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Leucine rich repeat kinase 2

 H0VB76_CAVPO            Unreviewed;      2450 AA.
H0VB76;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-NOV-2017, sequence version 2.
20-JUN-2018, entry version 57.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSCPOP00000007143};
Name=Lrrk2 {ECO:0000313|Ensembl:ENSCPOP00000007143};
Cavia porcellus (Guinea pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Hystricomorpha; Caviidae; Cavia.
NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000007143};
[1] {ECO:0000313|Ensembl:ENSCPOP00000007143}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007143};
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29
mammals.";
Nature 478:476-482(2011).
[2] {ECO:0000313|Ensembl:ENSCPOP00000007143}
IDENTIFICATION.
STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000007143};
Ensembl;
Submitted (JAN-2012) to UniProtKB.
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EMBL; AAKN02042427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02042428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02042429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02042430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02042431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 10141.ENSCPOP00000007143; -.
Ensembl; ENSCPOT00000008010; ENSCPOP00000007143; ENSCPOG00000007935.
eggNOG; ENOG410IRBK; Eukaryota.
eggNOG; KOG0192; Eukaryota.
eggNOG; COG1100; LUCA.
eggNOG; COG4886; LUCA.
GeneTree; ENSGT00910000144054; -.
InParanoid; H0VB76; -.
OrthoDB; EOG091G003N; -.
TreeFam; TF313679; -.
Proteomes; UP000005447; Unassembled WGS sequence.
Bgee; ENSCPOG00000007935; -.
GO; GO:0005524; F:ATP binding; IEA:InterPro.
GO; GO:0005525; F:GTP binding; IEA:InterPro.
GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
Gene3D; 1.25.10.10; -; 1.
Gene3D; 1.25.40.20; -; 1.
Gene3D; 2.130.10.10; -; 1.
Gene3D; 3.80.10.10; -; 2.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR011989; ARM-like.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR032171; COR.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR025875; Leu-rich_rpt_4.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR020859; ROC_dom.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
InterPro; IPR036322; WD40_repeat_dom_sf.
Pfam; PF16095; COR; 1.
Pfam; PF12799; LRR_4; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00369; LRR_TYP; 6.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF48371; SSF48371; 4.
SUPFAM; SSF50978; SSF50978; 1.
SUPFAM; SSF52540; SSF52540; 1.
SUPFAM; SSF56112; SSF56112; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS51450; LRR; 10.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PROSITE; PS51424; ROC; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000005447};
Leucine-rich repeat {ECO:0000256|SAAS:SAAS00537711};
Reference proteome {ECO:0000313|Proteomes:UP000005447};
Repeat {ECO:0000256|SAAS:SAAS00537628}.
DOMAIN 1251 1434 Roc. {ECO:0000259|PROSITE:PS51424}.
DOMAIN 1802 2069 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
COILED 317 341 {ECO:0000256|SAM:Coils}.
COILED 2427 2447 {ECO:0000256|SAM:Coils}.
SEQUENCE 2450 AA; 277842 MW; 904EC79D3FA60F48 CRC64;
MASGCEDQDE ETLKKLIVRL NNVQEGKQID TLVQILEDML VFTYSEHASK LFEGKNFHVP
LLIVLDSYMR VASVQQVGWS LLCKLIEVCP GTMQSLMGPQ DIGNDWEVLG VHQLIIKMLA
VHHASVNLST VGLKALDLLL TSGKITLLIL DEESDIFLLI FDAMNTFSNN DEVQKLGCKV
LHVLFERVSE EHLTEFVENK DYMVLLSALN SFKGEEEIVL HVLHCLHSLA IPCNNVEVLM
SGDVRCYNIK YPVSETNQNQ PTNQILKREI KSNFFNILVL NEVHAFVVKA VQQYPENAAL
QASALSCLAL LTETIFLNQD LEEKDENQEN EEEKEEEEDK LFWLEACYRA LTRHRKNKHV
QEAACWALNN LLMYQNGLHQ RIGDEDGQSV APILYLHIKY LDHINFRKIL LSKGIYVNVL
ELMQRHIHSP EVAESGCKML NRLFEGSNTS SDTMAGLVPK IITVMKSHET SLPVQLEALR
AILHFLVPEE SRDKSQWKLN MVRRQCLKND IHKLVLAALN RFIGNPGIQK CGLRVISSIA
HFPEALEVLS LEGAIDSVLR TLQKYPDDPE IQCLGLSLVG CLITKKHLCL GAGHLVAKIL
VYSLQRFKDD AEVQFKGFQT ILAILELSVS FSELLVHYSF DSVIFHQLSS GIVEQKDRKF
LSLCCKCFAK LAVDDELKSV MLRRACDQNN STMVECLLLL GADANQAKET TPLICQVCEK
ESSPKLVELL LSNGAREQDV RKALTISIQK GDSQIISLLL KRLALDMANN SICLGGFCIG
KIEASWLAPL FPDKTSNLRK QTNIGSVLAR MVLRYQMRSA VEEEAASDSD RNFSEDVLDK
FDDWTFIPES SMDCVFGQSD DLDSEGSEGS FLVKKKSSSV NVGELYRDPV LQRSSPSAQR
HSSSLGPIFD HEDFLRRKRK LLTSDDSLRT SKLQPHTRHL DSASSMACER EYITSLDLSA
NELRDIHALS QKCCISSHLE HIEKLELHQN ALTSFPQQLC EVMKCPTLRQ LNLSYNQLSS
FPETLPEVVE RLEQLLLEGN KISEIYFPLS LKELKILNLS KNRISSLPEN FFKACPKMEN
FSARMNSLDT MPFLPSSITS LKLAQNKFTC IPHSILDLPH LRSLDMSSND IDCLPGPANW
KSLNLRELLF NYNQISILDL SEKAYTWSRV EKLHLSHNKL KEIPPEIGCL ENLTSLDVSY
NVELRSFPNE MGKLSKIWDL PLDELHLNFD FKHIGCKAKD IIRFLQQRLK KAVPYNRMKL
MIVGNTGSGK TTLLQQLMKT KKSDLGVQGA TVGIDVKDWP IQIKGKKKKD LVLNVWDFAG
REEFYSTHPH FMTQRALYLA VFDLSKGQAE VDAMKPWLFN IKARASSSPV ILVGTHLDVS
DEKQHKACIS KITKELLNKR GFPAIRNYLF VNATEESDAL AKLRKTIVSE SLNFKIRDQP
VVGQLIPDCY VELEKIVLTE RKNVPIEFPV IDRKRLLQLV KENQLQLDEN ELTHAVHFLN
ESGVLLHFQD PALQLSDLYF VEPKWLCKVM AQILTVKVEG SPKYPKGIIS RRDVERFLSK
KRRFPKNYMT QYFKLLEKFQ IALPTGEEYL LVPSSLSDHR PVIELPHCEN SEIIIRLYEM
PYFPMGFWSR LINRLLEISP YMLSGRERAL RPNRMYWRQG IYLNWSPEAY CLVGSEVLDN
QQESFLKITV PSCRKGCILL GQVVDHIDSL MEEWFPGLLE IDICGEGETL LKKWALYSFN
DGEEHQKILL DDLMKKAEEG DLLVNPDQPR LTIPISQIAP DLILADLPRN IILNNDELDF
EQAPEFLLGD GSFGSVYRAA YEGEEVAVKI FNKHTSLRLL RQELVVLCHL HHPSLISLLA
AGIRPRMLVM ELAPKGSLDR LLQQDKASLT RTLQHRIALH VADGLRYLHS AMIIYRDLKP
HNVLLFTLYP NAAIIAKIAD YGIAQYCCRM GIKTSEGTPG FRAPEVARGN VIYNQQADVY
SFGLLLYDIL TTGGRILEGL KFPNEFDELA IQGKLPDPVK EYGCAPWPMV EKLIRKCLKE
NPQERPTSAQ VFDFLNSAEL ICLTRHILIP ENIIAECMVS MNSNSKNANI WLGCGHNDKG
QLSCLDLNTE GHTLEEVTDS RILCLALVHL PAEKESWIVS GTQSGALLVI NTDDRTKRHT
LQKMTDSITC LYCNSFPKQS KQNNFLLVGT ADGNLAIFED KTVKCEGATP LKTLNIGDVS
TPLMCLSESM NSSERSIMWG GCGTKIFSFS NDLTIQKLIE TRTNQLFSYS AFSDSNIIAV
AVDAALYIAK KNSPVVEVWD KKTEKLCELI DCVHLLKEVM VKMNQESKYK MSYSGRVKTL
CLQKNTALWI GTGGGHVLLL DLSTRRIIRI IYNFCDSVRV MMTAQLGSLK NVMLVLGYNR
KNTEDIQHQK EIQSCLSVWD LNFPHEVQNL EKHIEVRQEL AEKMRRTSVE


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