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Low density lipoprotein receptor (Low-density lipoprotein receptor isoform 1)

 F6W4Q9_CALJA            Unreviewed;       860 AA.
F6W4Q9;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
28-MAR-2018, entry version 56.
SubName: Full=Low density lipoprotein receptor {ECO:0000313|Ensembl:ENSCJAP00000051207};
SubName: Full=Low-density lipoprotein receptor isoform 1 {ECO:0000313|EMBL:JAB05713.1};
Name=LDLR {ECO:0000313|EMBL:JAB05713.1,
ECO:0000313|Ensembl:ENSCJAP00000051207};
Callithrix jacchus (White-tufted-ear marmoset).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000051207, ECO:0000313|Proteomes:UP000008225};
[1] {ECO:0000313|Ensembl:ENSCJAP00000051207, ECO:0000313|Proteomes:UP000008225}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSCJAP00000051207}
IDENTIFICATION.
Ensembl;
Submitted (JUN-2011) to UniProtKB.
[3] {ECO:0000313|EMBL:JAB05713.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Bladder {ECO:0000313|EMBL:JAB05713.1}, and
Skeletal muscle {ECO:0000313|EMBL:JAB38508.1};
PubMed=25243066; DOI=10.1186/2047-217X-3-14;
Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
Moriyama E.N., French J.A., Norgren R.B.Jr.;
"De novo assembly of the common marmoset transcriptome from NextGen
mRNA sequences.";
Gigascience 3:14-14(2014).
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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EMBL; ACFV01114053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01114054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01114055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01114056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACFV01114057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; GAMT01006148; JAB05713.1; -; mRNA.
EMBL; GAMQ01003343; JAB38508.1; -; mRNA.
RefSeq; XP_002761791.1; XM_002761745.3.
STRING; 9483.ENSCJAP00000051207; -.
Ensembl; ENSCJAT00000053995; ENSCJAP00000051207; ENSCJAG00000005907.
GeneID; 100385319; -.
KEGG; cjc:100385319; -.
CTD; 3949; -.
eggNOG; ENOG410KD0U; Eukaryota.
eggNOG; ENOG410Z5FJ; LUCA.
GeneTree; ENSGT00760000118968; -.
KO; K12473; -.
OMA; INVTLCE; -.
OrthoDB; EOG091G01MX; -.
TreeFam; TF351700; -.
Proteomes; UP000008225; Chromosome 22.
GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
GO; GO:0005905; C:clathrin-coated pit; IEA:Ensembl.
GO; GO:0005769; C:early endosome; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005770; C:late endosome; IEA:Ensembl.
GO; GO:0005764; C:lysosome; IEA:Ensembl.
GO; GO:1990666; C:PCSK9-LDLR complex; IEA:Ensembl.
GO; GO:0043235; C:receptor complex; IEA:Ensembl.
GO; GO:0036477; C:somatodendritic compartment; IEA:Ensembl.
GO; GO:0097443; C:sorting endosome; IEA:Ensembl.
GO; GO:0001540; F:amyloid-beta binding; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:Ensembl.
GO; GO:0005041; F:low-density lipoprotein receptor activity; IEA:Ensembl.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0030229; F:very-low-density lipoprotein particle receptor activity; IEA:Ensembl.
GO; GO:0097242; P:amyloid-beta clearance; IEA:Ensembl.
GO; GO:0071398; P:cellular response to fatty acid; IEA:Ensembl.
GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IEA:Ensembl.
GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
GO; GO:0070508; P:cholesterol import; IEA:Ensembl.
GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
GO; GO:0030299; P:intestinal cholesterol absorption; IEA:Ensembl.
GO; GO:0042159; P:lipoprotein catabolic process; IEA:Ensembl.
GO; GO:0007616; P:long-term memory; IEA:Ensembl.
GO; GO:0034383; P:low-density lipoprotein particle clearance; IEA:Ensembl.
GO; GO:1905907; P:negative regulation of amyloid fibril formation; IEA:Ensembl.
GO; GO:0061889; P:negative regulation of astrocyte activation; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:1903979; P:negative regulation of microglial cell activation; IEA:Ensembl.
GO; GO:0015914; P:phospholipid transport; IEA:Ensembl.
GO; GO:1900223; P:positive regulation of amyloid-beta clearance; IEA:Ensembl.
GO; GO:0045807; P:positive regulation of endocytosis; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
GO; GO:0010986; P:positive regulation of lipoprotein particle clearance; IEA:Ensembl.
GO; GO:1905167; P:positive regulation of lysosomal protein catabolic process; IEA:Ensembl.
GO; GO:0010867; P:positive regulation of triglyceride biosynthetic process; IEA:Ensembl.
GO; GO:0090118; P:receptor-mediated endocytosis involved in cholesterol transport; IEA:Ensembl.
GO; GO:2000188; P:regulation of cholesterol homeostasis; IEA:Ensembl.
GO; GO:0090181; P:regulation of cholesterol metabolic process; IEA:Ensembl.
GO; GO:0010899; P:regulation of phosphatidylcholine catabolic process; IEA:Ensembl.
GO; GO:0061771; P:response to caloric restriction; IEA:Ensembl.
CDD; cd00112; LDLa; 7.
Gene3D; 2.120.10.30; -; 1.
InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
InterPro; IPR018097; EGF_Ca-bd_CS.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR036055; LDL_receptor-like_sf.
InterPro; IPR023415; LDLR_class-A_CS.
InterPro; IPR000033; LDLR_classB_rpt.
InterPro; IPR002172; LDrepeatLR_classA_rpt.
Pfam; PF07645; EGF_CA; 1.
Pfam; PF00057; Ldl_recept_a; 7.
Pfam; PF00058; Ldl_recept_b; 5.
PRINTS; PR00261; LDLRECEPTOR.
SMART; SM00181; EGF; 3.
SMART; SM00179; EGF_CA; 2.
SMART; SM00192; LDLa; 7.
SMART; SM00135; LY; 5.
SUPFAM; SSF57184; SSF57184; 2.
SUPFAM; SSF57424; SSF57424; 6.
PROSITE; PS00010; ASX_HYDROXYL; 1.
PROSITE; PS01186; EGF_2; 2.
PROSITE; PS50026; EGF_3; 2.
PROSITE; PS01187; EGF_CA; 1.
PROSITE; PS01209; LDLRA_1; 3.
PROSITE; PS50068; LDLRA_2; 7.
PROSITE; PS51120; LDLRB; 5.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000008225};
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
ECO:0000256|SAAS:SAAS00601599};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
ECO:0000256|SAAS:SAAS00032677};
Lipoprotein {ECO:0000313|EMBL:JAB05713.1};
Membrane {ECO:0000256|SAAS:SAAS00492819, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000313|EMBL:JAB05713.1};
Reference proteome {ECO:0000313|Proteomes:UP000008225};
Repeat {ECO:0000256|SAAS:SAAS00594563};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00492819,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00492819,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 22 {ECO:0000256|SAM:SignalP}.
CHAIN 23 860 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014090215.
TRANSMEM 787 810 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 314 353 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 354 393 EGF-like. {ECO:0000259|PROSITE:PS50026}.
REPEAT 439 485 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 486 528 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 529 572 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 573 617 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
REPEAT 618 658 LDL-receptor class B.
{ECO:0000256|PROSITE-ProRule:PRU00461}.
DISULFID 27 39 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 34 52 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 89 104 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 109 121 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 116 134 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 128 143 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 148 160 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 155 173 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 197 209 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 204 222 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 216 231 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 236 248 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 243 261 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 255 270 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 284 302 {ECO:0000256|PROSITE-ProRule:PRU00124}.
DISULFID 358 368 {ECO:0000256|PROSITE-ProRule:PRU00076}.
SEQUENCE 860 AA; 95353 MW; 8C6C41EEB399B43E CRC64;
MGPWGWELRW TVALLLYAAG AAVGNRCERN EFQCQDGKCI SYKWVCDGRP ECQDGSDESQ
ETCLSVSCRS EDFSCGGRVN RCIPQLWRCD GQVDCENGSD EQGCVPKTCS QDEFRCHDGK
CISKQFLCDS EPDCLDGSDE DSCPMVTCGP ASFRCNSSTC IPQLWACDND PDCEDGSDEW
PERCGGLDVS QQNNGPCSAF EFQCRSGECI HSGWHCDGDP DCKDKSDEDN CTVATCRPDE
FQCSDGNCIH GSRQCDQEND CKDMSDEVGC VNVTLCEGPN KFKCHSGECI ALNKVCNSAR
DCRDWSDEPL KECGTNECLD NNGGCSHICN DLKIGHECLC PDGFQLVAQR RCEDIDECQD
PDTCSQLCVN LEGSYKCQCE EGFQLDPHTK ACKAVGSIAY LIFTNRHEVR KMTLDRSEYT
SLIPNLRNVV ALDMEVASNR IYWSDLSQRV IYSTQLDGAH GFSSYNTVIS KDLQAPDGLA
VDWIHSNIYW TDSVLGTVSV ADTRGVKRKT LFRETGSKPR AIVVDPVHGF MYWTDWGISA
KIKKGGLNGV DVYSLVTDNI QWPNGITLDL PRGRLYWADS KLHSISSIDV NGGNRKTILE
DEDRLAHPFS LAIFEDKVFW TDIINEAIFS ANRLTGSDVH LLAENLLSPE DMVLFHNRTQ
PSGVNWCERT TLSNGGCQYL CLPAPQINPR SPKFTCACPD GMLLARDMRS CLTEAEPTVA
TQETSTVRRM GSSTAARTQH TTTQPVADTS RLPGSTPELT TAEIVTMSHQ ALGDVAGRGT
EEKPRSVGAL SIILPIVLLV FLCVGAFLLW RNWRLKSINS INFDNPVYQK TTEDEVHICR
SQDGYSYPSR QMVSLEDDVA


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