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Leukocyte surface antigen CD47 (Integrin-associated protein) (IAP) (CD antigen CD47)

 CD47_MOUSE              Reviewed;         303 AA.
Q61735; Q921Z2;
27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
27-SEP-2005, sequence version 2.
20-JUN-2018, entry version 137.
RecName: Full=Leukocyte surface antigen CD47;
AltName: Full=Integrin-associated protein;
Short=IAP;
AltName: CD_antigen=CD47;
Flags: Precursor;
Name=Cd47;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND SUBCELLULAR LOCATION.
TISSUE=Pre-B cell;
PubMed=7691831; DOI=10.1083/jcb.123.2.485;
Lindberg F.P., Gresham H.D., Schwarz E., Brown E.J.;
"Molecular cloning of integrin-associated protein: an immunoglobulin
family member with multiple membrane spanning domains implicated in
alpha-v beta-3-dependent ligand binding.";
J. Cell Biol. 123:485-496(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
STRAIN=C57BL/6J; TISSUE=Stromal cell;
PubMed=9504415; DOI=10.1093/oxfordjournals.jbchem.a021895;
Furusawa T., Yanai N., Hara T., Miyajima A., Obinata M.;
"Integrin-associated protein (IAP, also termed CD47) is involved in
stroma-supported erythropoiesis.";
J. Biochem. 123:101-106(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE
SEQUENCE [LARGE SCALE MRNA] OF 83-303 (ISOFORM 2).
STRAIN=FVB/N; TISSUE=Mammary gland, and Salivary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PROTEIN SEQUENCE OF 86-99, AND IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=C57BL/6J; TISSUE=Brain;
Lubec G., Kang S.U.;
Submitted (APR-2007) to UniProtKB.
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Kidney, Lung, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Has a role in both cell adhesion by acting as an
adhesion receptor for THBS1 on platelets, and in the modulation of
integrins. Plays an important role in memory formation and
synaptic plasticity in the hippocampus. Receptor for SIRPA,
binding to which prevents maturation of immature dendritic cells
and inhibits cytokine production by mature dendritic cells.
Interaction with SIRPG mediates cell-cell adhesion, enhances
superantigen-dependent T-cell-mediated proliferation and
costimulates T-cell activation. May play a role in membrane
transport and/or integrin dependent signal transduction. May
prevent premature elimination of red blood cells. May be involved
in membrane permeability changes induced following virus infection
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer. Interacts with fibrinogen, PTPNS1, SIRPG, THBS1,
UBQLN1 and UBQLN2 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7691831};
Multi-pass membrane protein {ECO:0000269|PubMed:7691831}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q61735-1; Sequence=Displayed;
Name=2;
IsoId=Q61735-2; Sequence=VSP_015793;
-----------------------------------------------------------------------
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EMBL; Z25524; CAA80978.1; -; mRNA.
EMBL; AB012693; BAA25401.1; -; mRNA.
EMBL; BC009094; AAH09094.1; -; mRNA.
EMBL; BC012667; AAH12667.1; -; mRNA.
CCDS; CCDS28212.1; -. [Q61735-2]
PIR; S36646; S36646.
RefSeq; NP_034711.1; NM_010581.3. [Q61735-2]
RefSeq; XP_006521874.1; XM_006521811.3. [Q61735-1]
UniGene; Mm.31752; -.
UniGene; Mm.390865; -.
ProteinModelPortal; Q61735; -.
SMR; Q61735; -.
BioGrid; 200835; 2.
IntAct; Q61735; 5.
PhosphoSitePlus; Q61735; -.
SwissPalm; Q61735; -.
PeptideAtlas; Q61735; -.
PRIDE; Q61735; -.
Ensembl; ENSMUST00000084838; ENSMUSP00000099853; ENSMUSG00000055447. [Q61735-2]
GeneID; 16423; -.
KEGG; mmu:16423; -.
UCSC; uc007zkg.1; mouse. [Q61735-2]
UCSC; uc007zkh.1; mouse. [Q61735-1]
CTD; 961; -.
MGI; MGI:96617; Cd47.
GeneTree; ENSGT00390000007697; -.
HOGENOM; HOG000013020; -.
HOVERGEN; HBG003808; -.
InParanoid; Q61735; -.
KO; K06266; -.
OMA; VYMKFVA; -.
OrthoDB; EOG091G0HUR; -.
PhylomeDB; Q61735; -.
TreeFam; TF336026; -.
Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
Reactome; R-MMU-216083; Integrin cell surface interactions.
Reactome; R-MMU-391160; Signal regulatory protein family interactions.
Reactome; R-MMU-6798695; Neutrophil degranulation.
ChiTaRS; Cd47; mouse.
PRO; PR:Q61735; -.
Proteomes; UP000000589; Chromosome 16.
Bgee; ENSMUSG00000055447; -.
ExpressionAtlas; Q61735; baseline and differential.
Genevisible; Q61735; MM.
GO; GO:0070062; C:extracellular exosome; IDA:MGI.
GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0070053; F:thrombospondin receptor activity; ISO:MGI.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0016477; P:cell migration; ISO:MGI.
GO; GO:0008228; P:opsonization; IDA:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; ISO:MGI.
GO; GO:0022409; P:positive regulation of cell-cell adhesion; ISO:MGI.
GO; GO:0050729; P:positive regulation of inflammatory response; IMP:MGI.
GO; GO:0050766; P:positive regulation of phagocytosis; IDA:MGI.
GO; GO:0050870; P:positive regulation of T cell activation; ISO:MGI.
GO; GO:0009617; P:response to bacterium; IMP:MGI.
CDD; cd16090; IgV_CD47; 1.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR006704; CD47.
InterPro; IPR013147; CD47_TM.
InterPro; IPR013270; CD47_Vset.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR037805; IgV_CD47.
PANTHER; PTHR10613; PTHR10613; 1.
Pfam; PF04549; CD47; 1.
Pfam; PF08204; V-set_CD47; 1.
PROSITE; PS50835; IG_LIKE; 1.
1: Evidence at protein level;
Alternative splicing; Cell adhesion; Cell membrane; Complete proteome;
Direct protein sequencing; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Phosphoprotein;
Pyrrolidone carboxylic acid; Reference proteome; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 303 Leukocyte surface antigen CD47.
/FTId=PRO_0000042206.
TOPO_DOM 19 140 Extracellular. {ECO:0000255}.
TRANSMEM 141 161 Helical. {ECO:0000255}.
TOPO_DOM 162 173 Cytoplasmic. {ECO:0000255}.
TRANSMEM 174 194 Helical. {ECO:0000255}.
TOPO_DOM 195 206 Extracellular. {ECO:0000255}.
TRANSMEM 207 227 Helical. {ECO:0000255}.
TOPO_DOM 228 238 Cytoplasmic. {ECO:0000255}.
TRANSMEM 239 259 Helical. {ECO:0000255}.
TOPO_DOM 260 266 Extracellular. {ECO:0000255}.
TRANSMEM 267 287 Helical. {ECO:0000255}.
TOPO_DOM 288 303 Cytoplasmic. {ECO:0000255}.
DOMAIN 19 125 Ig-like V-type.
MOD_RES 19 19 Pyrrolidone carboxylic acid.
{ECO:0000250|UniProtKB:Q08722,
ECO:0000305}.
MOD_RES 87 87 Phosphoserine.
{ECO:0000250|UniProtKB:P97829}.
MOD_RES 89 89 Phosphoserine.
{ECO:0000250|UniProtKB:P97829}.
CARBOHYD 34 34 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 61 61 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 73 73 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 80 80 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 109 109 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 129 129 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 204 204 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 33 261 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 41 112 {ECO:0000255|PROSITE-ProRule:PRU00114}.
VAR_SEQ 131 131 T -> TAFNTDQGSACSYEEEKGGCKL (in isoform
2). {ECO:0000303|PubMed:15489334,
ECO:0000303|PubMed:7691831,
ECO:0000303|PubMed:9504415}.
/FTId=VSP_015793.
SEQUENCE 303 AA; 33098 MW; 87C0E6EF758FFF58 CRC64;
MWPLAAALLL GSCCCGSAQL LFSNVNSIEF TSCNETVVIP CIVRNVEAQS TEEMFVKWKL
NKSYIFIYDG NKNSTTTDQN FTSAKISVSD LINGIASLKM DKRDAMVGNY TCEVTELSRE
GKTVIELKNR TVSWFSPNEK ILIVIFPILA ILLFWGKFGI LTLKYKSSHT NKRIILLLVA
GLVLTVIVVV GAILLIPGEK PVKNASGLGL IVISTGILIL LQYNVFMTAF GMTSFTIAIL
ITQVLGYVLA LVGLCLCIMA CEPVHGPLLI SGLGIIALAE LLGLVYMKFV ASNQRTIQPP
RNR


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