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Low density lipoprotein receptor (Low-density lipoprotein receptor isoform 1)

 F6W4Q9_CALJA            Unreviewed;       844 AA.
F6W4Q9;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
20-JUN-2018, sequence version 2.
10-OCT-2018, entry version 62.
SubName: Full=Low density lipoprotein receptor {ECO:0000313|Ensembl:ENSCJAP00000051207};
Name=LDLR {ECO:0000313|Ensembl:ENSCJAP00000051207};
Callithrix jacchus (White-tufted-ear marmoset).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000051207, ECO:0000313|Proteomes:UP000008225};
[1] {ECO:0000313|Ensembl:ENSCJAP00000051207, ECO:0000313|Proteomes:UP000008225}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSCJAP00000051207}
IDENTIFICATION.
Ensembl;
Submitted (JUN-2011) to UniProtKB.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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STRING; 9483.ENSCJAP00000051207; -.
Ensembl; ENSCJAT00000053995; ENSCJAP00000051207; ENSCJAG00000005907.
CTD; 3949; -.
eggNOG; ENOG410KD0U; Eukaryota.
eggNOG; ENOG410Z5FJ; LUCA.
GeneTree; ENSGT00760000118968; -.
OMA; INVTLCE; -.
OrthoDB; EOG091G01MX; -.
TreeFam; TF351700; -.
Proteomes; UP000008225; Unplaced.
GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
GO; GO:0005905; C:clathrin-coated pit; IEA:Ensembl.
GO; GO:0005769; C:early endosome; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005770; C:late endosome; IEA:Ensembl.
GO; GO:0005764; C:lysosome; IEA:Ensembl.
GO; GO:1990666; C:PCSK9-LDLR complex; IEA:Ensembl.
GO; GO:0043235; C:receptor complex; IEA:Ensembl.
GO; GO:0036477; C:somatodendritic compartment; IEA:Ensembl.
GO; GO:0097443; C:sorting endosome; IEA:Ensembl.
GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:Ensembl.
GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:Ensembl.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0030229; F:very-low-density lipoprotein particle receptor activity; IEA:Ensembl.
GO; GO:0097242; P:amyloid-beta clearance; IEA:Ensembl.
GO; GO:0071398; P:cellular response to fatty acid; IEA:Ensembl.
GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IEA:Ensembl.
GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
GO; GO:0070508; P:cholesterol import; IEA:Ensembl.
GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO; GO:0030299; P:intestinal cholesterol absorption; IEA:Ensembl.
GO; GO:0042159; P:lipoprotein catabolic process; IEA:Ensembl.
GO; GO:0007616; P:long-term memory; IEA:Ensembl.
GO; GO:0034383; P:low-density lipoprotein particle clearance; IEA:Ensembl.
GO; GO:1905907; P:negative regulation of amyloid fibril formation; IEA:Ensembl.
GO; GO:0061889; P:negative regulation of astrocyte activation; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:1903979; P:negative regulation of microglial cell activation; IEA:Ensembl.
GO; GO:0015914; P:phospholipid transport; IEA:Ensembl.
GO; GO:1900223; P:positive regulation of amyloid-beta clearance; IEA:Ensembl.
GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0010986; P:positive regulation of lipoprotein particle clearance; IEA:Ensembl.
GO; GO:1905167; P:positive regulation of lysosomal protein catabolic process; IEA:Ensembl.
GO; GO:0010867; P:positive regulation of triglyceride biosynthetic process; IEA:Ensembl.
GO; GO:0090118; P:receptor-mediated endocytosis involved in cholesterol transport; IEA:Ensembl.
GO; GO:0090181; P:regulation of cholesterol metabolic process; IEA:Ensembl.
GO; GO:0010899; P:regulation of phosphatidylcholine catabolic process; IEA:Ensembl.
GO; GO:0061771; P:response to caloric restriction; IEA:Ensembl.
CDD; cd00112; LDLa; 6.
Gene3D; 2.120.10.30; -; 1.
InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
InterPro; IPR018097; EGF_Ca-bd_CS.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR036055; LDL_receptor-like_sf.
InterPro; IPR023415; LDLR_class-A_CS.
InterPro; IPR000033; LDLR_classB_rpt.
InterPro; IPR002172; LDrepeatLR_classA_rpt.
Pfam; PF07645; EGF_CA; 1.
Pfam; PF00057; Ldl_recept_a; 6.
Pfam; PF00058; Ldl_recept_b; 5.
PRINTS; PR00261; LDLRECEPTOR.
SMART; SM00181; EGF; 3.
SMART; SM00179; EGF_CA; 2.
SMART; SM00192; LDLa; 6.
SMART; SM00135; LY; 5.
SUPFAM; SSF57184; SSF57184; 2.
SUPFAM; SSF57424; SSF57424; 5.
PROSITE; PS00010; ASX_HYDROXYL; 1.
PROSITE; PS01186; EGF_2; 2.
PROSITE; PS50026; EGF_3; 2.
PROSITE; PS01187; EGF_CA; 1.
PROSITE; PS01209; LDLRA_1; 3.
PROSITE; PS50068; LDLRA_2; 6.
PROSITE; PS51120; LDLRB; 5.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000008225};
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124,
ECO:0000256|SAAS:SAAS00601599};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
ECO:0000256|SAAS:SAAS00032677};
Membrane {ECO:0000256|SAAS:SAAS00492819, ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000008225};
Repeat {ECO:0000256|SAAS:SAAS00594563};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00492819,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00492819,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 22 {ECO:0000256|SAM:SignalP}.
CHAIN 23 844 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5015363604.
TRANSMEM 771 794 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 298 337 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 338 377 EGF-like. {ECO:0000259|PROSITE:PS50026}.
REPEAT 423 469 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 470 512 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 513 556 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 557 601 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 602 642 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
DISULFID 28 40 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 35 53 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 93 105 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 100 118 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 112 127 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 132 144 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 139 157 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 181 193 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 188 206 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 200 215 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 220 232 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 227 245 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 239 254 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 268 286 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 342 352 {ECO:0000256|PROSITE-ProRule:PRU00076}.
SEQUENCE 844 AA; 93998 MW; B1F4F558B661D38E CRC64;
FFFYFFFLRW SFVLLLLPRL ECNVGNRCER NEFQCQDGKC ISYKWVCDGR PECQDGSDES
QETCCESPLG VILPKYYRCD GLGPSFPAVP KTCSQDEFRC HDGKCISKQF LCDSEPDCLD
GSDEDSCPMV TCGPASFRCN SSTCIPQLWA CDNDPDCEDG SDEWPERCGG LDVSQQNNGP
CSAFEFQCRS GECIHSGWHC DGDPDCKDKS DEENCTVATC RPDEFQCSDG NCIHGSRQCD
QENDCKDMSD EVGCVNVTLC EGPNKFKCHS GECIALNKVC NSARDCRDWS DEPLKECGTN
ECLDNNGGCS HICNDLKIGH ECLCPDGFQL VAQRRCEDID ECQDPDTCSQ LCVNLEGSYK
CQCEEGFQLD PHTKACKAVG SIAYLIFTNR HEVRKMTLDR SEYTSLIPNL RNVVALDMEV
ASNRIYWSDL SQRVIYSTQL DGAHGFSSYN TVISKDLQAP DGLAVDWIHS NIYWTDSVLG
TVSVADTRGV KRKTLFRETG SKPRAIVVDP VHGFMYWTDW GISAKIKKGG LNGVDVYSLV
TDNIQWPNGI TLDLPRGRLY WADSKLHSIS SIDVNGGNRK TILEDEDRLA HPFSLAIFED
KVFWTDIINE AIFSANRLTG SDVHLLAENL LSPEDMVLFH NRTQPSGVNW CERTTLSNGG
CQYLCLPAPQ INPRSPKFTC ACPDGMLLAR DMRSCLTEAE PTVATQETST VRRMGSSTAA
RTQHTTTQPV ADTSRLPGST PELTTAEIVT MSHQALGDVA GQGTEEKPRS VGALSIILPI
VLLVFLCVGA FLLWRNWRLK SINSINFDNP VYQKTTEDEV HICRSQDGYS YPSRQMVSLE
DDVA


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