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Leucine-rich repeat-containing G-protein coupled receptor 4 (G-protein coupled receptor 48)

 LGR4_MOUSE              Reviewed;         951 AA.
A2ARI4; A2ARI3; Q6PHA3; Q80T31; Q8BXS9;
11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
20-FEB-2007, sequence version 1.
28-FEB-2018, entry version 95.
RecName: Full=Leucine-rich repeat-containing G-protein coupled receptor 4;
AltName: Full=G-protein coupled receptor 48;
Flags: Precursor;
Name=Lgr4; Synonyms=Gpr48;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-196.
PubMed=12679517; DOI=10.1073/pnas.0230374100;
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
Bergmann J.E., Gaitanaris G.A.;
"The G protein-coupled receptor repertoires of human and mouse.";
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-951.
STRAIN=C57BL/6J; TISSUE=Retina;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 464-951.
STRAIN=Czech II; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
DISRUPTION PHENOTYPE.
PubMed=15192078; DOI=10.1210/me.2004-0133;
Mazerbourg S., Bouley D.M., Sudo S., Klein C.A., Zhang J.V.,
Kawamura K., Goodrich L.V., Rayburn H., Tessier-Lavigne M.,
Hsueh A.J.;
"Leucine-rich repeat-containing, G protein-coupled receptor 4 null
mice exhibit intrauterine growth retardation associated with embryonic
and perinatal lethality.";
Mol. Endocrinol. 18:2241-2254(2004).
[6]
DISRUPTION PHENOTYPE.
PubMed=16406039; DOI=10.1016/j.ydbio.2005.11.043;
Mendive F., Laurent P., Van Schoore G., Skarnes W., Pochet R.,
Vassart G.;
"Defective postnatal development of the male reproductive tract in
LGR4 knockout mice.";
Dev. Biol. 290:421-434(2006).
[7]
DISRUPTION PHENOTYPE.
PubMed=16785743; DOI=10.1159/000093999;
Kato S., Matsubara M., Matsuo T., Mohri Y., Kazama I., Hatano R.,
Umezawa A., Nishimori K.;
"Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4,
Gpr48) is essential for renal development in mice.";
Nephron Exp. Nephrol. 104:E63-E75(2006).
[8]
DISRUPTION PHENOTYPE.
PubMed=17079737; DOI=10.1095/biolreprod.106.054619;
Hoshii T., Takeo T., Nakagata N., Takeya M., Araki K., Yamamura K.;
"LGR4 regulates the postnatal development and integrity of male
reproductive tracts in mice.";
Biol. Reprod. 76:303-313(2007).
[9]
DISRUPTION PHENOTYPE.
PubMed=17850793; DOI=10.1016/j.febslet.2007.08.064;
Kato S., Mohri Y., Matsuo T., Ogawa E., Umezawa A., Okuyama R.,
Nishimori K.;
"Eye-open at birth phenotype with reduced keratinocyte motility in
LGR4 null mice.";
FEBS Lett. 581:4685-4690(2007).
[10]
DISRUPTION PHENOTYPE.
PubMed=18651655; DOI=10.1002/dvdy.21639;
Mohri Y., Kato S., Umezawa A., Okuyama R., Nishimori K.;
"Impaired hair placode formation with reduced expression of hair
follicle-related genes in mice lacking Lgr4.";
Dev. Dyn. 237:2235-2242(2008).
[11]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=18955481; DOI=10.1074/jbc.M800721200;
Song H., Luo J., Luo W., Weng J., Wang Z., Li B., Li D., Liu M.;
"Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs
definitive erythropoiesis at midgestation through down-regulation of
the ATF4 signaling pathway.";
J. Biol. Chem. 283:36687-36697(2008).
[12]
DISRUPTION PHENOTYPE.
PubMed=18424556; DOI=10.1073/pnas.0708257105;
Weng J., Luo J., Cheng X., Jin C., Zhou X., Qu J., Tu L., Ai D.,
Li D., Wang J., Martin J.F., Amendt B.A., Liu M.;
"Deletion of G protein-coupled receptor 48 leads to ocular anterior
segment dysgenesis (ASD) through down-regulation of Pitx2.";
Proc. Natl. Acad. Sci. U.S.A. 105:6081-6086(2008).
[13]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=19605502; DOI=10.1242/dev.033571;
Luo J., Zhou W., Zhou X., Li D., Weng J., Yi Z., Cho S.G., Li C.,
Yi T., Wu X., Li X.Y., de Crombrugghe B., Hook M., Liu M.;
"Regulation of bone formation and remodeling by G-protein-coupled
receptor 48.";
Development 136:2747-2756(2009).
[14]
DISRUPTION PHENOTYPE.
PubMed=20638054; DOI=10.1016/j.fertnstert.2010.05.050;
Mohri Y., Umezu T., Hidema S., Tomisawa H., Akamatsu A., Kato S.,
Nawa A., Nishimori K.;
"Reduced fertility with impairment of early-stage embryos observed in
mice lacking Lgr4 in epithelial tissues.";
Fertil. Steril. 94:2878-2881(2010).
[15]
DISRUPTION PHENOTYPE.
PubMed=21523854; DOI=10.1002/dvdy.22651;
Mohri Y., Oyama K., Akamatsu A., Kato S., Nishimori K.;
"Lgr4-deficient mice showed premature differentiation of ureteric bud
with reduced expression of Wnt effector Lef1 and Gata3.";
Dev. Dyn. 240:1626-1634(2011).
[16]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=21508962; DOI=10.1038/embor.2011.52;
Mustata R.C., Van Loy T., Lefort A., Libert F., Strollo S.,
Vassart G., Garcia M.I.;
"Lgr4 is required for Paneth cell differentiation and maintenance of
intestinal stem cells ex vivo.";
EMBO Rep. 12:558-564(2011).
[17]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=21727895; DOI=10.1038/nature10337;
de Lau W., Barker N., Low T.Y., Koo B.K., Li V.S., Teunissen H.,
Kujala P., Haegebarth A., Peters P.J., van de Wetering M.,
Stange D.E., van Es J.E., Guardavaccaro D., Schasfoort R.B., Mohri Y.,
Nishimori K., Mohammed S., Heck A.J., Clevers H.;
"Lgr5 homologues associate with Wnt receptors and mediate R-spondin
signalling.";
Nature 476:293-297(2011).
[18]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH RSPO1; RSPO2;
RSPO3 AND RSPO4.
PubMed=21693646; DOI=10.1073/pnas.1106083108;
Carmon K.S., Gong X., Lin Q., Thomas A., Liu Q.;
"R-spondins function as ligands of the orphan receptors LGR4 and LGR5
to regulate Wnt/beta-catenin signaling.";
Proc. Natl. Acad. Sci. U.S.A. 108:11452-11457(2011).
[19]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=23533175; DOI=10.1242/dev.093641;
Qian Y., Liu S., Guan Y., Pan H., Guan X., Qiu Z., Li L., Gao N.,
Zhao Y., Li X., Lu Y., Liu M., Li D.;
"Lgr4-mediated Wnt/beta-catenin signaling in peritubular myoid cells
is essential for spermatogenesis.";
Development 140:1751-1761(2013).
[20]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=23393138; DOI=10.1074/jbc.M112.436204;
Liu S., Qian Y., Li L., Wei G., Guan Y., Pan H., Guan X., Zhang L.,
Lu X., Zhao Y., Liu M., Li D.;
"Lgr4 gene deficiency increases susceptibility and severity of dextran
sodium sulfate-induced inflammatory bowel disease in mice.";
J. Biol. Chem. 288:8794-8803(2013).
[21]
FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF THR-755.
PubMed=23589304; DOI=10.1074/jbc.M113.455535;
Du B., Luo W., Li R., Tan B., Han H., Lu X., Li D., Qian M., Zhang D.,
Zhao Y., Liu M.;
"Lgr4/Gpr48 negatively regulates TLR2/4 associated pattern recognition
and innate immunity by targeting CD14 expression.";
J. Biol. Chem. 288:15131-15141(2013).
[22]
FUNCTION.
PubMed=23444378; DOI=10.1242/jcs.123471;
Deng C., Reddy P., Cheng Y., Luo C.W., Hsiao C.L., Hsueh A.J.;
"Multi-functional norrin is a ligand for the LGR4 receptor.";
J. Cell Sci. 126:2060-2068(2013).
[23]
FUNCTION, AND INDUCTION.
PubMed=24353284; DOI=10.1530/JME-13-0042;
Wang F., Zhang X., Wang J., Chen M., Fan N., Ma Q., Liu R., Wang R.,
Li X., Liu M., Ning G.;
"LGR4 acts as a link between the peripheral circadian clock and lipid
metabolism in liver.";
J. Mol. Endocrinol. 52:133-143(2014).
-!- FUNCTION: Receptor for R-spondins that potentiates the canonical
Wnt signaling pathway and is involved in the formation of various
organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4),
associates with phosphorylated LRP6 and frizzled receptors that
are activated by extracellular Wnt receptors, triggering the
canonical Wnt signaling pathway to increase expression of target
genes. In contrast to classical G-protein coupled receptors, does
not activate heterotrimeric G-proteins to transduce the signal.
Its function as activator of the Wnt signaling pathway is required
for the development of various organs, including liver, kidney,
intestine, bone, reproductive tract and eye. May also act as a
receptor for norrin (NDP), such results however require additional
confirmation in vivo. Required during spermatogenesis to activate
the Wnt signaling pathway in peritubular myoid cells. Required for
the maintenance of intestinal stem cells and Paneth cell
differentiation in postnatal intestinal crypts. Acts as a
regulator of bone formation and remodeling. Involved in kidney
development; required for maintaining the ureteric bud in an
undifferentiated state. Involved in the development of the
anterior segment of the eye. Required during erythropoiesis. Also
acts as a negative regulator of innate immunity by inhibiting
TLR2/TLR4 associated pattern-recognition and proinflammatory
cytokine production. Plays an important role in regulating the
circadian rhythms of plasma lipids, partially through regulating
the rhythmic expression of MTTP (PubMed:24353284).
{ECO:0000269|PubMed:18955481, ECO:0000269|PubMed:19605502,
ECO:0000269|PubMed:21508962, ECO:0000269|PubMed:21693646,
ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:23393138,
ECO:0000269|PubMed:23444378, ECO:0000269|PubMed:23533175,
ECO:0000269|PubMed:23589304, ECO:0000269|PubMed:24353284}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21693646};
Multi-pass membrane protein {ECO:0000269|PubMed:21693646}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=A2ARI4-1; Sequence=Displayed;
Name=2;
IsoId=A2ARI4-2; Sequence=VSP_047137;
-!- INDUCTION: Expressed in a circadian manner in the liver.
{ECO:0000269|PubMed:24353284}.
-!- DISRUPTION PHENOTYPE: Strong variations in phenotypes, probably
depending on the strain background used in the different
experiments. According to a first report done in a C57BL/6
background, mice show intra-uterine growth retardation leading to
embryonic and perinatal lethality (PubMed:15192078). A lethal
phenotype was confirmed by other groups. In some cases however,
few mice survive until adulthood. Mice that survive show wide
spectrum of anterior segment dysgenesis phenotypes, including
microphthalmia, iris hypoplasia, irdiocorneal angle malformation,
cornea dysgenesis and cataract (PubMed:18424556). Defects in
osteoblast differentiation and mineralization during embryonic
bone formation are also observed. Postnatal mice that survive show
defects in bone remodeling (PubMed:19605502). According to other
reports done in other strain backgrounds, mice do not die and
display defects in the male reproductive tract during the
postnatal period (PubMed:16406039, PubMed:17079737,
PubMed:23533175). Mice also show small kidneys, in which the total
number and density of the glomeruli are decreased
(PubMed:16785743). The use of conditional knockouts, leads to
defects in hair placode formation, possibly due to reduced
keratinocyte migration (PubMed:17079737, PubMed:17850793).
Decrease in epithelial cell proliferation and strong reduction in
terminal differentiation of Paneth cells in postnatal intestinal
crypts (PubMed:21508962, PubMed:23393138). Fetuses display
transient anemia during midgestation and abnormal definitive
erythropoiesis (PubMed:18955481). Mice are also more susceptible
and have much higher mortality to lipopolysaccharide (LPS)
stimulation due to over-activated innate immune response
(PubMed:23589304). Conditional knockout of both Lgr4 and Lgr5 in
the gut results in Wnt signaling inhibition and results in the
rapid demise of intestinal crypts (PubMed:21727895).
{ECO:0000269|PubMed:15192078, ECO:0000269|PubMed:16406039,
ECO:0000269|PubMed:16785743, ECO:0000269|PubMed:17079737,
ECO:0000269|PubMed:17850793, ECO:0000269|PubMed:18424556,
ECO:0000269|PubMed:18651655, ECO:0000269|PubMed:18955481,
ECO:0000269|PubMed:19605502, ECO:0000269|PubMed:20638054,
ECO:0000269|PubMed:21508962, ECO:0000269|PubMed:21523854,
ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:23393138,
ECO:0000269|PubMed:23533175, ECO:0000269|PubMed:23589304}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; AL845423; CAM17466.1; -; Genomic_DNA.
EMBL; AL928922; CAM17466.1; JOINED; Genomic_DNA.
EMBL; AL928922; CAM24131.1; -; Genomic_DNA.
EMBL; AL845423; CAM24131.1; JOINED; Genomic_DNA.
EMBL; BX294391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AY255619; AAO85131.1; -; mRNA.
EMBL; AK044357; BAC31882.1; -; mRNA.
EMBL; BC056637; AAH56637.1; -; mRNA.
CCDS; CCDS38195.1; -. [A2ARI4-1]
RefSeq; NP_766259.2; NM_172671.2. [A2ARI4-1]
UniGene; Mm.277351; -.
UniGene; Mm.485992; -.
ProteinModelPortal; A2ARI4; -.
SMR; A2ARI4; -.
STRING; 10090.ENSMUSP00000047325; -.
PhosphoSitePlus; A2ARI4; -.
MaxQB; A2ARI4; -.
PaxDb; A2ARI4; -.
PeptideAtlas; A2ARI4; -.
PRIDE; A2ARI4; -.
DNASU; 107515; -.
Ensembl; ENSMUST00000046548; ENSMUSP00000047325; ENSMUSG00000050199. [A2ARI4-1]
Ensembl; ENSMUST00000111037; ENSMUSP00000106666; ENSMUSG00000050199. [A2ARI4-2]
GeneID; 107515; -.
KEGG; mmu:107515; -.
UCSC; uc008lmq.1; mouse. [A2ARI4-1]
CTD; 55366; -.
MGI; MGI:1891468; Lgr4.
eggNOG; KOG0619; Eukaryota.
eggNOG; KOG2087; Eukaryota.
eggNOG; COG4886; LUCA.
GeneTree; ENSGT00760000119088; -.
HOGENOM; HOG000231829; -.
HOVERGEN; HBG031675; -.
InParanoid; A2ARI4; -.
KO; K04309; -.
OMA; DGYWSDC; -.
OrthoDB; EOG091G0QA0; -.
PhylomeDB; A2ARI4; -.
TreeFam; TF316814; -.
Reactome; R-MMU-4641263; Regulation of FZD by ubiquitination.
ChiTaRS; Lgr4; mouse.
PRO; PR:A2ARI4; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000050199; -.
Genevisible; A2ARI4; MM.
GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO; GO:0016500; F:protein-hormone receptor activity; IEA:InterPro.
GO; GO:0004888; F:transmembrane signaling receptor activity; IDA:UniProtKB.
GO; GO:0030282; P:bone mineralization; IMP:UniProtKB.
GO; GO:0046849; P:bone remodeling; IMP:UniProtKB.
GO; GO:0061290; P:canonical Wnt signaling pathway involved in metanephric kidney development; IMP:UniProtKB.
GO; GO:0072202; P:cell differentiation involved in metanephros development; IMP:UniProtKB.
GO; GO:0032922; P:circadian regulation of gene expression; IMP:UniProtKB.
GO; GO:0007623; P:circadian rhythm; IEP:UniProtKB.
GO; GO:0048565; P:digestive tract development; IMP:MGI.
GO; GO:0050673; P:epithelial cell proliferation; IMP:MGI.
GO; GO:2001013; P:epithelial cell proliferation involved in renal tubule morphogenesis; IGI:MGI.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:UniProtKB-KW.
GO; GO:0001942; P:hair follicle development; IMP:MGI.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0036335; P:intestinal stem cell homeostasis; IMP:MGI.
GO; GO:0030539; P:male genitalia development; IMP:MGI.
GO; GO:0072224; P:metanephric glomerulus development; IMP:UniProtKB.
GO; GO:0072282; P:metanephric nephron tubule morphogenesis; IMP:UniProtKB.
GO; GO:0050710; P:negative regulation of cytokine secretion; IMP:UniProtKB.
GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; IMP:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
GO; GO:0001649; P:osteoblast differentiation; IMP:UniProtKB.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:UniProtKB.
GO; GO:0007283; P:spermatogenesis; IMP:UniProtKB.
GO; GO:0035239; P:tube morphogenesis; IMP:MGI.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR002131; Gphrmn_rcpt_fam.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000372; LRRNT.
Pfam; PF00001; 7tm_1; 1.
Pfam; PF13855; LRR_8; 4.
Pfam; PF01462; LRRNT; 1.
PRINTS; PR00373; GLYCHORMONER.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM00369; LRR_TYP; 15.
SMART; SM00013; LRRNT; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE; PS51450; LRR; 15.
1: Evidence at protein level;
Alternative splicing; Biological rhythms; Cell membrane;
Complete proteome; Developmental protein; Differentiation;
Disulfide bond; G-protein coupled receptor; Glycoprotein; Immunity;
Innate immunity; Leucine-rich repeat; Membrane; Phosphoprotein;
Receptor; Reference proteome; Repeat; Signal; Spermatogenesis;
Transducer; Transmembrane; Transmembrane helix; Wnt signaling pathway.
SIGNAL 1 24 {ECO:0000255}.
CHAIN 25 951 Leucine-rich repeat-containing G-protein
coupled receptor 4.
/FTId=PRO_0000303240.
TOPO_DOM 25 544 Extracellular. {ECO:0000255}.
TRANSMEM 545 565 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 566 575 Cytoplasmic. {ECO:0000255}.
TRANSMEM 576 596 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 597 619 Extracellular. {ECO:0000255}.
TRANSMEM 620 640 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 641 661 Cytoplasmic. {ECO:0000255}.
TRANSMEM 662 682 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 683 703 Extracellular. {ECO:0000255}.
TRANSMEM 704 724 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 725 756 Cytoplasmic. {ECO:0000255}.
TRANSMEM 757 777 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 778 783 Extracellular. {ECO:0000255}.
TRANSMEM 784 804 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 805 951 Cytoplasmic. {ECO:0000255}.
DOMAIN 25 57 LRRNT.
REPEAT 58 79 LRR 1.
REPEAT 82 103 LRR 2.
REPEAT 106 127 LRR 3.
REPEAT 130 151 LRR 4.
REPEAT 154 177 LRR 5.
REPEAT 178 199 LRR 6.
REPEAT 202 223 LRR 7.
REPEAT 226 247 LRR 8.
REPEAT 249 270 LRR 9.
REPEAT 273 294 LRR 10.
REPEAT 320 341 LRR 11.
REPEAT 344 365 LRR 12.
REPEAT 366 387 LRR 13.
REPEAT 390 411 LRR 14.
REPEAT 414 435 LRR 15.
MOD_RES 920 920 Phosphoserine.
{ECO:0000250|UniProtKB:Q9BXB1}.
CARBOHYD 68 68 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 188 188 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 199 199 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 294 294 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 505 505 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 29 35 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 33 43 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 339 364 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 470 522 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 471 476 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 618 693 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VAR_SEQ 62 85 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_047137.
MUTAGEN 755 755 T->I: Confers constitutive activity.
{ECO:0000269|PubMed:23589304}.
CONFLICT 668 668 V -> L (in Ref. 4; AAH56637).
{ECO:0000305}.
CONFLICT 684 684 G -> R (in Ref. 4; AAH56637).
{ECO:0000305}.
CONFLICT 730 730 C -> F (in Ref. 3; BAC31882).
{ECO:0000305}.
CONFLICT 928 928 R -> P (in Ref. 4; AAH56637).
{ECO:0000305}.
SEQUENCE 951 AA; 104150 MW; AD41C68730A19C6B CRC64;
MPGPLRLLCF FALGLLGSAG PSGAAPPLCA APCSCDGDRR VDCSGKGLTA VPEGLSAFTQ
ALDISMNNIT QLPEDAFKNF PFLEELQLAG NDLSFIHPKA LSGLKELKVL TLQNNQLKTV
PSEAIRGLSA LQSLRLDANH ITSVPEDSFE GLVQLRHLWL DDNILTEVPV RPLSNLPTLQ
ALTLALNNIS SIPDFAFTNL SSLVVLHLHN NKIKSLSQHC FDGLDNLETL DLNYNNLDEF
PQAIKALPSL KELGFHSNSI SVIPDGAFAG NPLLRTIHLY DNPLSFVGNS AFHNLSDLHS
LVIRGASLVQ WFPNLAGTVH LESLTLTGTK ISSIPDDLCQ NQKMLRTLDL SYNDIRDLPS
FNGCRALEEI SLQRNQISLI KETTFQGLTS LRILDLSRNL IREIHSGAFA KLGTITNLDV
SFNELTSFPT EGLNGLNQLK LVGNFQLKDA LAARDFANLR SLSVPYAYQC CAFWGCDSYA
NLNTEDNSPQ DHSVTKEKGA TDAANATSTA ESEEHSQIII HCTPSTGAFK PCEYLLGSWM
IRLTVWFIFL VALLFNLLVI LTVFASCSSL PASKLFIGLI SVSNLLMGIY TGILTFLDAV
SWGRFAEFGI WWETGSGCKV AGSLAVFSSE SAVFLLTLAA VERSVFAKDV MKNGKSSHLR
QFQVAALVAL LGAAIAGCFP LFHGGQYSAS PLCLPFPTGE TPSLGFTVTL VLLNSLAFLL
MAIIYTKLYC NLEKEDPSEN SQSSMIKHVA WLIFTNCIFF CPVAFFSFAP LITAISISPE
IMKSVTLIFF PLPACLNPVL YVFFNPKFKD DWKLLKRRVT RKHGSVSVSI SSQGGCGEQD
FYYDCGMYSH LQGNLTVCDC CESFLLTKPV SCKHLIKSHS CPVLTVASCQ RPEAYWSDCG
TQSAHSDYAD EEDSFVSDSS DQVQACGRAC FYQSRGFPLV RYAYNLPRVR D


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