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Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26) (CD antigen CD37)

 CD37_HUMAN              Reviewed;         281 AA.
P11049; B4DVC1; Q3KPF9;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-NOV-1990, sequence version 2.
12-SEP-2018, entry version 155.
RecName: Full=Leukocyte antigen CD37;
AltName: Full=Tetraspanin-26;
Short=Tspan-26;
AltName: CD_antigen=CD37;
Name=CD37; Synonyms=TSPAN26;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=2466944; DOI=10.1084/jem.169.4.1497;
Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.;
"The primary structure of the human leukocyte antigen CD37, a species
homologue of the rat MRC OX-44 antigen.";
J. Exp. Med. 169:1497-1502(1989).
[2]
ERRATUM, AND SEQUENCE REVISION.
PubMed=2388030; DOI=10.1084/jem.172.3.1007;
Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.;
J. Exp. Med. 172:1007-1007(1990).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
Korn B., Zuo D., Hu Y., LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
INTERACTION WITH SCIMP.
PubMed=21930792; DOI=10.1128/MCB.05817-11;
Draber P., Vonkova I., Stepanek O., Hrdinka M., Kucova M.,
Skopcova T., Otahal P., Angelisova P., Horejsi V., Yeung M., Weiss A.,
Brdicka T.;
"SCIMP, a transmembrane adapter protein involved in major
histocompatibility complex class II signaling.";
Mol. Cell. Biol. 31:4550-4562(2011).
-!- SUBUNIT: Interacts with SCIMP. {ECO:0000269|PubMed:21930792}.
-!- INTERACTION:
P07948:LYN; NbExp=5; IntAct=EBI-6139068, EBI-79452;
P29350:PTPN6; NbExp=4; IntAct=EBI-6139068, EBI-78260;
P43405:SYK; NbExp=3; IntAct=EBI-6139068, EBI-78302;
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=P11049-1; Sequence=Displayed;
Name=2;
IsoId=P11049-2; Sequence=VSP_047228;
Note=Gene prediction based on EST data.;
Name=3;
IsoId=P11049-3; Sequence=VSP_047228, VSP_047229;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: B-lymphocytes.
-!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
{ECO:0000305}.
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EMBL; X14046; CAA32204.1; -; mRNA.
EMBL; AK301016; BAG62633.1; -; mRNA.
EMBL; CR541877; CAG46675.1; -; mRNA.
EMBL; BT019851; AAV38654.1; -; mRNA.
EMBL; AC010524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC011450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC106752; AAI06753.1; -; mRNA.
EMBL; BC110379; AAI10380.1; -; mRNA.
CCDS; CCDS12760.1; -. [P11049-1]
CCDS; CCDS46139.1; -. [P11049-2]
PIR; A47629; A47629.
RefSeq; NP_001035120.1; NM_001040031.1. [P11049-2]
RefSeq; NP_001765.1; NM_001774.2. [P11049-1]
RefSeq; XP_011525846.1; XM_011527544.2. [P11049-2]
RefSeq; XP_016883002.1; XM_017027513.1. [P11049-2]
UniGene; Hs.166556; -.
ProteinModelPortal; P11049; -.
IntAct; P11049; 9.
STRING; 9606.ENSP00000325708; -.
ChEMBL; CHEMBL3712880; -.
GuidetoPHARMACOLOGY; 3010; -.
iPTMnet; P11049; -.
PhosphoSitePlus; P11049; -.
SwissPalm; P11049; -.
BioMuta; CD37; -.
DMDM; 115983; -.
MaxQB; P11049; -.
PaxDb; P11049; -.
PeptideAtlas; P11049; -.
PRIDE; P11049; -.
ProteomicsDB; 52690; -.
DNASU; 951; -.
Ensembl; ENST00000323906; ENSP00000325708; ENSG00000104894. [P11049-1]
Ensembl; ENST00000426897; ENSP00000413151; ENSG00000104894. [P11049-2]
Ensembl; ENST00000598095; ENSP00000470394; ENSG00000104894. [P11049-3]
GeneID; 951; -.
KEGG; hsa:951; -.
UCSC; uc002pnd.4; human. [P11049-1]
CTD; 951; -.
DisGeNET; 951; -.
EuPathDB; HostDB:ENSG00000104894.11; -.
GeneCards; CD37; -.
HGNC; HGNC:1666; CD37.
HPA; CAB002492; -.
HPA; HPA032120; -.
HPA; HPA032121; -.
MIM; 151523; gene.
neXtProt; NX_P11049; -.
OpenTargets; ENSG00000104894; -.
PharmGKB; PA26213; -.
eggNOG; KOG3882; Eukaryota.
eggNOG; ENOG4111IRY; LUCA.
GeneTree; ENSGT00880000137858; -.
HOGENOM; HOG000230651; -.
HOVERGEN; HBG002324; -.
InParanoid; P11049; -.
KO; K06475; -.
OMA; RCCGWHS; -.
OrthoDB; EOG091G0H71; -.
PhylomeDB; P11049; -.
TreeFam; TF352892; -.
ChiTaRS; CD37; human.
GeneWiki; CD37; -.
GenomeRNAi; 951; -.
PRO; PR:P11049; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000104894; Expressed in 137 organ(s), highest expression level in leukocyte.
CleanEx; HS_CD37; -.
ExpressionAtlas; P11049; baseline and differential.
Genevisible; P11049; HS.
GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
GO; GO:0001772; C:immunological synapse; IDA:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
Gene3D; 1.10.1450.10; -; 1.
InterPro; IPR000301; Tetraspanin.
InterPro; IPR018499; Tetraspanin/Peripherin.
InterPro; IPR018503; Tetraspanin_CS.
InterPro; IPR008952; Tetraspanin_EC2_sf.
Pfam; PF00335; Tetraspannin; 1.
PIRSF; PIRSF002419; Tetraspanin; 1.
PRINTS; PR00259; TMFOUR.
SUPFAM; SSF48652; SSF48652; 2.
PROSITE; PS00421; TM4_1; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Glycoprotein; Membrane;
Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 281 Leukocyte antigen CD37.
/FTId=PRO_0000219209.
TOPO_DOM 1 17 Cytoplasmic. {ECO:0000255}.
TRANSMEM 18 38 Helical. {ECO:0000255}.
TOPO_DOM 39 59 Extracellular. {ECO:0000255}.
TRANSMEM 60 74 Helical. {ECO:0000255}.
TOPO_DOM 75 85 Cytoplasmic. {ECO:0000255}.
TRANSMEM 86 111 Helical. {ECO:0000255}.
TOPO_DOM 112 241 Extracellular. {ECO:0000255}.
TRANSMEM 242 266 Helical. {ECO:0000255}.
TOPO_DOM 267 281 Cytoplasmic. {ECO:0000255}.
CARBOHYD 170 170 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 183 183 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 188 188 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 1 68 Missing (in isoform 2 and isoform 3).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_047228.
VAR_SEQ 257 281 LGFMTLSIFLCRNLDHVYNRLARYR -> VIWPRPHPRSAL
NP (in isoform 3).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_047229.
SEQUENCE 281 AA; 31703 MW; 4342C5FB4479FDC8 CRC64;
MSAQESCLSL IKYFLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLA FVPLQIWSKV
LAISGIFTMG IALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRAQLERSLR
DVVEKTIQKY GTNPEETAAE ESWDYVQFQL RCCGWHYPQD WFQVLILRGN GSEAHRVPCS
CYNLSATNDS TILDKVILPQ LSRLGHLARS RHSADICAVP AESHIYREGC AQGLQKWLHN
NLISIVGICL GVGLLELGFM TLSIFLCRNL DHVYNRLARY R


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