanoid; O02750; -.
KO; K05424; -.
OrthoDB; 1350528at2759; -.
Proteomes; UP000002277; Unplaced.
GO; GO:0005615; C:extracellular space; ISS:HGNC.
GO; GO:0005179; F:hormone activity; IBA:GO_Central.
GO; GO:0051428; F:peptide hormone receptor binding; IBA:GO_Central.
GO; GO:1990051; P:activation of protein kinase C activity; ISS:UniProtKB.
GO; GO:0008343; P:adult feeding behavior; ISS:HGNC.
GO; GO:0098868; P:bone growth; ISS:UniProtKB.
GO; GO:0044320; P:cellular response to leptin stimulus; ISS:UniProtKB.
GO; GO:0006112; P:energy reserve metabolic process; IBA:GO_Central.
GO; GO:0032615; P:interleukin-12 production; ISS:UniProtKB.
GO; GO:0032635; P:interleukin-6 production; ISS:UniProtKB.
GO; GO:0072604; P:interleukin-6 secretion; ISS:UniProtKB.
GO; GO:0072606; P:interleukin-8 secretion; ISS:UniProtKB.
GO; GO:0050892; P:intestinal absorption; ISS:UniProtKB.
GO; GO:0033210; P:leptin-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0006629; P:lipid metabolic process; IBA:GO_Central.
GO; GO:0032099; P:negative regulation of appetite; ISS:HGNC.
GO; GO:0038108; P:negative regulation of appetite by leptin-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0010507; P:negative regulation of autophagy; ISS:UniProtKB.
GO; GO:0046325; P:negative regulation of glucose import; ISS:UniProtKB.
GO; GO:0006909; P:phagocytosis; ISS:UniProtKB.
GO; GO:0046427; P:positive regulation of JAK-STAT cascade; ISS:UniProtKB.
GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
GO; GO:1900745; P:positive regulation of p38MAPK cascade; ISS:UniProtKB.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISS:UniProtKB.
GO; GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB.
GO; GO:0032008; P:positive regulation of TOR signaling; ISS:UniProtKB.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
GO; GO:0032310; P:prostaglandin secretion; ISS:UniProtKB.
GO; GO:0045765; P:regulation of angiogenesis; ISS:UniProtKB.
GO; GO:0046850; P:regulation of bone remodeling; ISS:UniProtKB.
GO; GO:0090335; P:regulation of brown fat cell differentiation; ISS:UniProtKB.
GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
GO; GO:1900015; P:regulation of cytokine production involved in inflammatory response; ISS:UniProtKB.
GO; GO:0001936; P:regulation of endothelial cell proliferation; ISS:UniProtKB.
GO; GO:0032814; P:regulation of natural killer cell activation; ISS:UniProtKB.
GO; GO:0042269; P:regulation of natural killer cell mediated cytotoxicity; ISS:UniProtKB.
GO; GO:0032817; P:regulation of natural killer cell proliferation; ISS:UniProtKB.
GO; GO:0050999; P:regulation of nitric-oxide synthase activity; ISS:UniProtKB.
GO; GO:0032868; P:response to insulin; IBA:GO_Central.
GO; GO:0019953; P:sexual reproduction; ISS:UniProtKB.
GO; GO:0030217; P:T cell differentiation; ISS:UniProtKB.
GO; GO:0007260; P:tyrosine phosphorylation of STAT protein; IBA:GO_Central.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000065; Leptin.
PANTHER; PTHR11724; PTHR11724; 1.
Pfam; PF02024; Leptin; 1.
PIRSF; PIRSF001837; Leptin; 1.
ProDom; PD005698; Leptin; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Obesity; Reference proteome;
CHAIN 1 146 Leptin.
DISULFID 96 146 {ECO:0000250}.
SEQUENCE 146 AA; 16059 MW; 02C42A06B554D55C CRC64;

Related products :

Catalog number Product name Quantity
10-663-45096 Leptin (Anti Obesity Protein) Rat - Obesity factor; Obese protein N_A 0.5 mg
10-663-45096 Leptin (Anti Obesity Protein) Rat - Obesity factor; Obese protein N_A 0.2 mg
10-663-45096 Leptin (Anti Obesity Protein) Rat - Obesity factor; Obese protein N_A 1 mg
20-663-48064 Leptin (mAHuLeptin) - Mouse Anti Human Leptin (mAHuLeptin); Obesity factor; Obese protein Monoclonal 1 mg
20-663-48064 Leptin (mAHuLeptin) - Mouse Anti Human Leptin (mAHuLeptin); Obesity factor; Obese protein Monoclonal 0.5 mg
PR-482 Leptin Obesity Factor rat, recombinant, E. coli 1 mg
06-271-83297 Leptin (116-130) Mouse - Obesity factor 1 mg
06-271-83297 Leptin (116-130) Mouse - Obesity factor 0.5 mg
PR-482 Leptin Obesity Factor rat, recombinant, E. coli 1mg
E0084p ELISA kit LEP,Leptin,OB,Obesity factor,OBS,Pig,Sus scrofa 96T
PR-481 Leptin Obesity Factor murine, recombinant, E. coli 1 mg
PR-481 Leptin Obesity Factor murine, recombinant, E. coli 1mg
PR-480 Leptin Obesity Factor human, recombinant, E. coli 1mg
E0084p ELISA LEP,Leptin,OB,Obesity factor,OBS,Pig,Sus scrofa 96T
U0084p CLIA LEP,Leptin,OB,Obesity factor,OBS,Pig,Sus scrofa 96T
PR-480 Leptin Obesity Factor human, recombinant, E. coli 1 mg
10-663-45097 Leptin Human - Obesity factor; Obese protein N_A 0.5 mg
E0084r ELISA kit Lep,Leptin,Ob,Obesity factor,Rat,Rattus norvegicus 96T
15-288-20031F Leptin - Obesity factor; Obese protein Polyclonal 0.1 mg
E0084m ELISA kit Lep,Leptin,Mouse,Mus musculus,Ob,Obesity factor 96T
E0084r ELISA Lep,Leptin,Ob,Obesity factor,Rat,Rattus norvegicus 96T
10-663-45182 Leptin Mouse - Obesity factor; Obese protein N_A 0.2 mg
E0084m ELISA Lep,Leptin,Mouse,Mus musculus,Ob,Obesity factor 96T
10-663-45182 Leptin Mouse - Obesity factor; Obese protein N_A 0.5 mg
10-663-45097 Leptin Human - Obesity factor; Obese protein N_A 0.2 mg

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