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Linker for activation of T-cells family member 1 (36 kDa phospho-tyrosine adapter protein) (pp36) (p36-38)

 LAT_RAT                 Reviewed;         241 AA.
O70601;
01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
23-MAY-2018, entry version 119.
RecName: Full=Linker for activation of T-cells family member 1;
AltName: Full=36 kDa phospho-tyrosine adapter protein;
Short=pp36;
AltName: Full=p36-38;
Name=Lat;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=PVG; TISSUE=Natural killer cell;
PubMed=9529333; DOI=10.1084/jem.187.7.1157;
Weber J.R., Orstavik S., Torgersen K.M., Danbolt N.C., Berg S.F.,
Ryan J.C., Tasken K., Imboden J.B., Vaage J.T.;
"Molecular cloning of the cDNA encoding pp36, a tyrosine-
phosphorylated adaptor protein selectively expressed by T cells and
natural killer cells.";
J. Exp. Med. 187:1157-1161(1998).
[2]
TISSUE SPECIFICITY.
PubMed=16160011; DOI=10.1182/blood-2005-06-2273;
Tedoldi S., Paterson J.C., Hansmann M.-L., Natkunam Y., Rudiger T.,
Angelisova P., Du M.Q., Roberton H., Roncador G., Sanchez L.,
Pozzobon M., Masir N., Barry R., Pileri S., Mason D.Y., Marafioti T.,
Horejsi V.;
"Transmembrane adaptor molecules: a new category of lymphoid-cell
markers.";
Blood 107:213-221(2006).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; SER-104; SER-109;
SER-112 AND SER-199, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE
SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Required for TCR (T-cell antigen receptor)- and pre-TCR-
mediated signaling, both in mature T-cells and during their
development. Involved in FCGR3 (low affinity immunoglobulin gamma
Fc region receptor III)-mediated signaling in natural killer cells
and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated
signaling in mast cells. Couples activation of these receptors and
their associated kinases with distal intracellular events such as
mobilization of intracellular calcium stores, PKC activation, MAPK
activation or cytoskeletal reorganization through the recruitment
of PLCG1, GRB2, GRAP2, and other signaling molecules (By
similarity). {ECO:0000250}.
-!- SUBUNIT: When phosphorylated, interacts directly with the PIK3R1
subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2,
GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS,
VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK. Interacts with
FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation
in thymocytes (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type III membrane protein {ECO:0000250}. Note=Present in lipid
rafts. {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in NK cells. Present in lymph node,
spleen and thymus (at protein level).
{ECO:0000269|PubMed:16160011}.
-!- PTM: Phosphorylated on tyrosines by ZAP70 upon TCR activation, or
by SYK upon other immunoreceptor activation; which leads to the
recruitment of multiple signaling molecules. Is one of the most
prominently tyrosine-phosphorylated proteins detected following
TCR engagement. May be dephosphorylated by PTPRJ (By similarity).
{ECO:0000250}.
-!- PTM: Palmitoylation of Cys-27 and Cys-30 is required for raft
targeting and efficient phosphorylation. {ECO:0000250}.
-!- MISCELLANEOUS: Engagement of killer inhibitory receptors (KIR)
disrupts the interaction of PLCG1 with LAT and blocks target cell-
induced activation of PLC, maybe by inducing the dephosphorylation
of LAT. {ECO:0000250}.
-----------------------------------------------------------------------
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EMBL; AJ001184; CAA04577.1; -; mRNA.
RefSeq; NP_110480.1; NM_030853.1.
UniGene; Rn.9773; -.
STRING; 10116.ENSRNOP00000023563; -.
iPTMnet; O70601; -.
PhosphoSitePlus; O70601; -.
PaxDb; O70601; -.
Ensembl; ENSRNOT00000023563; ENSRNOP00000023563; ENSRNOG00000017429.
GeneID; 81511; -.
KEGG; rno:81511; -.
UCSC; RGD:620802; rat.
CTD; 27040; -.
RGD; 620802; Lat.
eggNOG; ENOG410IW3X; Eukaryota.
eggNOG; ENOG4111EFT; LUCA.
GeneTree; ENSGT00390000014223; -.
HOGENOM; HOG000081810; -.
HOVERGEN; HBG018198; -.
InParanoid; O70601; -.
KO; K07362; -.
OMA; GSHRMPS; -.
OrthoDB; EOG091G0QKO; -.
PhylomeDB; O70601; -.
TreeFam; TF337741; -.
Reactome; R-RNO-114604; GPVI-mediated activation cascade.
Reactome; R-RNO-202433; Generation of second messenger molecules.
Reactome; R-RNO-2424491; DAP12 signaling.
Reactome; R-RNO-2454202; Fc epsilon receptor (FCERI) signaling.
Reactome; R-RNO-2871796; FCERI mediated MAPK activation.
Reactome; R-RNO-2871809; FCERI mediated Ca+2 mobilization.
Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
PRO; PR:O70601; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000017429; -.
Genevisible; O70601; RN.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0008180; C:COP9 signalosome; ISS:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0042629; C:mast cell granule; IEA:GOC.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
GO; GO:0010467; P:gene expression; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0002260; P:lymphocyte homeostasis; IEA:Ensembl.
GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
GO; GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl.
GO; GO:0007265; P:Ras protein signal transduction; IEA:Ensembl.
GO; GO:0050863; P:regulation of T cell activation; IEA:Ensembl.
InterPro; IPR008359; Linker_for_activat_Tcells_prot.
PANTHER; PTHR15586; PTHR15586; 2.
Pfam; PF15234; LAT; 1.
PRINTS; PR01781; LATPROTEIN.
1: Evidence at protein level;
Adaptive immunity; Cell membrane; Complete proteome; Immunity;
Lipoprotein; Mast cell degranulation; Membrane; Palmitate;
Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane;
Transmembrane helix.
CHAIN 1 241 Linker for activation of T-cells family
member 1.
/FTId=PRO_0000083327.
TOPO_DOM 1 4 Extracellular. {ECO:0000255}.
TRANSMEM 5 28 Helical; Signal-anchor for type III
membrane protein. {ECO:0000255}.
TOPO_DOM 29 241 Cytoplasmic. {ECO:0000255}.
REGION 136 139 Interaction with PLCG1. {ECO:0000250}.
REGION 175 178 Interaction with GRB2, GRAP2 and PIK3R1.
{ECO:0000250}.
REGION 195 198 Interaction with GRB2, GRAP2 and PIK3R1.
{ECO:0000250}.
MOD_RES 41 41 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 44 44 Phosphoserine.
{ECO:0000250|UniProtKB:O43561}.
MOD_RES 87 87 Phosphoserine.
{ECO:0000250|UniProtKB:O43561}.
MOD_RES 104 104 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 109 109 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 112 112 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 175 175 Phosphotyrosine.
{ECO:0000250|UniProtKB:O43561}.
MOD_RES 199 199 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 212 212 Phosphoserine.
{ECO:0000250|UniProtKB:O54957}.
MOD_RES 215 215 Phosphoserine.
{ECO:0000250|UniProtKB:O43561}.
MOD_RES 234 234 Phosphotyrosine.
{ECO:0000250|UniProtKB:O43561}.
LIPID 27 27 S-palmitoyl cysteine. {ECO:0000250}.
LIPID 30 30 S-palmitoyl cysteine. {ECO:0000250}.
SEQUENCE 241 AA; 26193 MW; FBD5C4D4BBCE4275 CRC64;
MEADALSPVE LGLLLLPFVV MLLAALCVRC RELPASYDSA STESLYPRSI LIKPPQITVP
RTPATSYPLV TSFPPLRQPD LLPIPRSPQP LGGSHRMPSS RQNSDDANSV ASYENQEPAR
KNVDEDEDED DYPEGYLVVL PDSSPAAVPV VSSAPVPSNP DLGDSAFSME SCEDYVNVPE
SEESAEASLD GSREYVNVSQ DAQPVIRAEL ASVTSQEVED EEEEDVDGEE APDYENLQEL
N


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