Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)

 LZTS2_HUMAN             Reviewed;         669 AA.
Q9BRK4; B1AL14; D3DR72; Q8N3I0; Q96J79; Q96JL2;
13-APR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2004, sequence version 2.
22-NOV-2017, entry version 133.
RecName: Full=Leucine zipper putative tumor suppressor 2 {ECO:0000255|HAMAP-Rule:MF_03026};
Short=hLZTS2;
AltName: Full=Protein LAPSER1 {ECO:0000255|HAMAP-Rule:MF_03026};
Name=LZTS2 {ECO:0000255|HAMAP-Rule:MF_03026};
Synonyms=KIAA1813, LAPSER1 {ECO:0000255|HAMAP-Rule:MF_03026};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=11347906; DOI=10.1093/dnares/8.2.85;
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XX.
The complete sequences of 100 new cDNA clones from brain which code
for large proteins in vitro.";
DNA Res. 8:85-95(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164054; DOI=10.1038/nature02462;
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Uterus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 26-669, ALTERNATIVE SPLICING, AND TISSUE
SPECIFICITY.
TISSUE=Prostate;
PubMed=11709705; DOI=10.1038/sj.onc.1204866;
Cabeza-Arvelaiz Y., Thompson T.C., Sepulveda J.L., Chinault A.C.;
"LAPSER1: a novel candidate tumor suppressor gene from 10q24.3.";
Oncogene 20:6707-6717(2001).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 139-669.
TISSUE=Amygdala;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[7]
FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, NUCLEAR
EXPORT SIGNAL, AND MUTAGENESIS OF LEU-638 AND LEU-640.
PubMed=17000760; DOI=10.1128/MCB.01031-06;
Thyssen G., Li T.-H., Lehmann L., Zhuo M., Sharma M., Sun Z.;
"LZTS2 is a novel beta-catenin-interacting protein and regulates the
nuclear export of beta-catenin.";
Mol. Cell. Biol. 26:8857-8867(2006).
[8]
FUNCTION, INTERACTION WITH GAMMA-TUBULIN; KIF23 AND KATNB1, AND
SUBCELLULAR LOCATION.
PubMed=17351128; DOI=10.1096/fj.06-7254com;
Sudo H., Maru Y.;
"LAPSER1 is a putative cytokinetic tumor suppressor that shows the
same centrosome and midbody subcellular localization pattern as p80
katanin.";
FASEB J. 21:2086-2100(2007).
[9]
FUNCTION, AND INDUCTION.
PubMed=17950943; DOI=10.1016/j.bbamcr.2007.08.005;
Cho H.H., Joo H.J., Song J.S., Bae Y.C., Jung J.S.;
"Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated
by lzts2 in human adipose tissue-derived mesenchymal stem cells.";
Biochim. Biophys. Acta 1783:419-428(2008).
[10]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=18490357; DOI=10.1093/hmg/ddn153;
Sudo H., Maru Y.;
"LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the
inhibition of katanin-mediated microtubule severing.";
Hum. Mol. Genet. 17:2524-2540(2008).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21406692; DOI=10.1126/scisignal.2001570;
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
Blagoev B.;
"System-wide temporal characterization of the proteome and
phosphoproteome of human embryonic stem cell differentiation.";
Sci. Signal. 4:RS3-RS3(2011).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[13]
VARIANTS [LARGE SCALE ANALYSIS] HIS-121 AND ARG-291.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: Negative regulator of katanin-mediated microtubule
severing and release from the centrosome. Required for central
spindle formation and the completion of cytokinesis. May
negatively regulate axonal outgrowth by preventing the formation
of microtubule bundles that are necessary for transport within the
elongating axon. Negative regulator of the Wnt signaling pathway.
Represses beta-catenin-mediated transcriptional activation by
promoting the nuclear exclusion of beta-catenin.
{ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760,
ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943,
ECO:0000269|PubMed:18490357}.
-!- SUBUNIT: Interacts with KATNB1. Also interacts with CTNNB1, gamma-
tubulin and KIF23. {ECO:0000255|HAMAP-Rule:MF_03026,
ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128}.
-!- INTERACTION:
A8K932:-; NbExp=3; IntAct=EBI-741037, EBI-10174671;
P0C206:- (xeno); NbExp=4; IntAct=EBI-741037, EBI-9675596;
Q95HA4:-; NbExp=3; IntAct=EBI-741037, EBI-10236795;
Q9H6F0:-; NbExp=3; IntAct=EBI-741037, EBI-10307481;
Q9ULW3:ABT1; NbExp=3; IntAct=EBI-741037, EBI-2602396;
Q8WTP8:AEN; NbExp=3; IntAct=EBI-741037, EBI-8637627;
Q96IX9:ANKRD36BP1; NbExp=3; IntAct=EBI-741037, EBI-744859;
Q9BXS5:AP1M1; NbExp=3; IntAct=EBI-741037, EBI-541426;
A7KAX9:ARHGAP32; NbExp=3; IntAct=EBI-741037, EBI-308663;
Q9H6L4:ARMC7; NbExp=3; IntAct=EBI-741037, EBI-742909;
Q8N5M1:ATPAF2; NbExp=6; IntAct=EBI-741037, EBI-1166928;
Q8TBE0:BAHD1; NbExp=6; IntAct=EBI-741037, EBI-742750;
Q9BXY8:BEX2; NbExp=3; IntAct=EBI-741037, EBI-745073;
Q13895:BYSL; NbExp=5; IntAct=EBI-741037, EBI-358049;
Q9NVL8:C14orf105; NbExp=3; IntAct=EBI-741037, EBI-10238351;
Q9NX04:C1orf109; NbExp=5; IntAct=EBI-741037, EBI-8643161;
Q9H7E9:C8orf33; NbExp=3; IntAct=EBI-741037, EBI-715389;
Q9H257:CARD9; NbExp=3; IntAct=EBI-741037, EBI-751319;
Q9HC52:CBX8; NbExp=5; IntAct=EBI-741037, EBI-712912;
P24863:CCNC; NbExp=3; IntAct=EBI-741037, EBI-395261;
P51959:CCNG1; NbExp=3; IntAct=EBI-741037, EBI-3905829;
O75909:CCNK; NbExp=3; IntAct=EBI-741037, EBI-739806;
Q9UJX2:CDC23; NbExp=3; IntAct=EBI-741037, EBI-396137;
Q07002:CDK18; NbExp=3; IntAct=EBI-741037, EBI-746238;
Q8IVW4:CDKL3; NbExp=3; IntAct=EBI-741037, EBI-3919850;
Q8IYX8:CEP57L1; NbExp=3; IntAct=EBI-741037, EBI-1104570;
Q8IYX8-2:CEP57L1; NbExp=3; IntAct=EBI-741037, EBI-10181988;
Q8IYR0:CFAP206; NbExp=3; IntAct=EBI-741037, EBI-749051;
Q9NX63:CHCHD3; NbExp=3; IntAct=EBI-741037, EBI-743375;
Q8N3C7:CLIP4; NbExp=3; IntAct=EBI-741037, EBI-5655540;
Q8NE01:CNNM3; NbExp=3; IntAct=EBI-741037, EBI-741032;
Q8NE01-3:CNNM3; NbExp=3; IntAct=EBI-741037, EBI-10269984;
Q2TBE0:CWF19L2; NbExp=3; IntAct=EBI-741037, EBI-5453285;
Q96GG9:DCUN1D1; NbExp=5; IntAct=EBI-741037, EBI-740086;
Q9BY27:DGCR6L; NbExp=3; IntAct=EBI-741037, EBI-742953;
Q13627:DYRK1A; NbExp=3; IntAct=EBI-741037, EBI-1053596;
Q9Y463:DYRK1B; NbExp=3; IntAct=EBI-741037, EBI-634187;
Q92630:DYRK2; NbExp=3; IntAct=EBI-741037, EBI-749432;
Q08426:EHHADH; NbExp=3; IntAct=EBI-741037, EBI-2339219;
O15371:EIF3D; NbExp=3; IntAct=EBI-741037, EBI-353818;
O60573:EIF4E2; NbExp=3; IntAct=EBI-741037, EBI-398610;
Q9BTL3:FAM103A1; NbExp=3; IntAct=EBI-741037, EBI-744023;
O95990-3:FAM107A; NbExp=3; IntAct=EBI-741037, EBI-10192902;
Q9H5Z6:FAM124B; NbExp=3; IntAct=EBI-741037, EBI-741626;
Q3B820:FAM161A; NbExp=5; IntAct=EBI-741037, EBI-719941;
Q5TZK3:FAM74A6; NbExp=3; IntAct=EBI-741037, EBI-10247271;
Q9NW38:FANCL; NbExp=3; IntAct=EBI-741037, EBI-2339898;
Q8TES7-6:FBF1; NbExp=3; IntAct=EBI-741037, EBI-10244131;
Q96JP0:FEM1C; NbExp=3; IntAct=EBI-741037, EBI-2515330;
P61328:FGF12; NbExp=3; IntAct=EBI-741037, EBI-6657662;
O75344:FKBP6; NbExp=6; IntAct=EBI-741037, EBI-744771;
Q9BVV2:FNDC11; NbExp=3; IntAct=EBI-741037, EBI-744935;
Q14331:FRG1; NbExp=3; IntAct=EBI-741037, EBI-2515248;
Q96NE9:FRMD6; NbExp=3; IntAct=EBI-741037, EBI-741729;
P15976-2:GATA1; NbExp=3; IntAct=EBI-741037, EBI-9090198;
Q96CN9:GCC1; NbExp=3; IntAct=EBI-741037, EBI-746252;
P55040:GEM; NbExp=7; IntAct=EBI-741037, EBI-744104;
Q8NEA9:GMCL1P1; NbExp=5; IntAct=EBI-741037, EBI-745707;
Q9NVN8:GNL3L; NbExp=3; IntAct=EBI-741037, EBI-746682;
O95872:GPANK1; NbExp=3; IntAct=EBI-741037, EBI-751540;
Q9NWQ4:GPATCH2L; NbExp=3; IntAct=EBI-741037, EBI-5666657;
P62993:GRB2; NbExp=3; IntAct=EBI-741037, EBI-401755;
Q8TCT9:HM13; NbExp=3; IntAct=EBI-741037, EBI-347472;
Q9NSB8:HOMER2; NbExp=3; IntAct=EBI-741037, EBI-2126733;
P17482:HOXB9; NbExp=3; IntAct=EBI-741037, EBI-745290;
P10809:HSPD1; NbExp=7; IntAct=EBI-741037, EBI-352528;
Q92993:KAT5; NbExp=5; IntAct=EBI-741037, EBI-399080;
Q674X7:KAZN; NbExp=3; IntAct=EBI-741037, EBI-949239;
Q9H0B3:KIAA1683; NbExp=3; IntAct=EBI-741037, EBI-745878;
Q9BVG8:KIFC3; NbExp=3; IntAct=EBI-741037, EBI-2125614;
P52292:KPNA2; NbExp=3; IntAct=EBI-741037, EBI-349938;
Q14847:LASP1; NbExp=3; IntAct=EBI-741037, EBI-742828;
P06239:LCK; NbExp=3; IntAct=EBI-741037, EBI-1348;
Q96GY3:LIN37; NbExp=3; IntAct=EBI-741037, EBI-748884;
P25800:LMO1; NbExp=3; IntAct=EBI-741037, EBI-8639312;
P25791:LMO2; NbExp=3; IntAct=EBI-741037, EBI-739696;
Q8TAP4-4:LMO3; NbExp=4; IntAct=EBI-741037, EBI-11742507;
Q8N8X9:MAB21L3; NbExp=5; IntAct=EBI-741037, EBI-10268010;
O15481:MAGEB4; NbExp=3; IntAct=EBI-741037, EBI-751857;
Q9Y316:MEMO1; NbExp=3; IntAct=EBI-741037, EBI-1104564;
Q9UBU8:MORF4L1; NbExp=3; IntAct=EBI-741037, EBI-399246;
Q15014:MORF4L2; NbExp=3; IntAct=EBI-741037, EBI-399257;
Q6PF18:MORN3; NbExp=3; IntAct=EBI-741037, EBI-9675802;
P00540:MOS; NbExp=3; IntAct=EBI-741037, EBI-1757866;
Q13330:MTA1; NbExp=3; IntAct=EBI-741037, EBI-714236;
P52298:NCBP2; NbExp=3; IntAct=EBI-741037, EBI-464729;
O43639:NCK2; NbExp=3; IntAct=EBI-741037, EBI-713635;
O76041:NEBL; NbExp=3; IntAct=EBI-741037, EBI-2880203;
Q9HC98:NEK6; NbExp=3; IntAct=EBI-741037, EBI-740364;
Q9Y221:NIP7; NbExp=3; IntAct=EBI-741037, EBI-749003;
Q96DC9:OTUB2; NbExp=3; IntAct=EBI-741037, EBI-746259;
Q99569:PKP4; NbExp=3; IntAct=EBI-741037, EBI-726447;
Q494U1:PLEKHN1; NbExp=3; IntAct=EBI-741037, EBI-10241513;
Q8WUT1:POLDIP3; NbExp=5; IntAct=EBI-741037, EBI-10276663;
O15160:POLR1C; NbExp=3; IntAct=EBI-741037, EBI-1055079;
Q6NYC8:PPP1R18; NbExp=3; IntAct=EBI-741037, EBI-2557469;
O60828:PQBP1; NbExp=3; IntAct=EBI-741037, EBI-713867;
O43741:PRKAB2; NbExp=3; IntAct=EBI-741037, EBI-1053424;
Q8WWY3:PRPF31; NbExp=3; IntAct=EBI-741037, EBI-1567797;
P0CG20:PRR35; NbExp=4; IntAct=EBI-741037, EBI-11986293;
P25786:PSMA1; NbExp=3; IntAct=EBI-741037, EBI-359352;
P47897:QARS; NbExp=5; IntAct=EBI-741037, EBI-347462;
P47897-2:QARS; NbExp=3; IntAct=EBI-741037, EBI-10209725;
P63000:RAC1; NbExp=3; IntAct=EBI-741037, EBI-413628;
O75771:RAD51D; NbExp=8; IntAct=EBI-741037, EBI-1055693;
Q96T37:RBM15; NbExp=3; IntAct=EBI-741037, EBI-2514922;
Q96IZ5:RBM41; NbExp=3; IntAct=EBI-741037, EBI-740773;
Q9P2K3:RCOR3; NbExp=3; IntAct=EBI-741037, EBI-743428;
Q9BSD3:RHNO1; NbExp=3; IntAct=EBI-741037, EBI-9658624;
Q13671:RIN1; NbExp=5; IntAct=EBI-741037, EBI-366017;
Q9H4P4:RNF41; NbExp=3; IntAct=EBI-741037, EBI-2130266;
Q14D33:RTP5; NbExp=3; IntAct=EBI-741037, EBI-10217913;
Q06455-4:RUNX1T1; NbExp=3; IntAct=EBI-741037, EBI-10224192;
Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-741037, EBI-10313866;
Q9BWG6:SCNM1; NbExp=3; IntAct=EBI-741037, EBI-748391;
Q6NXQ0:SFRS2; NbExp=3; IntAct=EBI-741037, EBI-10251550;
Q9H788:SH2D4A; NbExp=3; IntAct=EBI-741037, EBI-747035;
Q08AM8:SH3RF2; NbExp=3; IntAct=EBI-741037, EBI-10225873;
Q05CH4:SLC15A3; NbExp=3; IntAct=EBI-741037, EBI-10223741;
P12236:SLC25A6; NbExp=3; IntAct=EBI-741037, EBI-356254;
O95391:SLU7; NbExp=3; IntAct=EBI-741037, EBI-750559;
Q9BZL3:SMIM3; NbExp=3; IntAct=EBI-741037, EBI-741850;
Q13573:SNW1; NbExp=3; IntAct=EBI-741037, EBI-632715;
Q8N9S9:SNX31; NbExp=3; IntAct=EBI-741037, EBI-9380649;
Q9UM82:SPATA2; NbExp=3; IntAct=EBI-741037, EBI-744066;
Q86W54:SPATA24; NbExp=3; IntAct=EBI-741037, EBI-3916986;
Q9H0A9:SPATC1L; NbExp=3; IntAct=EBI-741037, EBI-372911;
Q9UQ90:SPG7; NbExp=3; IntAct=EBI-741037, EBI-717201;
Q8WUK8:STAC; NbExp=3; IntAct=EBI-741037, EBI-10276615;
Q8IYB8:SUPV3L1; NbExp=3; IntAct=EBI-741037, EBI-2876787;
O43463:SUV39H1; NbExp=5; IntAct=EBI-741037, EBI-349968;
P03410:tax (xeno); NbExp=5; IntAct=EBI-741037, EBI-9676218;
Q9P0N9:TBC1D7; NbExp=3; IntAct=EBI-741037, EBI-3258000;
Q15560:TCEA2; NbExp=3; IntAct=EBI-741037, EBI-710310;
Q9BT92:TCHP; NbExp=3; IntAct=EBI-741037, EBI-740781;
D3DUQ6:TEAD4; NbExp=3; IntAct=EBI-741037, EBI-10176734;
Q9P2Z0:THAP10; NbExp=3; IntAct=EBI-741037, EBI-745404;
Q9BT49:THAP7; NbExp=5; IntAct=EBI-741037, EBI-741350;
Q96KP6:TNIP3; NbExp=5; IntAct=EBI-741037, EBI-2509913;
Q14134:TRIM29; NbExp=4; IntAct=EBI-741037, EBI-702370;
Q8IWZ5:TRIM42; NbExp=3; IntAct=EBI-741037, EBI-5235829;
Q99598:TSNAX; NbExp=5; IntAct=EBI-741037, EBI-742638;
Q5W5X9:TTC23; NbExp=3; IntAct=EBI-741037, EBI-6447954;
P83876:TXNL4A; NbExp=3; IntAct=EBI-741037, EBI-746539;
Q15853:USF2; NbExp=3; IntAct=EBI-741037, EBI-1055994;
O75604:USP2; NbExp=5; IntAct=EBI-741037, EBI-743272;
Q08E77:UTP14C; NbExp=4; IntAct=EBI-741037, EBI-10225961;
Q96HA8:WDYHV1; NbExp=3; IntAct=EBI-741037, EBI-741158;
Q06250:WT1-AS; NbExp=3; IntAct=EBI-741037, EBI-10223946;
P24278:ZBTB25; NbExp=3; IntAct=EBI-741037, EBI-739899;
Q8N5A5:ZGPAT; NbExp=3; IntAct=EBI-741037, EBI-3439227;
Q8N5A5-2:ZGPAT; NbExp=5; IntAct=EBI-741037, EBI-10183064;
Q9BRR0:ZKSCAN3; NbExp=3; IntAct=EBI-741037, EBI-1965777;
Q96NC0:ZMAT2; NbExp=3; IntAct=EBI-741037, EBI-2682299;
Q96E35:ZMYND19; NbExp=4; IntAct=EBI-741037, EBI-746595;
P17024:ZNF20; NbExp=3; IntAct=EBI-741037, EBI-717634;
P15622-3:ZNF250; NbExp=3; IntAct=EBI-741037, EBI-10177272;
Q8TAU3:ZNF417; NbExp=5; IntAct=EBI-741037, EBI-740727;
Q9BUY5:ZNF426; NbExp=3; IntAct=EBI-741037, EBI-743265;
Q9NWS9-2:ZNF446; NbExp=5; IntAct=EBI-741037, EBI-740232;
Q9ULM2:ZNF490; NbExp=3; IntAct=EBI-741037, EBI-1105370;
Q7Z3I7:ZNF572; NbExp=5; IntAct=EBI-741037, EBI-10172590;
Q9P0T4:ZNF581; NbExp=4; IntAct=EBI-741037, EBI-745520;
-!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton,
microtubule organizing center, centrosome. Note=Localized to the
centrosome throughout the cell cycle. Localized to the midbody in
cells undergoing cytokinesis.
-!- TISSUE SPECIFICITY: Highly expressed in prostate and testis, and
at slightly lower levels in spleen, thymus, uterus, small
intestine and colon. {ECO:0000269|PubMed:11709705}.
-!- INDUCTION: By inhibition of NF-kappa-B signaling.
{ECO:0000269|PubMed:17950943}.
-!- SIMILARITY: Belongs to the LZTS2 family. {ECO:0000255|HAMAP-
Rule:MF_03026}.
-!- SEQUENCE CAUTION:
Sequence=BAB47442.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB058716; BAB47442.1; ALT_INIT; mRNA.
EMBL; AL133215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471066; EAW49790.1; -; Genomic_DNA.
EMBL; CH471066; EAW49791.1; -; Genomic_DNA.
EMBL; CH471066; EAW49792.1; -; Genomic_DNA.
EMBL; BC006212; AAH06212.2; -; mRNA.
EMBL; BC058938; AAH58938.1; -; mRNA.
EMBL; AY029201; AAK31577.1; -; mRNA.
EMBL; AL834338; CAD39005.1; -; mRNA.
CCDS; CCDS7507.1; -.
RefSeq; NP_001305028.1; NM_001318099.1.
RefSeq; NP_001305029.1; NM_001318100.1.
RefSeq; NP_001305030.1; NM_001318101.1.
RefSeq; NP_115805.1; NM_032429.3.
RefSeq; XP_005270279.1; XM_005270222.4.
RefSeq; XP_016872269.1; XM_017016780.1.
UniGene; Hs.523221; -.
UniGene; Hs.734981; -.
ProteinModelPortal; Q9BRK4; -.
SMR; Q9BRK4; -.
BioGrid; 124083; 269.
IntAct; Q9BRK4; 252.
MINT; MINT-1199317; -.
STRING; 9606.ENSP00000359240; -.
iPTMnet; Q9BRK4; -.
PhosphoSitePlus; Q9BRK4; -.
BioMuta; LZTS2; -.
DMDM; 46396501; -.
EPD; Q9BRK4; -.
MaxQB; Q9BRK4; -.
PaxDb; Q9BRK4; -.
PeptideAtlas; Q9BRK4; -.
PRIDE; Q9BRK4; -.
DNASU; 84445; -.
Ensembl; ENST00000370220; ENSP00000359240; ENSG00000107816.
Ensembl; ENST00000370223; ENSP00000359243; ENSG00000107816.
GeneID; 84445; -.
KEGG; hsa:84445; -.
UCSC; uc001ksj.4; human.
CTD; 84445; -.
DisGeNET; 84445; -.
EuPathDB; HostDB:ENSG00000107816.17; -.
GeneCards; LZTS2; -.
HGNC; HGNC:29381; LZTS2.
HPA; HPA044956; -.
MIM; 610454; gene.
neXtProt; NX_Q9BRK4; -.
OpenTargets; ENSG00000107816; -.
PharmGKB; PA134944540; -.
eggNOG; ENOG410IGJE; Eukaryota.
eggNOG; ENOG4111JZA; LUCA.
GeneTree; ENSGT00510000046769; -.
HOGENOM; HOG000230889; -.
HOVERGEN; HBG052381; -.
InParanoid; Q9BRK4; -.
OMA; RRCATFE; -.
OrthoDB; EOG091G03L2; -.
PhylomeDB; Q9BRK4; -.
TreeFam; TF331420; -.
ChiTaRS; LZTS2; human.
GenomeRNAi; 84445; -.
PRO; PR:Q9BRK4; -.
Proteomes; UP000005640; Chromosome 10.
Bgee; ENSG00000107816; -.
CleanEx; HS_LZTS2; -.
ExpressionAtlas; Q9BRK4; baseline and differential.
Genevisible; Q9BRK4; HS.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IDA:HPA.
GO; GO:0031982; C:vesicle; IDA:BHF-UCL.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO; GO:1900181; P:negative regulation of protein localization to nucleus; IEA:Ensembl.
GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
HAMAP; MF_03026; LZTS2; 1.
InterPro; IPR028597; LZTS2.
PANTHER; PTHR19354:SF4; PTHR19354:SF4; 1.
1: Evidence at protein level;
Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm;
Cytoskeleton; Microtubule; Mitosis; Phosphoprotein; Polymorphism;
Reference proteome; Wnt signaling pathway.
CHAIN 1 669 Leucine zipper putative tumor suppressor
2.
/FTId=PRO_0000182974.
REGION 1 332 Required for centrosomal localization.
{ECO:0000250}.
REGION 447 669 Sufficient for interaction with CTNNB1.
{ECO:0000269|PubMed:17000760}.
REGION 450 669 Sufficient for interaction with KATNB1
and for inhibition of katanin-mediated
microtubule severing. {ECO:0000250}.
COILED 328 649 {ECO:0000255|HAMAP-Rule:MF_03026}.
MOTIF 631 640 Nuclear export signal.
COMPBIAS 188 306 Ser-rich.
MOD_RES 249 249 Phosphoserine.
{ECO:0000250|UniProtKB:Q91YU6}.
MOD_RES 296 296 Phosphoserine.
{ECO:0000250|UniProtKB:Q91YU6}.
MOD_RES 570 570 Phosphoserine.
{ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
VARIANT 121 121 R -> H (in a colorectal cancer sample;
somatic mutation; dbSNP:rs367898512).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036364.
VARIANT 291 291 G -> R (in a breast cancer sample;
somatic mutation).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_036365.
VARIANT 299 299 R -> W (in dbSNP:rs2275381).
/FTId=VAR_018277.
MUTAGEN 638 638 L->A: Induces nuclear accumulation.
Impairs nuclear exclusion of beta-
catenin; when associated with A-640.
{ECO:0000269|PubMed:17000760}.
MUTAGEN 640 640 L->A: Induces nuclear accumulation.
Impairs nuclear exclusion of beta-
catenin; when associated with A-38.
{ECO:0000269|PubMed:17000760}.
CONFLICT 289 289 V -> L (in Ref. 4; AAH58938).
{ECO:0000305}.
SEQUENCE 669 AA; 72759 MW; 1274FD9A36A217E6 CRC64;
MAIVQTLPVP LEPAPEAATA PQAPVMGSVS SLISGRPCPG GPAPPRHHGP PGPTFFRQQD
GLLRGGYEAQ EPLCPAVPPR KAVPVTSFTY INEDFRTESP PSPSSDVEDA REQRAHNAHL
RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP VLPKPRGAPS LPSFMGPRAT GLSGSQGSLT
QLFGGPASSS SSSSSSSAAD KPLAFSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTT
SSPGGHLPSH GSGRGALPGP ARGVPTGPSH SDSGRSSSSK STGSLGGRVA GGLLGSGTRA
SPDSSSCGER SPPPPPPPPS DEALLHCVLE GKLRDREAEL QQLRDSLDEN EATMCQAYEE
RQRHWQRERE ALREDCAAQA QRAQRAQQLL QLQVFQLQQE KRQLQDDFAQ LLQEREQLER
RCATLEREQR ELGPRLEETK WEVCQKSGEI SLLKQQLKES QAELVQKGSE LVALRVALRE
ARATLRVSEG RARGLQEAAR ARELELEACS QELQRHRQEA EQLREKAGQL DAEAAGLREP
PVPPATADPF LLAESDEAKV QRAAAGVGGS LRAQVERLRV ELQRERRRGE EQRDSFEGER
LAWQAEKEQV IRYQKQLQHN YIQMYRRNRQ LEQELQQLSL ELEARELADL GLAEQAPCIC
LEEITATEI


Related products :

Catalog number Product name Quantity
18-003-43277 Leucine zipper putative tumor suppressor 1 - F37_esophageal cancer-related gene-coding leucine-zipper motif; Fez1 Polyclonal 0.1 mg Protein A
E0089h Rat ELISA Kit FOR Leucine zipper putative tumor suppressor 1 96T
E13509h Human Leucine Zipper, Putative Tumor Suppressor 2 96T
ARF3_RAT Rat ELISA Kit FOR Leucine zipper putative tumor suppressor 1 96T
SC23A_CHICK Rat ELISA Kit FOR Leucine zipper putative tumor suppressor 1 96T
MA LZTS2 Gene leucine zipper, putative tumor suppressor 2
201-20-3201 LZTS1{leucine zipper, putative tumor suppressor 1}rabbit.pAb 0.2ml
CSB-EL013292RA Rat Leucine zipper putative tumor suppressor 2(LZTS2) ELISA kit 96T
LZTS1_MOUSE Mouse ELISA Kit FOR Leucine zipper putative tumor suppressor 1 96T
CSB-EL013291RA Rat Leucine zipper putative tumor suppressor 1(LZTS1) ELISA kit 96T
M6PR LZTS1 Gene leucine zipper, putative tumor suppressor 1
CSB-EL013291HU Human Leucine zipper putative tumor suppressor 1(LZTS1) ELISA kit 96T
CSB-EL013292HU Human Leucine zipper putative tumor suppressor 2(LZTS2) ELISA kit 96T
CSB-EL013292MO Mouse Leucine zipper putative tumor suppressor 2(LZTS2) ELISA kit 96T
CSB-EL013292RA Rat Leucine zipper putative tumor suppressor 2(LZTS2) ELISA kit SpeciesRat 96T
CSB-EL013292BO Bovine Leucine zipper putative tumor suppressor 2(LZTS2) ELISA kit 96T
CSB-EL013291RA Rat Leucine zipper putative tumor suppressor 1(LZTS1) ELISA kit SpeciesRat 96T
CSB-EL013291MO Mouse Leucine zipper putative tumor suppressor 1(LZTS1) ELISA kit 96T
CSB-EL013292HU Human Leucine zipper putative tumor suppressor 2(LZTS2) ELISA kit SpeciesHuman 96T
CSB-EL013292BO Bovine Leucine zipper putative tumor suppressor 2(LZTS2) ELISA kit SpeciesBovine 96T
CSB-EL013291HU Human Leucine zipper putative tumor suppressor 1(LZTS1) ELISA kit SpeciesHuman 96T
CSB-EL013291MO Mouse Leucine zipper putative tumor suppressor 1(LZTS1) ELISA kit SpeciesMouse 96T
CSB-EL013292MO Mouse Leucine zipper putative tumor suppressor 2(LZTS2) ELISA kit SpeciesMouse 96T
LZTS2_MOUSE ELISA Kit FOR Leucine zipper putative tumor suppressor 2; organism: Mouse; gene name: Lzts2 96T
LZTS1_MOUSE ELISA Kit FOR Leucine zipper putative tumor suppressor 1; organism: Mouse; gene name: Lzts1 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur