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Leukocyte surface antigen CD47 (Integrin-associated protein) (IAP) (CD antigen CD47)

 CD47_BOVIN              Reviewed;         303 AA.
Q9N0K1;
27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
28-FEB-2018, entry version 87.
RecName: Full=Leukocyte surface antigen CD47;
AltName: Full=Integrin-associated protein;
Short=IAP;
AltName: CD_antigen=CD47;
Flags: Precursor;
Name=CD47;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Monocyte;
Brooke G.P., Howard C.J.;
"Cloning and distribution of cattle CD47.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Has a role in both cell adhesion by acting as an
adhesion receptor for THBS1 on platelets, and in the modulation of
integrins. Plays an important role in memory formation and
synaptic plasticity in the hippocampus. Receptor for SIRPA,
binding to which prevents maturation of immature dendritic cells
and inhibits cytokine production by mature dendritic cells.
Interaction with SIRPG mediates cell-cell adhesion, enhances
superantigen-dependent T-cell-mediated proliferation and
costimulates T-cell activation. May play a role in membrane
transport and/or integrin dependent signal transduction. May
prevent premature elimination of red blood cells. May be involved
in membrane permeability changes induced following virus infection
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer. Interacts with fibrinogen, PTPNS1, SIRPG, THBS1,
UBQLN1 and UBQLN2 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-----------------------------------------------------------------------
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EMBL; AJ245943; CAB76905.1; -; mRNA.
EMBL; AJ291474; CAC13139.1; -; mRNA.
UniGene; Bt.87076; -.
ProteinModelPortal; Q9N0K1; -.
SMR; Q9N0K1; -.
STRING; 9913.ENSBTAP00000048646; -.
PaxDb; Q9N0K1; -.
PRIDE; Q9N0K1; -.
eggNOG; ENOG410IJTS; Eukaryota.
eggNOG; ENOG41113GI; LUCA.
HOGENOM; HOG000013020; -.
HOVERGEN; HBG003808; -.
InParanoid; Q9N0K1; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
CDD; cd16090; IgV_CD47; 1.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR006704; CD47.
InterPro; IPR013147; CD47_TM.
InterPro; IPR013270; CD47_Vset.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR037805; IgV_CD47.
PANTHER; PTHR10613; PTHR10613; 1.
Pfam; PF04549; CD47; 1.
Pfam; PF08204; V-set_CD47; 1.
PROSITE; PS50835; IG_LIKE; 1.
2: Evidence at transcript level;
Cell adhesion; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein;
Pyrrolidone carboxylic acid; Reference proteome; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 303 Leukocyte surface antigen CD47.
/FTId=PRO_0000042205.
TOPO_DOM 19 140 Extracellular. {ECO:0000255}.
TRANSMEM 141 161 Helical. {ECO:0000255}.
TOPO_DOM 162 174 Cytoplasmic. {ECO:0000255}.
TRANSMEM 175 195 Helical. {ECO:0000255}.
TOPO_DOM 196 207 Extracellular. {ECO:0000255}.
TRANSMEM 208 228 Helical. {ECO:0000255}.
TOPO_DOM 229 236 Cytoplasmic. {ECO:0000255}.
TRANSMEM 237 257 Helical. {ECO:0000255}.
TOPO_DOM 258 266 Extracellular. {ECO:0000255}.
TRANSMEM 267 287 Helical. {ECO:0000255}.
TOPO_DOM 288 303 Cytoplasmic. {ECO:0000255}.
DOMAIN 19 125 Ig-like V-type.
MOD_RES 19 19 Pyrrolidone carboxylic acid.
{ECO:0000250|UniProtKB:Q08722,
ECO:0000305}.
MOD_RES 89 89 Phosphoserine.
{ECO:0000250|UniProtKB:P97829}.
CARBOHYD 34 34 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 50 50 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 109 109 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 204 204 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 33 261 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 41 112 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 303 AA; 33294 MW; DA1A2AEB50E25D57 CRC64;
MWPLVVVLLL GSVRCGSAQL IFNAIKSVEY TLCNQTVVIP CFVNNVETKN ITELYVRWKF
KGENIFIFDG SQRMSKPSSN FSSAEIAPSE LLRGIASLKM AKSDAVLGNY TCEVTELSRE
GETIIELKYR VVSWFSPNEN ILIVIFPVLA ILLFWGQFGI VTLKYKSNYT KEKAIFLLVA
GLLLTVLVIV GAFLFIPGGY STKNASGLGL IVLPTIILIL LHYCVFMIAM GMSSFTISIL
ILQLLGYVLS VVGFSLCVSE CIPVHGPLLI SGLGIIALAE LLGLVYMKCV ASNHRTIQPP
RNN


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